Page last updated: 2024-08-07 17:17:18
Integrase
[no definition available]
Synonyms
Research
Bioassay Publications (130)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (11.54) | 18.2507 |
| 2000's | 56 (43.08) | 29.6817 |
| 2010's | 53 (40.77) | 24.3611 |
| 2020's | 6 (4.62) | 2.80 |
Compounds (113)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| digallic acid | Human immunodeficiency virus 1 | IC50 | 1.0667 | 6 | 6 |
| amitrole | Human immunodeficiency virus 1 | IC50 | 0.1700 | 1 | 1 |
| chloroxine | Human immunodeficiency virus 1 | IC50 | 20.0000 | 2 | 2 |
| ciprofloxacin | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| cloxyquin | Human immunodeficiency virus 1 | IC50 | 20.0000 | 2 | 2 |
| hypericin | Human immunodeficiency virus 1 | IC50 | 10.0000 | 1 | 1 |
| mitoxantrone | Human immunodeficiency virus 1 | IC50 | 5.9000 | 2 | 2 |
| 1,2,5,8-tetrahydroxy anthraquinone | Human immunodeficiency virus 1 | IC50 | 7.3333 | 3 | 3 |
| salicylamide | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| delavirdine | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| tetramethylsilane | Human immunodeficiency virus 1 | IC50 | 11.0000 | 2 | 2 |
| lawsone | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| 8-hydroxy-2-methylquinoline | Human immunodeficiency virus 1 | IC50 | 100.0000 | 3 | 3 |
| salicyl hydrazide | Human immunodeficiency virus 1 | IC50 | 59.0000 | 4 | 4 |
| psoromic acid | Human immunodeficiency virus 1 | IC50 | 12.4250 | 4 | 4 |
| camptothecin | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| 1,4,5,8-naphthalenetetracarboxylic acid | Human immunodeficiency virus 1 | IC50 | 167.2200 | 5 | 5 |
| sodium azide | Human immunodeficiency virus 1 | IC50 | 23,000.6000 | 2 | 2 |
| etoposide | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| chaetochromin | Human immunodeficiency virus 1 | IC50 | 7.0000 | 2 | 4 |
| piroxantrone | Human immunodeficiency virus 1 | IC50 | 13.5000 | 2 | 2 |
| zanamivir | Human immunodeficiency virus 1 | IC50 | 0.0025 | 1 | 1 |
| n,n'-bis(salicyl)hydrazine | Human immunodeficiency virus 1 | IC50 | 276.6118 | 17 | 17 |
| physodic acid | Human immunodeficiency virus 1 | IC50 | 33.9667 | 3 | 3 |
| 5,5'-methylenedisalicylic acid | Human immunodeficiency virus 1 | IC50 | 65.3250 | 4 | 4 |
| atranorin | Human immunodeficiency virus 1 | IC50 | 66.2800 | 5 | 5 |
| methyl fluorone black | Human immunodeficiency virus 1 | IC50 | 1.1500 | 4 | 4 |
| stictic acid | Human immunodeficiency virus 1 | IC50 | 4.7000 | 5 | 5 |
| 3,4,5-trihydroxybenzohydroxamic acid | Human immunodeficiency virus 1 | IC50 | 1.6000 | 4 | 4 |
| 5,6-dihydroxy-2-indolylcarboxylic acid | Human immunodeficiency virus 1 | IC50 | 10.0000 | 1 | 1 |
| tetrahydrocurcumin | Human immunodeficiency virus 1 | IC50 | 300.0000 | 2 | 2 |
| pannarin | Human immunodeficiency virus 1 | IC50 | 4.0167 | 6 | 6 |
| naringenin | Human immunodeficiency virus 1 | IC50 | 13.9000 | 3 | 3 |
| ferulic acid | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| tnk-651 | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| gs 4071 | Human immunodeficiency virus 1 | IC50 | 1.7850 | 2 | 2 |
| 5-(1,1-dioxido-1,2-thiazinan-2-yl)-n-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide | Human immunodeficiency virus 1 | IC50 | 0.9932 | 22 | 22 |
| l 731988 | Human immunodeficiency virus 1 | IC50 | 1.8950 | 9 | 10 |
| l 708906 | Human immunodeficiency virus 1 | IC50 | 123.2367 | 9 | 9 |
| (+)-usnic acid | Human immunodeficiency virus 1 | IC50 | 127.7000 | 3 | 3 |
| 4-phenyl-4-oxo-2-hydroxybuten-2-oic acid | Human immunodeficiency virus 1 | IC50 | 25.0000 | 1 | 1 |
| 2-hydroxy-4h-isoquinoline-1,3-dione | Human immunodeficiency virus 1 | IC50 | 2,503.1600 | 2 | 2 |
| isoliquiritigenin | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| 5-[(2-fluoroanilino)methyl]-8-quinolinol | Human immunodeficiency virus 1 | IC50 | 20.0000 | 2 | 2 |
| caffeic acid | Human immunodeficiency virus 1 | IC50 | 32.4000 | 4 | 4 |
