Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
inositol pentaphosphate: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 890 |
| CHEMBL ID | 1233511 |
| CHEMBL ID | 2005481 |
| CHEBI ID | 17401 |
| CHEBI ID | 187038 |
| SCHEMBL ID | 136587 |
| SCHEMBL ID | 19249 |
| SCHEMBL ID | 17006482 |
| SCHEMBL ID | 12138455 |
| SCHEMBL ID | 12137150 |
| SCHEMBL ID | 1682030 |
| SCHEMBL ID | 1681470 |
| SCHEMBL ID | 1681701 |
| SCHEMBL ID | 9164308 |
| SCHEMBL ID | 9741350 |
| SCHEMBL ID | 12549553 |
| SCHEMBL ID | 15374707 |
| MeSH ID | M0016819 |
| PubMed CID | 11706915 |
| CHEBI ID | 48405 |
| CHEBI ID | 191030 |
| SCHEMBL ID | 357421 |
| MeSH ID | M0016819 |
| Synonym |
|---|
| e391 |
| inositolhexaphosphoric acid |
| dermofeel pa-3 |
| CHEMBL1233511 |
| inositol hexaphosphoric acid |
| exfoderm |
| inosithexaphosphorsaeure |
| CHEBI:17401 , |
| saeure des phytins |
| phytine |
| acidum fyticum |
| acido fitico |
| acide fytique |
| inositol, hexakis(dihydrogen phosphate), myo- |
| (2,3,4,5,6-pentaphosphonooxycyclohexyl) dihydrogen phosphate |
| myo-inositol hexaphosphate |
| fytic acid |
| myo-inositol, hexakis(dihydrogen phosphate) |
| nsc-269896 |
| alkalovert |
| myo-inosistol hexakisphosphate |
| nsc269896 |
| NCI60_002200 |
| NCI60_038627 |
| einecs 201-506-6 |
| acido fitico [inn-spanish] |
| hexakis(dihydrogen phosphate) myo-inositol |
| acidum fyticum [inn-latin] |
| nsc 269896 |
| inosithexaphosphorsaure [german] |
| saure des phytins [german] |
| acide fytique [inn-french] |
| inositol hexakisphosphate |
| IHP , |
| inositol hexakis(phosphate) |
| myo-inositol hexakis(phosphate) |
| d-myo-inositol-1,2,3,4,5,6-hexaphosphate |
| meso-inositol hexaphosphate |
| alkovert |
| ccris 4513 |
| 1,2,3,4,5,6-cyclohexanehexol, hexakis(dihydrogen phosphate), (1alpha,2alpha,3alpha,4beta,5alpha,6beta)- |
| myo-inositol hexakisphosphate |
| myo-inositol 1,2,3,4,5,6-hexakisphosphate |
| 1d-myo-inositol hexakisphosphate |
| inositol hexaphosphate |
| 1d-myo-inositol 1,2,3,4,5,6-hexakisphosphate |
| d-myo-inositol 1,2,3,4,5,6-hexakisphosphate |
| C01204 |
| inositol 1,2,3,4,5,6-hexakisphosphate |
| phytic acid |
| 83-86-3 |
| phytate |
| ip6 , |
| 1ZSH |
| 1BQ3 |
| P0409 |
| diphosphoinositol tetrakisphosphate |
| CHEBI:187038 |
| A840671 |
| phyton |
| S3793 |
| FT-0689105 |
| 7igf0s7r8i , |
| fytic acid [inn] |
| myo-inositol, 1,2,3,4,5,6-hexakis(dihydrogen phosphate) |
| saure des phytins |
| unii-7igf0s7r8i |
| inosithexaphosphorsaure |
| myo-inositol hexakis(dihydrogen phosphate) |
| FT-0600486 |
| phytic acid [inci] |
| fytic acid [mart.] |
| ip-6 |
| fytic acid [who-dd] |
| phytic acid [mi] |
| EPITOPE ID:144992 |
| AKOS015901448 |
| AKOS015856604 |
| CHEMBL2005481 |
| SCHEMBL136587 |
| SCHEMBL19249 |
| IMQLKJBTEOYOSI-GPIVLXJGSA-N |
| IMQLKJBTEOYOSI-UHFFFAOYSA-N |
| SCHEMBL17006482 |
| SCHEMBL12138455 |
| SCHEMBL12137150 |
| SCHEMBL1682030 |
| SCHEMBL1681470 |
| SCHEMBL1681701 |
| Q-201578 |
| SCHEMBL9164308 |
| phyticacid |
| SCHEMBL9741350 |
| SCHEMBL12549553 |
| SCHEMBL15374707 |
| IMQLKJBTEOYOSI-OBXALCGXSA-N |
| rel-(1r,2r,3s,4r,5s,6s)-cyclohexane-1,2,3,4,5,6-hexayl hexakis(dihydrogen phosphate) |
| {[2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphonic acid |
| mfcd00082309 |
| AC-8037 |
| SR-01000944523-1 |
| sr-01000944523 |
| d-chiro inositol hexakisphosphate |
| CS-6330 |
| HY-N0814 |
| (1r,2r,3s,4r,5s,6s)-cyclohexane-1,2,3,4,5,6-hexayl hexakis(dihydrogen phosphate) |
| myo-inositol hexakisphosphate; inositol 1,2,3,4,5,6-hexakisphosphate |
| (1r,2s,3r,4r,5s,6s)-cyclohexane-1,2,3,4,5,6-hexayl hexakis[dihydrogen (phosphate)] |
| DTXSID40889331 |
| Q409679 |
| phytic acid (ca. 50% in water, ca. 1.1mol/l) |
| phytic acid (potassium) |
| DB14981 |
| A14529 |
| myo-inositol, 1,2,3,4,5,6-hexakis(dihydrogen phosphate),60% in water |
| hexasodium-phytate |
| CCG-270338 |
| NCGC00483012-01 |
| phytic acid (dry powder) |
| rel-(1r,2r,3s,4r,5s,6s)-cyclohexane-1,2,3,4,5,6-hexaylhexakis(dihydrogenphosphate) |
| cyclohexane-1,2,3,4,5,6-hexayl hexakis[dihydrogen (phosphate)] |
| DTXSID00861653 |
| phosphoric acid mono-(2,3,4,5,6-pentakis-phosphonooxy-cyclohexyl) ester |
| PD054429 |
| PD008378 |
| PD006549 |
| {[(1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphonic acid |
| EN300-19650970 |
| inositol polyphosphate, inositol hexakisphosphate |
| FS-10465 |
| myo-inositol 1,2,3,4,5-pentakisphosphate |
| 1l-myo-inositol 1,2,3,4,5-pentakisphosphate |
| 1d-myo-inositol 1,2,3,5,6-pentakisphosphate |
| myo-inositol 1,2,3,5,6-pentakisphosphate |
| inositol 1,2,3,5,6-pentakisphosphate |
| C04579 |
| (1r,2r,3r,4r,5s,6s)-6-hydroxycyclohexane-1,2,3,4,5-pentayl pentakis[dihydrogen (phosphate)] |
| 5ip , |
| 1d-myo-inositol 1,2,3,5,6-pentakis(dihydrogen phosphate) |
| (1r,2r,3s,4r,5s,6s)-6-hydroxycyclohexane-1,2,3,4,5-pentayl pentakis[dihydrogen (phosphate)] |
| CHEBI:48405 |
| ins(1,2,3,5,6)p5 |
| d-myo-inositol-1,2,3,5,6-pentaphosphate |
| CHEBI:191030 |
| [(1r,2r,4s,5r)-3-hydroxy-2,4,5,6-tetraphosphonooxycyclohexyl] dihydrogen phosphate |
| inositol pentaphosphate |
| 26326-85-2 |
| SCHEMBL357421 |
| d-myo-inositol-1,2,3,5,6-pentakis(dihydrogen phosphate) |
| CTPQAXVNYGZUAJ-UOTPTPDRSA-N |
| DTXSID10470896 |
| d-myo-inositol 1,2,3,5,6-pentakis-phosphate, >=80% (hplc) |
| 'd-myo-ins(1,2,3,5,6)p5' |
| Q27104611 |
| inositol 1,2,3,5,6-pentaphosphate |
| EA52J6WT2B , |
| dl-myo-inositol, 1,2,3,4,5-pentakis(dihydrogen phosphate) |
| myo-inositol, 1,2,3,4,5-pentakis(dihydrogen phosphate) |
| myo-inositol 1,2,3,4,5-pentaphosphate |
| 20298-96-8 |
| unii-ea52j6wt2b |
| PD009104 |
Phytic acid (PA) is a natural compound found in high-fiber diets, such as soybeans. It is an antinutritional compound that reduces the bioavailability of minerals and proteins. Phytic Acid is a component of cereal seeds and legumes.
Phytic acid (PA) has been reported to impair the absorption of minerals and trace elements such as calcium, zinc, and iron in humans. Low-phytic acid mutants have been used in genetic breeding, but it is not known what genes are responsible for the low-phytic acid phenotype. Phytic Acid has been shown to have positive nutritional benefits.
Phytic acid (PA) and lower inositolphosphates (InsP(n) ) is the main storage form of phosphorus in grains or seeds. It did not cause DNA damage and thus, it should not act as a prooxidant.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Phytic acid (PA) and lower inositolphosphates (InsP(n) ) is the main storage form of phosphorus in grains or seeds. " | ( Determination of phytic acid and inositolphosphates in barley. Copíková, J; Kvasnička, F; Sevčík, R; Synytsya, A; Václavíková, E; Vaculová, K; Voldřich, M, 2011) | 2.15 |
| "Phytic acid alone did not cause DNA damage and thus, it should not act as a prooxidant." | ( Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. Hiraku, Y; Kawanishi, S; Midorikawa, K; Murata, M; Oikawa, S, 2001) | 1.35 |
Pretreatment with phytic acid (25 and 50 mg/kg) daily for a period of 56 d positively altered activities of lysosomal hydrolases in ISO-induced rats. Both treatments increased (P < 0.05) endogenous loss of threonine, proline and serine.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Both phytic acid treatments also increased (P < 0.05) endogenous loss of threonine, proline and serine." | ( Phytic acid increases mucin and endogenous amino acid losses from the gastrointestinal tract of chickens. Adeola, O; Asem, EK; Onyango, EM, 2009) | 2.25 |
| "Phytic acid treatment significantly inhibited the growth of human gastric cancer cell SGC-7901 and markedly caused their apoptosis following downregulation of P53 protein expression." | ( [Growth inhibition and apoptosis-inducing effects of phytic acid in human gastric carcinoma cells]. Cheng, C; Cui, H; Wang, L; Wei, H; Yang, Z; Zhao, H, 2010) | 2.05 |
| "Pretreatment with phytic acid (25 and 50 mg/kg) daily for a period of 56 d positively altered activities of lysosomal hydrolases in ISO-induced rats." | ( Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. Brindha, E; Rajasekapandiyan, M, 2015) | 1.06 |
| "The treatments of phytic acid were given in two concentrations: 0.2% (w/v) and 0.5% (w/v) during the post-initiation phase of carcinogenesis phase via drinking water." | ( Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Hairuszah, I; Norashareena, MS; Norazalina, S; Norhaizan, ME, 2010) | 0.98 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The toxic manifestations of intravenous IHP are a function of rate of infusion as well as total dose, with some seemingly anomalous variations which may related to compensatory mechanisms." | ( The influence of infusion rate on the acute intravenous toxicity of phytic acid, a calcium-binding agent. Gersonde, K; Weiner, M, ) | 0.37 |
| " Based on histologic examination of a liver biopsy specimen, the diagnosis of toxic liver dysfunction caused by toluene poisoning was made." | ( Absence of hepatic uptake of Tc-99m phytate in a man with chronic toluene hepatotoxicity. Kobayashi, K; Kuroda, T; Kuroki, T; Nishiguchi, S; Ochi, H; Shiomi, S; Ueda, T, 1993) | 0.29 |
| "D-myo-Inositol hexakisphosphate (InsP6, phytate), a normal cellular constituent, was found to be toxic to neuronal perikarya when injected into the rat hippocampus." | ( Neuronal cytotoxicity of inositol hexakisphosphate (phytate) in the rat hippocampus. Lees, GJ; Leong, W, 1996) | 0.29 |
| " This study provides a novel and environmentally safe technique and increase in the nutritive quality." | ( Microwave drying for safe storage and improved nutritional quality of green gram seed (Vigna radiata). Mishra, HN; Pande, R; Singh, MN, 2012) | 0.38 |
| "The PA extract from rice bran displayed safe and promising anticancer properties in selected cancer cell lines and it is believed that its antioxidant capability is the likely contributor to the observed anticancer properties." | ( Antioxidant and cytotoxicity effect of rice bran phytic acid as an anticancer agent on ovarian, breast and liver cancer cell lines. Abdah, MA; Ng, SK; Norashareena, MS; Norhaizan, ME, 2011) | 0.62 |
| " The study revealed that there were no significant treatment related adverse effects in rats exposed to Longevinex for 28 days and considered safe at the given dose where compared to plain Resveratrol." | ( Sub-acute toxicity profile of a modified resveratrol supplement. Sali, VK; Sangeetha, MK; Thanka, J; Vallabi, DE; Vasanthi, HR, 2013) | 0.39 |
| " Ni(II) free ion was toxic to normal cells while InsP6-Ni(II) had no cytotoxic effect." | ( Cytotoxic effect of inositol hexaphosphate and its Ni(II) complex on human acute leukemia Jurkat T cells. de Andrade, LF; de Lima, EM; Granato, D; Kanunfre, CC; Rosso, ND, 2015) | 0.42 |
| " The results revealed the improved stability of phytase after immobilization and as a safe and significant additive for application in the food industry." | ( Enhanced production and immobilization of phytase from Aspergillus oryzae: a safe and ideal food supplement for improving nutrition. Kumar, S; Kumar, V; Sharma, KK; Singh, B; Singh, D, 2023) | 0.91 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Estimates of the radiation dose resulting from liver-spleen scintigraphy 99Tcm-labelled colloids are based on pharmacokinetic data mainly determined in animals." | ( Absolute quantification of pharmacokinetic distribution of RES colloids in individuals with normal liver function. Feinendegen, LE; Herzog, H; Notohamiprodjo, G; Spohr, G, 1987) | 0.27 |
| " The product was administered orally to rats and pharmacokinetic parameters were evaluated by comparing the results with that obtained by administering the SAM tosylated form (SAM PTS)." | ( Pharmacokinetic properties of a novel formulation of S-adenosyl-L-methionine phytate. Cavallaro, RA; d'Erme, M; Fanelli, S; Fontana, M; Francioso, A; Lendaro, E; Miraglia, N; Mosca, L, 2021) | 0.62 |
Phytic acid (PA) is a major inhibitor of iron bioavailability from beans. High PA concentrations might limit the positive effect of biofortified beans on iron status. Engineering crop plants to produce a heterologous phytase improves phosphate bioavailability.
