Proteins > ATP-dependent molecular chaperone HSP82
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ATP-dependent molecular chaperone HSP82
A protein that is a translation product of the HSP82 gene in yeast. [PRO:DNx, UniProtKB:P02829]
Synonyms
82 kDa heat shock protein;
Heat shock protein Hsp90 heat-inducible isoform
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| geldanamycin | Saccharomyces cerevisiae S288C | Kd | 1.2000 | 1 | 1 |
| monorden | Saccharomyces cerevisiae S288C | Kd | 0.0190 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| adenosine diphosphate | Saccharomyces cerevisiae S288C | Km | 150.0000 | 1 | 1 |
Discovery and development of heat shock protein 90 inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 17, Issue:6, 2009
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 15, Issue:14, 2005
Discovery and development of heat shock protein 90 inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 17, Issue:6, 2009
Identification of new Hsp90 inhibitors by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 19, Issue:16, 2009
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 15, Issue:14, 2005
Discovery and development of heat shock protein 90 inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 17, Issue:6, 2009
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.Chemistry & biology, , Volume: 13, Issue:11, 2006
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.Chemistry & biology, , Volume: 11, Issue:6, 2004