1-propanol has been researched along with Necrosis in 15 studies
1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.
propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine the hypothesis that excessive fibrosis in obesity arises in part from a predisposition to injury of the liver by drugs and xenobiotics, we administered 5, 10 and 25 mg/kg doses of the model periportal hepatotoxin, allyl alcohol, to obese Sprague-Dawley rats and age-matched non-obese controls." | 7.69 | Obesity decreases hepatic glutathione concentrations and markedly potentiates allyl alcohol-induced periportal necrosis in the overfed rat. ( Corcoran, GB; Jordan, SW; Salazar, DE; Sorge, CL, 1994) |
| " To examine the hypothesis that excessive fibrosis in obesity arises in part from a predisposition to injury of the liver by drugs and xenobiotics, we administered 5, 10 and 25 mg/kg doses of the model periportal hepatotoxin, allyl alcohol, to obese Sprague-Dawley rats and age-matched non-obese controls." | 3.69 | Obesity decreases hepatic glutathione concentrations and markedly potentiates allyl alcohol-induced periportal necrosis in the overfed rat. ( Corcoran, GB; Jordan, SW; Salazar, DE; Sorge, CL, 1994) |
| " Allyl alcohol (350 microM), a hepatotoxin that causes necrosis of periportal regions, was infused into livers from phenobarbital-treated rats for 60 min." | 3.67 | Trypan blue uptake as a new method to investigate hepatotoxicity in periportal and pericentral regions of the liver lobule: studies with allyl alcohol in the perfused liver. ( Belinsky, SA; Kauffman, FC; Popp, JA; Thurman, RG, 1984) |
| "The effects of allyl alcohol, galactosamine, bromobenzene, and corn oil administration were evaluated in male Fischer 344 rats at 4 to 5, 14 to 15, and 24 to 25 months of age to determine if susceptibility to hepatotoxic injury is modified as a consequence of aging." | 3.67 | Influence of aging on the susceptibility of rats to hepatotoxic injury. ( Rikans, LE, 1984) |
| "The ability of 14 serum biochemical assays to predict the presence of hepatic necrosis induced by carbon tetrachloride (CCl4) (centrilobular necrosis), allyl alcohol (periportal necrosis), and 1-napththylisothiocyanate (ANIT) (biliary duct necrosis) was evaluated in rats." | 3.67 | Evaluating toxin-induced hepatic injury in rats by laboratory results and discriminant analysis. ( Carakostas, MC; Church, GE; Cleghorn, BL; Gossett, KA, 1986) |
| "Pentobarbital sleeping time was significantly increased over that of corn oil control groups in rats but decreased in mice." | 1.27 | Rat hepatic mitochondria are more sensitive to allyl alcohol than are those of mice. ( Jacobs, JM; Roebuck, BD; Rutkowski, JV; Smith, RP, 1987) |
| "Dipyridamole was effective from 1 hr before through 6 hrs after the oral administration of CCl4." | 1.26 | Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole. ( Kast, A; Nishikawa, J; Yabe, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Noa, M | 1 |
| Herrera, M | 1 |
| Magraner, J | 1 |
| Más, R | 1 |
| Belinsky, SA | 1 |
| Popp, JA | 1 |
| Kauffman, FC | 1 |
| Thurman, RG | 1 |
| Rikans, LE | 1 |
| Kast, A | 1 |
| Nishikawa, J | 1 |
| Yabe, T | 1 |
| Willson, RA | 1 |
| Hart, JR | 1 |
| Yavorkovsky, L | 1 |
| Lai, E | 1 |
| Ilic, Z | 1 |
| Sell, S | 1 |
| Salazar, DE | 1 |
| Sorge, CL | 1 |
| Jordan, SW | 1 |
| Corcoran, GB | 1 |
| Virtanen, P | 1 |
| Lassila, V | 1 |
| Söderström, KO | 1 |
| Nizze, H | 1 |
| Lapis, K | 1 |
| Kovács, L | 1 |
| Butterworth, KR | 1 |
| Carpanini, FM | 1 |
| Dunnington, D | 1 |
| Grasso, P | 1 |
| Pelling, D | 1 |
| Maellaro, E | 1 |
| Casini, AF | 1 |
| Del Bello, B | 1 |
| Comporti, M | 1 |
| Wójcicki, J | 1 |
| Hinek, A | 1 |
| Samochowiec, L | 1 |
| Carakostas, MC | 1 |
| Gossett, KA | 1 |
| Church, GE | 1 |
| Cleghorn, BL | 1 |
| Brenner, DE | 1 |
| Anthony, LB | 1 |
| Halter, S | 1 |
| Harris, NL | 1 |
| Collins, JC | 1 |
| Hande, KR | 1 |
| Jacobs, JM | 1 |
| Rutkowski, JV | 1 |
| Roebuck, BD | 1 |
| Smith, RP | 1 |
15 other studies available for 1-propanol and Necrosis
| Article | Year |
|---|---|
Effect of policosanol on isoprenaline-induced myocardial necrosis in rats.