| Excerpt | Reference | Relevance |
|---|---|---|
| " "Amsoy") on the bioavailability of 59Fe to iron-depleted rats." | ( Iron availability to rats from soybeans. Van Campen, R; Welch, RM, 1975) | 0.25 |
| " Thus, effective fermentation will increase the bioavailability of iron in whole-meal bread." | ( Iron absorption from bread in humans: inhibiting effects of cereal fiber, phytate and inositol phosphates with different numbers of phosphate groups. Brune, M; Gleerup, A; Hallberg, L; Rossander-Hultén, L; Sandberg, AS, 1992) | 0.28 |
| " The discussion is focused on toxic levels of hydrocyanate and oxalate, and the significance of the molar ratios in predicting the bioavailability of dietary zinc." | ( Hydrocyanate, oxalate, phytate, calcium and zinc in selected brands of Nigerian cocoa beverage. Abara, AE; Aremu, CY, 1992) | 0.28 |
| "The inhibitory effect of phytic acid in soybean products on zinc bioavailability was evaluated in two experiments in rats." | ( Reduction of phytic acid in soybean products improves zinc bioavailability in rats. Burns, RA; Dickinson, DB; Erdman, JW; Fordyce, EJ; Raboy, V; Wong, MS; Zhou, JR, 1992) | 0.96 |
| " It is concluded that phytic acid is a major inhibitory factor of iron absorption in soy-protein isolates but that other factors contribute to the poor bioavailability of iron from these products." | ( Soy protein, phytate, and iron absorption in humans. Cook, JD; Dassenko, SA; Hurrell, RF; Juillerat, MA; Lynch, SR; Reddy, MB, 1992) | 0.6 |
| " Our findings indicate that it may be possible to predict the bioavailability of iron in a diet if due account is taken of the relative content in the diet of the major promoters and inhibitors of iron absorption." | ( Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. Baynes, RD; Bothwell, TH; Car, NG; Lamparelli, RD; Macfarlane, BJ; MacPhail, P; Mayet, F; Schmidt, U; Siegenberg, D; Tal, A, 1991) | 0.28 |
| " The bioavailability of iron in a meal composed of meat, a vegetable and rice varied about threefold (22." | ( Rice and iron absorption in man. Brune, M; Hallberg, L; Pleehachinda, R; Rossander-Hultén, L; Sritongkul, N; Suwanik, R; Tuntawiroon, M, 1990) | 0.28 |
| "The effect of phytate reduction, fat extraction, and addition of Ca in the form of skim or whole milk on Ca and Zn bioavailability from a breakfast containing bran muffins was studied in vitro and in vivo." | ( Effects of phytate reduction, fat extraction, and level of Ca on Ca and Zn bioavailability. Compared in vitro and in vivo. Nevins, P; Schwartz, R, ) | 0.13 |
| " The absorption rate of iron was improved and a series of fermented soya foods were produced." | ( [A study on the effect of fermented soybean in preventing iron deficiency anemia in children]. Qin, HS, 1989) | 0.28 |
| " Ascorbic acid has a marked effect on the bioavailability of dietary iron and is also known to directly influence various metabolic processes in the brain." | ( Search for nutritional confounding factors in the relationship between iron deficiency and brain function. Hallberg, L, 1989) | 0.28 |
| "Studies on effects of fiber, phytic acid, and oxalic acid on mineral bioavailability are reviewed." | ( Effects of fiber, phytic acid, and oxalic acid in the diet on mineral bioavailability. Kelsay, JL, 1987) | 0.9 |
| " The effects of these alterations of the stomach on the digestion of high-fiber foods and resultant mineral bioavailability have not been defined." | ( Effects of pH on mineral-phytate, protein-mineral-phytate, and mineral-fiber interactions. Possible consequences of atrophic gastritis on mineral bioavailability from high-fiber foods. Champagne, ET, 1988) | 0.27 |
| "To establish conditions for comparisons of mineral bioavailability from plant sources, seven male subjects consumed a constant diet containing bran fiber and phytate." | ( Apparent absorption and retention of Ca, Cu, Mg, Mn, and Zn from a diet containing bran. Apgar, BJ; Schwartz, R; Wien, EM, 1986) | 0.27 |
| "Phytic acid in food is considered to be responsible for a reduced bioavailability of essential dietary minerals; its detrimental effects can be diminished by hydrolysis with phytase during processing." | ( [Phytic acid and cereals and cereal products. I: Phytic acid and phytase in rye and rye products]. Fretzdorff, B; Weipert, D, 1986) | 2.62 |
| " It is believed that the beneficial effects respecting reduced pronenesses to various degenerative diseases are likely to far outweigh the possible adverse effects of reduced bioavailability of mineral nutrients." | ( Dietary fibre and mineral metabolism. Walker, AR, 1987) | 0.27 |
| " We concluded that selection of wheat varieties for increased yield or protein content has not adversely affected the bioavailability of iron in the grain." | ( Bioavailability to rats of iron in six varieties of wheat grain intrinsically labeled with radioiron. House, WA; Welch, RM, 1987) | 0.27 |
| "Low zinc bioavailability from soy formula may be the result of the formula's phytate content." | ( Effect of phytate removal on zinc absorption from soy formula. Bell, JG; Burns, RA; Hendrickx, AG; Keen, CL; Lönnerdal, B, 1988) | 0.27 |
| " The addition of phytic acid to diets fed to Cu-deficient rats significantly enhanced Cu bioavailability compared to that of rats fed diets without phytic acid." | ( Enhancement of Cu bioavailability in the rat by phytic acid. Gordon, DT; Lee, DY; Schroeder, J, 1988) | 0.87 |
| "Due to its high phytate content, the bioavailability of zinc in whole meal cereal products is distinctly lower as compared to foods of animal origin." | ( [Biological availability of zinc in whole grain products with different phytate contents]. Harmuth-Hoene, AE; Meuser, F, 1987) | 0.27 |
| "The literature indicates that phytate:zinc and phytate X calcium:zinc millimolar ratios of a diet may provide useful indexes of the bioavailability of dietary zinc." | ( Phytate:zinc and phytate X calcium:zinc millimolar ratios in self-selected diets of Americans, Asian Indians, and Nepalese. Ellis, R; Frazier, CW; Kelsay, JL; Morris, ER; Moser, PB; Reynolds, RD, 1987) | 0.27 |
| " Both of these ratios may provide useful indices of the bioavailability of dietary Zn." | ( The phytic acid mineral, trace element, protein and moisture content of UK Asian immigrant foods. Davies, NT; Warrington, S, 1986) | 0.83 |
| " Citric acid is thought to be the ligand which accounts for the high level of bioavailability of zinc in human milk." | ( [Zinc and chronic enteropathies]. Catassi, C; Giorgi, PL; Guerrieri, A, ) | 0.13 |
| " Rat bioassay methods were utilized to determine bioavailability of iron and zinc in the low-phytate brans and to study the effect of dietary phytate/zinc molar ratio on zinc bioavailability when the phytate source was bran." | ( Bioavailability to rats of iron and zinc in wheat bran: response to low-phytate bran and effect of the phytate/zinc molar ratio. Ellis, R; Morris, ER, 1980) | 0.26 |
| " The amount of meat in a meal is the only bioavailability factor known to influence absorption of heme iron." | ( An overview of current information on bioavailability of dietary iron to humans. Morris, ER, 1983) | 0.27 |
| " In a second study, extrinsic and intrinsic labeling techniques gave a similar assessment of bioavailability of zinc from egg- and soy flour-based diets when extrinsic labeling was accomplished by thoroughly mixing 65ZnCl2 with the protein source prior to incorporation into the diet." | ( Bioavailability of zinc from defatted soy flour, soy hulls and whole eggs as determined by intrinsic and extrinsic labeling techniques. Meyer, NR; Stuart, MA; Weaver, CM, 1983) | 0.27 |
| " Fe was less well absorbed from the phytate-rich pearlings of the albino sorghum than from the pearled albino sorghum (0." | ( Factors affecting the absorption of iron from cereals. Bezwoda, WR; Bothwell, TH; Charlton, RW; Derman, DP; Gillooly, M; MacPhail, AP; Mayet, F; Morrall, P; Novelli, L; Torrance, JD, 1984) | 0.27 |
| " The degree of bioavailability determines the total dietary zinc which must be consumed by humans to remain in metabolic equilibrium." | ( Zinc: requirements, bioavailabilities and recommended dietary allowances. Ellis, R; Morris, ER; Smith, JC, 1983) | 0.27 |
| " Bioavailability of zinc to experimental animals was early shown to be reduced by plant protein diets and to be further reduced by feeding excess calcium." | ( Use of laboratory animals to define physiological functions and bioavailability of zinc. Forbes, RM, 1984) | 0.27 |
| "The bioavailability of 65Zn from intrinsically and extrinsically labeled soy flour, acid-precipitated soy concentrate and neutralized soy concentrate was evaluated in rats." | ( Bioavailability of zinc to rats from defatted soy flour, acid-precipitated soy concentrate and neutralized soy concentrate as determined by intrinsic and extrinsic labeling techniques. Erdman, JW; Forbes, RM; Ketelsen, SM; Stuart, MA; Weaver, CM, 1984) | 0.27 |
| "An assay was conducted with young albino rats to compare the bioavailability of zinc contained in calcium- and in magnesium-precipitated tofu to zinc supplied as the carbonate in egg white diets." | ( Bioavailability of zinc in coagulated soy protein (tofu) to rats and effect of dietary calcium at a constant phytate:zinc ratio. Erdman, JW; Forbes, RM; Ketelsen, SM; Kondo, H; Parker, HM, 1983) | 0.27 |
| " The addition of the organic ligands EDTA and citric acid prevented precipitation and it is postulated that naturally occurring soluble ligands are an important controlling factor in determining the bioavailability of essential minerals." | ( Studies on the solubility of Ca, Mg, Zn, and Cu in cereal products. Lyon, DB, 1984) | 0.27 |
| " Excessive dietary intake of phytate is thought to suppress the bioavailability of important polycations, such as Fe3+ and Zn2+, through the formation of insoluble metal phytate complexes." | ( Effects of phytate on mineral bioavailability in mice. Eaton, JW; Graf, E, 1984) | 0.27 |
| " Hence, it is suggested that the impact of dietary phytate on trace mineral bioavailability will depend upon the presence of factors, including excess calcium, that alter the absorption and utilization of phytate." | ( Metabolism of 14C-phytate in rats: effect of low and high dietary calcium intakes. Nahapetian, A; Young, VR, 1980) | 0.26 |
| " Concern about its presence in food arises from evidence that it decreases the bioavailability of many essential minerals by interacting with multivalent cations and/or proteins to form complexes that may be insoluble or otherwise unavailable under physiologic conditions." | ( Phytic acid interactions in food systems. Cheryan, M, 1980) | 1.7 |
| "The effect of phytate to zinc (Zn) molar ratio on zinc bioavailability was evaluated in rats." | ( Effect of phytate:zinc molar ratio and isolated soybean protein on zinc bioavailability. Hopkins, DT; Lo, GS; Settle, SL; Steinke, FH, 1981) | 0.26 |
| "The use of stable isotopes in a study on zinc bioavailability was evaluated in rats by comparing the zinc absorption of a stable isotope 70Zn and a radioisotope 65Zn simultaneously." | ( Comparative measurement of zinc absorption in rats with stable isotope 70Zn and radioisotope 65Zn. Janghorbani, M; Lo, GS; Steinke, FH; Ting, BT; Young, VR, 1981) | 0.26 |
| "In rats fed semipurified diets, bioavailability of dietary zinc was tested at different phytate/zinc molar ratios; growth and zinc in femurs were the criteria of adequacy." | ( Effect of dietary phytate/zinc molar ratio on growth and bone zinc response of rats fed semipurified diets. Ellis, R; Morris, ER, 1980) | 0.26 |
| "The iron bioavailability from three typical diets consumed by socioeconomic stratum IV (SES IV--working class) of the Venezuelan population was determined by the extrinsic label method." | ( Iron bioavailability from diets consumed by different socioeconomic strata of the Venezuelan population. García Casal, MN; Jaffe, W; Landaeta-Jiménez, M; Leets, I; López de Blanco, M; Martínez-Torres, C; Méndez-Castellanos, H; Ramírez, J; Taylor, PG; Tropper, E, 1995) | 0.29 |
| " Roasting was the processing technique employed in developing weaning foods which resulted in significant increase in HC1-extractable minerals, an index of their bioavailability to humans." | ( Improvement in HC1-extractability of minerals in home made weaning foods. Gahlawat, P; Sehgal, S, 1995) | 0.29 |
| "The influence of phytic acid and ascorbic acid content of soy formula on iron (Fe) bioavailability was investigated in infants by analysis of the incorporation of stable isotopes of Fe into red blood cells 14 d after administration using a double stable isotope technique." | ( Iron bioavailability studied in infants: the influence of phytic acid and ascorbic acid in infant formulas based on soy isolate. Cherouvrier, F; Davidsson, L; Galan, P; Hercberg, S; Hurrell, RF; Juillerat, MA; Kastenmayer, P, 1994) | 0.87 |
| " By these investigations the contribution of element speciation to the evaluation of calcium bioavailability has been shown by the analytical methodology and the results of application." | ( [Analysis of element species and the question of the bioavailability of calcium from different types of bread]. Könecke, I; Schwedt, G, 1993) | 0.29 |
| " Our findings demonstrate that zinc absorption can be measured in humans from single foods containing a physiological dose of zinc by using the whole-gut lavage absorption technique and that zinc bioavailability from beef is about fourfold greater than from a high-fiber breakfast cereal." | ( Measurement of zinc bioavailability from beef and a ready-to-eat high-fiber breakfast cereal in humans: application of a whole-gut lavage technique. Mason, JB; Rosenberg, IH; Wood, RJ; Zheng, JJ, 1993) | 0.29 |
| "A continuous in vitro method for the estimation of the bioavailability of minerals and trace elements is presented." | ( A continuous in vitro method for estimation of the bioavailability of minerals and trace elements in foods: application to breads varying in phytic acid content. Hermus, RJ; Schreuder, HA; van den Heuvel, G; van Lonkhuijsen, HJ; Voragen, AG; Wolters, MG, 1993) | 0.49 |
| " The proteins were selected to cover a broad range of effects on bioavailability and included egg white, meat, and phytate-free soy protein." | ( The influence of different protein sources on phytate inhibition of nonheme-iron absorption in humans. Cook, JD; Hurrell, RF; Juillerat, MA; Reddy, MB, 1996) | 0.29 |
| " Bioavailability of copper from human milk is high, whereas it is lower from cow milk and infant formula." | ( Bioavailability of copper. Lönnerdal, B, 1996) | 0.29 |
| " Differences in calcium and magnesium bioavailability due to PA and microbial phytase may be one factor in the alteration of tissue cadmium accumulation." | ( Effect of phytic acid and microbial phytase on Cd accumulation, Zn status, and apparent absorption of Ca, P, Mg, Fe, Zn, Cu, and Mn in growing rats. Brandt, K; Most, E; Pallauf, J; Rimbach, G, 1995) | 0.69 |
| " The binding can result in very insoluble salts that are poorly absorbed from the gastrointestinal tract, which results in poor bioavailability (BV) of minerals." | ( Phytic acid in health and disease. Erdman, JW; Zhou, JR, 1995) | 1.73 |
| " In conclusion, CPP improved zinc and calcium bioavailability from high phytate meals in the rat pup model." | ( The effect of casein phosphopeptides on zinc and calcium absorption from high phytate infant diets assessed in rat pups and Caco-2 cells. Hansen, M; Lönnerdal, B; Sandström, B, 1996) | 0.29 |
| "Iron bioavailability from an infant cereal made of wheat flour with a low extraction rate (70%) and cow milk was measured in infants by using a stable-isotope technique." | ( Bioavailability in infants of iron from infant cereals: effect of dephytinization. Cherouvrier, F; Davidsson, L; Galan, P; Hercberg, S; Hurrell, RF; Juillerat, MA; Kastenmayer, P, 1997) | 0.3 |
