Proteins > 26S proteasome complex subunit SEM1
Page last updated: 2024-08-07 14:52:16
26S proteasome complex subunit SEM1
A 26S proteasome complex subunit DSS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P60896]
Synonyms
26S proteasome complex subunit DSS1;
Deleted in split hand/split foot protein 1;
Split hand/foot deleted protein 1;
Split hand/foot malformation type 1 protein
Research
Bioassay Publications (3)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
bortezomib | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
carfilzomib | Homo sapiens (human) | IC50 | 0.0086 | 1 | 1 |
belactosin a | Homo sapiens (human) | IC50 | 1.4200 | 2 | 2 |
Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.Journal of medicinal chemistry, , Mar-27, Volume: 57, Issue:6, 2014
Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.Journal of medicinal chemistry, , Mar-27, Volume: 57, Issue:6, 2014