Chromaffin granule amine transporter

A chromaffin granule amine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54219]

Solute carrier family 18 member 1;
Vesicular amine transporter 1;
VAT1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
reserpine	Homo sapiens (human)	IC50	0.0500	2	0

This protein enables 4 target(s):

Target	Category	Definition
monoamine transmembrane transporter activity	molecular function	Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. [GOC:mah]
monoamine:proton antiporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out). [TC:2.A.1.2.11, TC:2.A.1.2.12]
xenobiotic transmembrane transporter activity	molecular function	Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
serotonin:sodium:chloride symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in). [PMID:21752877, PMID:22519513]

This protein is located in 2 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
clathrin-sculpted monoamine transport vesicle membrane	cellular component	The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle. [GOC:mg2]

This protein is active in 2 target(s):

Target	Category	Definition
synaptic vesicle membrane	cellular component	The lipid bilayer surrounding a synaptic vesicle. [GOC:mah]
terminal bouton	cellular component	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]

This protein is involved in 5 target(s):

Target	Category	Definition
monoamine transport	biological process	The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
xenobiotic transport	biological process	The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
serotonin uptake	biological process	The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
aminergic neurotransmitter loading into synaptic vesicle	biological process	The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps. [GOC:ai]