| " These interactions, which depend on soya processing and treatment, can decrease the bioavailability of minerals and proteins." | ( Composition and characterization of soyabean and related products. García, MC; Laborda, F; Marina, ML; Torre, M, 1997) | 0.3 |
| " Similarly the bioavailability of different minerals and trace elements is considerably reduced by phytate complexes." | ( Nutritional significance of phytic acid and phytase. Pallauf, J; Rimbach, G, 1997) | 0.59 |
| "Dietary strategies to enhance the content and bioavailability of iron and zinc in vegetarian diets were compiled." | ( Dietary strategies to improve the iron and zinc nutriture of young women following a vegetarian diet. Donovan, UM; Gibson, RS; Heath, AL, 1997) | 0.3 |
| "The bioavailability of iron glycine added to a vegetable infant weaning food was compared with ferrous sulfate." | ( Bioavailability of iron glycine as a fortificant in infant foods. Eagles, J; Fairweather-Tait, SJ; Fox, TE, 1998) | 0.3 |
| "NaFe(III)EDTA is a promising iron (Fe) compound for food fortification programs because of its high Fe bioavailability from meals containing dietary inhibitors of Fe absorption such as phytic acid." | ( Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant does not influence absorption and urinary excretion of manganese in healthy adults. Almgren, A; Davidsson, L; Hurrell, RF, 1998) | 0.49 |
| " Young chicks were used to evaluate the efficacy of 2 new vitamin D3 analogs relative to 1 alpha-hydroxycholecalciferol (1 alpha-OH D3) for their ability to improve the bioavailability of phytate-bound phosphorus (P) when added to P-deficient maize-soyabean meal diets that were superadequate in cholecalciferol." | ( Activity of various hydroxylated vitamin D3 analogs for improving phosphorus utilisation in chicks receiving diets adequate in vitamin D3. Baker, DH; Biehl, RR; Deluca, HF, 1998) | 0.3 |
| "This review describes household dietary strategies to improve the content and bioavailability of zinc in predominantly plant-based diets and the implementation of these strategies in a community-based dietary intervention study in rural southern Malawi." | ( Dietary interventions to prevent zinc deficiency. Cullinan, T; Drost, N; Gibson, RS; Mtitimuni, B; Yeudall, F, 1998) | 0.3 |
| " Most or all appear to meet the estimated daily nutrient needs (per day; per 100 kcal) from complementary foods for protein, thiamin and copper (per day), but not for calcium, iron, and in some cases zinc, even if moderate bioavailability for iron and zinc is assumed." | ( Complementary foods for infant feeding in developing countries: their nutrient adequacy and improvement. Ferguson, EL; Gibson, RS; Lehrfeld, J, 1998) | 0.3 |
| "Even if strategies to improve the bioavailability of iron and zinc are employed, they are probably insufficient to overcome the deficits in calcium, iron and zinc." | ( Complementary foods for infant feeding in developing countries: their nutrient adequacy and improvement. Ferguson, EL; Gibson, RS; Lehrfeld, J, 1998) | 0.3 |
| " While most or all of the foods appear to meet the estimated daily nutrient requirements of complementary foods for protein, thiamin, and copper, they do not for calcium, iron, and, in some cases, zinc, even if moderate bioavailability for iron and zinc is assumed." | ( Complementary foods for infant feeding in developing countries: their nutrient adequacy and improvement. Ferguson, EL; Gibson, RS; Lehrfeld, J, 1998) | 0.3 |
| "Three experiments were conducted with 96 growing Landrace x Yorkshire x Duroc crossbreds to determine the collective effectiveness of cereal phytase from wheat middlings, microbial phytase, and citric acid in improving phytate-P bioavailability in corn-soy diets." | ( Adding wheat middlings, microbial phytase, and citric acid to corn-soybean meal diets for growing pigs may replace inorganic phosphorus supplementation. Han, YM; Lei, XG; Pond, WG; Roneker, KR, 1998) | 0.3 |
| " Impaired Mg bioavailability due to 15 g PA/kg diet was accompanied by an increase of hepatic thiobarbituric acid reactive substances and protein carbonyls as well as by a moderate decline in liver reduced glutathione (GSH) levels." | ( Effect of dietary phytate on magnesium bioavailability and liver oxidant status in growing rats. Pallauf, J; Rimbach, G, 1999) | 0.3 |
| "Phytase improves the bioavailability of phytate phosphorus in plant foods to humans and animals and reduces phosphorus pollution of animal waste." | ( Expression of an Aspergillus niger phytase gene (phyA) in Saccharomyces cerevisiae. Han, Y; Lei, XG; Wilson, DB, 1999) | 0.3 |
| "Our objective was to predict the bioavailability of iron from complex meals that are consumed commonly in the United States on the basis of the contents of factors that are known to promote or inhibit food iron absorption." | ( Estimation of nonheme-iron bioavailability from meal composition. Cook, JD; Hurrell, RF; Reddy, MB, 2000) | 0.31 |
| " Therefore, this rapid and inexpensive in vitro model could be a useful screening method for factors affecting calcium absorption, especially inhibitory factors, in future human calcium bioavailability studies." | ( Investigation of an in vitro model for predicting the effect of food components on calcium availability from meals. Cashman, KD; Kennefick, S, 2000) | 0.31 |
| " Three experiments with a total of 140 weanling crossbred pigs were conducted to examine the efficacy of this enzyme in improving the bioavailability of phytate-P in corn-soybean meal diets to young pigs." | ( A new phytase expressed in yeast effectively improves the bioavailability of phytate phosphorus to weanling pigs. Lei, XG; Roneker, KR; Stahl, CH; Thornton, JR, 2000) | 0.31 |
| "3 mg Zn/kg) were used to determine the relative bioavailability (RBV) of Zn in dehulled soybean meal (SBM) based on Zn depletion-repletion growth bioassays in young chicks." | ( Zinc bioavailability in soybean meal. Baker, DH; Edwards, HM, 2000) | 0.31 |
| " These results suggest that PFS may be a promising dietary protein source for improving the mineral bioavailability in humans." | ( Absorption of calcium, magnesium, phosphorus, iron and zinc in growing male rats fed diets containing either phytate-free soybean protein or soybean protein isolate or casein. Fukui, K; Imai, M; Kamao, M; Kawamoto, Y; Kuwata, G; Nakagawa, K; Okano, T; Takamatsu, K; Tsugawa, N, 2000) | 0.31 |
| "In spite of the strong evidence for the beneficial health effects of dietary fibres, one of the potential nutritional disadvantages of high fibre diets is the adverse effect on the bioavailability of micronutrients, especially minerals and trace elements." | ( Inhibitory effect of wheat fibre extract on calcium absorption in Caco-2 cells: evidence for a role of associated phytate rather than fibre per se. Cashman, KD; Kennefick, S, 2000) | 0.31 |
| "This study was conducted to determine the bioavailability of iron amino acid chelate (ferrochel) added to fortify breads prepared from either precooked corn flour or white wheat flour + cheese and margarine compared with the same basal breakfast enriched with either ferrous sulfate or iron-EDTA." | ( Iron bioavailability in humans from breakfasts enriched with iron bis-glycine chelate, phytates and polyphenols. Arguello, F; Barón, MA; García-Casal, MN; Layrisse, M; Leets, I; Llovera, D; Ramírez, J; Solano, L; Tropper, E, 2000) | 0.31 |
| " Furthermore, calcium-phytate-zinc interactions may adversely affect zinc bioavailability in growing rats." | ( Effect of calcium supplements to a maize-soya diet on the bioavailability of minerals and trace elements and the accumulation of heavy metals in growing rats. Most, E; Pallauf, J; Rimbach, G; Walter, A, 2000) | 0.31 |
| "Three chick experiments and two cecectomized rooster experiments were conducted to determine P bioavailability and amino acid (AA) digestibility in two low phytate corns (LP), a high protein corn (HP), and a corn containing both low phytate and high protein content (HP/LP) compared with conventional corn (CONV)." | ( Nutritional evaluation of low phytate and high protein corns. Baker, DH; Boling, SD; Douglas, MW; Parsons, CM; Peter, CM, 2000) | 0.31 |
| "This study aimed to develop and assess the feasibility of a home-based method to reduce the phytate content of maize and improve zinc bioavailability from maize-based complementary diets in rural Malawi." | ( A home-based method to reduce phytate content and increase zinc bioavailability in maize-based complementary diets. Gibson, RS; Hotz, C; Temple, L, 2001) | 0.31 |
| "Calcium bioavailability of vegetarian diets containing various proportions of candidate crops for a controlled ecological life-support system (CELSS) was determined by femur 45Ca uptake." | ( Calcium bioavailability of vegetarian diets in rats: potential application in a bioregenerative life-support system. Belury, MA; Mitchell, CA; Nickel, KP; Nielsen, SS; Smart, DJ, ) | 0.13 |
| "This study determined whether phytic acid in sweet potato greens influences the bioavailability of zinc in young adult rats used as models for adult humans." | ( Zinc bioavailability in young adult rats fed sweet potato greens containing phytic acid. Adeyeye, SO; Almazan, AM; Gordon, SE; Pace, RD, 1999) | 0.82 |
| "The objectives of this study were to estimate the quantity and nutritive quality of the complementary diet in rural Malawi, and to identify feeding practices, nutrients and dietary modifiers of iron and zinc bioavailability that may limit the quality of the diet." | ( Complementary feeding practices and dietary intakes from complementary foods amongst weanlings in rural Malawi. Gibson, RS; Hotz, C, 2001) | 0.31 |
| " The bioavailability of zinc was low due to a high phytate:zinc molar ratio." | ( Complementary feeding practices and dietary intakes from complementary foods amongst weanlings in rural Malawi. Gibson, RS; Hotz, C, 2001) | 0.31 |
| "Iron, zinc and calcium were the most limiting nutrients to the quality of the diet, partly exacerbated by the poor bioavailability of iron and zinc." | ( Complementary feeding practices and dietary intakes from complementary foods amongst weanlings in rural Malawi. Gibson, RS; Hotz, C, 2001) | 0.31 |
| " Participants in the Diet Group were given individual dietary counseling to increase the intake and bioavailability of dietary iron." | ( Can dietary treatment of non-anemic iron deficiency improve iron status? Gibson, RS; Heath, AL; O'Brien, SM; Skeaff, CM; Williams, SM, 2001) | 0.31 |
| " The results from this study imply that oxidation of polyphenols in high-tannin cereals, after reduction of phytate, may be used to increase the bioavailability of iron in foods prepared from these cereals." | ( Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron. Matuschek, E; Svanberg, U; Towo, E, 2001) | 0.31 |
| "Vegetarian diets often contain more copper than do nonvegetarian diets, but observations of decreased plasma copper associated with vegetarian diets suggest that these diets have lower copper bioavailability than do nonvegetarian diets." | ( Apparent copper absorption from a vegetarian diet. Hunt, JR; Vanderpool, RA, 2001) | 0.31 |
| " This paper reports on a study to investigate the bioavailability of calcium, iron and zinc in rats fed with a deficient diet supplemented with MM." | ( Phytate from an alternative dietary supplement has no effect on the calcium, iron and zinc status in undernourished rats. Arruda, SF; de Sousa, LM; de Souza, EM; Siqueira, EM, 2001) | 0.31 |
| " Simultaneous determination of Cu, Fe, and protein bioavailability in the small intestine of rat was carried out in single-dose, short-term (1 h) experiments." | ( Investigation of the mechanisms affecting Cu and Fe bioavailability from legumes: role of seed protein and antinutritional (nonprotein) factors. Aguzzi, A; Carbonaro, M; Grant, G; Mattera, M; Pusztai, A, 2001) | 0.31 |
| "Modern genetic and molecular technologies provide a number of tools that can be utilized for the development of staple foods with a higher iron and zinc content and improved bioavailability of these minerals." | ( Transgenic approaches in commonly consumed cereals to improve iron and zinc content and bioavailability. Holm, PB; Kristiansen, KN; Pedersen, HB, 2002) | 0.31 |
| " Engineering crop plants to produce a heterologous phytase improves phosphate bioavailability and reduces phytic acid excretion." | ( Engineering crop plants: getting a handle on phosphate. Brinch-Pedersen, H; Holm, PB; Sørensen, LD, 2002) | 0.53 |
| "An in vitro digestion/Caco-2 model was used to compare iron bioavailability from 15 selected Fe-dense and normal genotypes of unpolished rice from the International Rice Research Institute." | ( Comparison of iron bioavailability from 15 rice genotypes: studies using an in vitro digestion/caco-2 cell culture model. Cheng, Z; Glahn, RP; Gregorio, GB; Welch, RM, 2002) | 0.31 |
| " On the other hand, the possible inhibitatory effect of fiber has been also studied, without conclusive results between in vitro and in vivo studies and the role of phytic acid on impairs calcium bioavailability could be prevented by using fructo-oligosaccharides, which cannot be digested in the small intestine and arrive practically intact to the colon, where are fermented." | ( Influence of dietary factors on calcium bioavailability: a brief review. Amaro-López, MA; Cámara-Martos, F, 2002) | 0.51 |
| "The mineral content of legumes is generally high, but the bioavailability is poor due to the presence of phytate, which is a main inhibitor of Fe and Zn absorption." | ( Bioavailability of minerals in legumes. Sandberg, AS, 2002) | 0.31 |
| " Recently, it was shown, however, that the bioavailability of potential antioxidants from plant foods is generally too low to have any substantial direct effect on reactive oxygen species." | ( Bioactive substances of plant origin in food--impact on genomics. Berwid, SJ; Jank, M; Orzechowski, A; Ostaszewski, P, ) | 0.13 |
| " As the bioavailability and ecological effect of IP6-P appear to be regulated not only by pH-controlled enzyme activity but also by the associated counterions, the differential protective effects of cations influence the accuracy of manure PHP fraction estimates and increase phytate resistance to enzymatic dephosphorylation that may lead to its persistence in manure." | ( Polyvalent cation effects on myo-inositol hexakis dihydrogenphosphate enzymatic dephosphorylation in dairy wastewater. Dao, TH, ) | 0.13 |
| "The importance of trace element bioavailability in the etiology of nutritional deficiencies, for example in the etiology of iron deficiency and iron deficiency anemia, can be expected to be most pronounced in individuals with high requirements." | ( Approaches to improve iron bioavailability from complementary foods. Davidsson, L, 2003) | 0.32 |
| " Feces specimens were collected for all the subjects and absorption rate of calcium, iron and zinc were measured for all the children who took fortified and dephytinized soy milk, soy milk or cow milk, respectively." | ( [A study on absorption and utilization of calcium, iron and zinc in mineral-fortified and dephytinized soy milk powder consumed by boys aged 12 to 14 years]. Barclay, D; Hao, LY; Kastenmayor, P; Yin, SA; Zhao, XF, 2003) | 0.32 |
| "Iron absorption rate was (6." | ( [A study on absorption and utilization of calcium, iron and zinc in mineral-fortified and dephytinized soy milk powder consumed by boys aged 12 to 14 years]. Barclay, D; Hao, LY; Kastenmayor, P; Yin, SA; Zhao, XF, 2003) | 0.32 |
| "Mineral bioavailability from reconstituted whole wheat flour can be improved by bread making." | ( Making bread with sourdough improves mineral bioavailability from reconstituted whole wheat flour in rats. Coudray, C; Demigné, C; Duclos, V; Feillet-Coudray, C; Krespine, V; Lopez, HW; Messager, A; Rémésy, C, 2003) | 0.32 |
| "The current study was undertaken to estimate variance components for phytate P bioavailability (PBA) and the genetic correlations among PBA with growth and feed utilization (or intake) traits in an unselected random mating chicken population." | ( Genetics of phytate phosphorus bioavailability: heritability and genetic correlations with growth and feed utilization traits in a randombred chicken population. Aggrey, SE; Bakalli, RI; Edwards, HM; Pesti, GM; Zhang, W, 2003) | 0.32 |
| " Because iron and zinc deficiencies are widespread in infants and young children in developing countries, the bioavailability of iron and zinc from complementary food is a major concern." | ( Influence of vegetable protein sources on trace element and mineral bioavailability. Hurrell, RF, 2003) | 0.32 |
| " The aim was to enhance the content and bioavailability of micronutrients in maize-based diets of stunted children ages 30-90 mo." | ( Experiences of a community-based dietary intervention to enhance micronutrient adequacy of diets low in animal source foods and high in phytate: a case study in rural Malawian children. Cullinan, TR; Drost, N; Gibson, RS; Mtitimuni, BM; Yeudall, F, 2003) | 0.32 |
| "Expression of heterologous phytases in crops offers a great potential for improving phosphate and mineral bioavailability in food and feed." | ( Concerted action of endogenous and heterologous phytase on phytic acid degradation in seed of transgenic wheat (Triticum aestivum L.). Brinch-Pedersen, H; Hatzack, F; Holm, PB; Sørensen, LD, 2003) | 0.56 |
| " Hence, it is concluded that when up to 1% of phytate as sodium salt is consumed together with an equilibrated purified diet (free of phytate), no decrease in mineral bioavailability is observed in second generation rats, except for an indication of lower zinc availability by lower zinc concentrations in some organs, mainly bone." | ( Effect of phytate on element bioavailability in the second generation of rats. Costa-Bauzá, A; Grases, F; Perelló, J; Prieto, RM; Simonet, BM, 2004) | 0.32 |
| "50 mol/kg (critical level), thus indicating reduced bioavailability of Zn to a critical level." | ( Nutritional evaluation of some Nigerian wild seeds. Ekperigin, MM; Oboh, G, 2004) | 0.32 |
| "Identification of allelic variants in a single gene that determine the phytate content of maize kernels and the subsequent breeding of low-phytate maize have facilitated studies designed to determine quantitatively the effects of maize phytate on the bioavailability of minerals in maize." | ( Zinc absorption from low-phytate hybrids of maize and their wild-type isohybrids. Dorsch, JA; Grunwald, GK; Hambidge, KM; Huffer, JW; Krebs, NF; Miller, LV; Raboy, V; Sian, L; Westcott, JL, 2004) | 0.32 |
| " Phytate P bioavailability (PPB), Ca bioavailability (CaB), and N bioavailability (NB) were estimated from the disappearance of the nutrients during the passage of feed through the gastrointestinal tract." | ( Modeling of parameters affecting phytate phosphorus bioavailability in growing birds. Aggrey, SE; Ankra-Badu, GA; Bakalli, RI; Edwards, HM; Pesti, GM, 2004) | 0.32 |
| " Addition of phytases can improve the bioavailability of iron and zinc in food." | ( Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae. Andlid, TA; Sandberg, AS; Veide, J, 2004) | 0.32 |
| " Significant Mg bioavailability improvement in bread could be supplied by the choice of raw materials and the baking processes of cereals." | ( New data on the bioavailability of bread magnesium. Leenhardt, F; Lopez, HW; Remesy, C, 2004) | 0.32 |
| " Since an important factor in its causation is the poor bioavailability of iron in the cereal-based diets of many developing countries, SUSTAIN set up a Task Force, consisting of nutritional, medical, industry, and government experts to consider strategies for enhancing the absorption of fortification iron." | ( Enhancing the absorption of fortification iron. A SUSTAIN Task Force report. Bothwell, T; Cori, H; Glahn, R; Hertrampf, E; Hurrell, RF; Kratky, Z; Lynch, S; Miller, D; Rodenstein, M; Streekstra, H; Teucher, B; Turner, E; Yeung, CK; Zimmermann, MB, 2004) | 0.32 |
| "The current study was undertaken to evaluate the direct response to 3 generations of divergent selection for phytate P bioavailability (PBA) in the Athens-Canadian randombred chicken population." | ( Genetic analysis on the direct response to divergent selection for phytate phosphorus bioavailability in a randombred chicken population. Aggrey, SE; Bakalli, RI; Edwards, HM; Pesti, GM; Zhang, W, 2005) | 0.33 |
| "Phytate decreases iron and zinc bioavailability and contributes to deficiencies of iron and zinc, potentially causing anaemia, poor psychomotor development, impaired growth and increased risk of diarrhoea and respiratory infections." | ( Effects of weaning cereals with different phytate content on growth, development and morbidity: a randomized intervention trial in infants from 6 to 12 months of age. Hernell, O; Lind, T; Lönnerdal, B; Persson, L; Stenlund, H, 2004) | 0.32 |
| "The current study was undertaken to evaluate the correlated responses to 3 generations of divergent selection for phytate phosphorus bioavailability (PBA) in the Athens-Canadian randombred chicken population." | ( Correlated responses to divergent selection for phytate phosphorus bioavailability in a randombred chicken population. Aggrey, SE; Bakalli, RI; Edwards, HM; Pesti, GM; Zhang, W, 2005) | 0.33 |
| " Bioavailability of calcium is, however, compromised by phytate, which is present in large quantities in maize kernels and is only modestly reduced by nixtamalization." | ( Absorption of calcium from tortilla meals prepared from low-phytate maize. Hambidge, KM; Krebs, NF; Miller, LV; Peterson, KL; Raboy, V; Sian, L; Westcott, JL, 2005) | 0.33 |
| " The regular intake of probiotic preparation, may represent a cheap and safe tool in order to convert a diet with a low potential for bioavailability of trace minerals and proteins, such as the vegetarian diet, into a diet with a high bioavailability potential." | ( Probiotic lactobacilli: an innovative tool to correct the malabsorption syndrome of vegetarians? De Simone, C; Famularo, G; Minisola, G; Pandey, V; Sahu, AR, 2005) | 0.33 |
| " In marginally zinc-deficient rats, the enhancement of zinc bioavailability by RS occurs mostly when the diet contains phytic acid." | ( Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats. Suzuki, H; Yonekura, L, 2005) | 0.82 |
| "This study aims to investigate the effect of dietary zinc level and phytic acid on the cecal zinc pools and zinc bioavailability of rats fed RS." | ( Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats. Suzuki, H; Yonekura, L, 2005) | 0.85 |
| "The increase in zinc bioavailability by RS occurs when dietary zinc levels are adequate and/or zinc absorption is impaired in the small intestine, increasing the influx of unabsorbed zinc into the cecum and favoring the increase of zinc bioavailability when RS fermentation lowers the cecal pH." | ( Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats. Suzuki, H; Yonekura, L, 2005) | 0.61 |
| " Tricalcium phosphate (TCP)-fortified soymilk was shown to have a lower Ca bioavailability than cow's milk in men." | ( Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow's milk in young women. Martin, BR; Weaver, CM; Zhao, Y, 2005) | 0.33 |
| "The objectives of this study were to determine if lengthening the time that soybeans (SB) spend in the extractor during preparation of soybean meal (SBM) results in increased relative bioavailability of phosphorus without negatively impacting true amino acid digestibilities, and to compare those modified SBM with that produced from a low-phytate SB." | ( Relative bioavailability of phosphorus and true amino acid digestibility by poultry as affected by soybean extraction time and use of low-phytate soybeans. Fahey, GC; Karr-Lilienthal, LK; Martinez Amezcua, C; Merchen, NR; Parsons, CM; Utterback, PL, 2005) | 0.33 |
| " Phytate in foods impair the bioavailability of calcium, iron, and zinc, which to some extent depends upon food processing and cooking methods." | ( Phytate, calcium, iron, and zinc contents and their molar ratios in foods commonly consumed in China. Guusje, B; Jacobsen, E; Jin, Y; Kok, F; Ma, G; Piao, J, 2005) | 0.33 |
| "Poor bioavailability of zinc from high-phytate diets is an important contributory factor to zinc deficiency in low-income populations." | ( Zinc absorption in Guatemalan schoolchildren fed normal or low-phytate maize. Barahona, B; Campos, R; Grunwald, GK; Hambidge, KM; Krebs, NF; Lei, S; Mazariegos, M; Raboy, V; Solomons, NW; Westcott, JE, 2006) | 0.33 |
| " These changes seem to result not only from reduced bioavailability of minerals but also from interactions of PA with nutrients and enzymes in the liver." | ( Phytic acid-induced metabolic changes in the rat. Szkudelski, T, 2005) | 1.77 |
| "Myo-inositol hexaphosphate (IP6, phytate) is a potent anti-nutritional compound occurring in many plant-based staple foods, limiting the bioavailability of important nutrients such as iron and zinc." | ( Improved extracellular phytase activity in Saccharomyces cerevisiae by modifications in the PHO system. Andlid, T; Veide, J, 2006) | 0.33 |
| " Fe bioavailability and utilization in wheat bread (WB) and corn tortillas (CT) fortified with various Fe sources was assessed after the depletion and repletion periods." | ( Cooking and Fe fortification have different effects on Fe bioavailability of bread and tortillas. Hernández, M; López-Alarcón, M; Montalvo, I; Moreno, A; Sousa, V; Villalpando, S, 2006) | 0.33 |
| " Iron bioavailability indicators were best in rats fed CT fortified with ferrous sulfate and NaFe(III)EDTA than in those fed unfortified CT or CT plus reduced Fe." | ( Cooking and Fe fortification have different effects on Fe bioavailability of bread and tortillas. Hernández, M; López-Alarcón, M; Montalvo, I; Moreno, A; Sousa, V; Villalpando, S, 2006) | 0.33 |
| "We concluded that baking WF bread improved the bioavailability of native Fe with no further effect of fortification." | ( Cooking and Fe fortification have different effects on Fe bioavailability of bread and tortillas. Hernández, M; López-Alarcón, M; Montalvo, I; Moreno, A; Sousa, V; Villalpando, S, 2006) | 0.33 |
| "To develop a statistical model for predicting zinc bioavailability from cereal-based vegetarian meals using relative proportion of nutrients, non-nutrients and their interactive effects." | ( Predicting bioavailable zinc from lower phytate forms, folic Acid and their interactions with zinc in vegetarian meals. Agte, VV; Chiplonkar, SA, 2006) | 0.33 |
| "Zn bioavailability is often lower in vegetarian diets mainly due to low Zn and high phytic acid contents." | ( Total zinc absorption in young women, but not fractional zinc absorption, differs between vegetarian and meat-based diets with equal phytic acid content. Bügel, S; Hels, O; Kristensen, MB; Marving, J; Morberg, CM; Tetens, I, 2006) | 0.76 |
| " Diet-related factors in plant foods that affect bioavailability include: the chemical form of the nutrient in food and/or nature of the food matrix; interactions between nutrients and other organic components (e." | ( Improving the bioavailability of nutrients in plant foods at the household level. Gibson, RS; Hotz, C; Perlas, L, 2006) | 0.33 |
| "The objective of this study was to quantify the bioavailability of zinc (Zn) from sulphate and glycinate as representatives of inorganic and organic zinc sources." | ( Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. Schlegel, P; Windisch, W, 2006) | 0.33 |
| " Supplementation of monogastric animal feed with microbial-derived phytase increases the bioavailability of phytic acid bound phosphate." | ( Comparison of selected physicochemical characteristics of commercial phytases relevant to their application in phosphate pollution abatement. Boyce, A; Walsh, G, 2006) | 0.55 |
| " Evaluation of heat stability properties and kinetic properties unraveled that, under these deposition conditions, heat stability based on high unfolding temperature is superior to high refolding capacity and represents a realistic strategy for improving phosphate and mineral bioavailability in cereal-based feed and food." | ( Heat-stable phytases in transgenic wheat (Triticum aestivum L.): deposition pattern, thermostability, and phytate hydrolysis. Arcalis, E; Brinch-Pedersen, H; Hatzack, F; Holm, PB; Pontopidan, K; Stöger, E, 2006) | 0.33 |
| "Despite extensive use, information on the bioavailability of elemental iron powders to humans, as influenced by dose and other dietary constituents, is limited." | ( An irradiated electrolytic iron fortificant is poorly absorbed by humans and is less responsive than FeSO4 to the enhancing effect of ascorbic acid. Hunt, JR; Johnson, LK; Swain, JH, 2006) | 0.33 |
| " In this study, fresh leaves of Vernonia amygdalina were subjected to abrasion (to remove the bitter taste) as is normally done in soup preparation, subsequently the nutrient, anti-nutrient and zinc bioavailability of the processed and unprocessed leaf were determined." | ( Nutritive value and haemolytic properties (in vitro) of the leaves of Vernonia amygdalina on human erythrocyte. Oboh, G, 2006) | 0.33 |
| " We tested the effect of an oat gruel fermented with Lactobacillus plantarum 299v on non-haem Fe absorption from a low-Fe bioavailability meal compared with a pasteurised, fermented oat gruel and non-fermented oat gruels." | ( A lactic acid-fermented oat gruel increases non-haem iron absorption from a phytate-rich meal in healthy women of childbearing age. Berggren, A; Bering, S; Bukhave, K; Sjøltov, L; Suchdev, S; Tetens, I, 2006) | 0.33 |
| " In this study we have compared the iron, zinc, and calcium content, and estimated iron and zinc bioavailability of rice- and maize-based Filipino complementary foods prepared with and without soaking and/or enrichment with chicken liver, egg yolk, small soft-boned fish, and mung bean grits." | ( Household dietary strategies to enhance the content and bioavailability of iron, zinc and calcium of selected rice- and maize-based Philippine complementary foods. Gibson, RS; Perlas, LA, 2005) | 0.33 |
| " Phytate may impair the bioavailability of iron, calcium and zinc in the diets of people in China." | ( Phytate intake and molar ratios of phytate to zinc, iron and calcium in the diets of people in China. Jin, Y; Kok, FJ; Li, Y; Ma, G; Yang, X; Zhai, F, 2007) | 0.34 |
| " While improving the textural qualities of bread, sourdough fermentation also results in increased mineral bioavailability and reduced phytate content." | ( Impact of sourdough on the texture of bread. Arendt, EK; Dal Bello, F; Ryan, LA, 2007) | 0.34 |
| "The investigation was undertaken with the objective of comparing two in vitro techniques, measuring dialyzable iron (method A) and measuring ionizable iron (method B), for iron bioavailability in a model system." | ( Comparative analysis of influence of promoters and inhibitors on in vitro available iron using two methods. Gupta, S; Jyothi Lakshmi, A; Prakash, J, ) | 0.13 |
| " laurentii ABO 510 phytase may be considered for application as an animal feed additive to assist in the hydrolysis of phytate complexes to improve the bioavailability of phosphorus in plant feedstuff." | ( Phytase activity in Cryptococcus laurentii ABO 510. Botha, A; den Haan, R; van Staden, J; van Zyl, WH; Viljoen-Bloom, M, 2007) | 0.34 |
| "Many studies on the bioavailability of polyphenols have been reported." | ( Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans. Hirayama, M; Ichiyanagi, T; Ito, K; Konishi, T; Matsumoto, H; Tsuda, T; Yonekura, K, 2007) | 0.58 |
