Page last updated: 2024-12-08

enniatin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

enniatins: cyclohexadepsipeptides containing valine, isoleucine & valeric acid from Fusarian; form complexes with cations & cellular membranes; there are at least three different enniatins H, B & C; minor descriptor (76-86); on-line & INDEX MEDICUS search PEPTIDES, CYCLIC (76-86); see also record for enniatin D, E, F [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

enniatin B : An enniatin obtained from formal cyclocondensation of three N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-valine units. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID164754
CHEMBL ID469036
CHEBI ID64649
SCHEMBL ID20335498
MeSH IDM0263248

Synonyms (30)

Synonym
ACON1_001415
NCGC00180529-01
MEGXM0_000284
917-13-5
3-n-methylvaline enniatin
(3s,6r,9s,12r,15s,18r)-3,6,9,12,15,18-hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
enniatin b
2,8,14-triaza-3,6,9,12,15,18-hexakis(methylethyl)-2,8,14-trimethyl-5,11,17-trioxacyclooctadecane-1,4,7,10,13,16-hexaone
ACON0_000434
MLS000876784
smr000440570
enniatins
BRD-K01613490-001-01-9
CHEMBL469036
chebi:64649 ,
(3s,6r,9s,12r,15s,18r)-4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
unii-h02s2tzr95
h02s2tzr95 ,
HMS2269N19
cyclo((2r)-2-hydroxy-3-methylbutanoyl-n-methyl-l-valyl-(2r)-2-hydroxy-3-methylbutanoyl-n-methyl-l-valyl-(2r)-2-hydroxy-3-methylbutanoyl-n-methyl-l-valyl)
enniatin b [mi]
SCHEMBL20335498
AKOS032948909
DTXSID30891862
Q27133360
(3s,6r,9s,12r,15s,18r)-3,6,9,12,15,18-hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone
CS-0024254
HY-N3806
(3s,6r,9s,12r,15s,18r)-4,10,16-trimethyl-3,6,9,12,15, 18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8, 11,14,17-hexone
BE162722

Research Excerpts

Overview

Enniatin B (ENNB) is a mycotoxin produced by moulds from the Fusarium genera. Its toxic effects are still not fully elucidated, hence a safe reference exposure value has not been established yet.

ExcerptReferenceRelevance
"Enniatin B (ENNB) is a mycotoxin produced by moulds from the Fusarium genera and its toxic effects are still not fully elucidated, hence a safe reference exposure value has not been established yet. "( Occurrence and Dietary Exposure Assessment to Enniatin B through Consumption of Cereal-Based Products in Spain and the Catalonia Region.
Cano-Sancho, G; Gallardo, JA; Marín, S; Ramos, AJ; Sanchis, V, 2022
)
2.42
"Enniatin B is an emerging mycotoxin known to present biological activity because of its ionophoric characteristics. "( Investigating the in vitro catabolic fate of Enniatin B in a human gastrointestinal and colonic model.
Cavanna, D; Dall'Asta, C; Ferrer, E; Generotti, S; Pallarés, N; Righetti, L; Suman, M, 2020
)
2.26
"Enniatin B is a ionophoric and lipophilic mycotoxin which reaches the bloodstream and has the ability to penetrate into cellular membranes. "( Enniatin B induces expression changes in the electron transport chain pathway related genes in lymphoblastic T-cell line.
Alonso-Garrido, M; Escrivá, L; Font, G; Manyes, L, 2018
)
3.37

Toxicity

No mutagenicity was detected up to toxic levels (100 microM) of enniatin B. The intestinal toxicity was characterized by using two models from pig, the most sensitive species.

