Proteins > cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Page last updated: 2024-08-07 15:59:16
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
A protein that is a translation product of the Pde4b gene in rat. [PRO:DNx, UniProtKB:P14646]
Synonyms
EC 3.1.4.53;
DPDE4
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (22)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| rolipram | Rattus norvegicus (Norway rat) | Inhibition | 44.0750 | 4 | 4 |
| rolipram | Rattus norvegicus (Norway rat) | Log IC50 | 0.0057 | 1 | 1 |
| cilomilast | Rattus norvegicus (Norway rat) | Inhibition | 60.2750 | 4 | 4 |
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).Bioorganic & medicinal chemistry letters, , Jun-07, Volume: 14, Issue:11, 2004
Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics.Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003
Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002
Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.Bioorganic & medicinal chemistry letters, , Mar-12, Volume: 11, Issue:5, 2001
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ).Journal of medicinal chemistry, , Oct-19, Volume: 43, Issue:21, 2000
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.Journal of medicinal chemistry, , Jun-29, Volume: 43, Issue:13, 2000
N-arylrolipram derivatives as potent and selective PDE4 inhibitors.Bioorganic & medicinal chemistry letters, , Nov-17, Volume: 8, Issue:22, 1998
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.Bioorganic & medicinal chemistry letters, , Mar-12, Volume: 11, Issue:5, 2001
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994