Page last updated: 2024-08-07 22:49:05

isocitrate dehydrogenase 1, partial

[no definition available]

Synonyms

Research

Bioassay Publications (0)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0)18.7374
1990's0 (0)18.2507
2000's0 (0)29.6817
2010's0 (0)24.3611
2020's0 (0)2.80

Compounds (163)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3-hydroxyanthranilic acidHomo sapiens (human)Potency50.118710
amoxapineHomo sapiens (human)Potency50.118710
bay h 4502Homo sapiens (human)Potency70.794610
clotrimazoleHomo sapiens (human)Potency44.668410
diazinonHomo sapiens (human)Potency50.118710
dipyridamoleHomo sapiens (human)Potency44.668410
thiorphanHomo sapiens (human)Potency50.118710
ebselenHomo sapiens (human)Potency50.118710
ethacrynic acidHomo sapiens (human)Potency50.118710
ethotoinHomo sapiens (human)Potency50.118710
isoconazoleHomo sapiens (human)Potency44.668410
loratadineHomo sapiens (human)Potency50.118710
pomiferinHomo sapiens (human)Potency48.393920
protoporphyrin ixHomo sapiens (human)Potency28.183810
sulfinpyrazoneHomo sapiens (human)Potency44.668410
dimethylphenylpiperazinium iodideHomo sapiens (human)Potency50.118710
methylene blueHomo sapiens (human)Potency52.119410
7-amino-4-hydroxy-2-naphthalenesulfonic acidHomo sapiens (human)Potency52.119410
pyronineHomo sapiens (human)Potency18.492710
2-amino-5-nitrothiazoleHomo sapiens (human)Potency50.118710
sulfan blueHomo sapiens (human)Potency58.478910
imperatorinHomo sapiens (human)Potency15.848910
beclomethasone dipropionateHomo sapiens (human)Potency35.481310
diacereinHomo sapiens (human)Potency50.118710
thymolphthaleinHomo sapiens (human)Potency16.165220
butoconazole nitrateHomo sapiens (human)Potency63.095710
lovastatinHomo sapiens (human)Potency50.118710
sulconazole, mononitrate, (+-)-isomerHomo sapiens (human)Potency50.118710
IsobergaptenHomo sapiens (human)Potency50.118710
2,3-trimethylene-4-quinazoloneHomo sapiens (human)Potency43.638120
miconazole nitrateHomo sapiens (human)Potency50.118710
econazole nitrateHomo sapiens (human)Potency50.118710
cresolphthaleinHomo sapiens (human)Potency52.119410
5-aminovaleric acid hydrochlorideHomo sapiens (human)Potency44.668410
lobaric acidHomo sapiens (human)Potency50.118710
stictic acidHomo sapiens (human)Potency50.118710
9,10-phenanthrenequinone monoximeHomo sapiens (human)Potency50.118710
2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-oneHomo sapiens (human)Potency70.794610
diphyllinHomo sapiens (human)Potency32.604930
purpactin aHomo sapiens (human)Potency44.668410
cryptotanshinoneHomo sapiens (human)Potency50.118710
8-(4-benzenesulfonylamino)quinolineHomo sapiens (human)Potency41.399910
ajmalicine, hydrochloride(19alpha)-isomerHomo sapiens (human)Potency50.118710
gant58Homo sapiens (human)Potency39.767930
medrogestoneHomo sapiens (human)Potency58.478910
oxopurpureineHomo sapiens (human)Potency35.481310
discretamineHomo sapiens (human)Potency50.118710
mometasone furoateHomo sapiens (human)Potency22.196920
amcinonideHomo sapiens (human)Potency10.602520
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diolHomo sapiens (human)Potency50.118710
menadione sodium bisulfite, trihydrateHomo sapiens (human)Potency50.118710
4-chloro-N-(4-chloro-2,5-dimethoxyphenyl)-5-dithiazolimineHomo sapiens (human)Potency45.560010
averufinHomo sapiens (human)Potency50.118710
calmidazoliumHomo sapiens (human)Potency23.464830
3-(benzenesulfonyl)-2-imino-1-(2-oxolanylmethyl)-5-dipyrido[1,2-d-3',4'-f]pyrimidinoneHomo sapiens (human)Potency28.115220
2-[[2-(1-benzotriazolyl)-1-oxoethyl]-(2-furanylmethyl)amino]-N-cyclohexyl-2-(2-fluorophenyl)acetamideHomo sapiens (human)Potency12.156020