Topics: Administration, Oral; Animals; Aspirin; Fatty Alcohols; Glycosaminoglycans; Heart; Isoproterenol; Ma | 1994 |
Trypan blue uptake as a new method to investigate hepatotoxicity in periportal and pericentral regions of the liver lobule: studies with allyl alcohol in the perfused liver.
Topics: 1-Propanol; Animals; Female; Liver; Methods; Necrosis; Perfusion; Propanols; Rats; Rats, Inbred Stra | 1984 |
Influence of aging on the susceptibility of rats to hepatotoxic injury.
Topics: 1-Propanol; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Chemic | 1984 |
Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole.
Topics: 1-Propanol; Animals; Body Temperature; Carbon Tetrachloride; Dipyridamole; Dose-Response Relationshi | 1982 |
In vivo drug metabolism and liver lobule heterogeneity in the rat.
Topics: 1-Propanol; Aminopyrine; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Ethanol; In | 1981 |
Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol.
Topics: 1-Propanol; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Biomarkers; Cell Division; Desmin; | 1995 |
Obesity decreases hepatic glutathione concentrations and markedly potentiates allyl alcohol-induced periportal necrosis in the overfed rat.
Topics: 1-Propanol; Alanine Transaminase; Animals; Glutathione; Liver; Liver Cirrhosis, Experimental; Male; | 1994 |
Protoberberine alkaloids from Enantia chlorantha therapy of allyl-alcohol- and D-galactosamine-traumatized rats.
Topics: 1-Propanol; Alanine Transaminase; Alkaline Phosphatase; Animals; Berberine Alkaloids; Drug Combinati | 1993 |
Allyl alcohol-induced changes in the rat exocrine pancreas.
Topics: 1-Propanol; Alcohol Oxidoreductases; Allyl Compounds; Animals; Cytoplasm; Female; Liver; Male; Micro | 1979 |
The productoin of periportal necrosis by allyl alcohol in the rat [proceedings].
Topics: 1-Propanol; Allyl Compounds; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Propan | 1978 |
Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents.
Topics: 1-Propanol; Animals; Antioxidants; Ascorbic Acid; Bromobenzenes; Chromatography, High Pressure Liqui | 1990 |
The protective effect of pollen extracts against allyl alcohol damage of the liver.
Topics: 1-Propanol; Animals; Inclusion Bodies; Liver; Male; Necrosis; Phytotherapy; Plant Extracts; Pollen; | 1985 |
Evaluating toxin-induced hepatic injury in rats by laboratory results and discriminant analysis.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; 5'-Nucleotidase; Alanine Transaminase; Animals; Carbon Tetrach | 1986 |
Effect of allyl alcohol-induced sublethal hepatic damage upon doxorubicin metabolism and toxicity in the rabbit.
Topics: 1-Propanol; Aminopyrine; Animals; Breath Tests; Doxorubicin; Drug Synergism; Female; Liver; Necrosis | 1987 |
Rat hepatic mitochondria are more sensitive to allyl alcohol than are those of mice.
Topics: 1-Propanol; Alanine Transaminase; Animals; Drug Resistance; Hepatitis, Alcoholic; Mice; Mitochondria | 1987 |