Page last updated: 2024-08-07 23:43:33
Cholinesterase
[no definition available]
Synonyms
EC 3.1.1.8;
Acylcholine acylhydrolase;
Butyrylcholine esterase;
Choline esterase II;
EQ-BCHE;
Pseudocholinesterase
Research
Bioassay Publications (287)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (3.48) | 29.6817 |
| 2010's | 229 (79.79) | 24.3611 |
| 2020's | 48 (16.72) | 2.80 |
Compounds (89)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| rivastigmine | Equus caballus (horse) | Kd | 1.1500 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| physostigmine | Equus caballus (horse) | K | 0.1208 | 3 | 3 |
| ellagic acid | Equus caballus (horse) | EC16 | 250.0000 | 1 | 1 |
| augustic acid | Equus caballus (horse) | Kiuc | 10.5800 | 1 | 1 |
Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
[no title available]Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 234, 2022
Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.Journal of medicinal chemistry, , 05-27, Volume: 64, Issue:10, 2021
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Bioactive Azepine-Indole Alkaloids from Journal of natural products, , 04-24, Volume: 83, Issue:4, 2020
Search for new multi-target compounds against Alzheimer's disease among histamine HEuropean journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 30, Issue:24, 2020
Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 30, Issue:9, 2020
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 29, Issue:16, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors.MedChemComm, , Jan-01, Volume: 9, Issue:1, 2018
Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.Bioorganic & medicinal chemistry, , 09-01, Volume: 26, Issue:16, 2018
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors MMedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 11-01, Volume: 25, Issue:21, 2017
Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.Journal of medicinal chemistry, , 07-13, Volume: 60, Issue:13, 2017
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
[no title available]Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEuropean journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.European journal of medicinal chemistry, , Jun-30, Volume: 116, 2016
Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 06-15, Volume: 24, Issue:12, 2016
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.European journal of medicinal chemistry, , Oct-21, Volume: 122, 2016
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.European journal of medicinal chemistry, , Jan-07, Volume: 89, 2015
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 25, Issue:17, 2015
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
Synthesis and cholinesterase inhibition of cativic acid derivatives.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 64, 2013
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 63, 2013
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 62, 2013
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 69, 2013
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.European journal of medicinal chemistry, , Volume: 68, 2013
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 22, Issue:13, 2012
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.Bioorganic & medicinal chemistry, , Oct-01, Volume: 20, Issue:19, 2012
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.Journal of medicinal chemistry, , Jun-14, Volume: 55, Issue:11, 2012
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.European journal of medicinal chemistry, , Volume: 46, Issue:1, 2011
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.Journal of medicinal chemistry, , Mar-11, Volume: 53, Issue:5, 2010
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:4, 2010
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.Journal of medicinal chemistry, , Jul-08, Volume: 53, Issue:13, 2010
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 18, Issue:13, 2008
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:3, 2008
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.Journal of natural products, , Volume: 69, Issue:9, 2006
BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 234, 2022
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease.Bioorganic & medicinal chemistry, , 10-01, Volume: 71, 2022
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 09-15, Volume: 46, 2021
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.European journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 46, 2021
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Novel arylcarbamate-N-acylhydrazones derivatives as promising BuChE inhibitors: Design, synthesis, molecular modeling and biological evaluation.Bioorganic & medicinal chemistry, , 02-15, Volume: 32, 2021
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.European journal of medicinal chemistry, , Apr-05, Volume: 215, 2021
Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 52, 2021
Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease.European journal of medicinal chemistry, , Jul-15, Volume: 198, 2020
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 30, Issue:20, 2020
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 30, Issue:4, 2020
Search for new multi-target compounds against Alzheimer's disease among histamine HEuropean journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 192, 2020
The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors.European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Design, synthesis, and biological evaluation of novel 4-oxobenzo[d]1,2,3-triazin-benzylpyridinum derivatives as potent anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 07-01, Volume: 27, Issue:13, 2019
A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.European journal of medicinal chemistry, , Jul-15, Volume: 174, 2019
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , 07-15, Volume: 27, Issue:14, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 27, Issue:18, 2019
Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 29, Issue:19, 2019
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 28, Issue:17, 2018
Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors.European journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.European journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Jun-16, Volume: 133, 2017