| " The objective of this study was to determine the effects of processing on iron bioavailability in common maize products and elucidate better processing techniques for enhancing iron bioavailability." | ( Fermentation and lactic acid addition enhance iron bioavailability of maize. Proulx, AK; Reddy, MB, 2007) | 0.34 |
| " The bioavailability of ferritin iron was assessed using coupled in vitro digestion/Caco-2 cell model in the presence or absence of ascorbic acid and phytic acid." | ( Gastric digestion of pea ferritin and modulation of its iron bioavailability by ascorbic and phytic acids in caco-2 cells. Bejjani, S; Nair, KM; Pullakhandam, R; Punjal, R, 2007) | 0.76 |
| " However, few studies have shown a significant effect on iron status following iron fortification of low bioavailability diets." | ( The importance of bioavailability of dietary iron in relation to the expected effect from iron fortification. Hallberg, L; Hoppe, M; Hulthén, L, 2008) | 0.35 |
| " Iron absorption and rate of change in iron stores were calculated from nine diets representing a broad range of iron bioavailability and iron contents." | ( The importance of bioavailability of dietary iron in relation to the expected effect from iron fortification. Hallberg, L; Hoppe, M; Hulthén, L, 2008) | 0.35 |
| " The combined action of fortification (6 mg/day) and modest bioavailability changes in a low bioavailability diet results approximately in 40 and 70% greater increases in iron stores than through iron fortification or dietary modification alone." | ( The importance of bioavailability of dietary iron in relation to the expected effect from iron fortification. Hallberg, L; Hoppe, M; Hulthén, L, 2008) | 0.35 |
| " Phosphorus excretion, net absorption, and apparent absorption rate were affected by dietary phytate level but not by the age of the subjects." | ( Fecal phytate excretion varies with dietary phytate and age in women. Jeun, BY; Joung, H; Kim, J; King, JC; Li, SJ; Paik, HY; Welch, RM; Woodhouse, LR, 2007) | 0.34 |
| " The primary goal of this research was to use an in vitro digestion/Caco-2 model to study iron bioavailability in eight genotypes (three Mesoamerican and five Andean) that represent the diversity of grain types in this crop." | ( Screening of iron bioavailability patterns in eight bean (Phaseolus vulgaris L.) genotypes using the Caco-2 cell in vitro model. Ariza-Nieto, M; Blair, MW; Glahn, RP; Welch, RM, 2007) | 0.34 |
| " However, the presence of phytic acid (InsP(6)) could partly limit their benefits because it decreases the mineral bioavailability due to its chelating properties." | ( Selection of phytate-degrading human bifidobacteria and application in whole wheat dough fermentation. Haros, M; Palacios, MC; Rosell, CM; Sanz, Y, 2008) | 0.65 |
| " Incorporation of rice bran into bread made from white rice flour adds flavor but also phytic acid, which can reduce the bioavailability of minerals." | ( Effects of yeast and bran on phytate degradation and minerals in rice bread. Kadan, RS; Phillippy, BQ, 2007) | 0.56 |
| " Our objective was to study iron, vitamin C, and phytic acid composition and also iron bioavailability from 4 species of marine algae included in a rice-based meal." | ( High iron content and bioavailability in humans from four species of marine algae. García-Casal, MN; Leets, I; Pereira, AC; Quiroga, MF; Ramírez, J, 2007) | 0.59 |
| " In this paper, progresses in researches on physiology of Zn deficiency in animals, phytate effect on bioavailability of Zn, and role of phytase in healing Zn deficiency of animals were reviewed." | ( Treatment of zinc deficiency without zinc fortification. Harland, BF; Oberleas, D, 2008) | 0.35 |
| "The reduced iron powder has considerable potential for use as an iron fortificant because it does not change organoleptically during storage or food preparation for cereal flour, and its bioavailability is scarcely influenced by iron absorption inhibitors in foods." | ( Comparison of iron uptake from reduced iron powder and FeSO4 using the Caco-2 cell model: effects of ascorbic acid, phytic acid, and pH. Feng, Y; He, WL; Li, XL; Yang, XE, 2008) | 0.56 |
| "To evaluate the effect of consuming sous vide cooked salmon fish on non-heme iron bioavailability from a bean meal, rich in phytate, in iron-deficient women." | ( Oily fish increases iron bioavailability of a phytate rich meal in young iron deficient women. Carbajal, A; Fairweather-Tait, SJ; Navas-Carretero, S; Pedrosa, MM; Pérez-Granados, AM; Roe, MA; Sarriá, B; Vaquero, MP, 2008) | 0.35 |
| " Iron bioavailability was measured as the incorporation of stable isotopes into erythrocytes 14 d after meals consumption." | ( Oily fish increases iron bioavailability of a phytate rich meal in young iron deficient women. Carbajal, A; Fairweather-Tait, SJ; Navas-Carretero, S; Pedrosa, MM; Pérez-Granados, AM; Roe, MA; Sarriá, B; Vaquero, MP, 2008) | 0.35 |
| "Extracellular phosphohydrolases mediate the dephosphorylation of phosphoesters and influence bioavailability and loss of agricultural P to the environment to pose risks of impairment of sensitive aquatic ecosystems." | ( Dephosphorylation and quantification of organic phosphorus in poultry litter by purified phytic-acid high affinity Aspergillus phosphohydrolases. Dao, TH; Hoang, KQ, 2008) | 0.35 |
| "The effects of ascorbic acid (AA), phytate and tannic acid (TA) on Fe bioavailability from Fe supplied as reconstituted ferritin were compared with FeSO4 using an in vitro digestion-Caco-2 cell model." | ( Effects of ascorbic acid, phytic acid and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model. Frohman, C; Glahn, RP; Jin, F; Thannhauser, TW; Welch, RM, 2009) | 0.65 |
| " Moderate pulque intake appears to increase the bioavailability of iron and zinc bound by phytate in corn." | ( Pulque, an alcoholic drink from rural Mexico, contains phytase. Its in vitro effects on corn tortilla. Gutierrez, ME; Olivos, M; Tovar, LR, 2008) | 0.35 |
| " Reduced phytate consumption coincident with increased Zn intake suggests that Zn bioavailability also improved, particularly by 1998." | ( The impact of rapid economic growth and globalization on zinc nutrition in South Korea. Beattie, JH; Chung, HR; Do, MS; Kim, YH; Kwun, IS, 2009) | 0.35 |
| "Although total Zn intake was not greatly affected over the initial period of economic growth in South Korea (1969-1988), Zn contributions from different food sources changed markedly and both Zn intake and potential bioavailability were improved by 1998." | ( The impact of rapid economic growth and globalization on zinc nutrition in South Korea. Beattie, JH; Chung, HR; Do, MS; Kim, YH; Kwun, IS, 2009) | 0.35 |
| " Multivariate data analysis performed on 22 components analyzed in this study using principal component analysis and cluster methods demonstrate that differences in phytase, antioxidant activity, mineral contents, and bioavailability are much larger within market class than among bean cultivars." | ( Phytic acid, phytase, minerals, and antioxidant activity in Canadian dry bean ( Phaseolus vulgaris L.) cultivars. Balasubramanian, P; Blanchard, C; Oomah, BD, 2008) | 1.79 |
| "An investigation was conducted to study insulin-like growth factor (IGF)-I, IGF-II, insulin, glucagon, leptin, triiodothyronine (T(3)), and thyroxine (T(4)) levels in a chicken population divergently selected for P bioavailability (PBA)." | ( Physiological responses to divergent selection for phytate phosphorus bioavailability in a randombred chicken population. Aggrey, SE; Edwards, HM; McMurtry, JP; Pesti, GM; Sethi, PK, 2008) | 0.35 |
| "Although calcium inhibits zinc bioavailability in rats, especially from high-phytate diets, the effect of calcium on zinc absorption by humans from practical diets remains unclear." | ( Dietary calcium does not exacerbate phytate inhibition of zinc absorption by women from conventional diets. Beiseigel, JM; Hunt, JR, 2009) | 0.35 |
| " Mineral contents were determined by inductively coupled plasma atomic emission; phytic acid and tannin contents by a colorimetric and titrimetric method, respectively; and the potential mineral bioavailability by the molar ratio of phytic acid/mineral." | ( Minerals, phytic acid and tannin contents of 18 fruits from the Brazilian savanna. Arruda, SF; Marin, AM; Siqueira, EM, 2009) | 0.98 |
| "To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells." | ( Effect of dephytinization on bioavailability of iron, calcium and zinc from infant cereals assessed in the Caco-2 cell model. Ferruzza, S; Frontela, C; Martínez, C; Ros, G; Scarino, ML, 2009) | 0.35 |
| "Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water." | ( Effect of dephytinization on bioavailability of iron, calcium and zinc from infant cereals assessed in the Caco-2 cell model. Ferruzza, S; Frontela, C; Martínez, C; Ros, G; Scarino, ML, 2009) | 0.35 |
| "Iron bioavailability from supplements and fortificants varies depending upon the form of the iron and the presence or absence of iron absorption enhancers and inhibitors." | ( Comparing soluble ferric pyrophosphate to common iron salts and chelates as sources of bioavailable iron in a Caco-2 cell culture model. Glahn, RP; Miller, DD; Nelson, D; Zhu, L, 2009) | 0.35 |
| " Several conditioning factors will contribute to the potential for this strategy to meet its goal, including the additional amount of zinc that can be bred into the staple crop food, the amount of zinc that remains in the staple crop food following usual processing methods, and the bioavailability of zinc from the staple crop food in the context of the usual diet." | ( The potential to improve zinc status through biofortification of staple food crops with zinc. Hotz, C, 2009) | 0.35 |
| " Proxy measures were used to assess Fe and Zn bioavailability and protein digestibility of a bean recipe (fríjol sancochado) and a maize-milk recipe (mazamorra) prepared with enhanced or conventional crops in Colombia." | ( Iron, zinc, and protein bioavailability proxy measures of meals prepared with nutritionally enhanced beans and maize. Araujo, C; Blair, MW; Ortiz, DA; Pachón, H; Restrepo, J, 2009) | 0.35 |
| "A 3 x 2 factorial experiment was designed to evaluate the effects of FOS (in the presence or absence of PA) on the apparent absorption rate of minerals and the mineral status (plasma, hepatic, and bone) in mice." | ( Fructo-oligosaccharides enhance the mineral absorption and counteract the adverse effects of phytic acid in mice. Wang, Q; Wang, SE; Wang, W; Wang, Y; Yu, HX; Zeng, T, 2010) | 0.58 |
| " In addition, FOS effectively boosted the apparent absorption rate of calcium (FOS1, +7%; FOS2, +9%, P<0." | ( Fructo-oligosaccharides enhance the mineral absorption and counteract the adverse effects of phytic acid in mice. Wang, Q; Wang, SE; Wang, W; Wang, Y; Yu, HX; Zeng, T, 2010) | 0.58 |
| "These data indicate that FOS effectively enhances the mineral apparent absorption rate and counteracts the deleterious effects of PA." | ( Fructo-oligosaccharides enhance the mineral absorption and counteract the adverse effects of phytic acid in mice. Wang, Q; Wang, SE; Wang, W; Wang, Y; Yu, HX; Zeng, T, 2010) | 0.58 |
| "The main objective of this study was to assess the amount of bioavailable iron in Kenyan complementary foods and to determine whether strategies such as food diversification using locally available foods would improve the bioavailability of iron from these foods." | ( In vitro estimates of iron bioavailability in some Kenyan complementary foods. Glahn, RP; Lung'aho, MG, 2009) | 0.35 |
| "The in vitro iron bioavailability system/ Caco-2 cell model that mirrors the gastric and intestinal digestion of humans was used in this study to estimate the amount of bioavailable iron in the porridges." | ( In vitro estimates of iron bioavailability in some Kenyan complementary foods. Glahn, RP; Lung'aho, MG, 2009) | 0.35 |
| "In addition to diet diversity, more approaches to address iron inadequacy of complementary foods are required to improve the bioavailability of iron from the Kenyan complementary foods analyzed." | ( In vitro estimates of iron bioavailability in some Kenyan complementary foods. Glahn, RP; Lung'aho, MG, 2009) | 0.35 |
| " Effects of phytate on mineral and trace element bioavailability are reported and phytate degradation during processing and storage is described." | ( Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Frølich, W; Grases, F; Prieto, RM; Schlemmer, U, 2009) | 0.35 |
| "The objectives of this research were to assess the bioavailability of iron in foodstuffs found in the Mexican diet, to provide data on the content of iron absorption inhibitors present in plant origin products and to assess the inhibitory effect of these compounds and of cooking on iron bioavailability; therefore, total content and bioavailable iron, tannins, phytic and oxalic acid were determined in vegetables, cereals, legumes and animal products, before and after cooking." | ( Role of oxate, phytate, tannins and cooking on iron bioavailability from foods commonly consumed in Mexico. González-Osnaya, L; Sánchez-Chinchillas, A; Sotelo, A; Trejo, A, 2010) | 0.36 |
| " For a significant detoxification of antinutrient substances and for optimal bioavailability of the component nutrients of bambaragroundnut seeds, an optimum cooking time of 60 min at 100 degrees C is therefore recommended." | ( Effect of cooking time on some nutrient and antinutrient components of bambaragroundnut seeds. Aruna, MB; Bamgbose, AM; Omoikhoje, SO, 2009) | 0.35 |
| "Microbes such as yeast and Aspergillus are known to produce phytase, and Aspergillus phytase has been used as a feed additive for improving phytate-phosphorus bioavailability in monogastric animals." | ( Brewer's yeast efficiently degrades phytate phosphorus in a corn-soybean meal diet during soaking treatment. Chu, GM; Funaba, M; Kawashima, T; Matsui, T; Ohmori, H, 2009) | 0.35 |
| " The principal dietary factor known to impair zinc bioavailability is inositol hexa- (and penta-) phosphate or phytate." | ( Zinc bioavailability and homeostasis. Hambidge, KM; Krebs, NF; Miller, LV; Sheng, X; Westcott, JE, 2010) | 0.36 |
| "This article provides a review of how the challenge of bioavailability was approached in establishing the Dietary Reference Intakes, with a special focus on folic acid, vitamin B-12, beta-carotene, iron, selenium, and zinc, the targeted micronutrients for this workshop." | ( Micronutrient bioavailability: Dietary Reference Intakes and a future perspective. Hambidge, KM, 2010) | 0.36 |
| " On the basis of intake data and isotope studies, iron bioavailability has been estimated to be in the range of 14-18% for mixed diets and 5-12% for vegetarian diets in subjects with no iron stores, and these values have been used to generate dietary reference values for all population groups." | ( Iron bioavailability and dietary reference values. Egli, I; Hurrell, R, 2010) | 0.36 |
| " Additionally, high phytate intakes compromise the bioavailability of zinc." | ( Neither a zinc supplement nor phytate-reduced maize nor their combination enhance growth of 6- to 12-month-old Guatemalan infants. Das, A; Goco, N; Hambidge, KM; Kindem, M; Krebs, NF; Mazariegos, M; Raboy, V; Solomons, NW; Westcott, JE; Wright, LL, 2010) | 0.36 |
| " The recent literature contains examples of enhancing bioavailability of iron via enzyme-catalyzed degradation of phytate in wheat bran, increasing diacyl-glycerol and conjugated linoleic acid levels by lipase action, enhancing the absorption of the citrus flavonoid hesperetin via rhamnosidase treatment, and obtaining solubilized dietary fiber via enzymatic modification of potato starch processing residues." | ( Enzyme technology for precision functional food ingredient processes. Meyer, AS, 2010) | 0.36 |