| methyl caffeate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 3 | 3 |
| cyqualon | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| chlorogenic acid | Human immunodeficiency virus 1 | IC50 | 59.4500 | 6 | 6 |
| australifungin | Human immunodeficiency virus 1 | IC50 | 20.0000 | 1 | 1 |
| jtk-303 | Human immunodeficiency virus 1 | IC50 | 0.9110 | 26 | 26 |
| quercetin | Human immunodeficiency virus 1 | IC50 | 13.1600 | 5 | 5 |
| apigenin | Human immunodeficiency virus 1 | IC50 | 13.8333 | 3 | 3 |
| luteolin | Human immunodeficiency virus 1 | IC50 | 17.4500 | 5 | 5 |
| kaempferol | Human immunodeficiency virus 1 | IC50 | 81.2500 | 2 | 2 |
| genistein | Human immunodeficiency virus 1 | IC50 | 13.7000 | 3 | 3 |
| butein | Human immunodeficiency virus 1 | IC50 | 19.9763 | 2 | 2 |
| baicalein | Human immunodeficiency virus 1 | IC50 | 3.2960 | 5 | 5 |
| chrysin | Human immunodeficiency virus 1 | IC50 | 13.8000 | 3 | 3 |
| fisetin | Human immunodeficiency virus 1 | IC50 | 18.4500 | 2 | 2 |
| morin | Human immunodeficiency virus 1 | IC50 | 54.1000 | 2 | 2 |
| myricetin | Human immunodeficiency virus 1 | IC50 | 3.1750 | 4 | 4 |
| quercetagetin | Human immunodeficiency virus 1 | IC50 | 0.6429 | 7 | 7 |
| rhamnetin | Human immunodeficiency virus 1 | IC50 | 45.1500 | 2 | 2 |
| robinetin | Human immunodeficiency virus 1 | IC50 | 3.7500 | 2 | 2 |
| chicoric acid | Human immunodeficiency virus 1 | IC50 | 5.1180 | 8 | 8 |
| cynarine | Human immunodeficiency virus 1 | IC50 | 1.6000 | 1 | 1 |
| caffeic acid phenethyl ester | Human immunodeficiency virus 1 | IC50 | 33.2159 | 5 | 5 |
| rosmarinic acid | Human immunodeficiency virus 1 | IC50 | 17.2100 | 5 | 5 |
| acteoside | Human immunodeficiency virus 1 | IC50 | 7.8000 | 1 | 1 |
| ellagic acid | Human immunodeficiency virus 1 | IC50 | 5.1000 | 2 | 2 |
| phenylethyl 3-methylcaffeate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| bisdemethoxycurcumin | Human immunodeficiency virus 1 | IC50 | 100.0000 | 4 | 4 |
| ethyl caffeate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 3 | 3 |
| fumarprotocetraric acid | Human immunodeficiency virus 1 | IC50 | 5.2600 | 5 | 5 |
| octadecyl caffeate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| salazinic acid | Human immunodeficiency virus 1 | IC50 | 13.4500 | 4 | 4 |
| ag 99 | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| 1,3,5-triphenylformazan | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| tetrahydroxycurcumin | Human immunodeficiency virus 1 | IC50 | 4.5500 | 2 | 2 |
| bornyl caffeate | Human immunodeficiency virus 1 | IC50 | 19.9000 | 1 | 1 |
| 2,4,2'-trihydroxychalcone | Human immunodeficiency virus 1 | IC50 | 50.0000 | 2 | 2 |
| benzyl caffeate | Human immunodeficiency virus 1 | IC50 | 39.3042 | 3 | 3 |
| palitantin | Human immunodeficiency virus 1 | IC50 | 260.5000 | 4 | 4 |
| s 1360 | Human immunodeficiency virus 1 | IC50 | 3.8733 | 9 | 9 |
| 4,5-di-O-caffeoylquinic acid | Human immunodeficiency virus 1 | IC50 | 0.6675 | 6 | 8 |
| indigo carmine | Human immunodeficiency virus 1 | IC50 | 0.9700 | 2 | 2 |
| hylin | Human immunodeficiency virus 1 | IC50 | 37.0768 | 2 | 2 |
| 6-(1-(4-fluorophenyl)methyl-1h-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acid ethyl ester | Human immunodeficiency virus 1 | IC50 | 93.3333 | 2 | 3 |
| n-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide | Human immunodeficiency virus 1 | IC50 | 0.0288 | 5 | 5 |
| clavaric acid | Human immunodeficiency virus 1 | IC50 | 66.0000 | 2 | 2 |
| propyl caffeate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| octyl caffeate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| 3,4-methylenedioxy-3',4',5'-trimethoxy chalcone | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| complestatin | Human immunodeficiency virus 1 | IC50 | 1.6400 | 5 | 5 |
| neuroprotectin a | Human immunodeficiency virus 1 | IC50 | 6.6500 | 2 | 2 |