N-(1,3-benzodioxol-5-yl)-N-[1-(4-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl]-2-pyrazinecarboxamideHomo sapiens (human)Potency35.395020
2-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]thio]-3-ethyl-4-quinazolinoneHomo sapiens (human)Potency41.399910
LSM-26505Homo sapiens (human)Potency23.280910
9,10-dimethoxy-2-(2-pyridinylmethylamino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-oneHomo sapiens (human)Potency58.478910
4-[(4-chloro-5-dithiazolylidene)amino]benzonitrileHomo sapiens (human)Potency52.119410
LSM-34582Homo sapiens (human)Potency26.257430
1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamineHomo sapiens (human)Potency58.478910
2-[[2-[4-(4-chlorophenyl)-1-piperazinyl]-2-oxoethyl]thio]-3-ethyl-4-quinazolinoneHomo sapiens (human)Potency11.668110
6-(4-benzoyl-1-piperazinyl)-3,3-dimethyl-8-propan-2-yl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrileHomo sapiens (human)Potency25.848020
4-chloro-N-[3-chloro-4-(4-morpholinyl)phenyl]benzamideHomo sapiens (human)Potency35.481310
6-bromo-3-(4-morpholinyl)-4-phenyl-1H-quinolin-2-oneHomo sapiens (human)Potency50.118710
(E)-4-Phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acidHomo sapiens (human)Potency28.599240
2-[[(2,3-dimethoxyphenyl)-oxomethyl]amino]-5-propan-2-yl-3-thiophenecarboxamideHomo sapiens (human)Potency52.119410
5-(2,3-dihydroindol-1-ylsulfonyl)-1,3-diethyl-2-benzimidazoloneHomo sapiens (human)Potency58.478910
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(3-pyridinyl)-4-quinolinecarboxamideHomo sapiens (human)Potency58.478910
5-[(5-tert-butyl-2,3-dimethylphenyl)sulfonylamino]-2-hydroxybenzoic acidHomo sapiens (human)Potency37.317620
9-(3-bromo-4-hydroxyphenyl)-10-phenyl-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dioneHomo sapiens (human)Potency27.250020
2-[2,5-dimethyl-3-[(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]-1-pyrrolyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl esterHomo sapiens (human)Potency19.298930
[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-thiophen-2-ylmethanoneHomo sapiens (human)Potency44.668410
8,9-dimethyl-N-(3-methylphenyl)-3-[2-(4-morpholinyl)ethyl]-4H-[1,3]thiazino[6,5-b]quinolin-2-imineHomo sapiens (human)Potency12.954720
4,6-bis(1-imidazolyl)-N,N-diphenyl-1,3,5-triazin-2-amineHomo sapiens (human)Potency20.800220
3-(benzenesulfonyl)-2-imino-1-propyl-5-dipyrido[1,2-d-3',4'-f]pyrimidinoneHomo sapiens (human)Potency29.881620
(2S)-3-(1H-indol-3-yl)-2-[[2-[(4-methyl-6-oxo-3-benzo[c][1]benzopyranyl)oxy]-1-oxoethyl]amino]propanoic acidHomo sapiens (human)Potency63.095710
N,N-dibutyl-2-(pyridin-4-yl)quinazolin-4-amineHomo sapiens (human)Potency32.885110
3-cyclohexyl-10-methyl-2-thiophen-2-ylpyrimido[4,5-b]quinoline-4,5-dioneHomo sapiens (human)Potency26.373320
mcb-613Homo sapiens (human)Potency41.871120
N-(4-ethoxyphenyl)-4-[[4-(methylthio)phenyl]sulfonylamino]benzenesulfonamideHomo sapiens (human)Potency58.478910
reversanHomo sapiens (human)Potency32.885110
2-(2-chlorophenyl)-N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-4-quinolinecarboxamideHomo sapiens (human)Potency58.478910
2-pyridin-4-yl-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamideHomo sapiens (human)Potency58.478910
2-[(3-acetyl-5-oxo-4H-imidazol-2-yl)thio]-N-(4,5-diphenyl-2-thiazolyl)acetamideHomo sapiens (human)Potency52.119410
2-chloro-1-[1-[2-(4-chlorophenyl)ethyl]-2,5-dimethyl-3-pyrrolyl]ethanoneHomo sapiens (human)Potency52.119410
2-chloro-N-[4-[(3,4-dimethylphenyl)thio]phenyl]acetamideHomo sapiens (human)Potency57.121030
5-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-1-piperidinyl)thieno[2,3-d]pyrimidineHomo sapiens (human)Potency50.118710