| " The main objective of the study was to determine whether a change from red beans to white beans in the complementary food recipe would improve iron bioavailability from the mixture, as recent studies had indicated that iron bioavailability in white beans is significantly higher compared to that in the colored beans." | ( Use of white beans instead of red beans may improve iron bioavailability from a Tanzanian complementary food mixture. Glahn, RP; Lung'aho, MG, 2010) | 0.36 |
| " The supplementation of animal feed with phytases results in increased bioavailability to animals and decreased environmental contamination." | ( Heterologous expression and functional characterization of a plant alkaline phytase in Pichia pastoris. Johnson, SC; Murthy, PP; Yang, M, 2010) | 0.36 |
| " Certain lactic acid bacteria (LAB) produce the enzyme phytase that degrades phytates and therefore may potentially improve mineral bioavailability and absorption." | ( Phytase activity from Lactobacillus spp. in calcium-fortified soymilk. Ashton, JF; Shah, NP; Stojanovska, L; Tang, AL; Walker, KZ; Wilcox, G, 2010) | 0.36 |
| " Also estimated were zinc and divalent cation bioavailability of the seeds using millimolar ratios/kg dry weight of [calcium]/[phytate], [phytate]/[zinc], [calcium][phytate]/[Zn], and [phytate]/[total phosphorus]." | ( The proximate, mineral, and toxicant compositions of four possible food security crops from southeastern Nigeria. Agha, NC; Ogbuji, CA; Ojiako, OA; Onwuliri, VA, 2010) | 0.36 |
| "A random-mating population was used to study the genetic interrelationship between phytate P (PPB), Ca (CaB), N (NB), and energy bioavailability (EB), BW at 4 wk of age, relative growth (RG), and feed conversion ratio (FCR)." | ( Genetic interrelationships among phosphorus, nitrogen, calcium, and energy bioavailability in a growing chicken population. Aggrey, SE; Ankra-Badu, GA; Pesti, GM, 2010) | 0.36 |
| "Phytate is an antinutritional factor that influences the bioavailability of essential minerals by forming complexes with them and converting them into insoluble salts." | ( β-propeller phytase hydrolyzes insoluble Ca(2+)-phytate salts and completely abrogates the ability of phytate to chelate metal ions. Auh, JH; Choi, WC; Jung, WJ; Jung, YS; Kim, H; Kim, JW; Kim, KK; Kim, OH; Kim, YO; Lee, H; Lee, SJ; Oh, BC; Oh, TK; Shim, JH, 2010) | 0.36 |
| "Dietary phytic acid is a major causative factor for low Zn bioavailability in many cereal- and legume-based diets." | ( Zinc absorption from low phytic acid genotypes of maize (Zea mays L.), Barley (Hordeum vulgare L.), and Rice (Oryza sativa L.) assessed in a suckling rat pup model. Brown, KH; Lönnerdal, B; Mendoza, C; Raboy, V; Rutger, JN, 2011) | 1.11 |
| " It is therefore of primary importance to understand the mechanisms underlying metal ion accumulation, distribution, storage, and bioavailability in aleurone subcellular organelles for seed fortification purposes." | ( New insights into globoids of protein storage vacuoles in wheat aleurone using synchrotron soft X-ray microscopy. Eichert, D; Gianoncelli, A; Kaulich, B; Kreft, I; Pongrac, P; Regvar, M; Vogel-Mikus, K, 2011) | 0.37 |
| "Several bioavailability algorithms have been proposed for iron and zinc, confirming the need for these tools while emphasizing the challenge of deriving algorithms with accepted accuracy." | ( Algorithms for iron and zinc bioavailability: are they accurate? Hunt, JR, 2010) | 0.36 |
| " Dietary ligands selectively chelate iron and zinc in definite stoichiometric proportions and thus alter the bioavailability from food matrices." | ( Dietary ligands as determinants of iron-zinc interactions at the absorptive enterocyte. Iyengar, V; Nair, KM; Pullakhandam, R, 2010) | 0.36 |
| " The objective of the study, therefore, was to test the bioavailability of iron and zinc in 2 multiple micronutrient beverage premixes in the absence and presence of chapatti." | ( Bioavailability of iron and zinc from multiple micronutrient fortified beverage premixes in Caco-2 cell model. Nair, KM; Pamini, H; Pullakhandam, R; Punjal, R, 2011) | 0.37 |
| "Excess P decreased the distribution of Zn in grain, while Zn enhanced the uptake of Zn and P in grain, The combined application of Zn fertilizer with the extensive use of P fertilizer can effectively increase the P and Zn concentration and Zn bioavailability of wheat grain, and hence Zn nutritional quality." | ( Impacts of phosphorus and zinc levels on phosphorus and zinc nutrition and phytic acid concentration in wheat (Triticum aestivum L.). Cao, YX; Chen, ZH; Lu, XC; Tian, XH; Yang, XW, 2011) | 0.6 |
| "Inherent phytic acid and tannins interfere with bioavailability of iron and zinc from plant-based foods." | ( Influence of combinations of promoter and inhibitor on the bioaccessibility of iron and zinc from food grains. Gautam, S; Platel, K; Srinivasan, K, 2011) | 0.79 |
| "A coupled in vitro digestion/Caco-2 model was employed to assess iron bioavailability from wheat Aegilops derivatives selected for high iron and protein contents." | ( Bioavailability of iron from wheat aegilops derivatives selected for high grain iron and protein contents. Dhaliwal, HS; Neelam, K; Randhawa, GS; Rawat, N; Roy, P; Salunke, R; Tiwari, VK, 2011) | 0.37 |
| " Therefore, biofortification of maize by increasing Fe concentration and or bioavailability has great potential to alleviate this deficiency." | ( Genetic and physiological analysis of iron biofortification in maize kernels. Glahn, RP; Hart, JJ; Hoekenga, OA; Kochian, LV; Lung'aho, MG; Mwaniki, AM; Rutzke, MA; Szalma, SJ, 2011) | 0.37 |
| "Quantitative trait locus (QTL) analysis was used to dissect grain Fe concentration (FeGC) and Fe bioavailability (FeGB) from the Intermated B73 × Mo17 (IBM) recombinant inbred (RI) population." | ( Genetic and physiological analysis of iron biofortification in maize kernels. Glahn, RP; Hart, JJ; Hoekenga, OA; Kochian, LV; Lung'aho, MG; Mwaniki, AM; Rutzke, MA; Szalma, SJ, 2011) | 0.37 |
| " During the last decade, phytase has been used by aqua feed industries to enhance the growth performance, nutrient utilization and bioavailability of macro and micro minerals in fish and also to reduce the P pollution into the aquatic environment." | ( Phytate and phytase in fish nutrition. Becker, K; De Boeck, G; Kumar, V; Makkar, HP; Sinha, AK, 2012) | 0.38 |
| " Thus, we recommend the ratios as bioavailability traits in biofortification research." | ( Quantitative trait loci for biofortification traits in maize grain. Brkić, A; Brkić, I; Brkić, J; Jambrović, A; Ledencan, T; Mladenović Drinić, S; Simić, D; Zdunić, Z, ) | 0.13 |
| "The objective of the present study was to evaluate the effect of the bread supplemented with whole amaranth flour (0, 20 and 40%) on iron bioavailability using Caco-2 cells model." | ( Bread supplemented with amaranth (Amaranthus cruentus): effect of phytates on in vitro iron absorption. Haros, M; Laparra, JM; Mario Sanz-Penella, J; Sanz, Y, 2012) | 0.38 |
| "In this study the chemical composition and iron bioavailability of hull and hull-less soybean flour from the new cultivar UFVTN 105AP was evaluated." | ( Heat-treated hull flour does not affect iron bioavailability in rats. Carvalho, AW; Costa, NM; Dantas, MI; Martino, HS; Natal, DI; Ribeiro, SM; Silva, CO, 2011) | 0.37 |
| " The results demonstrated the usefulness of phytase-producing bifidobacteria to reduce phytate during the breadmaking process and to increase Fe accessibility, although the effects appeared to be still insufficient to improve Fe bioavailability in Caco-2 cells." | ( Assessment of iron bioavailability in whole wheat bread by addition of phytase-producing bifidobacteria. Haros, M; Laparra, JM; Sanz, Y; Sanz-Penella, JM, 2012) | 0.38 |
| " The objectives of this study were (1) to establish a rapid, high capacity Caco-2 cell model to determine the relative bioavailability of zinc (Zn) from samples of staple food breeding lines for potential use as a guideline for selection/breeding and (2) to determine the relative bioavailability of Zn from conventional rice varieties and one Zn-biofortified type." | ( Biofortification of rice with zinc: assessment of the relative bioavailability of zinc in a Caco-2 cell model and suckling rat pups. Du, X; Hotz, C; Jou, MY; Lönnerdal, B, 2012) | 0.38 |
| " Little is known about phytic acid intakes or indices of zinc bioavailability in type 2 diabetes mellitus (DM), a condition that predisposes to zinc deficiency." | ( Dietary fiber intake increases the risk of zinc deficiency in healthy and diabetic women. Chu, A; Foster, M; Hancock, DP; Karra, M; Petocz, P; Picone, T; Samman, S, 2012) | 0.69 |
| " When seeds are used as food/feed, PA and the bound cations are poorly bioavailable for human and monogastric livestock due to their lack of phytase activity." | ( Study of low phytic acid1-7 (lpa1-7), a new ZmMRP4 mutation in maize. Amelotti, M; Cassani, E; Cerino Badone, F; Pilu, R, 2012) | 0.75 |
| " These data indicate that in rats fed a high PA diet, bioavailability of commonly used inorganic or chelated Zn compounds does not differ appreciably, but Zn supplied as an EDTA disodium salt has superior bioavailability." | ( EDTA disodium zinc has superior bioavailability compared to common inorganic or chelated zinc compounds in rats fed a high phytic acid diet. Bertinato, J; Plouffe, LJ; Sherrard, L, 2012) | 0.59 |
| " Such foods are high in phytate, which limits the bioavailability of nutrients, including iron, calcium, zinc, and in some cases proteins, which are crucial to the development of infants." | ( Sweet potato-based complementary food for infants in low-income countries. Amagloh, FK; Brough, L; Coad, J; Hardacre, A; Mutukumira, AN; Weber, JL, 2012) | 0.38 |
| " The aim of this study is to evaluate the effect of the addition of okra seed flour on the nutrients, functional properties, minerals and zinc bioavailability of plantain flour." | ( Impact of okra (Abelmoschus esculentus) seed flour on nutrients, functional properties and zinc bioavailability of plantain flour. Adelabu, HA; Adetuyi, FO, 2011) | 0.37 |
| " Low-phytate (LP) grain is distinguished by containing not only a reduced level of phytate P but also an increased level of inorganic P, resulting in greater bioavailability of P and mineral cations in animal diets." | ( Compositional equivalence of barleys differing only in low- and normal-phytate levels. Bregitzer, P; Hicks, KB; Liu, K; Moreau, RA, 2012) | 0.38 |
| "Few studies have evaluated the impact of fortification with iron-rich foods such as amaranth grain and multi-micronutrient powder (MNP) containing low doses of highly bioavailable iron to control iron deficiency anemia (IDA) in children." | ( Maize porridge enriched with a micronutrient powder containing low-dose iron as NaFeEDTA but not amaranth grain flour reduces anemia and iron deficiency in Kenyan preschool children. Brouwer, ID; Kok, FJ; Macharia-Mutie, CW; Moretti, D; Mwangi, AM; Omusundi, AM; Van den Briel, N; Zimmermann, MB, 2012) | 0.38 |
| " This data will support mechanistic modeling efforts to improve prediction of P digestion, allowing more accurate estimation of P bioavailability in feeds." | ( Disappearance of infused phytate from the large intestine of dairy heifers. Knowlton, KF; Pearson, RE; Ray, PP; Shang, C, 2012) | 0.38 |
| " Bioavailability generally increased in storage, significantly so in year-old INTA Linea 628 in accelerated ageing." | ( Content of zinc, iron and their absorption inhibitors in Nicaraguan common beans (Phaseolus vulgaris L.). Martinez Meyer, MR; Rojas, A; Santanen, A; Stoddard, FL, 2013) | 0.39 |
| " However, little is known about the biofortification efficiency and bioavailability of rice grain from different forms of foliar Zn fertilizers." | ( Biofortification and bioavailability of rice grain zinc as affected by different forms of foliar zinc fertilization. Shohag, MJ; Wei, Y; Yang, X, 2012) | 0.38 |
| " Zinc bioavailability was assessed by in vitro digestion/Caco-2 cell model." | ( Biofortification and bioavailability of rice grain zinc as affected by different forms of foliar zinc fertilization. Shohag, MJ; Wei, Y; Yang, X, 2012) | 0.38 |
| " Dietary Zn bioavailability is affected by phytate, phytase and Zn supplemented in organic form is considered as more bioavailable than inorganic sources." | ( Bioavailability of zinc sources and their interaction with phytates in broilers and piglets. Jondreville, C; Sauvant, D; Schlegel, P, 2013) | 0.39 |
| " A glass house pot experiment was conducted to evaluate the effect of foliar FeSO₄ containing applications on concentrations of Fe, Zn, and Fe bioavailability in polished rice among five rice cultivars." | ( Effects of foliar iron application on iron concentration in polished rice grain and its bioavailability. Shohag, MJ; Wei, Y; Yang, X; Yibin, Z, 2012) | 0.38 |
| "Both the high phosphorus (P) content and P bioavailability of the animal feed coproducts of the corn-ethanol industry could potentially contribute to increased manure and soil P levels and associated environmental issues (e." | ( Phosphorus flow and characterization in dry-grind corn ethanol plants. Alkan-Ozkaynak, A; Karthikeyan, KG, ) | 0.13 |
| " Composting is a process used to improve the bioavailability of phytate in organic wastes through degradation by microorganisms." | ( Phytate degradation by fungi and bacteria that inhabit sawdust and coffee residue composts. Fathallh Eida, M; Kouno, K; Nagaoka, T; Wasaki, J, 2013) | 0.39 |
| "Dietary antinutritional factors have been reported to adversely affect the digestibility of protein, bioavailability of amino acids and protein quality of foods." | ( Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. Cockell, KA; Sarwar Gilani, G; Wu Xiao, C, 2012) | 0.38 |
| "To compare iron bioavailability (Fe BV) from ten selected kinds of Chinese wheat flours in order to provide scientific basis for further human trials and enable plant breeding programs to screen biofortified wheat cultivars." | ( Assessment of iron bioavailability in ten kinds of Chinese wheat flours using an in vitro digestion/Caco-2 cell model. Bai, L; Chen, XG; Huang, CY; Ivan, OM; Lei, J; Zhang, MQ; Zhang, Y, 2012) | 0.38 |
| "Significant differences were observed in both Fe BV and Fe bioavailability per gram of food (Fe BVPG) among cultivars (P<0." | ( Assessment of iron bioavailability in ten kinds of Chinese wheat flours using an in vitro digestion/Caco-2 cell model. Bai, L; Chen, XG; Huang, CY; Ivan, OM; Lei, J; Zhang, MQ; Zhang, Y, 2012) | 0.38 |
| "Dietary components influencing zinc (Zn) bioavailability were implicated in the first cases of human Zn deficiency in the Middle East in the 1960s." | ( A historical review of progress in the assessment of dietary zinc intake as an indicator of population zinc status. Gibson, RS, 2012) | 0.38 |
| ") lines with contrasting Fe bioavailability (ie." | ( High bioavailability iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro (Caco-2 model) and in vivo (Gallus gallus). Glahn, RP; Hoekenga, OA; Kochian, LV; Tako, E, 2013) | 0.39 |
| " Hemoglobin maintenance efficiency (HME) and total body Hb Fe values were used to estimate Fe bioavailability from the diets." | ( High bioavailability iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro (Caco-2 model) and in vivo (Gallus gallus). Glahn, RP; Hoekenga, OA; Kochian, LV; Tako, E, 2013) | 0.39 |
| "The aim of the present study was to assess the effects of sorghum bioprocessing into Gowé on iron bioavailability and antioxidant properties of the final products." | ( Fate of phytochemicals during malting and fermentation of type III tannin sorghum and impact on product biofunctionality. Brat, P; Guyot, JP; Kayodé, AP; Mertz, C; Mouquet-Rivier, C, 2013) | 0.39 |
