Page last updated: 2024-08-07 16:29:49
Cholecystokinin receptor type A
A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238]
Synonyms
CCK-A receptor;
CCK-AR;
Cholecystokinin-1 receptor;
CCK1-R
Research
Bioassay Publications (28)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (42.86) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (19)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5-methoxytryptamine | Homo sapiens (human) | Ki | 0.3020 | 1 | 1 |
| propranolol | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| indopan | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| paclitaxel | Homo sapiens (human) | IC50 | 11.3800 | 1 | 0 |
| paclitaxel | Homo sapiens (human) | Ki | 2.2760 | 1 | 0 |
| 5-methoxy-alpha-methyltryptamine | Homo sapiens (human) | Ki | 0.3450 | 1 | 1 |
| loxiglumide | Homo sapiens (human) | IC50 | 0.1950 | 1 | 1 |
| ci 988 | Homo sapiens (human) | IC50 | 1.0471 | 1 | 1 |
| a 71623 | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| sr 27897 | Homo sapiens (human) | IC50 | 0.0006 | 1 | 1 |
| devazepide | Homo sapiens (human) | IC50 | 0.0002 | 3 | 3 |
| devazepide | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| asperlicin | Homo sapiens (human) | IC50 | 1.4000 | 2 | 2 |
| cholecystokinin (26-33) | Homo sapiens (human) | IC50 | 0.0282 | 1 | 1 |
| l 365260 | Homo sapiens (human) | IC50 | 0.1585 | 1 | 1 |
| l 365260 | Homo sapiens (human) | Ki | 0.1738 | 1 | 1 |
| sincalide | Homo sapiens (human) | IC50 | 0.0006 | 11 | 11 |
| sincalide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| yf 476 | Homo sapiens (human) | Ki | 0.0302 | 3 | 3 |
| naluzotan | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| a 803467 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| gastrin 17 | Homo sapiens (human) | IC50 | 0.8511 | 1 | 1 |
| nitd 609 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| propranolol | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| cholecystokinin (26-33) | Homo sapiens (human) | EC50 | 0.0280 | 1 | 1 |
| sincalide | Homo sapiens (human) | EC50 | 0.0113 | 4 | 5 |
| sincalide | Homo sapiens (human) | Kd | 0.0019 | 1 | 1 |
| gastrin 17 | Homo sapiens (human) | EC50 | 0.2692 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cholecystokinin receptor activity | molecular function | Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. [GOC:signaling, PMID:9835394] |
| peptide hormone binding | molecular function | Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732] |
| peptide binding | molecular function | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| neuron migration | biological process | The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. [CL:0000540, GOC:go_curators] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| axonogenesis | biological process | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] |
| forebrain development | biological process | The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain] |
| cholecystokinin signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:11181948] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| cellular response to hormone stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah] |
| regulation of hormone secretion | biological process | Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai] |