ExcerptReferenceRelevance
" This study indicates that enniatins, fungal metabolites that are commonly found in grain in Northern Europe, may have an underestimated toxic potential."( Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum.
Eriksen, GS; Ivanova, L; Skjerve, E; Uhlig, S, 2006
)
0.33
" However, data from the brine shrimp bioassay showed that further toxic metabolites within this complex need to be characterized."( Further data on the production of beauvericin, enniatins and fusaproliferin and toxicity to Artemia salina by Fusarium species of Gibberella fujikuroi species complex.
Logrieco, A; Moretti, A; Mulè, G; Ritieni, A, 2007
)
0.34
" This study indicates that ENs, fungal metabolites that are commonly found in corn and in general in product composed by corn, may have a toxic potential for human health."( Isolation and purification of enniatins A, A(1), B, B(1), produced by Fusarium tricinctum in solid culture, and cytotoxicity effects on Caco-2 cells.
Font, G; Mañes, J; Meca, G; Moretti, A; Ritieni, A; Ruiz, MJ; Soriano, JM, 2010
)
0.36
" In this study, the intestinal toxicity of enniatin B1 (ENN) alone and mixed with the most toxic trichothecene T-2 toxin (T2) was characterized by using two biological models from pig, the most sensitive species: the intestinal cell line IPEC1 (in vitro exposure) and jejunal explants (ex vivo exposure)."( The emerging mycotoxin, enniatin B1, down-modulates the gastrointestinal toxicity of T-2 toxin in vitro on intestinal epithelial cells and ex vivo on intestinal explants.
Alassane-Kpembi, I; Borin, C; Kolf-Clauw, M; Lucioli, J; Lyazhri, F; Oswald, IP; Rubira-Gerez, J; Sassahara, M, 2013
)
0.96
" Although enniatins have not been associated with toxic outbreaks, they have caused toxicity in vitro in several cell lines."( Fusarium mycotoxin enniatin B: Cytotoxic effects and changes in gene expression profile.
Anthoni, M; Hallikainen, V; Jestoi, M; Jonsson, M; Kankainen, M; Koivisto, P; Loivamaa, I; Lysøe, E; Peltonen, K; Welling, A, 2016
)
0.76
" Unfortunately, we still know very little about the bioavailability and toxic potentials of many of these less characterized mycotoxins, including the large family of enniatins."( Enniatin B and beauvericin are common in Danish cereals and show high hepatotoxicity on a high-content imaging platform.
Have Rasmussen, P; Jensen, U; Lund Hansen, N; Svingen, T; Taxvig, C; Vinggaard, AM, 2017
)
1.9
" Although a wide range of toxic effects, like antibacterial, antifungal, insecticidal and cytotoxic properties, have been described in vitro, so far, no cases of mycotoxicosis connected to enniatins in vivo are reported."( Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.
Behrens, M; Esselen, M; Humpf, HU; Krug, I, 2018
)
0.85
" Cyclodepsipeptides are fungal molecules with potentially adverse and positive effects."( Comparative Structure-Activity Analysis of the Antimicrobial Activity, Cytotoxicity, and Mechanism of Action of the Fungal Cyclohexadepsipeptides Enniatins and Beauvericin.
Baydoun, E; Courvoisier-Dezord, E; Hijazi, A; Lafond, M; Maresca, M; Nicoletti, C; Olleik, H; Perrier, J; Xue, P, 2019
)
0.51

Pharmacokinetics

ExcerptReferenceRelevance
" In the pharmacokinetic study, male mice received a single oral or intravenous dose of ENNB [30 mg/kg body weight (BW) and 1 mg/kg BW, respectively]."( Pharmacokinetics and 28-day repeated-dose toxicity of enniatin B after oral administration in mice.
Jin, M; Ojiro, R; Okano, H; Ozawa, S; Sasaki, K; Shibutani, M; Tang, Q; Yamagata, H; Yoshida, T; Yoshinari, T; Zou, X, 2023
)
1.16

