dimethyl-4-toluidine profile

Dimethyl-4-toluidine, also known as N,N-dimethyl-p-toluidine, is a colorless to pale yellow liquid with a characteristic amine odor. It is a common organic compound used as an intermediate in the synthesis of dyes, pharmaceuticals, and other chemicals. Dimethyl-4-toluidine is synthesized by the reaction of p-toluidine with methanol in the presence of a catalyst. It is a strong base and can be readily protonated to form the corresponding ammonium salt. Dimethyl-4-toluidine has been studied for its potential applications in various fields, including organic synthesis, polymer chemistry, and materials science. It is also a valuable starting material for the preparation of other important compounds, such as 4-toluidine diazonium salt, which is used in the production of azo dyes.'

ID Source	ID
PubMed CID	7471
CHEMBL ID	1462714
SCHEMBL ID	28378
MeSH ID	M0065387

Synonym
AC-368
dimethyl-p-toluidine
n,n-dimethyl-4-methylaniline
p-methyl-n,n-dimethylaniline
n,n-dimethyl-p-toluidine
99-97-8
nsc1785
benzenamine,n,4-trimethyl-
n,4-trimethylaniline
p-n,n-trimethylaniline
n,n-dimethyl-p-tolylamine
nsc-1785
benzenamine, n,n,4-trimethyl-
p-toluidine, n,n-dimethyl-
n,n,4-trimethylaniline
ccris 1001
dimethyl-4-toluidine
p-(dimethylamino)toluene
dimetil-p-toluidina [italian]
p,n,n-trimethylaniline
nsc 1785
einecs 202-805-4
NCGC00091397-01
4,n,n-trimethylaniline, 99%
4-dimethylaminotoluene
D0807
MLS001050174
smr001216586
FT-0656134
NCGC00091397-02
NCGC00091397-03
dimethyl-(p-tolyl)-amine
n,n-dimethyl-para-toluidine
NCGC00254201-01
cas-99-97-8
tox21_201370
NCGC00258922-01
tox21_300062
dtxcid401832
dtxsid0021832 ,
dimetil-p-toluidina
ec 202-805-4
n,n,4-trimethylbenzenamine
unii-s8xc5939vu
hsdb 8202
s8xc5939vu ,
FT-0629511
FT-0636092
AKOS015915159
CHEMBL1462714
SCHEMBL28378
dimethyltolylamine [inci]
1-(dimethylamino)-4-methylbenzene
dimethyltolylamine
n,n-dimethyl-p-toluidine [iarc]
4-dimethylamino-1-methylbenzene
n,n-dimethyl-p-methylphenylamine
n,n-dimethyl-4-toluidine
benzeneamine,n,n,4-trimethyl-
W-100002
4,n,n-trimethylaniline
mfcd00008316
4,n,n-trimethylaniline, purum, >=98.0% (gc)
E75885
Q2051705
nl 65-100
n,n-dibenzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
EN300-7266829
Z1002998236

Excerpt	Reference	Relevance
" It is verified that DMPT's toxic effect on cell cultures is dose-related; a delay in the cell replication cycle is induced in vitro."	( High-performance liquid chromatography assay of N,N-dimethyl-p-toluidine released from bone cements: evidence for toxicity. Cavedagna, D; Ciapetti, G; Granchi, D; Pizzoferrato, A; Stea, S; Visentin, M; Zolezzi, C, 1997)	0.3
" This study aimed to examine possible time-dependent toxic effects of provisional crown and bridge restoration materials, manipulated intraorally or extraorally, on epithelia cells."	( Cytotoxicity of provisional crown and bridge restoration materials: an in vitro study. Dogan, A; Ergün, G; Karaoglu, T; Mutlu-Sagesen, L, 2001)	0.31

Excerpt	Reference	Relevance
" At lower oral doses, [14C]DMPT-derived radioactivity was well absorbed and rapidly excreted, primarily in urine."	( Disposition of [14C]N,N-dimethyl-p-toluidine in F344 rats and B6C3F1 mice. Dix, KJ; Ghanbari, K; Hedtke-Weber, BM, 2007)	0.34

Excerpt	Relevance	Reference
" Mean body weights of all surviving dosed groups of males and females were significantly less than those of the vehicle controls."	( Toxicology and carcinogenesis studies of N,N-dimethyl-p-toluidine (CAS No. 99-97-8) in F344/N rats and B6C3F1/N mice (gavage studies). , 2012)	0.38

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	2.4337	0.0060	38.0041	19,952.5996	AID1159521
GLI family zinc finger 3	Homo sapiens (human)	Potency	15.2617	0.0007	14.5928	83.7951	AID1259369
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	39.8107	0.0112	12.4002	100.0000	AID1030
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	1.5849	0.0013	18.0743	39.8107	AID926; AID938
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	16.9503	0.0010	22.6508	76.6163	AID1224838; AID1224839; AID1224893
pregnane X nuclear receptor	Homo sapiens (human)	Potency	54.4827	0.0054	28.0263	1,258.9301	AID1346982
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	61.2143	0.0002	29.3054	16,493.5996	AID743069; AID743079
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	50.1187	0.0010	19.4141	70.9645	AID588537
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	58.5737	0.0007	23.0674	1,258.9301	AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	61.3700	0.0017	23.8393	78.1014	AID743083
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (13.56)	18.7374
1990's	16 (27.12)	18.2507
2000's	26 (44.07)	29.6817
2010's	9 (15.25)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (1.61%)	6.00%
Case Studies	6 (9.68%)	4.05%
Observational	0 (0.00%)	0.25%
Other	55 (88.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	2.03	1	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
propionaldehyde propionaldehyde: may cause respiratory irritation; RN given refers to parent cpd; structure. propanal : An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals.	2.05	1	alpha-CH2-containing aldehyde; propanals	Escherichia coli metabolite
diacetyl butane-2,3-dione : An alpha-diketone that is butane substituted by oxo groups at positions 2 and 3. It is a metabolite produced during the malolactic fermentation.	2.05	1	alpha-diketone	Escherichia coli metabolite; Saccharomyces cerevisiae metabolite
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.97	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
hydroquinone [no description available]	2.41	2	benzenediol; hydroquinones	antioxidant; carcinogenic agent; cofactor; Escherichia coli metabolite; human xenobiotic metabolite; mouse metabolite; skin lightening agent
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	1.99	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
n,n-dimethylaniline N,N-dimethylaniline: RN given refers to parent cpd; structure. dimethylaniline : A methylaniline carrying at least two methyl groups.. N,N-dimethylaniline : A tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups.	2.38	2	dimethylaniline; tertiary amine
4-aminobenzoic acid 4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.	2.06	1	aminobenzoic acid; aromatic amino-acid zwitterion	allergen; Escherichia coli metabolite; plant metabolite
xanthine 7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.. 9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.	1.99	1	xanthine	Saccharomyces cerevisiae metabolite
camphor, (+-)-isomer [no description available]	2.74	3	bornane monoterpenoid; cyclic monoterpene ketone	plant metabolite
4-cresol 4-cresol: RN given refers to parent cpd. p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.	1.99	1	cresol	Escherichia coli metabolite; human metabolite; uremic toxin
benzophenone benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.	2.03	1	benzophenones	photosensitizing agent; plant metabolite
quinone benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.. 1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.. quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).	2.04	1	1,4-benzoquinones	cofactor; human xenobiotic metabolite; mouse metabolite
4-aminobenzoic acid para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.. 4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.	2.06	1	aminobenzoate; aromatic amino-acid anion	Escherichia coli metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
urethane [no description available]	2	1	carbamate ester	fungal metabolite; mutagen
4-nitroquinoline-1-oxide 4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.	2.03	1	C-nitro compound; quinoline N-oxide	carcinogenic agent
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.03	1	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
egtazic acid Egtazic Acid: A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.. ethylene glycol bis(2-aminoethyl)tetraacetic acid : A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.	1.97	1	diether; tertiary amino compound; tetracarboxylic acid	chelator
methylmethacrylate Methylmethacrylate: The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.. methyl methacrylate : An enoate ester having methacrylic acid as the carboxylic acid component and methanol as the alcohol component.	3.79	11	enoate ester; methyl ester	allergen; polymerisation monomer
n-vinyl-2-pyrrolidinone N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source	2.11	1	pyrrolidin-2-ones
benzoyl peroxide Benzoyl Peroxide: A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.	4.09	15	carbonyl compound
butyl methacrylate [no description available]	2	1	enoate ester
methylaniline methylaniline: RN given refers to parent cpd. methylaniline : A substituted aniline carrying one or more methyl groups at unspecified positions.	1.99	1	methylaniline; phenylalkylamine; secondary amine
methylphenylsulfide thioanisole : An aryl sulfide that is thiophenol in which the hydrogen of the thiol group has been replaced by a methyl group.	1.99	1	aryl sulfide; benzenes
4-toluidine 4-toluidine: RN given refers to parent cpd. p-toluidine : An aminotoluene in which the amino substituent is para to the methyl group.	2.15	1	aminotoluene
triethylene glycol dimethacrylate [no description available]	3.4	7
mequinol mequinol: depigmenting agent; RN given refers to parent cpd	1.99	1	methoxybenzenes; phenols	metabolite
9-fluorenone fluoren-9-one : The simplest member of the class fluoren-9-ones that is 9H-fluorene bearing an oxo substituent at position 9.	2.04	1	fluoren-9-ones	fungal xenobiotic metabolite
2,6-diethylaniline 2,6-diethylaniline: one of the major metabolites of the herbicide alachlor	2.03	1
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.44	2	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
4-(dimethylamino)benzoic acid [no description available]	2.06	1
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	2.03	1	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
bisphenol a-glycidyl methacrylate Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.	3.25	6	diarylmethane
tetrahydrofurfuryl methacrylate [no description available]	2	1	oxolanes
2-(dimethylamino)ethyl methacrylate 2-(dimethylamino)ethyl methacrylate: reducing agent; structure given in first source	3.51	8
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.03	1	fluorescein isothiocyanate
tert-nitrosobutane [no description available]	1.97	1
dimethylpropiothetin dimethylpropiothetin: has antineoplastic activity; RN given refers to hydroxide inner salt. S,S-dimethyl-beta-propiothetin : A sulfonium betaine obtained by deprotonation of the carboxy group of 3-dimethylsulfoniopropionic acid.	2.03	1	sulfonium betaine	marine metabolite; osmolyte
mercury Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.	2	1	elemental mercury; zinc group element atom	neurotoxin
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2	1	titanium group element atom
copper sulfate Copper Sulfate: A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.. copper(II) sulfate : A metal sulfate compound having copper(2+) as the metal ion.	2	1	metal sulfate	emetic; fertilizer; sensitiser
camphoroquinone camphoroquinone: a natural monoterpene, non-aromatic quinone; structure given in first source. bornane-2,3-dione : A bornane monoterpenoid that is bicyclo[2.2.1]heptane substituted by methyl groups at positions 1, 7 and 7 and oxo groups at positions 2 and 3.	3.97	13	bornane monoterpenoid; carbobicyclic compound
fluorides [no description available]	2.05	1	halide anion; monoatomic fluorine
tri-n-butylborane [no description available]	2.42	2
1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: structure in first source	1.97	1	polyamino carboxylic acid; tetracarboxylic acid	chelator
n-(4-tolyl)glycine-glycidyl methacrylate N-(4-tolyl)glycine-glycidyl methacrylate: dental bonding material; structure given in first source	1.98	1
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.03	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
fumarates Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)	2.11	1	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite
chlorhexidine Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.	2	1	biguanides; monochlorobenzenes	antibacterial agent; antiinfective agent
silicate cement Silicate Cement: A relatively hard, translucent, restorative material used primarily in anterior teeth. (From Boucher's Clinical Dental Terminology, 4th ed, p50)	2	1
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.03	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
orabase Orabase: used in therapy of oral mucosal ulcers	2.08	1
guanine [no description available]	2.11	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
allopurinol Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.	1.99	1	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger
8-hydroxyguanine 7,8-dihydro-8-oxoguanine: was substituted for guanine at G(8), G(9), G(14), or G(15) in the human telomeric oligonucleotide 5'-d[AGGGTTAG(8)G(9)GTT AG(14)G(15)GTTAGGGTGT]-3'. 7,8-dihydro-8-oxoguanine : An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.	2.11	1	oxopurine

