A 17-beta-hydroxysteroid dehydrogenase type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37058]
EC 1.1.1.64;
17-beta-hydroxysteroid dehydrogenase type 3;
17-beta-HSD 3;
Estradiol 17-beta-dehydrogenase 2;
1.1.1.62;
Short chain dehydrogenase/reductase family 12C member 2;
Testicular 17-beta-hydroxysteroid dehydrogenase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bicalutamide | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| etiocholanolone | Homo sapiens (human) | IC50 | 0.2930 | 4 | 4 |
| androstenedione | Homo sapiens (human) | IC50 | 0.6826 | 5 | 5 |
| 4-hydroxypropiophenone | Homo sapiens (human) | IC50 | 150.5600 | 1 | 1 |
| 4-hydroxyacetophenone | Homo sapiens (human) | IC50 | 1,708.9200 | 1 | 1 |
| phenylbenzoquinone | Homo sapiens (human) | IC50 | 5.7000 | 1 | 1 |
| dihydrotestosterone | Homo sapiens (human) | IC50 | 0.0026 | 1 | 1 |
| phenylhydroquinone | Homo sapiens (human) | IC50 | 14.8000 | 1 | 1 |
| 6-hydroxyflavone | Homo sapiens (human) | IC50 | 16.4000 | 1 | 1 |
| zuclomiphene | Homo sapiens (human) | IC50 | 76.2000 | 1 | 1 |
| biochanin a | Homo sapiens (human) | IC50 | 10.8000 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 18.8500 | 1 | 2 |
| hymecromone | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| genistein | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 97.6100 | 2 | 2 |
| fisetin | Homo sapiens (human) | IC50 | 32.4000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 100.5000 | 1 | 1 |
| 7-hydroxyflavone | Homo sapiens (human) | IC50 | 37.9900 | 2 | 2 |
| chlorferron | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| 7-hydroxy-4-trifluoromethylcoumarin | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| estradiol 17-beta-dehydrogenase [NAD(P)] activity | molecular function | Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62] |
| testosterone dehydrogenase [NAD(P)] activity | molecular function | Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. [EC:1.1.1.51] |
| testosterone 17-beta-dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] |
| 17-beta-hydroxysteroid dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+. [GOC:kad, PMID:17074428] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| androgen biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732] |
| male genitalia development | biological process | The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. [GOC:ems, ISBN:0140512888] |
| testosterone biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5. [GOC:dph, GOC:yaf] |
| steroid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators] |