Bioavailability

ExcerptReferenceRelevance
" However, both mycotoxins potently interact with ABCB1 and ABCG2 transport functions suggesting influences on bioavailability of xenobiotics and pharmaceuticals."( Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin.
Berger, W; Chiba, P; Dornetshuber, R; Heffeter, P; Koellensperger, G; Kopp, S; Lemmens-Gruber, R; Micksche, M; Schumacher, R; Sulyok, M, 2009
)
0.35
"The bioavailability of the minor Fusarium mycotoxins enniatins (ENs) utilizing an in vitro method which allows the simulation of the small and large intestine tracts has been studied."( Study of the potential toxicity of enniatins A, A(1), B, B(1) by evaluation of duodenal and colonic bioavailability applying an in vitro method by Caco-2 cells.
Font, G; Mañes, J; Meca, G; Ruiz, MJ, 2012
)
0.38
"0μmol/g concentrations, their transepithelial transport and bioavailability using Caco-2 cells as a model of the human intestinal epithelium."( Study of the potential toxicity of commercial crispy breads by evaluation of bioaccessibility and bioavailability of minor Fusarium mycotoxins.
Font, G; Mañes, J; Meca, G; Ruiz, MJ, 2012
)
0.38
"The aim of present study was to reveal the toxicokinetic properties and absolute oral bioavailability of enniatin B1 in pigs."( Pilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs.
Broekaert, N; Croubels, S; De Backer, P; De Mil, T; Devreese, M; Fraeyman, S, 2014
)
0.84
" Unfortunately, we still know very little about the bioavailability and toxic potentials of many of these less characterized mycotoxins, including the large family of enniatins."( Enniatin B and beauvericin are common in Danish cereals and show high hepatotoxicity on a high-content imaging platform.
Have Rasmussen, P; Jensen, U; Lund Hansen, N; Svingen, T; Taxvig, C; Vinggaard, AM, 2017
)
1.9

Dosage Studied

ExcerptRelevanceReference
" Dose-response curves were generated for each mycotoxin and the isobologram method was used to determine the interactive effects of tested mixtures."( Interaction effects of Fusarium enniatins (A, A1, B and B1) combinations on in vitro cytotoxicity of Caco-2 cells.
Font, G; Prosperini, A; Ruiz, MJ, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
enniatinA class of six-membered cyclodepsipeptides found in several species of Fusarium fungi as mixtures.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (33)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency11.22020.044717.8581100.0000AID485341
Chain A, Ferritin light chainEquus caballus (horse)Potency35.48135.623417.292931.6228AID485281
glp-1 receptor, partialHomo sapiens (human)Potency6.30960.01846.806014.1254AID624417
thioredoxin reductaseRattus norvegicus (Norway rat)Potency89.12510.100020.879379.4328AID588453; AID588456
ATAD5 protein, partialHomo sapiens (human)Potency4.60900.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency3.68690.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency39.81070.180013.557439.8107AID1460
Smad3Homo sapiens (human)Potency5.62340.00527.809829.0929AID588855
PINK1Homo sapiens (human)Potency2.81842.818418.895944.6684AID624263
67.9K proteinVaccinia virusPotency10.61010.00018.4406100.0000AID720579; AID720580
ParkinHomo sapiens (human)Potency2.81840.819914.830644.6684AID624263
IDH1Homo sapiens (human)Potency4.10950.005210.865235.4813AID686970
serine-protein kinase ATM isoform aHomo sapiens (human)Potency31.62280.707925.111941.2351AID485349
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency4.46680.01262.451825.0177AID485313
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency3.66260.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency8.91253.548119.542744.6684AID743266
huntingtin isoform 2Homo sapiens (human)Potency3.98110.000618.41981,122.0200AID1688
importin subunit beta-1 isoform 1Homo sapiens (human)Potency0.65135.804836.130665.1308AID540253
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.81070.039816.784239.8107AID1454
ras-related protein Rab-9AHomo sapiens (human)Potency3.54810.00022.621531.4954AID485297
eyes absent homolog 2 isoform aHomo sapiens (human)Potency100.00001.199814.641950.1187AID488837
snurportin-1Homo sapiens (human)Potency0.65135.804836.130665.1308AID540253
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency0.65135.804816.996225.9290AID540253
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.16230.15855.287912.5893AID540303
plasminogen precursorMus musculus (house mouse)Potency3.16230.15855.287912.5893AID540303
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.16230.15855.287912.5893AID540303
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency27.00500.00798.23321,122.0200AID2546; AID2551
gemininHomo sapiens (human)Potency29.09290.004611.374133.4983AID624296
neuropeptide S receptor isoform AHomo sapiens (human)Potency10.00000.015812.3113615.5000AID1461
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency70.79466.309660.2008112.2020AID720707
Glycoprotein hormones alpha chainHomo sapiens (human)Potency8.91254.46688.344810.0000AID624291
Guanine nucleotide-binding protein GHomo sapiens (human)Potency35.48131.995325.532750.1187AID624288
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
heat shock protein 90Candida albicansEC50 (µMol)150.00000.12006.485533.8530AID2423
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (37)