2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]thio]-3-ethyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinoneHomo sapiens (human)Potency58.478910
thioureaHomo sapiens (human)Potency44.668410
5-(4-Chloro-benzenesulfonyl)-pyrimidine-2,4-diamineHomo sapiens (human)Potency58.478910
2-[4-[[4-[bis(2-hydroxyethyl)amino]-2-chlorophenyl]-(2-chlorophenyl)methyl]-3-chloro-N-(2-hydroxyethyl)anilino]ethanolHomo sapiens (human)Potency23.630930
1-[8-chloro-4-(1-naphthalenyl)-3,3a,4,9b-tetrahydrocyclopenta[c]quinolin-5-yl]ethanoneHomo sapiens (human)Potency20.269830
4-(3-methoxyphenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazoline-2-thioneHomo sapiens (human)Potency58.478910
2-(3-hydroxyphenyl)-6-(1-piperidinyl)benzo[de]isoquinoline-1,3-dioneHomo sapiens (human)Potency50.118710
1-(2,4-dimethoxyphenyl)-3-[4-(4-morpholinyl)anilino]pyrrolidine-2,5-dioneHomo sapiens (human)Potency52.119410
N-[3-chloro-4-(4-morpholinyl)phenyl]-1,1-dioxo-1,2-benzothiazol-3-amineHomo sapiens (human)Potency52.119410
1-[1-(4-methoxyphenyl)-2,5-dimethyl-3-pyrrolyl]-2-[[4-methyl-5-(2-methyl-3-furanyl)-1,2,4-triazol-3-yl]thio]ethanoneHomo sapiens (human)Potency13.091810
2-[(4-chlorophenyl)-[2-[5-(4-chlorophenyl)-2-thiazolyl]-5-methyl-3-oxo-1H-pyrazol-4-yl]methyl]propanedinitrileHomo sapiens (human)Potency70.794610
2-[(3-cyano-4,6-diphenyl-2-pyridinyl)thio]-3-methylbutanoic acidHomo sapiens (human)Potency58.478910
3-[[5,6-bis(4-methoxyphenyl)-4-furo[2,3-d]pyrimidinyl]amino]-1-propanolHomo sapiens (human)Potency44.668410
6-amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid (phenylmethyl) esterHomo sapiens (human)Potency47.079530
N-cyclohexyl-2-[3-methoxy-N-(1-oxo-2-thiophen-2-ylethyl)-4-(1-tetrazolyl)anilino]-2-(4-methylphenyl)acetamideHomo sapiens (human)Potency15.180220
CID 3192987Homo sapiens (human)Potency21.988930
N-[2-(cyclohexylamino)-2-oxo-1-thiophen-2-ylethyl]-2,2,2-trifluoro-N-(4-methylphenyl)acetamideHomo sapiens (human)Potency12.954720
2-(4-ethoxyphenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-6-pyrazolo[1,5-a]pyrimidinecarboxylic acidHomo sapiens (human)Potency36.679930
N,N-diethyl-4-[[5-oxo-6-(phenylmethyl)-7H-pyrrolo[3,4-b]pyridin-7-yl]amino]benzenesulfonamideHomo sapiens (human)Potency58.478910
1-methyl-N-(2-methylcyclohexyl)-4-oxo-6-(1-pyrrolidinylsulfonyl)-3-quinolinecarboxamideHomo sapiens (human)Potency17.739520
benzoic acid [4-(6-amino-5-cyano-3-methyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-2-methoxyphenyl] esterHomo sapiens (human)Potency58.478910
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholineHomo sapiens (human)Potency58.478910
3-(3-bromoanilino)-2-oxo-1H-indole-3-carbonitrileHomo sapiens (human)Potency44.668410
2-chloro-N-(2-methyl-6-oxo-5H-benzo[b][1,4]benzoxazepin-8-yl)acetamideHomo sapiens (human)Potency30.065330
N-(2,2,4-trimethyl-3H-benzofuran-7-yl)benzenesulfonamideHomo sapiens (human)Potency9.268310
1-bromo-3-(5,5-dimethyl-3-phenyl-4H-pyrazolo[4,3-a]carbazol-10-yl)-2-propanolHomo sapiens (human)Potency29.308910
2-[(2,6-dichlorophenyl)methyl]-6-phenyl-5-(1-piperidinyl)-3-pyridazinoneHomo sapiens (human)Potency17.437220
2-[(4-hydroxy-3-nitrophenyl)sulfonylamino]benzoic acid [2-(4-methoxyphenyl)-2-oxoethyl] esterHomo sapiens (human)Potency52.119410
3,3-bis(4-hydroxy-2-methylphenyl)-1-isobenzofuranoneHomo sapiens (human)Potency58.478910
2-[[6-amino-2-(4-methoxyanilino)-5-nitro-4-pyrimidinyl]amino]ethanolHomo sapiens (human)Potency58.478910
LSM-16826Homo sapiens (human)Potency34.559820
2-(3-oxo-2,4-dihydroquinoxalin-1-yl)-2-phenyl-N-(4-propan-2-ylphenyl)acetamideHomo sapiens (human)Potency32.464820
LSM-28572Homo sapiens (human)Potency46.451510
[5-(4-fluorophenyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[2-(3-pyridinyl)-1-piperidinyl]methanoneHomo sapiens (human)Potency50.118710
