Proteins > Carbonic anhydrase-related protein 11
Page last updated: 2024-08-08 00:45:06
Carbonic anhydrase-related protein 11
A carbonic anhydrase-related protein 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75493]
Synonyms
CA-RP XI;
CA-XI;
CARP XI;
Carbonic anhydrase-related protein 2;
CA-RP II;
CARP-2
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| acetazolamide | Homo sapiens (human) | Ki | 0.0057 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| acetazolamide | Homo sapiens (human) | Kinact | 0.0057 | 1 | 1 |
| topiramate | Homo sapiens (human) | Kinact | 0.0038 | 1 | 1 |
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| hydro-lyase activity | molecular function | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. [EC:4.2.1.-] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |