Page last updated: 2024-08-07 16:08:31
Thymidine phosphorylase
A thymidine phosphorylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19971]
Synonyms
TP;
EC 2.4.2.4;
Gliostatin;
Platelet-derived endothelial cell growth factor;
PD-ECGF;
TdRPase
Research
Bioassay Publications (19)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| captopril | Homo sapiens (human) | EC50 | 1,422.6600 | 1 | 1 |
Drugs with Other Measurements
Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.Journal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:6, 2008
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.Journal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model.Bioorganic & medicinal chemistry letters, , Jan-06, Volume: 13, Issue:1, 2003
Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase.European journal of medicinal chemistry, , Volume: 65, 2013
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 20, Issue:3, 2010
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:6, 2008
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.Journal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.European journal of medicinal chemistry, , Volume: 67, 2013
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:6, 2008
Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| 1,4-alpha-oligoglucan phosphorylase activity | molecular function | Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. [EC:2.4.1.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| growth factor activity | molecular function | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194] |
| thymidine phosphorylase activity | molecular function | Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. [RHEA:16037] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|
| mitochondrial genome maintenance | biological process | The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. [GOC:ai, GOC:vw] |
| angiogenesis | biological process | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453] |
| pyrimidine nucleobase metabolic process | biological process | The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators] |
| pyrimidine nucleoside metabolic process | biological process | The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713] |
| chemotaxis | biological process | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732] |
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| cell differentiation | biological process | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| regulation of myelination | biological process | Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah] |
| dTMP catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate. [GOC:go_curators] |
| regulation of transmission of nerve impulse | biological process | Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai] |
| regulation of gastric motility | biological process | Any process that modulates the frequency, rate or extent of gastric motility. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:9924029] |