duocarmycin sa

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

duocarmycin SA: structure similar to CC-1065 and yatakemycin, composed of a pyrrolo-indole plus an indole; isolated from Streptomyces [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	115369
CHEMBL ID	308086
SCHEMBL ID	61916
MeSH ID	M0181506

Synonyms (14)

Synonym
duocarmycin sa
antibiotic dc113
cyclopropa(c)pyrrolo(3,2-e)indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-((5,6,7-trimethoxy-1h-indol-2-yl)carbonyl)-, methyl ester, (7br)-
(+)-duocarmycin sa
CHEMBL308086
130288-24-3
SCHEMBL61916
DTXSID30926663
AKOS032946598
EX-A7932
methyl (1r,12s)-7-oxo-10-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-4-carboxylate
CS-0011400
HY-12456
duocarmycinsa

Research Excerpts

Overview

Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy. It is distinguished by the manner in which they bind to and react with DNA substrates.

Excerpt	Reference	Relevance
"Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. "	( The structural basis for in situ activation of DNA alkylation by duocarmycin SA. Bifulco, G; Boger, DL; Case, DA; Chazin, WJ; Gomez-Paloma, L; Smith, JA, 2000)	1.99

Effects

Excerpt	Reference	Relevance
"New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells, and in vivo antitumor activity against murine sarcoma 180 in mice. "	( Studies on duocarmycin SA and its derivatives. Asai, A; Gomi, K; Kobayashi, E; Nagamura, S; Saito, H, 1997)	1.24

Compound-Compound Interactions

Excerpt	Reference	Relevance
" Here, the lacZ-carrying vaccinia virus (VACV) strain GLV-1h68 was used in combination with a β-galactosidase-activatable prodrug derived from a seco-analog of the natural antibiotic duocarmycin SA."	( Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a β-galactosidase-activatable prodrug seco-analog of duocarmycin SA. Chen, N; Donat, U; Gentschev, I; Hess, M; Krewer, B; Seubert, CM; Stritzker, J; Sturm, JB; Szalay, AA; Tietze, LF; von Hof, JM, 2011)	0.76

Dosage Studied

Excerpt	Relevance	Reference
" In vivo evaluation of the prodrug 6 showed that it exhibits extraordinary efficacy (T/C > 1500, L1210; 6/10 one year survivors), substantially exceeding that of the free drug, that its therapeutic window of activity is much larger, permitting a dosing ≥ 40-fold higher than the free drug, and yet that it displays a potency in vivo that approaches the free drug (within 3-fold)."	( Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs. Boger, DL; Brown, D; Duncan, KK; Parelkar, NK; Vielhauer, GA; Wolfe, AL, 2013)	0.39
" This in turn permitted elevated dosing levels, leading to higher systemic exposure and a significantly improved response in tumor xenograft models."	( A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. Fontaine, SD; Hann, B; Mattis, AN; Renslo, AR; Sambucetti, L; Shi, Y; Spangler, B; Wells, JA, 2016)	0.43

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (35)