| " These results introduce an opportunity for improvement of soil and seed phytate-P bioavailability through genetic manipulation of oilseed rape, thereby increasing plant production and P nutrition for monogastric animals." | ( Overexpression of phyA and appA genes improves soil organic phosphorus utilisation and seed phytase activity in Brassica napus. Ding, G; Wang, Y; Xu, F; Ye, X, 2013) | 0.39 |
| "The objective of this study was to evaluate iron bioavailability of maize genotypes, and analyze the correlation between in vitro and in vivo methods." | ( Iron bioavailability of different maize genotypes developed in a breeding program: in vitro and in vivo studies. Costa, NM; Guimarães, PE; Martino, HS; Nakajima, VM; Oliveira, PV; Queiroz, VA, 2012) | 0.38 |
| "According to the World Health Organization parameters, the results denote a moderate/high Zn bioavailability in the evaluated meal, with a variability in the absorption percentage that is similar to other studies." | ( Zinc absorption in Brazilian subjects fed a healthy meal. Cominetti, C; Cozzolino, SM; Dainty, J; Fox, TE; Kakazu, MH; Ribeiro, MA; Sarkis, JE, 2014) | 0.4 |
| "Iron bioavailability from common beans is negatively influenced by phytic acid (PA) and polyphenols (PPs)." | ( Genetic reduction of phytate in common bean (Phaseolus vulgaris L.) seeds increases iron absorption in young women. Campion, B; Egli, I; Hurrell, R; Nielsen, E; Petry, N, 2013) | 0.63 |
| "This review compares iron and zinc food sources, dietary intakes, dietary recommendations, nutritional status, bioavailability and interactions, with a focus on adults in economically-developed countries." | ( Iron and zinc nutrition in the economically-developed world: a review. Booth, AO; Lim, KH; Nowson, CA; Riddell, LJ; Szymlek-Gay, EA, 2013) | 0.39 |
| " The phosphorus inside its molecule (PPhy) is not available because of its low solubility, though the bioavailability could be increased by the activity of phytase enzymes (PhyA)." | ( [Phytic phosphorus and phytase activity in cereal-based infant formulas]. Linares, Z; Ojeda, A; Villavicencio, I, 2012) | 0.38 |
| " Even though iron and zinc are present in significant amounts in the plant-based diets typically consumed in developing countries, their bioavailability is low due to high levels of absorption inhibitors such as phytate." | ( Absorption studies show that phytase from Aspergillus niger significantly increases iron and zinc bioavailability from phytate-rich foods. Fowler, A; Jing, H; Laillou, A; Troesch, B, 2013) | 0.39 |
| "Evidence from human studies testing the effect of phytase on iron and zinc bioavailability using stable isotopes was reviewed." | ( Absorption studies show that phytase from Aspergillus niger significantly increases iron and zinc bioavailability from phytate-rich foods. Fowler, A; Jing, H; Laillou, A; Troesch, B, 2013) | 0.39 |
| " Phytic acid degradation in fonio porridge using whole grain cereals as phytase source and effect on iron bioavailability when added to iron fortified fonio meals were investigated." | ( Dephytinisation with intrinsic wheat phytase and iron fortification significantly increase iron absorption from fonio (Digitaria exilis) meals in West African women. Brouwer, ID; Dossa, RA; Egli, I; Fanou-Fogny, N; Koréissi-Dembélé, Y; Moretti, D; Schuth, S; Zimmermann, MB, 2013) | 1.3 |
| " Exogenous phytase supplementation in poultry and swine diets improves bioavailability of P, and limited research suggests that this strategy may have some application in dairy cattle rations." | ( The effects of forage particle length and exogenous phytase inclusion on phosphorus digestion and absorption in lactating cows. Jarrett, JP; Knowlton, KF; Ray, PP; Wilson, JW, 2014) | 0.4 |
| "The aim of this study is to examine the relationship between zinc bioavailability and subclinical atherosclerosis in healthy Korean adults." | ( Lower zinc bioavailability may be related to higher risk of subclinical atherosclerosis in Korean adults. Choi, BY; Chun, BY; Jung, SK; Kim, MK; Lee, YH; Shin, DH; Shin, MH, 2013) | 0.39 |
| "Lower zinc bioavailability may be related to higher atherosclerosis risk." | ( Lower zinc bioavailability may be related to higher risk of subclinical atherosclerosis in Korean adults. Choi, BY; Chun, BY; Jung, SK; Kim, MK; Lee, YH; Shin, DH; Shin, MH, 2013) | 0.39 |
| " In contrast, foliar Zn application increased grain Zn concentration by an average of 61%, and Zn bioavailability by an average of 36%." | ( Comparison of soil and foliar zinc application for enhancing grain zinc content of wheat when grown on potentially zinc-deficient calcareous soils. Cao, YX; Liu, T; Lu, XC; Tian, XH; Zhao, AQ, 2014) | 0.4 |
| " In this study we measured the effects of sugars on non-heme iron bioavailability in human intestinal Caco-2 cells and HepG2 hepatoma cells using ferritin formation as a surrogate marker for iron uptake." | ( Sugars increase non-heme iron bioavailability in human epithelial intestinal and liver cells. Christides, T; Sharp, P, 2013) | 0.39 |
| " However, poor oral bioavailability of these flavonoids limits the clinical applications of TFH." | ( Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. Duan, J; Hong, C; Ji, G; Li, G; Luo, H; Ma, P; Wu, T; Xie, Y; Zhang, T, 2014) | 1.85 |
| "The oral bioavailability of isorhamnetin, kaempferol, and quercetin in TFH was enhanced by the co-administration of IP6." | ( Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. Duan, J; Hong, C; Ji, G; Li, G; Luo, H; Ma, P; Wu, T; Xie, Y; Zhang, T, 2014) | 1.85 |
| " Breeding for low phytate maize genotypes is an effective strategy for decreasing the content of kernel phytic acid (a chelator of cations such as Ca(2+) and Fe(3+) ) and thereby increasing the bioavailability of nutritive minerals in human diet and animal feed." | ( Marker assisted selection of low phytic acid trait in maize (Zea mays L.). Balagopal, R; Ganesan, KN; Nagarajan, P; Raveendran, M; Senthil, N; Shobana, V; Sureshkumar, S; Tamilkumar, P; Thangavelu, AU; Vellaikumar, S; Vijayalakshmi, G, 2014) | 0.9 |
| " The above results demonstrated that water management of AWD combined with ZnSO4 fertilization was an effective agricultural practice to elevate grain yield and increase Zn accumulation and bioavailability in rice grains." | ( Improved yield and Zn accumulation for rice grain by Zn fertilization and optimized water management. Dong, LX; Feng, Y; Lu, LL; Pan, FS; Wang, YY; Wei, YY; Yang, XE; Zhang, J, 2014) | 0.4 |
| " Presented here are the results of two reviews: a narrative review of zinc losses from the human body and a systematic review of factors affecting zinc bioavailability in adult and elderly populations." | ( Factors that affect zinc bioavailability and losses in adult and elderly populations. Bel-Serrat, S; Hermoso, M; Iglesia-Altaba, I; Lowe, NM; Moran, VH; Moreno, LA; Stammers, AL; Warthon-Medina, M, 2014) | 0.4 |
| " Adsorption, desorption, and precipitation reactions at environmental interfaces govern the reactivity, speciation, mobility, and bioavailability of inositol hexakisphosphates in terrestrial and aquatic environments." | ( Mechanism of myo-inositol hexakisphosphate sorption on amorphous aluminum hydroxide: spectroscopic evidence for rapid surface precipitation. Feng, X; Li, W; Liu, F; Sparks, DL; Yan, Y; Yang, J; Zheng, A, 2014) | 0.4 |
| " Research on nutrient digestibility, food processing properties, and bioavailability is needed." | ( Mung bean: technological and nutritional potential. Dahiya, PK; Grewal, RB; Khetarpaul, N; Linnemann, AR; Nout, MJ; Van Boekel, MA, 2015) | 0.42 |
| " The aim of this study was to assess the effect of prebiotics from wheat on Fe bioavailability in vitro (Caco-2 cells) and in vivo (broiler chickens, Gallus gallus)." | ( The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens. Glahn, RP; Knez, M; Stangoulis, JC; Tako, E, 2014) | 0.4 |
| "The in vivo results are in agreement with the in vitro observations, showing no differences in the hatchling Fe status between the treatment groups, as Fe bioavailability was not increased in vitro and no significant differences were measured in the intestinal expression of DMT1, Ferroportin and DcytB in vivo." | ( The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens. Glahn, RP; Knez, M; Stangoulis, JC; Tako, E, 2014) | 0.4 |
| " Nevertheless, the increase in relative amounts of bifidobacteria and lactobacilli in the presence of wheat prebiotics is an important finding as these bacterial populations may affect Fe bioavailability in long-term studies." | ( The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens. Glahn, RP; Knez, M; Stangoulis, JC; Tako, E, 2014) | 0.4 |
| "Phytase 50104 enzyme (also known as VR003) can be added to swine and poultry diets to catalyze the hydrolysis of phosphate from phytic acid, thereby increasing phosphorus bioavailability in these animals." | ( Safety evaluation of phytase 50104 enzyme preparation (also known as VR003), expressed in Pseudomonas fluorescens, intended for increasing digestibility of phytate in monogastrics. Ciofalo, V; Krygier, S; Shanahan, D; Solbak, A, 2014) | 0.61 |
| " However, phytate is only part of the answer to the multifaceted bioavailability question, albeit an important one." | ( Zn and Fe biofortification: the right chemical environment for human bioavailability. Clemens, S, 2014) | 0.4 |
| "Phytate is an antinutritional factor that impacts the bioavailability of essential minerals such as Ca(2+), Mg(2+), Mn(2+), Zn(2+), and Fe(2+) by forming insoluble mineral-phytate salts." | ( Molecular and biochemical characteristics of β-propeller phytase from marine Pseudomonas sp. BS10-3 and its potential application for animal feed additives. Auh, JH; Chun, KH; Kang, JK; Kim, YO; Ko, TK; Lee, CS; Lee, IK; Nam, SJ; Oh, BC; Park, S, 2014) | 0.4 |
| " The supplementation of feed with phytases increases the bioavailability of phosphorus and minerals in non-ruminant animals and reduces the phosphorus pollution due to phosphorus excretion in the areas of intensive livestock production." | ( Fungal phytases: characteristics and amelioration of nutritional quality and growth of non-ruminants. Satyanarayana, T; Singh, B, 2015) | 0.42 |
| "The objectives of this research were to assess the bioavailability of calcium using equilibrium dialysis after simulated gastric digestion method in 20 commonly consumed green leafy vegetables (GLVs) from the typical Indian diet, provide data on the content of calcium absorption inhibitors, like oxalate, phytate, tannin and dietary fibres, and evaluate the inhibitory effect of these compounds on calcium bioavailability in raw and cooked GLVs." | ( Bioavailability of calcium and its absorption inhibitors in raw and cooked green leafy vegetables commonly consumed in India--an in vitro study. Amalraj, A; Pius, A, 2015) | 0.42 |
| "The present study evaluated the impact of PA on iron bioavailability from iron-biofortified beans." | ( Phytic acid concentration influences iron bioavailability from biofortified beans in Rwandese women with low iron status. Boy, E; Egli, I; Gahutu, JB; Hurrell, R; Petry, N; Tugirimana, PL, 2014) | 1.85 |
| "PA strongly decreases iron bioavailability from iron-biofortified beans, and a high PA concentration is an important impediment to the optimal effectiveness of bean iron biofortification." | ( Phytic acid concentration influences iron bioavailability from biofortified beans in Rwandese women with low iron status. Boy, E; Egli, I; Gahutu, JB; Hurrell, R; Petry, N; Tugirimana, PL, 2014) | 1.85 |
| "To determine the effect of phytic acid, tannic acid and pectin on fasting non-heme iron bioavailability in both the presence and absence of calcium." | ( Effect of phytic acid, tannic acid and pectin on fasting iron bioavailability both in the presence and absence of calcium. Andrews, M; Arredondo, M; Briones, L; Brito, A; Jaramillo, Á; Olivares, M; Pizarro, F, 2015) | 1.12 |
| "The geometric means of iron bioavailability (range±1SD) for iron alone, iron with phytic acid, iron with tannic acid, and iron with citrus pectin were 25." | ( Effect of phytic acid, tannic acid and pectin on fasting iron bioavailability both in the presence and absence of calcium. Andrews, M; Arredondo, M; Briones, L; Brito, A; Jaramillo, Á; Olivares, M; Pizarro, F, 2015) | 1.05 |
| "Tannic acid decreases the fasting bioavailability of non-heme iron, however this effect did not exist in the presence of calcium." | ( Effect of phytic acid, tannic acid and pectin on fasting iron bioavailability both in the presence and absence of calcium. Andrews, M; Arredondo, M; Briones, L; Brito, A; Jaramillo, Á; Olivares, M; Pizarro, F, 2015) | 0.82 |
| " The apparent calcium absorption rate decreased following ovariectomy and was not replenished by oral administration of phytate-removed soybean β-conglycinin (PrS) or casein." | ( Prevention of osteoporosis by oral administration of phytate-removed and deamidated soybean β-conglycinin. Abe, R; Akao, M; Hasegawa-Tanigome, A; Kumagai, H; Sato, N, 2015) | 0.42 |
| " In the absence of animal tissue sources of zinc and with increased intake of inhibitors of zinc absorption, phytic acid in particular, the bioavailability of zinc is thought to be lower from vegetarian as compared to omnivorous diets." | ( Vegetarian diets across the lifecycle: impact on zinc intake and status. Foster, M; Samman, S, 2015) | 0.63 |
| " Currently, information on Mg bioavailability from different compounds and their efficacy in improving Mg status is scant." | ( Bioavailability of magnesium from inorganic and organic compounds is similar in rats fed a high phytic acid diet. Bertinato, J; Lavergne, C; Ly, C; Plouffe, LJ, ) | 0.35 |
| " Large intakes of micronutrient-poor staple crops, coupled with low intakes of highly bioavailable dietary iron, are a major cause of this deficiency." | ( Differences in relative iron bioavailability in traditional Bangladeshi meal plans. DellaValle, DM; Glahn, RP, 2014) | 0.4 |
| "To examine the concentration and relative bioavailability of iron in several models (n = 23) of traditional Bangladeshi meals (rice, lentils/dal, vegetable, and fish), as well as the effect of removal of the lentil seed coat on the nutritional quality of iron." | ( Differences in relative iron bioavailability in traditional Bangladeshi meal plans. DellaValle, DM; Glahn, RP, 2014) | 0.4 |
| "The relative bioavailability of iron was assessed by the in vitro/Caco-2 cell culture method, iron concentration by an inductively coupled argon-plasma emission spectrometer (ICAP-ES), and phytic acid concentration by colorimetric assay." | ( Differences in relative iron bioavailability in traditional Bangladeshi meal plans. DellaValle, DM; Glahn, RP, 2014) | 0.59 |
| "005), seed coat removal doubled relative iron bioavailability and increased phytic acid concentration (p < ." | ( Differences in relative iron bioavailability in traditional Bangladeshi meal plans. DellaValle, DM; Glahn, RP, 2014) | 0.63 |
| " Thus, along with breeding for high iron concentration and bioavailability (i." | ( Differences in relative iron bioavailability in traditional Bangladeshi meal plans. DellaValle, DM; Glahn, RP, 2014) | 0.4 |
| " However, to our knowledge, there are no data to support that the bioavailability of iron is affected by lactic fermentation." | ( Increased iron bioavailability from lactic-fermented vegetables is likely an effect of promoting the formation of ferric iron (Fe(3+)). Rossander-Hulthen, L; Sandberg, AS; Scheers, N; Torsdottir, I, 2016) | 0.43 |