Processvia Protein(s)Taxonomy
angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 3Homo sapiens (human)
signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 3Homo sapiens (human)
associative learningRap guanine nucleotide exchange factor 3Homo sapiens (human)
Rap protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of actin cytoskeleton organizationRap guanine nucleotide exchange factor 3Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
intracellular signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of GTPase activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of protein export from nucleusRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of stress fiber assemblyRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
establishment of endothelial barrierRap guanine nucleotide exchange factor 3Homo sapiens (human)
cellular response to cAMPRap guanine nucleotide exchange factor 3Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 3Homo sapiens (human)
G protein-coupled receptor signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell population proliferationGlycoprotein hormones alpha chainHomo sapiens (human)
hormone-mediated signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
regulation of signaling receptor activityGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of steroid biosynthetic processGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell migrationGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid gland developmentGlycoprotein hormones alpha chainHomo sapiens (human)
luteinizing hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid hormone generationGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein domain specific bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
protein bindingGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Processvia Protein(s)Taxonomy
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
cortical actin cytoskeletonRap guanine nucleotide exchange factor 3Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
microvillusRap guanine nucleotide exchange factor 3Homo sapiens (human)
endomembrane systemRap guanine nucleotide exchange factor 3Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
lamellipodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
filopodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular exosomeRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular regionGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
Golgi lumenGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone complexGlycoprotein hormones alpha chainHomo sapiens (human)
pituitary gonadotropin complexGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1055417Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa B 63230 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
AID1055423Antibacterial activity against Bacillus subtilis 168 trpC2 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
AID402258Antifungal activity against Botrytis cinerea 98G1 spore germination after 24 hrs at 20 degC in darkness by microtiter plate method2004Journal of natural products, May, Volume: 67, Issue:5
Enniatins of Fusarium sp. strain F31 and their inhibition of Botrytis cinerea spore germination.
AID1055418Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
AID402259Antifungal activity against Botrytis cinerea 98G1 assessed as drug level required for detectable inhibition of fungal growth after 24 hrs at 20 degC in darkness by microtiter plate method2004Journal of natural products, May, Volume: 67, Issue:5
Enniatins of Fusarium sp. strain F31 and their inhibition of Botrytis cinerea spore germination.
AID1055422Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
AID1055420Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
AID1055419Antibacterial activity against multidrug and vancomycin-resistant Enterococcus faecalis UW 2689 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
AID1055421Antibacterial activity against multidrug and methicillin-resistant Staphylococcus aureus 25697 assessed as growth inhibition by broth microdilution method2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (201)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (1.99)18.7374
1990's5 (2.49)18.2507
2000's46 (22.89)29.6817
2010's109 (54.23)24.3611
2020's37 (18.41)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.86 (24.57)
Research Supply Index5.32 (2.92)
Research Growth Index5.40 (4.65)
Search Engine Demand Index50.26 (26.88)
Search Engine Supply Index1.96 (0.95)

This Compound (36.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews8 (3.92%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other196 (96.08%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]