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Beta-lactamase
A beta-lactamase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P00811]
Synonyms
EC 3.5.2.6;
Cephalosporinase
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 15 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (40)
Drugs with Inhibition Measurements
Structure-based approach for binding site identification on AmpC beta-lactamase.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.Journal of medicinal chemistry, , Nov-05, Volume: 41, Issue:23, 1998
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Structure-based approach for binding site identification on AmpC beta-lactamase.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.Journal of medicinal chemistry, , Apr-11, Volume: 45, Issue:8, 2002
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.Journal of medicinal chemistry, , Nov-05, Volume: 41, Issue:23, 1998
A high-throughput screen for aggregation-based inhibition in a large compound library.Journal of medicinal chemistry, , May-17, Volume: 50, Issue:10, 2007
Identification and prediction of promiscuous aggregating inhibitors among known drugs.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Identification and prediction of promiscuous aggregating inhibitors among known drugs.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
A high-throughput screen for aggregation-based inhibition in a large compound library.Journal of medicinal chemistry, , May-17, Volume: 50, Issue:10, 2007
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Identification and prediction of promiscuous aggregating inhibitors among known drugs.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Interpreting steep dose-response curves in early inhibitor discovery.Journal of medicinal chemistry, , Dec-14, Volume: 49, Issue:25, 2006
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.Journal of medicinal chemistry, , Apr-11, Volume: 45, Issue:8, 2002
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.Journal of medicinal chemistry, , Apr-11, Volume: 45, Issue:8, 2002
Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase.Bioorganic & medicinal chemistry letters, , Aug-02, Volume: 14, Issue:15, 2004
Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase.Chemistry & biology, , Volume: 8, Issue:6, 2001
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.Journal of medicinal chemistry, , Nov-05, Volume: 41, Issue:23, 1998
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.Journal of medicinal chemistry, , Apr-11, Volume: 45, Issue:8, 2002
Design and synthesis of bridged gamma-lactams as analogues of beta-lactam antibiotics.Bioorganic & medicinal chemistry letters, , May-17, Volume: 14, Issue:10, 2004
Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Interpreting steep dose-response curves in early inhibitor discovery.Journal of medicinal chemistry, , Dec-14, Volume: 49, Issue:25, 2006
A specific mechanism of nonspecific inhibition.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.Bioorganic & medicinal chemistry letters, , Mar-08, Volume: 14, Issue:5, 2004
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999