A fatty acid-binding protein, heart that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05413]
Fatty acid-binding protein 3;
Heart-type fatty acid-binding protein;
H-FABP;
Mammary-derived growth inhibitor;
MDGI;
Muscle fatty acid-binding protein;
M-FABP
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| truxillic acid | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| cocaine | Homo sapiens (human) | IC50 | 0.3670 | 1 | 1 |
| linoleic acid | Homo sapiens (human) | IC50 | 1.0000 | 3 | 3 |
| linoleic acid | Homo sapiens (human) | Ki | 9.3000 | 1 | 1 |
| HTS 01037 | Homo sapiens (human) | Ki | 9.0700 | 1 | 1 |
| bms 309403 | Homo sapiens (human) | IC50 | 14.7000 | 1 | 1 |
| bms 309403 | Homo sapiens (human) | Ki | 3.7233 | 3 | 3 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| cytoskeletal protein binding | molecular function | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah] |
| long-chain fatty acid binding | molecular function | Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:pm, PMID:12641450] |
| oleic acid binding | molecular function | Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. [GOC:lp, GOC:mah] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of cell population proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| long-chain fatty acid transport | biological process | The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ai] |
| intracellular lipid transport | biological process | The directed movement of lipids within cells. [GOC:mah] |
| cholesterol homeostasis | biological process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| regulation of fatty acid oxidation | biological process | Any process that modulates the frequency, rate or extent of fatty acid oxidation. [GOC:ai] |
| brown fat cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [PMID:12588810] |
| phospholipid homeostasis | biological process | Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell. [GOC:BHF, GOC:rl] |
| positive regulation of phospholipid biosynthetic process | biological process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah] |
| positive regulation of long-chain fatty acid import into cell | biological process | Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell. [PMID:28178239] |
| regulation of phosphatidylcholine biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol] |