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 27, Issue:5, 2017
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEuropean journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors.ACS medicinal chemistry letters, , May-12, Volume: 7, Issue:5, 2016
Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 06-15, Volume: 24, Issue:12, 2016
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.Bioorganic & medicinal chemistry, , Mar-01, Volume: 23, Issue:5, 2015
Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 25, Issue:22, 2015
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.Journal of medicinal chemistry, , Apr-09, Volume: 58, Issue:7, 2015
Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Oct-01, Volume: 23, Issue:19, 2015
Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.European journal of medicinal chemistry, , Feb-12, Volume: 73, 2014
Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 68, 2013
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 22, Issue:13, 2012
Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 22, Issue:14, 2012
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:3, 2008
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies.Bioorganic & medicinal chemistry letters, , 02-15, Volume: 34, 2021
Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 64, 2013
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Dec-15, Volume: 20, Issue:24, 2012
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Synthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Natural cholinesterase inhibitors from Myristica cinnamomea King.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 26, Issue:15, 2016
Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.Journal of medicinal chemistry, , Mar-10, Volume: 59, Issue:5, 2016
Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.ACS medicinal chemistry letters, , Nov-08, Volume: 3, Issue:11, 2012
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.Journal of natural products, , Volume: 64, Issue:6, 2001
Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.Bioorganic & medicinal chemistry, , 08-15, Volume: 68, 2022
New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.European journal of medicinal chemistry, , Nov-05, Volume: 241, 2022
Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors.ACS medicinal chemistry letters, , Nov-11, Volume: 12, Issue:11, 2021
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 29, Issue:11, 2019
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Dispiropyrrolidinyl-piperidone embedded indeno[1,2-b]quinoxaline heterocyclic hybrids: Synthesis, cholinesterase inhibitory activity and their molecular docking simulation.Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.European journal of medicinal chemistry, , Sep-08, Volume: 137, 2017
Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling.Bioorganic & medicinal chemistry letters, , May-01, Volume: 26, Issue:9, 2016
Alkaloids from Hippeastrum argentinum and Their Cholinesterase-Inhibitory Activities: An in Vitro and in Silico Study.Journal of natural products, , 05-27, Volume: 79, Issue:5, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.European journal of medicinal chemistry, , Sep-18, Volume: 102, 2015
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 24, Issue:7, 2014
Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines.Bioorganic & medicinal chemistry, , Jan-15, Volume: 22, Issue:2, 2014
Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Ionic liquid mediated synthesis of mono- and bis-spirooxindole-hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-15, Volume: 24, Issue:10, 2014
Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.European journal of medicinal chemistry, , Volume: 67, 2013
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 64, 2013
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 23, Issue:10, 2013
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 69, 2013
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 22, Issue:13, 2012
Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 22, Issue:14, 2012
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.European journal of medicinal chemistry, , Volume: 46, Issue:7, 2011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.Journal of natural products, , Nov-29, Volume: 73, Issue:11, 2010
Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.European journal of medicinal chemistry, , Volume: 44, Issue:6, 2009
Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity.Bioorganic & medicinal chemistry, , Sep-15, Volume: 21, Issue:18, 2013
Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:4, 2010
Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 77, 2022
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.European journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents.Bioorganic & medicinal chemistry, , 01-01, Volume: 28, Issue:1, 2020
The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors.European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , 03-01, Volume: 28, Issue:5, 2020
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.European journal of medicinal chemistry, , Aug-25, Volume: 119, 2016
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:5, 2011
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Converting maslinic acid into an effective inhibitor of acylcholinesterases.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 20, Issue:11, 2010
Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:1, 2008
Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives.Journal of natural products, , Volume: 69, Issue:10, 2006
Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A.Journal of natural products, , Volume: 68, Issue:12, 2005
Acetylene Group, Friend or Foe in Medicinal Chemistry.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
[no title available]MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.Journal of medicinal chemistry, , May-10, Volume: 55, Issue:9, 2012
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors MMedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Mar-21, Volume: 75, 2014
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011