Assay ID	Title	Year	Journal	Article
AID1395997	Cytotoxicity against human U138MG cells assessed as cell survival at 0.5 nM after 72 hrs by trypan blue dye based assay	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID537230	Cytotoxicity against mouse L1210 cells	2010	Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21	Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
AID1396000	Cytotoxicity against human U138MG cells assessed as dose enhancement ratio at 0.1 nM after 72 hrs in presence of 2 Gy dose of proton irradiation by trypan blue dye based assay	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID512680	Induction of thermal cleavage in protein free alpha satellite DNA 5'-GGAAAC-3' at 10 uM at 25 degC after 17 hrs by non-denaturating gel electrophoresis	2006	Nature chemical biology, Feb, Volume: 2, Issue:2	Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
AID1635392	Induction of alkylation at Simian virus 40 150-bp DNA w794 after 24 hrs by PAGE and autoradiography method	2016	Bioorganic & medicinal chemistry, 10-15, Volume: 24, Issue:20	Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
AID1396011	Anticlonogenic activity against human U138MG cells assessed as dose enhancement ratio pretreated for 2 hrs followed by 1 to 8 Gy dose of proton irradiation measured after 10 to 14 days by methylene blue staining based method	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID431576	Stability assessed as half life at pH 7	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
AID431574	Cytotoxicity against mouse L1210 cells	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
AID464157	Alkylation of cell free 32p end labeled double stranded w794 DNA at 10 uM after 48 hrs by PAGE and autoradiography	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
AID1396009	Anticlonogenic activity against human U138MG cells assessed as decrease in cell survival pretreated for 2 hrs followed by 1 to 8 Gy dose of proton irradiation measured after 10 to 14 days by methylene blue staining based method	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID1395999	Cytotoxicity against human U138MG cells assessed as decrease in cell viability after 72 hrs by trypan blue dye based assay	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID512675	Induction of thermal cleavage in alpha satellite DNA at 10 uM at 25 degC after 1 hr by non-denaturating gel electrophoresis	2006	Nature chemical biology, Feb, Volume: 2, Issue:2	Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
AID464156	Cytotoxicity against mouse L1210 cells	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
AID1396010	Anticlonogenic activity against human U138MG cells assessed as cell survival at 0.001 nM pretreated for 2 hrs followed by 1 to 8 Gy dose of proton irradiation measured after 10 to 14 days by methylene blue staining based method	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID1635390	Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition	2016	Bioorganic & medicinal chemistry, 10-15, Volume: 24, Issue:20	Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
AID1396002	Induction of apoptosis in human U138MG cells at 0.1 nM after 72 hrs by Annexin V staining based flow cytometry	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID464158	Alkylation of cell free 32p end labeled double stranded w794 DNA at 100 uM after 48 hrs by PAGE and autoradiography	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
AID98333	In vitro cytotoxicity against L1210 cell line	2000	Bioorganic & medicinal chemistry letters, Mar-06, Volume: 10, Issue:5	Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
AID1396003	Induction of necrosis in human U138MG cells at 0.1 nM after 72 hrs by 7-AAD staining based flow cytometry	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID1396005	Induction of necrosis in human U138MG cells at 0.1 nM after 72 hrs in presence of 6 Gy dose of proton irradiation by 7-AAD staining based flow cytometry	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID740033	Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 72 hrs by phosphatase assay	2013	Journal of medicinal chemistry, May-23, Volume: 56, Issue:10	Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs.
AID470790	Cytotoxicity against mouse L1210 cells	2009	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 19, Issue:24	Synthesis and evaluation of a thio analogue of duocarmycin SA.
AID1396006	Induction of apoptosis in human U138MG cells assessed as dose enhancement ratio at 0.1 nM after 72 hrs in presence of 2 Gy dose of proton irradiation by Annexin V staining based flow cytometry	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID470791	Induction of w794 DNA alkylation at 10 uM after 24 hrs by PAGE	2009	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 19, Issue:24	Synthesis and evaluation of a thio analogue of duocarmycin SA.
AID1396004	Induction of apoptosis in human U138MG cells at 0.1 nM after 72 hrs in presence of 6 Gy dose of proton irradiation by Annexin V staining based flow cytometry	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID1395996	Cytotoxicity against human U138MG cells assessed as cell survival at 0.1 nM after 72 hrs by trypan blue dye based assay	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID1396007	Induction of necrosis in human U138MG cells assessed as dose enhancement ratio at 0.1 nM after 72 hrs in presence of 2 Gy dose of proton irradiation by 7-AAD staining based flow cytometry	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID512676	Induction of thermal cleavage in alpha satellite DNA at 10 uM at 25 degC after 30 mins by non-denaturating gel electrophoresis	2006	Nature chemical biology, Feb, Volume: 2, Issue:2	Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
AID1395998	Cytotoxicity against human U138MG cells assessed as cell survival at higher doses after 72 hrs by trypan blue dye based assay	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID482107	Cytotoxicity against mouse L1210 cells	2010	Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9	Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.
AID431575	Stability assessed as half life at pH 3	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