| raltegravir potassium | Human immunodeficiency virus 1 | IC50 | 0.0494 | 3 | 3 |
| chi 1043 | Human immunodeficiency virus 1 | IC50 | 0.1155 | 11 | 11 |
| raltegravir | Human immunodeficiency virus 1 | IC50 | 2.6698 | 54 | 54 |
| tetracycline | Human immunodeficiency virus 1 | IC50 | 196.0000 | 2 | 2 |
| dicumarol | Human immunodeficiency virus 1 | IC50 | 166.6667 | 2 | 3 |
| 4-hydroxy-1-(2-methylpropyl)-2-oxo-N-(2-sulfamoylphenyl)-3-quinolinecarboxamide | Human immunodeficiency virus 1 | IC50 | 28.0000 | 4 | 4 |
| 4,7-Dihydroxy-2H-1-benzopyran-2-one | Human immunodeficiency virus 1 | IC50 | 316.6667 | 3 | 3 |
| 4-hydroxycoumarin | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| rolitetracycline | Human immunodeficiency virus 1 | IC50 | 31.0000 | 2 | 2 |
| ethyl biscoumacetate | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| nsc 158393 | Human immunodeficiency virus 1 | IC50 | 1.2714 | 6 | 7 |
| gsk1265744 | Human immunodeficiency virus 1 | IC50 | 0.0030 | 1 | 1 |
| gsk364735 | Human immunodeficiency virus 1 | IC50 | 0.0076 | 5 | 5 |
| dolutegravir | Human immunodeficiency virus 1 | IC50 | 0.0414 | 5 | 5 |
| bictegravir | Human immunodeficiency virus 1 | IC50 | 0.0075 | 1 | 1 |
| 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
Drugs with Activation Measurements
Drugs with Other Measurements
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Developing a dynamic pharmacophore model for HIV-1 integrase.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
Active site binding modes of HIV-1 integrase inhibitors.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.Journal of natural products, , Aug-24, Volume: 75, Issue:8, 2012
Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.Journal of medicinal chemistry, , Jan-24, Volume: 51, Issue:2, 2008
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Metal-dependent inhibition of HIV-1 integrase.Journal of medicinal chemistry, , Dec-19, Volume: 45, Issue:26, 2002
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Hydrazide-containing inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors.Journal of medicinal chemistry, , 05-26, Volume: 65, Issue:10, 2022
[no title available]Journal of medicinal chemistry, , 09-08, Volume: 65, Issue:17, 2022
Pyridopyrimidinone inhibitors of HIV-1 RNase H.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:3, 2009
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:8, 2008
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:3, 2008
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.Journal of medicinal chemistry, , Apr-24, Volume: 51, Issue:8, 2008
A potent and orally active HIV-1 integrase inhibitor.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.Journal of medicinal chemistry, , Nov-03, Volume: 48, Issue:22, 2005
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.Journal of medicinal chemistry, , Mar-24, Volume: 59, Issue:6, 2016
Discovery of a Potent HIV Integrase Inhibitor that Leads to a Prodrug with Significant anti-HIV Activity.ACS medicinal chemistry letters, , Oct-05, Volume: 2, Issue:12, 2011
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 17, Issue:7, 2009
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.Journal of medicinal chemistry, , Aug-14, Volume: 51, Issue:15, 2008
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 14, Issue:7, 2004
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.Journal of medicinal chemistry, , Dec-28, Volume: 43, Issue:26, 2000
Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:8, 2008
Development of integrase inhibitors for treatment of AIDS: an overview.European journal of medicinal chemistry, , Volume: 42, Issue:9, 2007
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.Journal of medicinal chemistry, , Jul-14, Volume: 48, Issue:14, 2005
