Proteins > Dihydroorotate dehydrogenase (quinone), mitochondrial
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Dihydroorotate dehydrogenase (quinone), mitochondrial
A dihydroorotate dehydrogenase (quinone), mitochondrial that is encoded in the genome of rat. [OMA:Q63707, PRO:DNx]
Synonyms
DHOdehase;
EC 1.3.5.2;
Dihydroorotate oxidase
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| leflunomide | Rattus norvegicus (Norway rat) | IC50 | 0.0090 | 1 | 1 |
| brequinar | Rattus norvegicus (Norway rat) | IC50 | 0.2042 | 4 | 5 |
| atovaquone | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| dsm 74 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| teriflunomide | Rattus norvegicus (Norway rat) | IC50 | 0.0172 | 6 | 6 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| atovaquone | Rattus norvegicus (Norway rat) | Kic | 0.0600 | 1 | 1 |
On dihydroorotate dehydrogenases and their inhibitors and uses.Journal of medicinal chemistry, , Apr-25, Volume: 56, Issue:8, 2013
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.European journal of medicinal chemistry, , Volume: 49, 2012
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.Protein science : a publication of the Protein Society, , Volume: 13, Issue:4, 2004
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.Journal of medicinal chemistry, , 05-14, Volume: 63, Issue:9, 2020
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.European journal of medicinal chemistry, , Volume: 49, 2012
Biaryl analogues of teriflunomide as potent DHODH inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 21, Issue:24, 2011
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.Journal of medicinal chemistry, , Nov-08, Volume: 39, Issue:23, 1996