Proteins > D(1B) dopamine receptor
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D(1B) dopamine receptor

A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918]

Synonyms

D(5) dopamine receptor;
D1beta dopamine receptor;
Dopamine D5 receptor

Research

Bioassay Publications (46)

TimeframeStudies on this Protein(%)All Drugs %
pre-19904 (8.70)18.7374
1990's2 (4.35)18.2507
2000's16 (34.78)29.6817
2010's19 (41.30)24.3611
2020's5 (10.87)2.80

Compounds (49)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sk&f-38393Homo sapiens (human)Ki0.124011
1h-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-Homo sapiens (human)Ki0.002733
amitriptylineHomo sapiens (human)Ki0.170011
chlorpromazineHomo sapiens (human)Ki0.172011
fluphenazineHomo sapiens (human)Ki0.021011
haloperidolHomo sapiens (human)IC500.005011
haloperidolHomo sapiens (human)Ki0.101044
maprotilineHomo sapiens (human)Ki0.429011
7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-olHomo sapiens (human)IC500.000622
rbi 257Homo sapiens (human)Ki10.000011
lysergic acid diethylamideHomo sapiens (human)Ki0.340011
apomorphineHomo sapiens (human)IC500.025011
apomorphineHomo sapiens (human)Ki0.015011
phenyltoloxamineHomo sapiens (human)Ki0.414011
indopanHomo sapiens (human)Ki10.000011
canadine, (s)-isomerHomo sapiens (human)Ki0.062111
penfluridolHomo sapiens (human)Ki0.125011
butaclamolHomo sapiens (human)IC500.050011
aripiprazoleHomo sapiens (human)Ki1.600022
dopamine hydrochlorideHomo sapiens (human)Ki1.091612
tetrahydropalmatineHomo sapiens (human)Ki0.305011
1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizineHomo sapiens (human)Ki10.000011
gr 127935Homo sapiens (human)Ki10.000011
ecopipamHomo sapiens (human)Ki0.002022
pramipexoleHomo sapiens (human)Ki10.000011
chloroethylnorapomorphineHomo sapiens (human)IC508.000011
harmalanHomo sapiens (human)Ki10.000011
corydalmineHomo sapiens (human)Ki0.242011
nantenine, (+-)-isomerHomo sapiens (human)Ki2.397011
1-methyl-6-methoxy-dihydro-beta-carbolineHomo sapiens (human)Ki10.000011
tetrahydrocolumbamineHomo sapiens (human)Ki0.009511
chlorprothixeneHomo sapiens (human)Ki0.009011
sch 23390Homo sapiens (human)IC500.001111
sch 23390Homo sapiens (human)Ki0.002944
le 300Homo sapiens (human)Ki0.009666
harmineHomo sapiens (human)Ki10.000011
l 745870Homo sapiens (human)Ki10.000011
sk&f-38393Homo sapiens (human)Ki0.164323
stepholidineHomo sapiens (human)Ki0.004411
ngb 2904Homo sapiens (human)Ki10.000011
akuammicineHomo sapiens (human)Ki10.000011
meridianin aHomo sapiens (human)Ki10.000011
cariprazineHomo sapiens (human)Ki7.900011
naluzotanHomo sapiens (human)Ki2.000011
le 404Homo sapiens (human)Ki0.001555
a 803467Homo sapiens (human)IC5010.000011
sp 203Homo sapiens (human)Ki10.000011
n,n-diallyl-5-methoxytryptamineHomo sapiens (human)Ki10.000011
clozapineHomo sapiens (human)Ki0.489022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sk&f 81297Homo sapiens (human)EC500.001411
ropiniroleHomo sapiens (human)EC500.100012
sk&f 89124Homo sapiens (human)EC500.001812

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
chlorpromazineHomo sapiens (human)Kb1.000011
haloperidolHomo sapiens (human)Kb0.001411
apomorphineHomo sapiens (human)ID500.039011
clozapineHomo sapiens (human)Kb10.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
dopamine neurotransmitter receptor activity, coupled via Gsmolecular functionCombining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260]
dopamine neurotransmitter receptor activitymolecular functionCombining with the neurotransmitter dopamine to initiate a change in cell activity. [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
dopamine bindingmolecular functionBinding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. [ISBN:0198506732]
G protein-coupled receptor activitymolecular functionCombining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
ciliumcellular componentA specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]
brush border membranecellular componentThe portion of the plasma membrane surrounding the brush border. [GOC:mah]
synapsecellular componentThe junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
ciliary membranecellular componentThe portion of the plasma membrane surrounding a cilium. [GOC:cilia, GOC:dph, GOC:rph]
non-motile ciliumcellular componentA cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 25 target(s):

TargetCategoryDefinition
synaptic transmission, dopaminergicbiological processThe vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, GOC:dph]
response to amphetaminebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]
regulation of systemic arterial blood pressure by vasopressinbiological processThe regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. [GOC:mtg_cardio, ISBN:0721643949]
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressurebiological processA process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure. [GOC:mtg_cardio, ISBN:0721643949]
intracellular calcium ion homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
activation of adenylate cyclase activitybiological processAny process that initiates the activity of the inactive enzyme adenylate cyclase. [GOC:ai]
adenylate cyclase-activating dopamine receptor signaling pathwaybiological processAn adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
associative learningbiological processLearning by associating a stimulus (the cause) with a particular outcome (the effect). [ISBN:0582227089]
transmission of nerve impulsebiological processThe neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. [GOC:curators, ISBN:0815316194]
negative regulation of NAD(P)H oxidase activitybiological processAny process that stops or reduces the activity of the enzyme NAD(P)H oxidase. [GOC:mah]
wound healingbiological processThe series of events that restore integrity to a damaged tissue, following an injury. [GOC:bf, PMID:15269788]
response to cocainebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]
positive regulation of adenylate cyclase activitybiological processAny process that activates or increases the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]
negative regulation of blood pressurebiological processAny process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]
regulation of female receptivitybiological processAny process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances. [GOC:dph, GOC:go_curators, GOC:tb]
sensitizationbiological processAn increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched. [ISBN:0582227089]
phospholipase C-activating dopamine receptor signaling pathwaybiological processA phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914]
long-term synaptic depressionbiological processA process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]
cellular response to catecholamine stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. [GOC:BHF, GOC:mah]
reactive oxygen species metabolic processbiological processThe chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. [GOC:mah]
positive regulation of MAPK cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
adenylate cyclase-activating adrenergic receptor signaling pathwaybiological processAn adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF, GOC:mah, GOC:signaling]
dopamine receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:mah, PMID:21711983]