quinacrine has been researched along with Necrosis in 7 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine (QUIN) is a well known inhibitor of PLA2." | 5.29 | Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis. ( Castro, JA; de Toranzo, EG; González Padrón, A, 1993) |
| "In quinacrine-treated animals left ventricular phospholipids and CK also fell during the first hours post-occlusion; however, 24 and 48 h after the occlusion they were significantly higher than in controls (phospholipids: 0." | 5.27 | [Limitation of the area of necrosis induced by quinacrine after coronary occlusion in the dog]. ( Ambrosio, G; Bigazzi, MC; Brigante, F; Chiariello, M; Focaccio, A; Migliaccio, C; Tritto, I, 1985) |
| " Intratumor injection of quinacrine induces intense recruitment of activated immune cells that leads to necrosis and elimination of experimental malignant neoplasms; this effect seems to be mediated by immune molecules." | 3.72 | Interstitial quinacrine activates a distinctive immune response effective for tumor immunotherapy. ( Diaz, C; Guevara, P; Pineda, B; Sotelo, J, 2004) |
| " In the present study we sought to assess whether administration of the phospholipase inhibitor quinacrine would reduce the extent of myocardial necrosis after coronary artery occlusion." | 3.68 | Reduction in infarct size by the phospholipase inhibitor quinacrine in dogs with coronary artery occlusion. ( Ambrosio, G; Cappelli-Bigazzi, M; Chiariello, M; Golino, P; Nevola, E; Perrone-Filardi, P; Tritto, I, 1990) |
| "Quinacrine (QUIN) is a well known inhibitor of PLA2." | 1.29 | Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis. ( Castro, JA; de Toranzo, EG; González Padrón, A, 1993) |
| "In quinacrine-treated animals left ventricular phospholipids and CK also fell during the first hours post-occlusion; however, 24 and 48 h after the occlusion they were significantly higher than in controls (phospholipids: 0." | 1.27 | [Limitation of the area of necrosis induced by quinacrine after coronary occlusion in the dog]. ( Ambrosio, G; Bigazzi, MC; Brigante, F; Chiariello, M; Focaccio, A; Migliaccio, C; Tritto, I, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, JT | 1 |
| Liu, SH | 1 |
| Yan, YE | 1 |
| Wu, Y | 1 |
| Wu, HT | 1 |
| Xing, C | 1 |
| Ge, XM | 1 |
| Wang, H | 1 |
| Zhao, YQ | 1 |
| Fan, M | 1 |
| Sotelo, J | 1 |
| Guevara, P | 1 |
| Pineda, B | 1 |
| Diaz, C | 1 |
| González Padrón, A | 1 |
| de Toranzo, EG | 1 |
| Castro, JA | 1 |
| Chiariello, M | 2 |
| Ambrosio, G | 2 |
| Cappelli-Bigazzi, M | 1 |
| Perrone-Filardi, P | 1 |
| Tritto, I | 2 |
| Nevola, E | 1 |
| Golino, P | 1 |
| Bigazzi, MC | 1 |
| Focaccio, A | 1 |
| Brigante, F | 1 |
| Migliaccio, C | 1 |
| Schenker, JG | 1 |
| Polishuk, WZ | 1 |
| Joseph, AA | 1 |
| Kincl, FA | 1 |
7 other studies available for quinacrine and Necrosis
| Article | Year |
|---|---|
Quinacrine protects neuronal cells against heat-induced injury.
Topics: Animals; Animals, Newborn; Apoptosis; Arachidonic Acid; Hot Temperature; Microscopy, Atomic Force; N | 2009 |
Interstitial quinacrine activates a distinctive immune response effective for tumor immunotherapy.
Topics: Animals; Antineoplastic Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemokine CC | 2004 |
Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis.
Topics: Animals; Body Temperature; Calcium; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug In | 1993 |
Reduction in infarct size by the phospholipase inhibitor quinacrine in dogs with coronary artery occlusion.
Topics: Animals; Coronary Disease; Dogs; Hemodynamics; Myocardial Infarction; Myocardium; Necrosis; Phosphol | 1990 |
[Limitation of the area of necrosis induced by quinacrine after coronary occlusion in the dog].
Topics: Animals; Constriction; Coronary Disease; Creatine Kinase; Dogs; Male; Myocardium; Necrosis; Phosphol | 1985 |
Regeneration of rabbit endometrium following intrauterine instillation of chemical agents.
Topics: Animals; Copper; Endometrium; Female; Formaldehyde; Granulation Tissue; Irritants; Necrosis; Quinacr | 1973 |
Toxic and antifertility effects of quinacrine hydrochloride in rats.
Topics: Animals; Atrophy; Autopsy; Colonic Diseases; Dose-Response Relationship, Drug; Drug Synergism; Embry | 1974 |