Regulatory-associated protein of mTOR

A regulatory-associated protein of mTOR that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N122]

Synonyms

Raptor;
p150 target of rapamycin (TOR)-scaffold protein

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	8 (88.89)	24.3611
2020's	1 (11.11)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sirolimus	Homo sapiens (human)	IC50	0.2250	2	2
everolimus	Homo sapiens (human)	IC50	0.0000	1	1
pi103	Homo sapiens (human)	IC50	0.0200	2	2
dactolisib	Homo sapiens (human)	IC50	0.0440	1	1
ku 0063794	Homo sapiens (human)	IC50	0.3350	2	2
azd2014	Homo sapiens (human)	IC50	0.2000	1	1
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	Homo sapiens (human)	IC50	0.0139	2	2
4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester	Homo sapiens (human)	IC50	0.0050	1	1
5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine	Homo sapiens (human)	IC50	0.0010	1	1
torin 1	Homo sapiens (human)	IC50	0.0020	1	1
torin 2	Homo sapiens (human)	IC50	0.0100	1	1
cc214-2	Homo sapiens (human)	IC50	0.2940	3	3
cc-223	Homo sapiens (human)	IC50	0.0300	1	1
cc-115	Homo sapiens (human)	IC50	0.0230	1	1
pp242	Homo sapiens (human)	IC50	0.0080	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
torin 2	Homo sapiens (human)	EC50	0.0002	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein serine/threonine kinase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. [GOC:mah]
protein kinase activator activity	molecular function	Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]
protein-macromolecule adaptor activity	molecular function	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
14-3-3 protein binding	molecular function	Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]
enzyme-substrate adaptor activity	molecular function	An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity. [PMID:16250895, PMID:34358446]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoplasmic stress granule	cellular component	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
TORC1 complex	cellular component	A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]

Involved In

This protein is involved in 28 target(s):

Target	Category	Definition
regulation of cell growth	biological process	Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
positive regulation of endothelial cell proliferation	biological process	Any process that activates or increases the rate or extent of endothelial cell proliferation. [GOC:add]
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
regulation of cell size	biological process	Any process that modulates the size of a cell. [GOC:go_curators]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
negative regulation of autophagy	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
positive regulation of peptidyl-threonine phosphorylation	biological process	Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]
positive regulation of cell growth	biological process	Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
cellular response to nutrient levels	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]
TOR signaling	biological process	The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. [PMID:12372295]
positive regulation of TOR signaling	biological process	Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]
positive regulation of peptidyl-serine phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
social behavior	biological process	Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
TORC1 signaling	biological process	A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]
positive regulation of osteoclast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]
positive regulation of glycolytic process	biological process	Any process that activates or increases the frequency, rate or extent of glycolysis. [GOC:go_curators]
positive regulation of transcription by RNA polymerase III	biological process	Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III. [GOC:go_curators, GOC:txnOH]
positive regulation of lipid biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]
cellular response to amino acid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah]
cellular response to L-leucine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus. [GOC:mah]
cellular response to glucose stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
cellular response to osmotic stress	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]
positive regulation of G1/S transition of mitotic cell cycle	biological process	Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
positive regulation of odontoblast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of odontoblast differentiation. [GOC:TermGenie]
positive regulation of pentose-phosphate shunt	biological process	Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt. [GO_REF:0000058, GOC:TermGenie, PMID:19015259]
regulation of autophagy	biological process	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
cellular response to starvation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl]