Proteins > 5-hydroxytryptamine receptor 3C
Page last updated: 2024-08-07 17:20:22

5-hydroxytryptamine receptor 3C

A 5-hydroxytryptamine receptor 3C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXA8]

Synonyms

5-HT3-C;
5-HT3C;
Serotonin receptor 3C

Research

Bioassay Publications (32)

TimeframeStudies on this Protein(%)All Drugs %
pre-19901 (3.13)18.7374
1990's12 (37.50)18.2507
2000's18 (56.25)29.6817
2010's0 (0.00)24.3611
2020's1 (3.13)2.80

Compounds (52)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
1-(1-naphthyl)piperazineHomo sapiens (human)Ki0.175012
1-(2-methoxyphenyl)piperazineHomo sapiens (human)Ki2.500012
1-(3-chlorophenyl)biguanideHomo sapiens (human)Ki0.017445
1-(3-chlorophenyl)piperazineHomo sapiens (human)Ki0.062012
cgs 12066Homo sapiens (human)IC501.318311
cisaprideHomo sapiens (human)Ki0.152011
granisetronHomo sapiens (human)Ki0.016723
mianserinHomo sapiens (human)IC501.412522
1-(3-trifluoromethylphenyl)piperazineHomo sapiens (human)Ki1.390012
ondansetronHomo sapiens (human)Ki0.010523
phenyl biguanideHomo sapiens (human)Ki1.200034
quipazineHomo sapiens (human)IC500.000411
quipazineHomo sapiens (human)Ki0.001923
6-nitroquipazineHomo sapiens (human)Ki0.058011
n-methylquipazineHomo sapiens (human)IC500.004711
n-methylquipazineHomo sapiens (human)Ki0.003012
rizatriptanHomo sapiens (human)IC5010.000011
sumatriptanHomo sapiens (human)IC502.505524
phenylpiperazineHomo sapiens (human)Ki3.000012
amanozineHomo sapiens (human)Ki10.000011
phenylguanidineHomo sapiens (human)Ki2.340023
4-chlorophenylbiguanideHomo sapiens (human)Ki0.203323
aripiprazoleHomo sapiens (human)Ki0.501211
ziprasidoneHomo sapiens (human)Ki0.398111
4-phenylpiperidineHomo sapiens (human)Ki10.000012
nicotineHomo sapiens (human)Ki71.000012
1-(4-chlorophenyl)piperazineHomo sapiens (human)Ki2.160012
gr 127935Homo sapiens (human)Ki6.309611
sb 204070aHomo sapiens (human)Ki0.225422
sr 57227aHomo sapiens (human)Ki0.103011
sc 53116Homo sapiens (human)Ki0.152011
harmalanHomo sapiens (human)Ki10.000011
1-(4-methoxyphenyl)piperazineHomo sapiens (human)Ki1.640012
1-methyl-6-methoxy-dihydro-beta-carbolineHomo sapiens (human)Ki10.000011
tropisetronHomo sapiens (human)Ki0.014523
bemesetronHomo sapiens (human)IC500.009311
bemesetronHomo sapiens (human)Ki0.010011
2-(4-chlorophenyl)guanidineHomo sapiens (human)Ki0.322023
harmineHomo sapiens (human)Ki10.000011
l 745870Homo sapiens (human)Ki9.900011
naltrexoneHomo sapiens (human)Ki0.060011
batimastatHomo sapiens (human)IC500.025011
1-(3-(5-(1,2,4-triazol-4-yl)-1h-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazineHomo sapiens (human)IC509.000013
pnu-282987Homo sapiens (human)Ki3.101022
s 21007Homo sapiens (human)IC500.001422
s 21007Homo sapiens (human)Ki0.001011
m-chlorophenylguanidineHomo sapiens (human)Ki0.033845
fauc 113Homo sapiens (human)Ki12.000011
sp 203Homo sapiens (human)Ki10.000011
clozapineHomo sapiens (human)Ki0.409122
olanzapineHomo sapiens (human)Ki0.199511

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
methylbufoteninHomo sapiens (human)Kd0.079411
granisetronHomo sapiens (human)Kd0.000122
metoclopramideHomo sapiens (human)Kd0.050111
ondansetronHomo sapiens (human)Kd0.000222
quipazineHomo sapiens (human)EC500.001011
tropacocaineHomo sapiens (human)Kd0.063111
tropisetronHomo sapiens (human)Kd0.053022
bemesetronHomo sapiens (human)Kd0.006522
methylhistaprodifenHomo sapiens (human)Kd1.584914
histaprodifenHomo sapiens (human)Kd1.995314

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
granisetronHomo sapiens (human)Kb0.012911
ondansetronHomo sapiens (human)Kb0.019411
tropisetronHomo sapiens (human)Kb0.009311

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
serotonin-gated monoatomic cation channel activitymolecular functionEnables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, PMID:12867984]
excitatory extracellular ligand-gated monoatomic ion channel activitymolecular functionEnables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. [GOC:mah, ISBN:0323037070]
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialmolecular functionAny transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, PMID:20200227]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic membranecellular componentA specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
synapsecellular componentThe junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
serotonin-activated cation-selective channel complexcellular componentA protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]
transmembrane transporter complexcellular componentA transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. [GOC:bhm, GOC:TermGenie, PMID:18024586]

Involved In

This protein is involved in 6 target(s):

TargetCategoryDefinition
serotonin receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. [GOC:mah]
monoatomic ion transmembrane transportbiological processA process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]
excitatory postsynaptic potentialbiological processA process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
inorganic cation transmembrane transportbiological processA process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
regulation of membrane potentialbiological processAny process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]