Proteins > Gamma-aminobutyric acid receptor subunit alpha-4
Page last updated: 2024-08-07 13:05:03
Gamma-aminobutyric acid receptor subunit alpha-4
A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of cow. [OMA:P20237, PRO:DNx]
Synonyms
GABA(A) receptor subunit alpha-4
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| l 755507 | Bos taurus (cattle) | EC50 | 0.0004 | 1 | 1 |
| brl 37344 | Bos taurus (cattle) | EC50 | 0.4500 | 1 | 1 |
Drugs with Other Measurements
Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ligands.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Specific inhibition of benzodiazepine receptor binding by some N-(indol-3-ylglyoxylyl)amino acid derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.Journal of medicinal chemistry, , Jul-05, Volume: 44, Issue:14, 2001
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.Journal of medicinal chemistry, , Apr-20, Volume: 49, Issue:8, 2006
Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.Journal of medicinal chemistry, , Dec-19, Volume: 45, Issue:26, 2002
Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.Journal of medicinal chemistry, , Jun-17, Volume: 42, Issue:12, 1999
Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 33, Issue:9, 1990
Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ligands.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Specific inhibition of benzodiazepine receptor binding by some N-(indol-3-ylglyoxylyl)amino acid derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.Journal of medicinal chemistry, , Apr-20, Volume: 49, Issue:8, 2006
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.Journal of medicinal chemistry, , Dec-19, Volume: 45, Issue:26, 2002
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.Journal of medicinal chemistry, , Jul-05, Volume: 44, Issue:14, 2001
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives.Journal of medicinal chemistry, , Jun-12, Volume: 35, Issue:12, 1992
Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 33, Issue:9, 1990
Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Volume: 33, Issue:9, 1990
beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.Journal of medicinal chemistry, , Volume: 26, Issue:4, 1983
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.Journal of medicinal chemistry, , Jul-05, Volume: 44, Issue:14, 2001
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.Journal of medicinal chemistry, , Jul-05, Volume: 44, Issue:14, 2001
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996