Page last updated: 2024-12-08

yh 439

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

YH 439: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID148185
CHEMBL ID3301677
CHEBI ID135409
SCHEMBL ID8752155
MeSH IDM0257526

Synonyms (30)

Synonym
mivotilate
mivotilate [inn]
isopropyl 2-(1,3-dithietane-2-ylidine)-2-(n-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate
isopropyl n-(4-methyl-2-thiazolyl)-1,3-dithietane-delta(sup 2),l-malonamate
ccris 8469
yh 439
yh439
yh-439
CHEBI:135409
propan-2-yl 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-1,3-thiazol-2-yl)amino]-3-oxopropanoate
ccris 8109
130112-42-4
0789652qul ,
unii-0789652qul
propanedioic acid, (dimercaptomethylene)-, bis(1-methylethyl) ester
126164-80-5
isopropyl-2-(1,3-dithietane-2-ylidene)-2-(n-(4-methylthiazol-2-yl)carbamoyl)acetate
isopropyl n-(4-methyl-2-thiazolyl)-1,3-dithietane-.delta.2,l-malonamate
CHEMBL3301677
smr002529705
MLS006010714
SCHEMBL8752155
DTXSID90156348
yh439, >=98% (hplc)
HY-100242
CS-0018393
isopropyl-2-(1,3-dithietane-2-ylidene)-2-[n-(4-methylthiazol-2-yl)carbamoyl]acetate
Q27236278
MS-24969
AKOS040742144

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Pharmacokinetic parameters of azosemide were not significantly different between the two groups of rats except t(1/2), MRT, and V(ss)."( Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats.
Kim, ND; Kim, SH; Lee, JW; Lee, MG; Park, KJ; Yoon, WH, 1996
)
0.29

Bioavailability

ExcerptReferenceRelevance
"To improve bioavailability of poorly water-soluble YH439, a thermal reversible microemulsion system was prepared using modified fatty acids such as capric acid and palmitic acid with PEG 400."( Thermal reversible microemulsion system for poorly water-soluble YH439 for oral delivery.
Gao, ZG; Han, DH; Jin, YZ; Jin, ZH; Shen, YY; Yin, XZ, 2010
)
0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
aromatic amideAn amide in which the amide linkage is bonded directly to an aromatic system.
isopropyl esterAny carboxylic ester resulting from the formal condensation of a carboxylic acid with the hydroxy group of propan-2-ol.
secondary carboxamideA carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1897744Inhibition of Hedgehog-signalling dependent purmorphamine induced osteoblast differentiation in mouse C3H 10T1/2 cells assessed as reduction in ALP expression at 0.01 to 100 uM incubated for 96 hrs by CDP-Star luminogenic substrate based assay2022Journal of medicinal chemistry, 12-22, Volume: 65, Issue:24
The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's14 (66.67)18.2507
2000's4 (19.05)29.6817
2010's2 (9.52)24.3611
2020's1 (4.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.44 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.53 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.44)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]