quinazolines has been researched along with Necrosis in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (48.15) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, Y; Geng, X; Gong, J; Liu, D; Ma, Z; Meng, H; Song, G; Song, Z; Yang, T; Zhou, B | 1 |
| Arimura, A; Fujii, K; Hashiguchi, T; Hayashida, M; Higashi, Y; Kanekura, T | 1 |
| Cloughesy, TF; Faiq, N; Green, R; Green, S; Hu, J; Lai, A; Mellinghoff, I; Nghiemphu, PL; Yu, A | 1 |
| Harter, PN; Mittelbronn, M; Pietsch, T; Reuter, D; Ronellenfitsch, MW; Senft, C; Steinbach, JP; Urban, H; Westphal, M; Zeiner, PS | 1 |
| Azzariti, A; Cocco, T; Ferretta, A; Guida, G; Guida, M; Guida, S; Iacobazzi, RM; Maida, I; Porcelli, L; Quatrale, AE; Sidella, L; Stolfa, DA; Strippoli, S; Tommasi, S | 1 |
| Abraham, RR; Girotra, M; Jones, J; Klair, JS | 1 |
| Chang, J; Shi, Y; Su, C; Yang, G; Zhao, L | 1 |
| Kawabe, J; Ohsaki, Y; Osanai, S; Sasaki, T; Shibukawa, K; Tanno, S | 1 |
| Babur, M; Shannon, AM; Stratford, IJ; Telfer, BA; Wedge, SR; Williams, KJ | 1 |
| Hui, RC; Ko, JH; Shih, YC; Yang, CH | 1 |
| Busch, AM; Cyrus, J; Dmitrovsky, E; Dragnev, KH; Erkmen, CP; Freemantle, SJ; Galimberti, F; Johnstone, D; Kurie, JM; Liu, X; Ma, T; Memoli, V; Nugent, W; Rigas, JR; Seltzer, M; Tsongalis, GJ; Waxman, S | 1 |
| Ager, E; Chung, E; Duyverman, AM; Eichler, AF; Engelman, JA; Farrar, CT; Fukumura, D; Goel, S; Hiddingh, L; Huang, Y; Incio, J; Jain, RK; Kamoun, W; Kodack, DP; Lussiez, A; Mahmood, S; Snuderl, M; Song, Y; Tannous, BA; Yamashita, H | 1 |
| Fletcher, EV; Knudson, CM; Love-Homan, L; Martin, SM; Parsons, AD; Simons, AL; Sobhakumari, A; Spitz, DR | 1 |
| Gao, X; Li, YL; Liu, XX; Ma, XL; Nie, W; Sang, YX; Shen, GB; Shi, HS; Wang, FT; Wei, YQ; Xu, GC | 1 |
| Hénichart, JP; Mimeault, M; Pommery, N | 1 |
| Ikejima, T; Onodera, S; Tashiro, S; Wu, LJ; Zhang, Y | 1 |
| Chansel, D; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Placier, S; Tharaux, PL | 1 |
| Bianco, AR; Bianco, C; Bianco, R; Bunn, P; Ciardiello, F; Cionini, L; D'Armiento, FP; Damiano, V; Melisi, D; Mignogna, C; Raben, D; Tortora, G | 1 |
| de Waal, R; Heerschap, A; Küsters, B; Leenders, WP; Maass, C; Ruiter, D; Ryan, A; Verrijp, K; Wesseling, P | 1 |
| Biddle, A; Davis, TH; Desai, NB; Dmitrovsky, E; Dragnev, KH; Hamilton, M; Iwata, KK; Ma, Y; Memoli, N; Memoli, VA; Nugent, WC; Petty, WJ; Rigas, JR | 1 |
| Lafayette, RA; Rodwell, GE; Troxell, ML | 1 |
| Figlin, R; Fishbein, MC; Truell, JS | 1 |
| Ikejima, T; Onodera, S; Tashino, S; Wu, LJ; Yang, J | 1 |
| Cipák, L; Jantová, S; Kubíková, J; Maliar, T; Mikulásová, M; Rauko, P; Spirková, K; Stankovský, S; Urbancíková, M | 1 |
| Barak, V; Eshhar, Z; Gavish, Z; Nagler, A; Pines, M; Pinthus, JH; Ramon, J | 1 |
| Buchanan, JO; Buyniski, JP; Fleming, JS | 1 |
| Danielsson, B; Kronberg, L | 1 |
3 trial(s) available for quinazolines and Necrosis
| Article | Year |
|---|---|
Report of safety of pulse dosing of lapatinib with temozolomide and radiation therapy for newly-diagnosed glioblastoma in a pilot phase II study.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Drug Administration Schedule; Female; Glioblastoma; Humans; Karnofsky Performance Status; Lapatinib; Male; Middle Aged; Necrosis; Pilot Projects; Quinazolines; Temozolomide; Thrombocytopenia; Treatment Outcome | 2017 |
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.
Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal, Humanized; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Calcium-Binding Proteins; Cohort Studies; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; ErbB Receptors; Female; Glioblastoma; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Microfilament Proteins; Necrosis; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Ribosomal Protein S6; Signal Transduction; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2018 |
Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models.
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cyclin D1; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Immunoblotting; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Transgenic; Middle Aged; Mouth Mucosa; Mutation; Necrosis; Neoplasm Recurrence, Local; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Salvage Therapy; Survival Rate; Tetrahydronaphthalenes; Treatment Outcome; Tumor Cells, Cultured | 2011 |
24 other study(ies) available for quinazolines and Necrosis
| Article | Year |
|---|---|
Resveratrol improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells in rats with severe acute pancreatitis.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Necrosis; Pancreas; Pancreatitis; Paracrine Communication; Phosphatidylinositol 3-Kinase; Piperidines; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Resveratrol; Severity of Illness Index; Signal Transduction; Taurocholic Acid; Vascular Endothelial Growth Factor A | 2020 |
Anagrelide with low-dose aspirin promptly epithelized ulceronecrotic lesion secondary to essential thrombocythemia.
Topics: Aspirin; Bone Marrow; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Janus Kinase 2; Karyotyping; Male; Middle Aged; Mutation; Necrosis; Quinazolines; Re-Epithelialization; Skin; Skin Ulcer; Thrombocythemia, Essential; Toes; Treatment Outcome | 2020 |
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
Topics: Albumins; Apoptosis; Aurora Kinase B; Cell Line, Tumor; Cell Movement; Cell Nucleus Shape; Cell Proliferation; Cell Shape; Cell Survival; Drug Resistance, Neoplasm; Extracellular Space; Humans; Lactic Acid; Melanoma; Mitosis; Necrosis; Neoplasm Metastasis; Organophosphates; Paclitaxel; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Quinazolines | 2015 |
A 'shock-ing' endoscopic finding on esophagogastroduodenoscopy.
Topics: Adenocarcinoma; Antineoplastic Agents; Endoscopy, Digestive System; Erlotinib Hydrochloride; Esophagus; Fatal Outcome; Female; Humans; Lung Neoplasms; Middle Aged; Multiple Organ Failure; Necrosis; Quinazolines | 2015 |
Co-delivery of Gefitinib and chloroquine by chitosan nanoparticles for overcoming the drug acquired resistance.
Topics: Adenosine Triphosphate; Annexin A5; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Chitosan; Chloroquine; Drug Delivery Systems; Drug Resistance, Neoplasm; Endocytosis; Fluorescein-5-isothiocyanate; Gefitinib; Humans; Intracellular Space; Nanoparticles; Necrosis; Quinazolines | 2015 |
Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts.
Topics: Animals; Apoptosis; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; In Situ Nick-End Labeling; Lung Neoplasms; Mice; Necrosis; Neovascularization, Pathologic; Piperidines; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2008 |
Inhibition of vascular endothelial growth factor signalling using cediranib (RECENTIN; AZD2171) enhances radiation response and causes substantial physiological changes in lung tumour xenografts.
Topics: Animals; Apoptosis; Carcinoma; Combined Modality Therapy; Female; Lung Neoplasms; Mice; Mice, Nude; Necrosis; Quinazolines; Vascular Endothelial Growth Factor A | 2008 |
Necrotizing vasculitis triggered by gefitinib: an unusual clinical presentation.
