Proteins > 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Page last updated: 2024-08-07 13:18:01
1-deoxy-D-xylulose 5-phosphate reductoisomerase
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P45568]
Synonyms
DXP reductoisomerase;
EC 1.1.1.267;
1-deoxyxylulose-5-phosphate reductoisomerase;
2-C-methyl-D-erythritol 4-phosphate synthase
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase.Bioorganic chemistry, , Volume: 59, 2015
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR).Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.Journal of medicinal chemistry, , Dec-11, Volume: 57, Issue:23, 2014
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.Journal of medicinal chemistry, , Dec-14, Volume: 49, Issue:25, 2006
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.Journal of medicinal chemistry, , Apr-20, Volume: 49, Issue:8, 2006
AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.Journal of medicinal chemistry, , Apr-20, Volume: 49, Issue:8, 2006
AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005