Voltage-dependent calcium channel gamma-5 subunit

A voltage-dependent calcium channel gamma-5 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF02]

Synonyms

Neuronal voltage-gated calcium channel gamma-5 subunit;
Transmembrane AMPAR regulatory protein gamma-5;
TARP gamma-5

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	IC50	17.0000	1	1
nimodipine	Homo sapiens (human)	IC50	14.0000	1	1
ith 4012	Homo sapiens (human)	IC50	20.0000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
monoatomic ion transmembrane transporter activity	molecular function	Enables the transfer of an ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
channel regulator activity	molecular function	Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:mah]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
postsynaptic density membrane	cellular component	The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
AMPA glutamate receptor complex	cellular component	An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. [GOC:ef]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
regulation of AMPA receptor activity	biological process	Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. [GOC:BHF]
postsynaptic neurotransmitter receptor diffusion trapping	biological process	The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. [PMID:18832033]
neurotransmitter receptor transport, postsynaptic endosome to lysosome	biological process	The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation. [GOC:dos]
neurotransmitter receptor internalization	biological process	A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor. [GOC:dos]
transmission of nerve impulse	biological process	The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. [GOC:curators, ISBN:0815316194]
positive regulation of synaptic transmission, glutamatergic	biological process	Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]

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