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.1	1
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	2.49	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.1	1
Mandibular Fractures Fractures of the lower jaw.	2.11	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.07	1
Adenoma, Hepatocellular [description not available]	2.07	1
Follicular Thyroid Carcinoma [description not available]	2.07	1
Adenoma, Basal Cell [description not available]	2.07	1
Hepatocellular Carcinoma [description not available]	2.07	1
Cancer of Liver [description not available]	2.07	1
Cancer of the Thyroid [description not available]	2.07	1
Nasal Diseases [description not available]	2.07	1
Adenoma A benign epithelial tumor with a glandular organization.	2.07	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.07	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.07	1
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	2.07	1
Adenocarcinoma, Follicular An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)	2.07	1
Chromosome-Defective Micronuclei [description not available]	2.03	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.03	1
Allergy, Drug [description not available]	2.39	2
Coxarthrosis [description not available]	1.98	1
Prosthesis Durability [description not available]	2.39	2
Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	2.39	2
Osteoarthritis, Hip Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.	1.98	1
Aneuploid [description not available]	1.98	1
Abnormalities, Autosome [description not available]	1.98	1
Bone Cancer [description not available]	1.99	1
Osteogenic Sarcoma [description not available]	1.99	1
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	1.99	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	1.99	1
Methemoglobinemia The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)	2.38	2
Allergic Contact Dermatitis [description not available]	2.4	2
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.4	2
Chronic Illness [description not available]	2	1
Hives [description not available]	2	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2	1
Urticaria A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.	2	1
Stomatitis, Denture Inflammation of the mouth due to denture irritation.	2.38	2
Mucositis, Oral [description not available]	1.97	1
Stomatitis INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.	1.97	1
Air Embolism [description not available]	2.88	1

dimethyl-4-toluidine

Cross-References

Synonyms (69)

Research Excerpts

Toxicity

Bioavailability

Dosage Studied

Protein Targets (10)

Potency Measurements

Research

Studies (59)

Market Indicators

Research Demand Index: 10.47

Study Types