Large neutral amino acids transporter small subunit 1

A large neutral amino acids transporter small subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01650]

Synonyms

4F2 light chain;
4F2 LC;
4F2LC;
CD98 light chain;
Integral membrane protein E16;
E16;
L-type amino acid transporter 1;
hLAT1;
Solute carrier family 7 member 5;
y+ system cationic amino acid transporter

Research

Bioassay Publications (5)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glycine	Homo sapiens (human)	IC50	200.0000	1	1
levodopa	Homo sapiens (human)	IC50	100.0000	1	1
tyrosine	Homo sapiens (human)	IC50	68.0000	1	1
leucine	Homo sapiens (human)	IC50	86.0000	2	2
methionine	Homo sapiens (human)	IC50	175.0000	2	2
phenylalanine	Homo sapiens (human)	IC50	69.0000	2	2
histidine	Homo sapiens (human)	IC50	65.0000	2	2
valine	Homo sapiens (human)	IC50	68.0000	1	1
tryptophan	Homo sapiens (human)	IC50	160.0000	2	2
isoleucine	Homo sapiens (human)	IC50	145.0000	2	2
D-tryptophan	Homo sapiens (human)	IC50	380.0000	1	1
copper histidine	Homo sapiens (human)	IC50	460.0000	1	1
D-tyrosine	Homo sapiens (human)	IC50	380.0000	1	1
D-valine	Homo sapiens (human)	IC50	50,000.0000	1	1
phenylalanine	Homo sapiens (human)	IC50	46.0000	1	1
1-methylhistidine	Homo sapiens (human)	IC50	190.0000	2	2
2-aminobicyclo(2,2,1)heptane-2-carboxylic acid	Homo sapiens (human)	IC50	112.0000	1	1
D-leucine	Homo sapiens (human)	IC50	220.0000	1	1
3-tyrosine	Homo sapiens (human)	IC50	130.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phenylalanine	Homo sapiens (human)	Km	12.6000	2	2
phenylalanine	Homo sapiens (human)	Km	121.0000	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
amino acid transmembrane transporter activity	molecular function	Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
aromatic amino acid transmembrane transporter activity	molecular function	Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
neutral L-amino acid transmembrane transporter activity	molecular function	Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
L-leucine transmembrane transporter activity	molecular function	Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
L-tryptophan transmembrane transporter activity	molecular function	Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
antiporter activity	molecular function	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
thyroid hormone transmembrane transporter activity	molecular function	Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:ai]
peptide antigen binding	molecular function	Binding to an antigen peptide. [GOC:add, GOC:jl, GOC:rv]
L-amino acid transmembrane transporter activity	molecular function	Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
microvillus membrane	cellular component	The portion of the plasma membrane surrounding a microvillus. [GOC:mah]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
external side of apical plasma membrane	cellular component	The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:ab, GOC:dos]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
amino acid transport complex	cellular component	A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane. [GOC:kmv, PMID:14668347]

Involved In

This protein is involved in 28 target(s):

Target	Category	Definition
negative regulation of autophagy	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
response to muscle activity	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. [GOC:mtg_muscle]
neutral amino acid transport	biological process	The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
isoleucine transport	biological process	The directed movement of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
L-leucine transport	biological process	The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
methionine transport	biological process	The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
phenylalanine transport	biological process	The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
proline transport	biological process	The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
tryptophan transport	biological process	The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
tyrosine transport	biological process	The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
valine transport	biological process	The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
alanine transport	biological process	The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
cellular response to glucose starvation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]
xenobiotic transport	biological process	The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
response to hyperoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:kmv]
positive regulation of glial cell proliferation	biological process	Any process that activates or increases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]
thyroid hormone transport	biological process	The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:rph]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
amino acid import across plasma membrane	biological process	The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]
liver regeneration	biological process	The regrowth of lost or destroyed liver. [GOC:gap, PMID:19447520]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
L-histidine transport	biological process	The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:kmv, GOC:TermGenie, PMID:22822152]
cellular response to L-arginine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
L-leucine import across plasma membrane	biological process	The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
L-tryptophan transmembrane transport	biological process	The directed movement of L-tryptophan across a membrane. [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
negative regulation of vascular associated smooth muscle cell apoptotic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
positive regulation of L-leucine import across plasma membrane	biological process	Any process that activates or increases the frequency, rate or extent of L-leucine import across plasma membrane. [GO_REF:0000058, GOC:TermGenie, PMID:10467003]
amino acid transmembrane transport	biological process	The process in which an amino acid is transported across a membrane. [GOC:dph, GOC:tb]