oxytocin and Necrosis

Ischemic heart disease (IHD) is among the most important and top ranked causes of death in the world, and its preventive and interventional mechanisms are actively being investigated. Preconditioning may still be beneficial in some situations such as IHD. Development of cardioprotective agents to improve myocardial function, to decrease the incidence of arrhythmias, to delay the onset of necrosis, and to limit the total extent of infarction during IHD is of great clinical importance. In order to reduce morbidity, a new treatment modality must be developed, and oxytocin may indeed be one of the candidates. There is increasing experimental evidence indicating that oxytocin may have cardioprotective effects either by decreasing the extent of reperfusion injury or by pharmacologic preconditioning activity. This review shows that in the presence of oxytocin, the cardioprotective effects may be increased to some extent. The presented board of evidence focuses on the valuable effects of oxytocin on myocardial function and candidates it for future clinical studies in the realm of ischemic heart diseases.

Topics: Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Artery Disease; Humans; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Oxytocin

Wound healing was studied in 90 patients with "diabetic foot" receiving complex treatment which included oxytocin (40 patients) or did not use it (50 patients). Intraarterial injection or local application of oxytocin resulted in significant differences of wound process characteristics as compared with those ones in control group. The necrobiotic and necrotic changes in the tissues of skin, subcutaneous adipose tissue and skeletal muscles, located within the purulent-necrotic foci, were less expressed. The number of sludged capillaries, as well as of arterioles and venules with the signs of microthrombosis, was significantly decreased. Simultaneously, the regenerative potential of endotheliocytes, fibroblasts and adventitial cells was increased, showing a significant stimulation of their DNA-synthesizing capacity. The histological findings obtained indicate that the introduction of oxytocin in complex treatment activates the processes of vasculogenesis, proliferation of endotheliocytes anf histiocytes, that, in turn, results in the effective clearance of the wound and optimal granulation tissue formation.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amputation, Surgical; Combined Modality Therapy; Diabetic Foot; DNA; Female; Humans; Injections, Intra-Arterial; Male; Middle Aged; Necrosis; Oxytocin; Suppuration; Surgical Procedures, Operative; Wound Healing

The results of treatment of 90 patients with diabetes mellitus and pyo-necrotic lesions of the feet were compared. Oxytocin was used in 40 of the patients. It was found that parenteral administration of oxytocin resulted in more favorable course of diabetes mellitus in such patients. The intra-arterial or local use of Oxytocin was found to reliably increase the DNA synthesis by the endothelial cells, fibroblasts and histiocytes, which in its turn creates favorable conditions for the reparative process in the wounds and allows quality of the treatment to be considerably improved.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Chronic Disease; Combined Modality Therapy; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Foot; DNA; Female; Foot; Humans; Male; Middle Aged; Necrosis; Oxytocin

The repair processes in the pancreas in infected pancreonecrosis after oxytocin (OT) administration were studied in 120 male rats with the body mass of 280-310 g, using light microscopy, histochemistry, electron microscopy and immunocytochemistry (p53 protein detection). Pancreonecrosis was induced by microtraumatizing the pancreatic lobules with bile injection and Staphylococcus aureus suspension infusion. During days 3-14, the intensifying processes of ischemia, acinar and ductal lysis, pancreatocyte dystrophy and death were observed in experimental animals. In paranecrotic areas, acinar discomplexation was found together with the signs of increased secretory activiry in pancreatocytes. Pancreatic tissues were infiltrated with erythrocytes, granulocytes, lymphocytes and macrophages which were actively engaged in phagocytosis. OT was found to create the conditions necessary for adequate realization of the regenerative properties of pancreatocytes, microvessels, cells of fibroblastic line, and macrophages with a concomitant decrease of apoptotic dominant in cellular elements.

Topics: Animals; Histocytochemistry; Lymphocytes; Macrophages; Male; Necrosis; Oxytocin; Pancreas; Pancreatitis; Rats; Regeneration; Staphylococcus aureus; Tumor Suppressor Protein p53

Topics: Abortion, Induced; Abortion, Therapeutic; Adult; Animals; Female; Haplorhini; Humans; Hypertonic Solutions; Hysterectomy; Macaca; Muscle Contraction; Necrosis; Oxytocin; Pregnancy; Prostaglandins; Sodium Chloride; Uterine Diseases; Uterus

Topics: Acidosis; Actinomycosis; Animals; Chronic Disease; Endometritis; Ergotism; Female; Hypocalcemia; Lactation Disorders; Mammary Glands, Animal; Mastitis; Necrosis; Obstetric Labor Complications; Oxytocin; Pregnancy; Swine; Swine Diseases

Topics: Adult; Age Factors; Animals; Behavior, Animal; Diabetes Insipidus; Female; Headache; Humans; Hypertonic Solutions; Hypopituitarism; Hypothalamo-Hypophyseal System; Kidney; Necrosis; Osmolar Concentration; Oxytocin; Parity; Postpartum Hemorrhage; Pregnancy; Puerperal Disorders; Vasopressins; Water-Electrolyte Balance

Topics: Abruptio Placentae; Castration; Estradiol; Estrogens; Female; Humans; Ischemia; Kidney; Kidney Cortex Necrosis; Kidney Diseases; Necrosis; Ovary; Oxytocin; Pharmacology; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Research; Toxicology