Page last updated: 2024-08-07 18:36:35
Prolyl endopeptidase
A prolyl endopeptidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48147]
Synonyms
PE;
EC 3.4.21.26;
Post-proline cleaving enzyme
Research
Bioassay Publications (24)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| berberine | Homo sapiens (human) | IC50 | 143.5000 | 2 | 2 |
| galantamine | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| jkl 1073a | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Berberine chloride (TN) | Homo sapiens (human) | IC50 | 144.0000 | 3 | 3 |
| palmatine | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| baicalin | Homo sapiens (human) | IC50 | 12.1500 | 2 | 2 |
| n-benzyloxycarbonylprolylprolinal | Homo sapiens (human) | IC50 | 0.0019 | 2 | 2 |
| n-benzyloxycarbonylprolylprolinal | Homo sapiens (human) | Ki | 0.0034 | 4 | 4 |
| boswellic acid | Homo sapiens (human) | IC50 | 9.7500 | 1 | 1 |
| berbamine | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| aromoline | Homo sapiens (human) | IC50 | 189.0000 | 1 | 1 |
| obamegine | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| n-(n-(phenyl)butyryl-l-prolyl)pyrrolidine | Homo sapiens (human) | IC50 | 0.0847 | 3 | 3 |
| n-(n-(phenyl)butyryl-l-prolyl)pyrrolidine | Homo sapiens (human) | Ki | 0.0010 | 1 | 1 |
| sitagliptin | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| quercetin | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| rutin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| 3,7-dihydroxyflavone | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| vildagliptin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| talabostat | Homo sapiens (human) | IC50 | 4.4916 | 8 | 8 |
| 11-keto-boswellic acid | Homo sapiens (human) | IC50 | 36.3200 | 1 | 1 |
| (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole | Homo sapiens (human) | IC50 | 0.0020 | 1 | 1 |
| (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole | Homo sapiens (human) | Ki | 0.0015 | 2 | 2 |
| linagliptin | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| alanylpyrrolidine-boronic acid | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| acetyl-11-ketoboswellic acid | Homo sapiens (human) | IC50 | 7.8900 | 1 | 1 |
| kyp 2047 | Homo sapiens (human) | Ki | 0.0006 | 3 | 3 |
| gosogliptin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| beta-Elemonic acid | Homo sapiens (human) | IC50 | 39.7400 | 1 | 1 |
| mk-3102 | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| n-carbobenzoxyglycyl-prolyl-4-methylcoumarinyl amide | Homo sapiens (human) | Km | 7.7600 | 5 | 5 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| serine-type peptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| oligopeptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds. [GOC:mah, ISBN:0198506732] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |