Proteins > Group IIE secretory phospholipase A2
Page last updated: 2024-08-07 21:47:42

Group IIE secretory phospholipase A2

A group IIE secretory phospholipase A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZK7]

Synonyms

GIIE sPLA2;
sPLA2-IIE;
EC 3.1.1.4;
Phosphatidylcholine 2-acylhydrolase 2E

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
varespladibHomo sapiens (human)IC500.086344
indoxamHomo sapiens (human)IC500.010011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3-octylthio-1,1,1-trifluoro-2-propanoneHomo sapiens (human)XI500.000111
varespladibHomo sapiens (human)XI500.001077

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
phospholipase A2 activitymolecular functionCatalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
calcium-dependent phospholipase A2 activitymolecular functionCatalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4]
phospholipid bindingmolecular functionBinding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
lipid catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
low-density lipoprotein particle remodelingbiological processThe acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
phosphatidylcholine metabolic processbiological processThe chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. [ISBN:0198506732]
phosphatidylglycerol metabolic processbiological processThe chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. [ISBN:0198506732]
arachidonic acid secretionbiological processThe controlled release of arachidonic acid from a cell or a tissue. [GOC:ai]
phospholipid metabolic processbiological processThe chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
negative regulation of T cell proliferationbiological processAny process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]