85/88 kDa calcium-independent phospholipase A2

An 85/88 kDa calcium-independent phospholipase A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60733]

Synonyms

CaI-PLA2;
EC 3.1.1.4;
2-lysophosphatidylcholine acylhydrolase;
3.1.1.5;
Group VI phospholipase A2;
GVI PLA2;
Intracellular membrane-associated calcium-independent phospholipase A2 beta;
iPLA2-beta;
Palmitoyl-CoA hydrolase;

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-octylthio-1,1,1-trifluoro-2-propanone	Homo sapiens (human)	IC50	0.0643	12	12
varespladib	Homo sapiens (human)	IC50	3.0076	8	8

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-octylthio-1,1,1-trifluoro-2-propanone	Homo sapiens (human)	XI50	0.0001	16	16
varespladib	Homo sapiens (human)	XI50	0.0047	8	8

Enables

This protein enables 11 target(s):

Target	Category	Definition
1-alkyl-2-acetylglycerophosphocholine esterase activity	molecular function	Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. [EC:3.1.1.47]
lysophospholipase activity	molecular function	Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. [EC:3.1.1.5]
phospholipase A2 activity	molecular function	Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
hydrolase activity	molecular function	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732]
serine hydrolase activity	molecular function	Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
calcium-independent phospholipase A2 activity	molecular function	Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. [EC:3.1.1.4]
long-chain fatty acyl-CoA hydrolase activity	molecular function	Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [RHEA:67680]
phosphatidyl phospholipase B activity	molecular function	Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate. [GOC:pz, MetaCyc:RXN-14899]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
microtubule cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172]
nuclear speck	cellular component	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]
pseudopodium	cellular component	A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. [ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
antibacterial humoral response	biological process	An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]
cardiolipin biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. [GOC:mah]
phosphatidylcholine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp]
positive regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]
cardiolipin acyl-chain remodeling	biological process	Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. [GOC:bf, GOC:rb, PMID:19244244]
Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GOC:phg, PMID:12488490, PMID:15466916]
phosphatidylethanolamine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]
platelet activating factor metabolic process	biological process	The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]
phosphatidic acid metabolic process	biological process	The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732]
positive regulation of ceramide biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process. [GOC:dph]