Page last updated: 2024-08-07 13:48:48
Aurora kinase C
An aurora kinase C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQB9]
Synonyms
EC 2.7.11.1;
Aurora 3;
Aurora/IPL1-related kinase 3;
ARK-3;
Aurora-related kinase 3;
Aurora/IPL1/Eg2 protein 2;
Serine/threonine-protein kinase 13;
Serine/threonine-protein kinase aurora-C
Research
Bioassay Publications (36)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (44.44) | 29.6817 |
| 2010's | 15 (41.67) | 24.3611 |
| 2020's | 5 (13.89) | 2.80 |
Compounds (97)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| indirubin-3'-monoxime | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| imatinib | Homo sapiens (human) | IC50 | 37.8625 | 1 | 8 |
| staurosporine | Homo sapiens (human) | IC50 | 0.0022 | 2 | 2 |
| 2-(4-morpholinoanilino)-6-cyclohexylaminopurine | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| 6-bromoindirubin-3'-oxime | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| su 6656 | Homo sapiens (human) | IC50 | 0.0170 | 1 | 1 |
| orantinib | Homo sapiens (human) | IC50 | 0.2100 | 1 | 1 |
| vx680 | Homo sapiens (human) | IC50 | 1.4649 | 6 | 26 |
| vx680 | Homo sapiens (human) | Ki | 0.0286 | 14 | 19 |
| cyc 116 | Homo sapiens (human) | IC50 | 0.0650 | 1 | 1 |
| pha 680632 | Homo sapiens (human) | IC50 | 0.1200 | 3 | 3 |
| danusertib | Homo sapiens (human) | IC50 | 0.0610 | 4 | 4 |
| danusertib | Homo sapiens (human) | Ki | 0.0610 | 1 | 1 |
| azd 1152 | Homo sapiens (human) | IC50 | 0.0627 | 2 | 4 |
| mln8054 | Homo sapiens (human) | IC50 | 0.0118 | 1 | 3 |
| azd 1152-hqpa | Homo sapiens (human) | Ki | 0.0170 | 1 | 1 |
| cct129202 | Homo sapiens (human) | IC50 | 0.2270 | 1 | 1 |
| mk 5108 | Homo sapiens (human) | IC50 | 0.0120 | 1 | 1 |
| amg 900 | Homo sapiens (human) | IC50 | 0.0010 | 1 | 1 |
| sns 314 | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]anilino]-5-fluoro-4-pyrimidinyl]amino]benzamide | Homo sapiens (human) | IC50 | 0.6051 | 1 | 3 |
| Mps1-IN-2 | Homo sapiens (human) | IC50 | 0.1450 | 1 | 1 |
| abt-348 | Homo sapiens (human) | IC50 | 0.0070 | 1 | 1 |
| gsk 1070916 | Homo sapiens (human) | IC50 | 0.0065 | 4 | 3 |
| gsk 1070916 | Homo sapiens (human) | Ki | 0.0015 | 3 | 3 |
| urmc-099 | Homo sapiens (human) | IC50 | 0.2900 | 1 | 1 |
| centrinone | Homo sapiens (human) | IC50 | 0.4930 | 1 | 1 |
| 7-bromoindirubin-3'-oxime | Homo sapiens (human) | IC50 | 0.4000 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sb 202190 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| imatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| pyrazolanthrone | Homo sapiens (human) | Kd | 5.3000 | 1 | 1 |
| staurosporine | Homo sapiens (human) | Kd | 0.0190 | 3 | 3 |
| gefitinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| lestaurtinib | Homo sapiens (human) | Kd | 0.0041 | 2 | 2 |
| vatalanib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| ruboxistaurin | Homo sapiens (human) | Kd | 7.6667 | 3 | 3 |
| canertinib | Homo sapiens (human) | Kd | 3.0333 | 3 | 3 |
| birb 796 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| cyc 202 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| enzastaurin | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| erlotinib | Homo sapiens (human) | Kd | 0.6000 | 2 | 2 |
| lapatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| sorafenib | Homo sapiens (human) | Kd | 0.2100 | 3 | 3 |
| pd 173955 | Homo sapiens (human) | Kd | 5.1000 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bms 387032 | Homo sapiens (human) | Kd | 7.5000 | 2 | 2 |
| tandutinib | Homo sapiens (human) | Kd | 1.6000 | 3 | 3 |
| vx-745 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| dasatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| zd 6474 | Homo sapiens (human) | Kd | 1.5000 | 2 | 2 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| alvocidib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| bosutinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 11248 | Homo sapiens (human) | Kd | 0.2560 | 5 | 5 |
| jnj-7706621 | Homo sapiens (human) | Kd | 0.0860 | 1 | 1 |
| vx680 | Homo sapiens (human) | Kd | 0.0062 | 3 | 3 |
| ekb 569 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| axitinib | Homo sapiens (human) | Kd | 0.0013 | 1 | 1 |
| pd 184352 | Homo sapiens (human) | Kd | 1.8000 | 1 | 1 |
| bms345541 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| midostaurin | Homo sapiens (human) | Kd | 0.1700 | 3 | 3 |
| ki 20227 | Homo sapiens (human) | Kd | 0.1500 | 1 | 1 |
| cp 724714 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pi103 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| hki 272 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tofacitinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| cediranib | Homo sapiens (human) | Kd | 2.1000 | 1 | 1 |
| masitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pazopanib | Homo sapiens (human) | Kd | 0.7500 | 2 | 2 |
| azd 6244 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 14813 | Homo sapiens (human) | Kd | 0.8100 | 2 | 2 |
| bibw 2992 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tg100-115 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pha 665752 | Homo sapiens (human) | Kd | 0.3000 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Kd | 0.0410 | 1 | 1 |
| brivanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| at 7519 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bi 2536 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| nvp-ast487 | Homo sapiens (human) | Kd | 0.7400 | 2 | 2 |
| kw 2449 | Homo sapiens (human) | Kd | 0.0590 | 1 | 1 |
| abt 869 | Homo sapiens (human) | Kd | 0.0710 | 2 | 2 |
| gw 2580 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| crizotinib | Homo sapiens (human) | Kd | 4.3000 | 1 | 1 |
| chir-265 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| motesanib | Homo sapiens (human) | Kd | 1.9000 | 2 | 2 |
| mln8054 | Homo sapiens (human) | Kd | 0.0260 | 2 | 2 |
| GDC-0879 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 461364 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| azd 1152-hqpa | Homo sapiens (human) | Kd | 0.0044 | 2 | 2 |
| nvp-tae684 | Homo sapiens (human) | Kd | 0.0330 | 1 | 1 |
| fedratinib | Homo sapiens (human) | Kd | 0.3500 | 1 | 1 |
| gsk690693 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gdc 0941 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| plx 4720 | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
| sgx 523 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| quizartinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| incb-018424 | Homo sapiens (human) | Kd | 8.7000 | 1 | 1 |
| gsk 1838705a | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 1363089 | Homo sapiens (human) | Kd | 0.0120 | 1 | 1 |
| xmd 8-92 | Homo sapiens (human) | Kd | 0.0800 | 1 | 1 |
| gsk 1070916 | Homo sapiens (human) | EC50 | 0.0460 | 1 | 0 |
| chir 258 | Homo sapiens (human) | Kd | 1.1000 | 2 | 2 |
| nintedanib | Homo sapiens (human) | Kd | 0.1900 | 1 | 1 |
| pp242 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| protein kinase activity | molecular function | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640] |
| protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
| protein serine/threonine/tyrosine kinase activity | molecular function | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| protein serine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| condensed chromosome | cellular component | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. [GOC:elh] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| spindle | cellular component | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. [ISBN:0198547684] |
| midbody | cellular component | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194] |
| spindle midzone | cellular component | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749] |
Active In
This protein is active in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| kinetochore | cellular component | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:elh] |
| spindle midzone | cellular component | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749] |
| spindle pole centrosome | cellular component | A centrosome from which one pole of a mitotic or meiotic spindle is organized. [GOC:mah] |
| spindle microtubule | cellular component | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. [ISBN:0815316194] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| chromosome passenger complex | cellular component | A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. [GOC:vw, PMID:16824200, PMID:19570910] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein phosphorylation | biological process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
| attachment of spindle microtubules to kinetochore | biological process | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. [GOC:vw, PMID:10322137] |
| positive regulation of cytokinesis | biological process | Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah] |
| mitotic spindle midzone assembly | biological process | The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| meiotic cell cycle | biological process | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. [GOC:ai] |
| regulation of cytokinesis | biological process | Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. [GOC:mah] |
| mitotic spindle organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:go_curators, GOC:mah] |