Topics: Antineoplastic Agents; Biopsy, Needle; Carcinoma, Non-Small-Cell Lung; Follow-Up Studies; Gefitinib; Humans; Immunohistochemistry; Lower Extremity; Lung Neoplasms; Male; Middle Aged; Necrosis; Neoplasm Invasiveness; Neoplasm Staging; Prednisolone; Quinazolines; Risk Assessment; Skin Diseases, Vascular; Treatment Outcome; Vasculitis | 2011 |
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Brain Neoplasms; Breast Neoplasms; Cell Death; Cell Proliferation; Diagnostic Imaging; Disease Models, Animal; Female; Gene Amplification; Humans; Killer Cells, Natural; Lapatinib; Mice; Molecular Targeted Therapy; Necrosis; Neovascularization, Pathologic; Quinazolines; Receptor, ErbB-2; Receptors, Vascular Endothelial Growth Factor; Survival Analysis; Trastuzumab; Treatment Outcome; Xenograft Model Antitumor Assays | 2012 |
Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Auranofin; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Catalase; Cell Line, Tumor; Cell Survival; Drug Synergism; Erlotinib Hydrochloride; Female; Gene Knockdown Techniques; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Necrosis; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Quinazolines; RNA, Small Interfering; Thioredoxin-Disulfide Reductase; Thioredoxins; Xenograft Model Antitumor Assays | 2012 |
Synergic antitumor effect of SKLB1002 and local hyperthermia in 4T1 and CT26.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Histocytochemistry; Hyperthermia, Induced; Immunohistochemistry; Mice, Inbred BALB C; Necrosis; Platelet Endothelial Cell Adhesion Molecule-1; Quinazolines; Thiadiazoles; Treatment Outcome | 2014 |
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Division; Cell Separation; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Male; Membrane Potentials; Mitochondria; Necrosis; Prostatic Neoplasms; Protease Inhibitors; Quinazolines; Tumor Cells, Cultured | 2003 |
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Cycle; DNA Fragmentation; Dose-Response Relationship, Drug; Evodia; HeLa Cells; Humans; Melanoma; Mitogen-Activated Protein Kinases; Necrosis; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Plants, Medicinal; Quinazolines; Time Factors | 2004 |
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis; Gefitinib; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Hypertension; Ischemia; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proteinuria; Quinazolines; Rats; Rats, Sprague-Dawley | 2004 |
Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Immunohistochemistry; Ki-67 Antigen; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Necrosis; Neoplasm Transplantation; Neovascularization, Pathologic; Organophosphorus Compounds; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Time Factors | 2004 |
Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option.
Topics: Angiogenesis Inhibitors; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Disease Progression; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Melanoma; Mice; Mice, Inbred BALB C; Necrosis; Neoplasm Metastasis; Neovascularization, Pathologic; Oligonucleotides, Antisense; Phenotype; Piperidines; Placebos; Quinazolines; RNA; Transfection; Treatment Outcome; Vascular Endothelial Growth Factor A | 2004 |
Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers.
Topics: Biomarkers, Tumor; Bronchi; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Cyclin D1; DNA; Dose-Response Relationship, Drug; Epithelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Exons; G1 Phase; Gastrointestinal Neoplasms; Gastrointestinal Tract; Humans; Immunoblotting; Immunohistochemistry; Ki-67 Antigen; Kinetics; Luciferases; Necrosis; Neoplasms; Quinazolines; Sequence Analysis, DNA; Time Factors; Transcriptional Activation | 2004 |
Renal tubular injury associated with anagrelide use.
Topics: Humans; Kidney Tubules; Male; Middle Aged; Necrosis; Quinazolines | 2005 |
Myocarditis temporally related to the use of gefitinib (Iressa).
Topics: Acute Disease; Aged; Antineoplastic Agents; Drug Hypersensitivity; Fatal Outcome; Gefitinib; Humans; Male; Myocarditis; Myocytes, Cardiac; Necrosis; Quinazolines | 2005 |
Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells.
Topics: Acridine Orange; Apoptosis; Autophagy; bcl-X Protein; Cadaverine; Cell Nucleus; Cell Survival; HeLa Cells; Humans; Mitochondria; Necrosis; Nitric Oxide; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species | 2008 |
Biological activity of some 4-anilinoquinazolines: cytotoxic, genotoxic and antiprotease effects, induction of necrosis and changes of actin cytoskeleton.
Topics: Animals; CHO Cells; Cricetinae; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia; Melanoma; Mice; Mutagenicity Tests; Necrosis; Protease Inhibitors; Quinazolines; Skin Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Growth inhibition of prostate cancer xenografts by halofuginone.
Topics: Adenocarcinoma; Administration, Oral; Androgens; Animals; Antineoplastic Agents; Apoptosis; Collagen Type I; Disease Progression; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; In Situ Hybridization; Injections, Intraperitoneal; Male; Mice; Mice, SCID; Necrosis; Neovascularization, Pathologic; Phenotype; Piperidines; Prostatic Neoplasms; Quinazolines; Quinazolinones | 2002 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Male; Myocardial Infarction; Necrosis; Phenoxybenzamine; Platelet Aggregation; Propranolol; Quinazolines | 1976 |
Studies on the medicinal chemistry of oxoquinazolines. II. Synthesis and local anaesthetic activity of homologous derivatives of 1,2,3,4-tetrahydro-2,4-dioxoquinazoline and 3,4-dihydro-4-oxoquinazoline.
Topics: Anesthetics, Local; Animals; Anura; Chemical Phenomena; Chemistry; Cornea; Guinea Pigs; In Vitro Techniques; Lidocaine; Mice; Necrosis; Quinazolines; Rabbits; Sciatic Nerve; Tremor | 1969 |