AID512677	Binding affinity to alpha satellite DNA assessed as neucleosome reconstitution after 17 hrs at 25 degC by non-denaturating gel electrophoresis	2006	Nature chemical biology, Feb, Volume: 2, Issue:2	Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
AID1396001	Cytotoxicity against human U138MG cells assessed as decrease in cell viability at 0.5 to 1 nM after 72 hrs in presence of 2 Gy dose of proton irradiation by trypan blue dye based assay	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
AID690883	Cytotoxicity against mouse L1210 cells	2012	Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12	A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct.
AID1396008	Anticlonogenic activity against human U138MG cells assessed as decrease in cell survival after 14 days by methylene blue staining based method	2018	Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16	Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (75)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	11 (14.67)	18.2507
2000's	44 (58.67)	29.6817
2010's	19 (25.33)	24.3611
2020's	1 (1.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.61 (24.57)
Research Supply Index	4.33 (2.92)
Research Growth Index	4.65 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.61)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	5 (6.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	70 (93.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	2.94	4	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
benzene [no description available]	7	1	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
malic acid malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.. 2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.	1.99	1	2-hydroxydicarboxylic acid; C4-dicarboxylic acid	food acidity regulator; fundamental metabolite
indole [no description available]	2.17	1	indole; polycyclic heteroarene	Escherichia coli metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	7.02	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
bisbenzimidazole Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.	3.1	1	bibenzimidazole; N-methylpiperazine	anthelminthic drug; fluorochrome
chlorambucil Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.	3.1	1	aromatic amine; monocarboxylic acid; nitrogen mustard; organochlorine compound; tertiary amino compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
stallimycin [no description available]	3.51	2
netropsin Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.	3.1	1
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	2.01	1	mitomycin	alkylating agent; antineoplastic agent
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.69	3	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
cyclopropane cyclopropane : A cycloalkane composed of three carbon atoms to form a ring.	7.02	1	cycloalkane; cyclopropanes	inhalation anaesthetic
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	8.02	72	pyrrole; secondary amine
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.42	2	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	2.05	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.04	1	metal allergen; nickel group element atom; platinum group metal atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.01	1	iron group element atom; platinum group metal atom
bromine Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.	1.97	1	diatomic bromine
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	1.97	1	diatomic chlorine; gas molecular entity	bleaching agent
glucuronic acid Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.	2.04	1	D-glucuronic acid	algal metabolite
lexitropsin lexitropsin: structure given in first source; information reading oligopeptide	3.1	1
pyrindamycin a pyrindamycin A: isolated from Streptomyces sp. SF2582	3.79	3
duocarmycin b2 duocarmycin B2: from Streptomyces sp. DO-89	4	4
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	3.1	1
adozelesin [no description available]	3.1	1
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	2.01	1	actinomycin	mutagen
glycosides [no description available]	2.74	3
carzelesin carzelesin: a cyclopropylpyrroloindole analog of U 73975; longer lasting than U 77779; structure in first source	3.53	2
indole-2-carboxylate indole-2-carboxylate: structure in first source	7.42	2
pyrroloquinoline pyrroloquinoline: check to see if actually PYRROLOQUINOLINE QUINONE (PQQ COFACTOR)	2.02	1
anthramycin [no description available]	3.5	2
nsc 716970 centanamycin: a potent antimalarial and transmission-blocking DNA-binding agent inspired from ( )-duocarmycin SA that lacks a stereocenter; structure in first source. AS-I-145 : An indolecarboxamide obtained by the formal condensation of the carboxy group of 5,6,7-trimethoxyindole-2-carboxylic acid with the 2-amino group of 1-(2-chloroethyl)-2,4-diaminonaphthalene.	2.04	1	aromatic amine; aromatic ether; indolecarboxamide; organochlorine compound	antineoplastic agent
pentagastrin Pentagastrin: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	2.04	1	organic molecular entity
cc 1065 CC 1065: from Streptomyces zelensis; structure in second sourc	6.36	21
dc 88-a duocarmycin A: from a Streptomycete	5.04	13
duocarmycin b1 duocarmycin B1: from Streptomyces sp. DO-89	4	4
oligonucleotides [no description available]	2.42	2

Condition	Relationship Strength	Studies
Leukemia L 1210 [description not available]	4.32	7
Astrocytoma, Grade IV [description not available]	2.17	1
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	7.17	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.17	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.41	1
Benign Neoplasms [description not available]	4.37	7
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.37	7
Experimental Mammary Neoplasms [description not available]	2.13	1
Breast Cancer [description not available]	2.06	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.06	1
Cancer of Lung [description not available]	2.46	2
Lung Neoplasms Tumors or cancer of the LUNG.	2.46	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.44	2
Sarcoma 180 An experimental sarcoma of mice.	2.39	2
Neoplasms, Bronchial [description not available]	2	1
Bronchial Neoplasms Tumors or cancer of the BRONCHI.	2	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.97	1

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