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazoleHomo sapiens (human)Potency50.118710
luteolin-7-glucosideHomo sapiens (human)Potency50.118710
gamma-linolenic acidHomo sapiens (human)Potency50.118710
indocyanine greenHomo sapiens (human)Potency44.668410
prostaglandin f2 methyl esterHomo sapiens (human)Potency44.668410
neoglycyrolHomo sapiens (human)Potency50.118710
4-amino-6,7-diphenyl-3H-pteridine-2-thioneHomo sapiens (human)Potency50.118710
morusinolHomo sapiens (human)Potency70.794610
3,3'-diethylthiacarbocyanine iodideHomo sapiens (human)Potency44.668410
2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acidHomo sapiens (human)Potency40.151620
4-[3-[(3-chloro-4-fluoroanilino)-oxomethyl]-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid tert-butyl esterHomo sapiens (human)Potency16.960030
1-[2-(2,5-dimethylphenoxy)ethyl]-3-indolecarboxylic acidHomo sapiens (human)Potency32.885110
u 74389gHomo sapiens (human)Potency44.668410
lissamine rhodamine bHomo sapiens (human)Potency2.238710
cnidicinHomo sapiens (human)Potency39.810710
pimaric acidHomo sapiens (human)Potency50.118710
5-methoxy-8,8-dimethyl-2-phenyl-4H,8H-pyrano[2,3-h]chromen-4-oneHomo sapiens (human)Potency30.127230
glabrolHomo sapiens (human)Potency50.118710
Dihydro-beta-erythroidine hydrobromideHomo sapiens (human)Potency50.118710
efaroxan hydrochlorideHomo sapiens (human)Potency50.118710
microcolin aHomo sapiens (human)Potency44.668410
5-[[3-bromo-4-[(2-fluorophenyl)methoxy]-5-methoxyphenyl]methylamino]-1,3-dihydrobenzimidazol-2-oneHomo sapiens (human)Potency50.118710
3-bromo-N-[5-(4-morpholinylsulfonyl)-1,3,4-thiadiazol-2-yl]benzamideHomo sapiens (human)Potency43.034110
3-[3-(4-fluorophenyl)-2,5,7-trimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-N-(2-methoxyphenyl)propanamideHomo sapiens (human)Potency58.478910
[5-(4-bromophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-pyridin-4-ylmethanoneHomo sapiens (human)Potency25.665120
N-[1,4-dimethyl-2,3-dioxo-7-(1-piperidinyl)-6-quinoxalinyl]-4-ethylbenzenesulfonamideHomo sapiens (human)Potency58.478910
acid blue 129Homo sapiens (human)Potency58.478910
N-[5-Ethyl-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide;hydron;chlorideHomo sapiens (human)Potency38.746330
N-[5-Bromo-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide;hydron;chlorideHomo sapiens (human)Potency58.478910
N-[5-Fluoro-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide;hydron;chlorideHomo sapiens (human)Potency58.478910
6-(3-cyclopentyloxy-4-methoxyphenyl)-3-(2,5-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineHomo sapiens (human)Potency14.125410
6-[3-(cyclopropylmethoxy)-4-methoxyphenyl]-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineHomo sapiens (human)Potency44.668410
N-(2-aminophenyl)-4-[[[(2S,3S)-10-[[cyclohexyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl-methylamino]methyl]benzamideHomo sapiens (human)Potency37.554330
1-[[(2S,3S)-10-[[(cyclohexylamino)-oxomethyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]ureaHomo sapiens (human)Potency35.481310
1-[[(2S,3S)-10-(dimethylamino)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]ureaHomo sapiens (human)Potency44.668410
N-[4-[2-[3-(dimethylsulfamoyl)anilino]-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamideHomo sapiens (human)Potency41.399910
N-[4-[2-(2-methoxyethylamino)-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamideHomo sapiens (human)Potency44.668410
LSM-20825Homo sapiens (human)Potency13.914320
N-[4-[2-(2-oxolanylmethylamino)-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamideHomo sapiens (human)Potency37.539230