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Pyridopyrimidinone inhibitors of HIV-1 RNase H.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Synthesis and antiviral properties of some polyphenols related to Salvia genus.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Hydroxylated aromatic inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Developing a dynamic pharmacophore model for HIV-1 integrase.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold.Bioorganic & medicinal chemistry, , 04-01, Volume: 59, 2022
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.Bioorganic & medicinal chemistry, , 09-01, Volume: 27, Issue:17, 2019
Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.Journal of medicinal chemistry, , Jun-11, Volume: 58, Issue:11, 2015
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.European journal of medicinal chemistry, , Volume: 46, Issue:2, 2011
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 55, Issue:2, 2011
CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase.European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.Journal of medicinal chemistry, , Aug-13, Volume: 52, Issue:15, 2009
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:8, 2008
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:3, 2008
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.Journal of medicinal chemistry, , Aug-28, Volume: 51, Issue:16, 2008
Development of integrase inhibitors for treatment of AIDS: an overview.European journal of medicinal chemistry, , Volume: 42, Issue:9, 2007
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Developing a dynamic pharmacophore model for HIV-1 integrase.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Developing a dynamic pharmacophore model for HIV-1 integrase.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995
Evaluation of novel MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , 04-01, Volume: 28, Issue:6, 2018
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.European journal of medicinal chemistry, , Volume: 43, Issue:10, 2008
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.Bioorganic & medicinal chemistry letters, , Aug-21, Volume: 10, Issue:16, 2000
Active site binding modes of HIV-1 integrase inhibitors.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Chicoric acid analogues as HIV-1 integrase inhibitors.Journal of medicinal chemistry, , Apr-22, Volume: 42, Issue:8, 1999
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Hydroxylated aromatic inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.Journal of medicinal chemistry, , Apr-24, Volume: 51, Issue:8, 2008
Developing a dynamic pharmacophore model for HIV-1 integrase.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Hydroxylated aromatic inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Hydroxylated aromatic inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Hydroxylated aromatic inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 23, Issue:22, 2013
Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 15, Issue:3, 2007
Calculation of binding energy using BLYP/MM for the HIV-1 integrase complexed with the S-1360 and two analogues.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.Journal of medicinal chemistry, , Nov-03, Volume: 48, Issue:22, 2005
New approaches toward anti-HIV chemotherapy.Journal of medicinal chemistry, , Mar-10, Volume: 48, Issue:5, 2005
Developing a dynamic pharmacophore model for HIV-1 integrase.Journal of medicinal chemistry, , Jun-01, Volume: 43, Issue:11, 2000
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Synthesis and antiviral properties of some polyphenols related to Salvia genus.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.Journal of medicinal chemistry, , Feb-11, Volume: 42, Issue:3, 1999
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 14, Issue:7, 2004
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 18, Issue:19, 2008
A potent and orally active HIV-1 integrase inhibitor.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 16, Issue:11, 2006
