perhexiline has been researched along with Necrosis in 3 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Inducers of apoptosis (staurosporine) and necrosis (perhexiline) were used to validate the mechanistic aspects of cell death." | 3.75 | Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds. ( Adams, SP; Barber, L; Connors, D; Hanumegowda, UM; Jayachandra, S; Wu, Y, 2009) |
| "The authors report the cases of 2 patients who died from cirrhosis after receiving perhexiline maleate, a drug widely used in Europe for the treatment of angina pectoris." | 3.66 | Perhexiline maleate-induced cirrhosis. ( Benhamou, JP; Bichara, M; Degott, C; Feldmann, G; Pessayre, D; Potet, F, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, Y | 1 |
| Connors, D | 1 |
| Barber, L | 1 |
| Jayachandra, S | 1 |
| Hanumegowda, UM | 1 |
| Adams, SP | 1 |
| McDonald, GS | 1 |
| Pessayre, D | 1 |
| Bichara, M | 1 |
| Degott, C | 1 |
| Potet, F | 1 |
| Benhamou, JP | 1 |
| Feldmann, G | 1 |
3 other studies available for perhexiline and Necrosis
| Article | Year |
|---|---|
Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds.
Topics: Apoptosis; Cells, Cultured; Cost-Benefit Analysis; Drug-Related Side Effects and Adverse Reactions; | 2009 |
Liver damage after perhexiline maleate.
Topics: Aged; Alcoholism; Female; Humans; Liver; Male; Middle Aged; Necrosis; Perhexiline; Piperidines | 1977 |
Perhexiline maleate-induced cirrhosis.
Topics: Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Female; Hepatic | 1979 |