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.Journal of natural products, , Volume: 64, Issue:7, 2001
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.Journal of natural products, , Volume: 64, Issue:7, 2001
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 55, Issue:2, 2011
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 20, Issue:19, 2010
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
A review on recent developments of indole-containing antiviral agents.European journal of medicinal chemistry, , Jan-07, Volume: 89, 2015
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.Bioorganic & medicinal chemistry, , Apr-01, Volume: 22, Issue:7, 2014
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.European journal of medicinal chemistry, , Volume: 46, Issue:2, 2011
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:8, 2008
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.Journal of medicinal chemistry, , 04-14, Volume: 65, Issue:7, 2022
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.Journal of medicinal chemistry, , 06-24, Volume: 64, Issue:12, 2021
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.Bioorganic & medicinal chemistry, , 09-01, Volume: 27, Issue:17, 2019
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline.Bioorganic & medicinal chemistry, , 08-15, Volume: 27, Issue:16, 2019
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.Journal of medicinal chemistry, , Feb-26, Volume: 58, Issue:4, 2015
Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 25, Issue:15, 2015
Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase.European journal of medicinal chemistry, , Nov-02, Volume: 104, 2015
Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors.ACS medicinal chemistry letters, , Oct-08, Volume: 6, Issue:10, 2015
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.Journal of medicinal chemistry, , Jun-11, Volume: 58, Issue:11, 2015
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
Synthesis, anti-HIV activity, integrase enzyme inhibition and molecular modeling of catechol, hydroquinone and quinol labdane analogs.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.ACS medicinal chemistry letters, , Jul-11, Volume: 4, Issue:7, 2013
Design and synthesis of novel β-diketo derivatives as HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.European journal of medicinal chemistry, , Volume: 46, Issue:2, 2011
Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 19, Issue:16, 2009
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 19, Issue:13, 2009
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:3, 2009
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:8, 2008
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:3, 2008
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 17, Issue:7, 2009
Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.Journal of medicinal chemistry, , Dec-15, Volume: 48, Issue:25, 2005
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.Bioorganic & medicinal chemistry letters, , Mar-22, Volume: 14, Issue:6, 2004
Coumarin-based inhibitors of HIV integrase.Journal of medicinal chemistry, , Jan-17, Volume: 40, Issue:2, 1997
Coumarin-based inhibitors of HIV integrase.Journal of medicinal chemistry, , Jan-17, Volume: 40, Issue:2, 1997
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.Journal of medicinal chemistry, , Jun-21, Volume: 39, Issue:13, 1996
Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors.European journal of medicinal chemistry, , Jul-19, Volume: 117, 2016
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 24, Issue:14, 2014
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 23, Issue:2, 2013
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:3, 2008
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.Bioorganic & medicinal chemistry, , 09-01, Volume: 27, Issue:17, 2019
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).Journal of medicinal chemistry, , Jul-25, Volume: 56, Issue:14, 2013