| "The objective of the present study was to investigate whether the bioavailability of iron from a vegetable mix was affected by lactic fermentation and to propose a mechanism for such an event, by conducting human and cell (Caco-2, HepG2) studies and iron speciation measurements (voltammetry)." | ( Increased iron bioavailability from lactic-fermented vegetables is likely an effect of promoting the formation of ferric iron (Fe(3+)). Rossander-Hulthen, L; Sandberg, AS; Scheers, N; Torsdottir, I, 2016) | 0.43 |
| "The mechanism for the increased bioavailability of iron from lactic-fermented vegetables is likely an effect of the increase in ferric iron (Fe(3+)) species caused by the lactic fermentation." | ( Increased iron bioavailability from lactic-fermented vegetables is likely an effect of promoting the formation of ferric iron (Fe(3+)). Rossander-Hulthen, L; Sandberg, AS; Scheers, N; Torsdottir, I, 2016) | 0.43 |
| " This suggests that the bioavailability of peptides may be determined in part by their protease resistance in the intestinal membrane." | ( Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses. Akiyama, S; Hong, SM; Hu, QQ; Matsui, T; Tanaka, M, 2015) | 0.42 |
| " However, literature on the role of dietary fiber on mineral bioavailability has not followed pace." | ( The unresolved role of dietary fibers on mineral absorption. Baye, K; Guyot, JP; Mouquet-Rivier, C, 2017) | 0.46 |
| "4), which were below the critical values for reduced mineral bioavailability in humans." | ( Reduction of Phytate in Soy Drink by Fermentation with Lactobacillus casei Expressing Phytases From Bifidobacteria. García-Mantrana, I; Haros, M; Monedero, V, 2015) | 0.42 |
| "The absence of a detectable phytate effect on zinc absorption raises caution about use of dietary phytate:zinc molar ratios to predict zinc bioavailability and does not support phytate reduction as a strategy to improve zinc status of young children." | ( Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies. Hambidge, KM; Krebs, NF; Miller, LV, 2015) | 0.42 |
| " Many soil microorganisms improve the bioavailability of phosphate by releasing it from various organic compounds, including phytate." | ( Novel Glucose-1-Phosphatase with High Phytase Activity and Unusual Metal Ion Activation from Soil Bacterium Pantoea sp. Strain 3.5.1. Balaban, NP; Beinhauer, A; Chastukhina, IB; Greiner, R; Shakirov, EV; Sharipova, MR; Suleimanova, AD; Valeeva, LR, 2015) | 0.42 |
| "Total (heme and nonheme) iron bioavailability from the US diet has been estimated to be 18% based on a single human absorption study." | ( Total Iron Bioavailability from the US Diet Is Lower Than the Current Estimate. Armah, SM; Carriquiry, AL; Reddy, MB, 2015) | 0.42 |
| "We estimated total iron bioavailability from the US diet with the use of our recently reported algorithm that estimates nonheme iron absorption and a conservative value for heme iron absorption." | ( Total Iron Bioavailability from the US Diet Is Lower Than the Current Estimate. Armah, SM; Carriquiry, AL; Reddy, MB, 2015) | 0.42 |
| "This study provides useful data for evaluating the current value of iron bioavailability from the US diet." | ( Total Iron Bioavailability from the US Diet Is Lower Than the Current Estimate. Armah, SM; Carriquiry, AL; Reddy, MB, 2015) | 0.42 |
| " pentosaceus KTU05-9 and KTU05-8 strains could be recommended to use as a starter for sourdough preparation for increasing of mineral bioavailability from wholemeal wheat bread." | ( Phytase activity of lactic acid bacteria and their impact on the solubility of minerals from wholemeal wheat bread. Bartkiene, E; Cizeikiene, D; Damasius, J; Juodeikiene, G; Paskevicius, A, 2015) | 0.42 |
| " Inoculation with Pseudomonas improved the bioavailability of CaIHP to tobacco plants, but there was no difference in plant growth response due to Gcd function." | ( The role of gluconate production by Pseudomonas spp. in the mineralization and bioavailability of calcium-phytate to Nicotiana tabacum. Giles, CD; Hill, JE; Hsu, PC; Hurst, MR; Richardson, AE, 2015) | 0.42 |
| "The oral bioavailability (BA) of risedronate sodium (RS), an antiresorptive agent, is less than 1% due to its low membrane permeability as well as the formation of non-absorbable complexes with multivalent cations such as calcium ion (Ca(2+)) in the gastrointestinal tract." | ( Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability. Jang, SW; Kang, MJ; Kim, BM; Kim, JS; Son, M, 2016) | 0.67 |
| " Iron bioavailability was measured by the depletion/repletion method." | ( Rice and Bean Targets for Biofortification Combined with High Carotenoid Content Crops Regulate Transcriptional Mechanisms Increasing Iron Bioavailability. de Castro Moreira, ME; Dias, DM; Gomes, MJ; Lopes Toledo, RC; Martino, HS; Nutti, MR; Pinheiro Sant'Ana, HM, 2015) | 0.42 |
| " These studies demonstrated that orally-delivered antibodies to IAP limit dietary phytate-phosphate utilization in chicks treated with 1α-(OH) D3, and implicate IAP as an important host enzyme in increasing phytate phosphate bioavailability in 1α-(OH) D3 fed chicks." | ( Oral antibodies to human intestinal alkaline phosphatase reduce dietary phytate phosphate bioavailability in the presence of dietary 1α-hydroxycholecalciferol. Bobeck, EA; Cook, ME; Hellestad, EM; Helvig, CF; Petkovich, PM, 2016) | 0.43 |
| "Enzymatic dephosphorylation of phytic acid (inositol hexakisphosphate) in cereals may improve mineral bioavailability in humans." | ( Phytase-mediated mineral solubilization from cereals under in vitro gastric conditions. Meyer, AS; Nielsen, AV, 2016) | 0.72 |
| " The data infer that acid-stable microbial phytases can help improve iron bioavailability from phytate-rich cereal substrates via post-ingestion activity." | ( Phytase-mediated mineral solubilization from cereals under in vitro gastric conditions. Meyer, AS; Nielsen, AV, 2016) | 0.43 |
| "Low phytic acid (lpa) crops are potentially eco-friendly alternative to conventional normal phytic acid (PA) crops, improving mineral bioavailability in monogastric animals as well as decreasing phosphate pollution." | ( Genome-wide transcriptome analyses of developing seeds from low and normal phytic acid soybean lines. Biyashev, RM; Grabau, EA; Helm, RF; Jensen, RV; Maroof, MA; Redekar, NR, 2015) | 1.21 |
| " Only AB and ChB had a significant influence on Fe bioavailability at the investigated level of substitution." | ( Inclusion of ancient Latin-American crops in bread formulation improves intestinal iron absorption and modulates inflammatory markers. Haros, M; Laparra, JM, 2016) | 0.43 |
| " Further prospective studies must be performed to elucidate the benefits of a phytate-rich diet and the associated risk of phosphorus bioavailability in these patients." | ( Protective Effect of Myo-Inositol Hexaphosphate (Phytate) on Abdominal Aortic Calcification in Patients With Chronic Kidney Disease. Berga, F; Bernabeu, MR; Buades, JM; Costa-Bauzá, A; García, S; Gelabert, MM; Gonzalez, J; Grases, F; Íñigo, MV; Molina, M; Sanchis, P, 2016) | 0.43 |
| " Determination of bioavailability of myo-inositol phosphates from bread was performed by an in vitro digestion method followed by the measurement of an uptake by Caco-2 cells in culture." | ( Profile and bioavailability analysis of myo-inositol phosphates in rye bread supplemented with phytases: a study using an in vitro method and Caco-2 monolayers. Byczyński, Ł; Cielecka, EK; Duliński, R; Pierzchalska, M; Żyła, K, 2016) | 0.43 |
| "Phytic acid (PA) is a major inhibitor of iron bioavailability from beans, and high PA concentrations might limit the positive effect of biofortified beans (BBs) on iron status." | ( In Rwandese Women with Low Iron Status, Iron Absorption from Low-Phytic Acid Beans and Biofortified Beans Is Comparable, but Low-Phytic Acid Beans Cause Adverse Gastrointestinal Symptoms. Boy, E; Campion, B; Gahutu, JB; Moretti, D; Petry, N; Rohner, F; Tugirimana, PL; Wirth, JP; Zimmerman, MB; Zwahlen, C, 2016) | 2.11 |
| " Percent ionizable iron and bioavailability was found maximum with boiling (13." | ( Effect of processing on nutrients and fatty acid composition of garden cress (Lepidium sativum) seeds. Grover, K; Jain, T; Kaur, G, 2016) | 0.43 |
| " Zinc bioavailability was determined by the phytate/zinc molar ratio." | ( Zinc status, dietary zinc intake and metabolic risk in Australian children and adolescents; Nepean Longitudinal Study. Baur, LA; Cowell, CT; Garnett, SP; Ho, M; Samman, S, 2017) | 0.46 |
| "Phytate is a major constituent of wheat seeds and chelates metal ions, thus reducing their bioavailability and so the nutritional value of grains." | ( Transgenic expression of phytase in wheat endosperm increases bioavailability of iron and zinc in grains. Abid, N; Asif, I; Bashir, A; Brinch-Pedersen, H; Irfan, M; Khatoon, A; Malik, KA; Maqbool, A; Saeed, A; Shahid, M, 2017) | 0.46 |
| " Plant-phosphorus (legumes and nuts), mainly associated with InsP6, is less absorbable by the human gastrointestinal tract as the bioavailability of phosphorous from plant-derived foods is very low." | ( Plant phosphates, phytate and pathological calcifications in chronic kidney disease. Buades Fuster, JM; Grases Freixedas, F; Perelló Bestard, J; Sanchís Cortés, P, ) | 0.13 |
| " Supplementation of microbial phytases (fungal and bacterial) resulted in improved bioavailability of nutritional components with the concomitant liberation of inorganic phosphorus, reducing sugar, soluble protein and amino acids, thus mitigating anti-nutritional properties of phytic acid." | ( Phytase Production and Development of an Ideal Dephytinization Process for Amelioration of Food Nutrition Using Microbial Phytases. Jain, J; Singh, B, 2017) | 0.63 |
| " The seed mineral concentrations during seed maturation and the seed Fe bioavailability were analyzed." | ( Zinc and selenium accumulation and their effect on iron bioavailability in common bean seeds. Boldrin, PF; de Andrade, MJB; de Figueiredo, MA; Glahn, RP; Guilherme, LRG; Hart, JJ; Li, L, 2017) | 0.46 |
| " The effect of Zn biofortification (via application of six rates of Zn fertilizer to soil) on Zn bioavailability in wheat grain and flour and its impacts on human health was evaluated." | ( Agronomic Approach of Zinc Biofortification Can Increase Zinc Bioavailability in Wheat Flour and thereby Reduce Zinc Deficiency in Humans. Chen, X; Liu, D; Liu, Y; Zhang, W; Zou, C, 2017) | 0.46 |
| " In this study, 46 durum varieties grown under full and reduced irrigation, were analyzed for micronutrients and phytate content to determine the potential bioavailability of the micronutrients." | ( Variability in iron, zinc and phytic acid content in a worldwide collection of commercial durum wheat cultivars and the effect of reduced irrigation on these traits. Ammar, K; Crossa, J; Guzmán, C; Hernandez-Espinosa, N; Magallanes-López, AM; Ordoñez-Villegas, VMG; Posadas-Romano, G; Velu, G, 2017) | 0.74 |
| "Due to low Fe bioavailability and low consumption per meal, lentil must be fortified to contribute significant bioavailable Fe in the Bangladeshi diet." | ( Relative Bioavailability of Iron in Bangladeshi Traditional Meals Prepared with Iron-Fortified Lentil Dal. M DellaValle, D; P Glahn, R; Podder, R; T Tyler, R; Tako, E; Vandenberg, A, 2018) | 0.48 |
| " Mature dry peas are rich in iron in the form of ferritin, but little is known about the content, form or bioavailability of iron in immature stages of seed development." | ( The stage of seed development influences iron bioavailability in pea (Pisum sativum L.). Balk, J; Domoney, C; Fairweather-Tait, S; Halsey, K; Jones, EJ; Jones, ER; Moore, KL; Rodríguez-Celma, J; Rodríguez-Ramiro, I; Shewry, PR, 2018) | 0.48 |
| " Although single-meal studies clearly show an increase in iron bioavailability from dephytinization of cereals, medium-term consumption of reduced phytate bread under free-living conditions suggests that this strategy does not work to improve iron status in healthy women of reproductive age." | ( Low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12-week, randomized, parallel-design intervention study. Hoppe, M; Hulthén, L; Ross, AB; Sandberg, AS; Svelander, C, 2019) | 0.51 |
| " Dietary phytate-to-iron and phytate-to-zinc molar ratios are used to estimate iron and zinc bioavailability and to identify dietary iron and zinc requirements according to diet type." | ( Implications of phytate in plant-based foods for iron and zinc bioavailability, setting dietary requirements, and formulating programs and policies. Gibson, RS; King, JC; Raboy, V, 2018) | 0.48 |
| " These results can provide important insights for the study of mineral bioavailability and diverse processes that involve protein and minerals in several areas of knowledge." | ( Influence of Ternary Complexation between Bovine Serum Albumin, Sodium Phytate, and Divalent Salts on Turbidity and In Vitro Digestibility of Protein. Igarashi-Mafra, L; Kaspchak, E; Mafra, MR, 2018) | 0.48 |
| " This reduction appears to be able to increase zinc bioavailability but remains insufficient for iron." | ( Evidence of a Synergistic Effect between Pea Seed and Wheat Grain Endogenous Phytase Activities. Chouchene, A; Lullien-Pellerin, V; Micard, V, 2018) | 0.48 |
| "Biofortification aims to improve the micronutrient concentration and bioavailability in staple food crops." | ( Iron Biofortified Carioca Bean ( Binyamin, D; Dias, DM; Glahn, RP; Kolba, N; Koren, O; Martino, HSD; Regini Nutti, M; Tako, E; Ziv, O, 2018) | 0.48 |
| " Further, this review paper summarizes the effects of different processing techniques (milling, soaking, dehulling, fermentation, germination and thermal processing) on mineral bioaccessibility and bioavailability of plant-based foods." | ( Barriers impairing mineral bioaccessibility and bioavailability in plant-based foods and the perspectives for food processing. Celus, M; Grauwet, T; Hendrickx, MEG; Kyomugasho, C; Rousseau, S, 2020) | 0.56 |
| " However, all samples, except full replacement by rice flour, might not provide adequate zinc bioavailability when the effect of calcium and phytate on zinc absorption was collectively considered." | ( Promoting the use of locally produced crops in making cereal-legume-based composite flours: An assessment of nutrient, antinutrient, mineral molar ratios, and aflatoxin content. Ilukor, J; Nimbona, P; Njukwe, E; Sridonpai, P; Tirawattanawanich, C; Udomkun, P; Vanlauwe, B, 2019) | 0.51 |
| " Foliar Zn spray is found to escape most of the soil reactions; thus, Zn bioavailability is higher either through increase in grain Zn or through decrease in phytate content." | ( Zinc biofortification of cereals-role of phosphorus and other impediments in alkaline calcareous soils. Akhtar, M; Hussain, S; Sarwar, N; Yousaf, S, 2019) | 0.51 |
| " It also aimed to evaluate the accessibility of iron, zinc, and calcium and to estimate their bioavailability before and after the fermentation of flours with starter culture." | ( Fermentation of pseudocereals quinoa, canihua, and amaranth to improve mineral accessibility through degradation of phytate. Almgren, A; Bergenståhl, B; Carlsson, NG; Castro-Alba, V; Granfeldt, Y; Lazarte, CE; Perez-Rea, D, 2019) | 0.51 |
| " Fermentation with Lactobacillus plantarum 299v® improved mineral accessibility and estimated bioavailability in flours." | ( Fermentation of pseudocereals quinoa, canihua, and amaranth to improve mineral accessibility through degradation of phytate. Almgren, A; Bergenståhl, B; Carlsson, NG; Castro-Alba, V; Granfeldt, Y; Lazarte, CE; Perez-Rea, D, 2019) | 0.51 |
| " This was completed by the operational determination of the iron bioavailability using an in-vitro simulated model for gastro-intestinal digestion." | ( Mass spectrometry-based analytical developments to link iron speciation to iron bioavailability in maize. Hoekenga, O; Lobinski, R; Ouerdane, L; Szpunar, J; Wang, S, 2019) | 0.51 |
| " Phytate, the main phosphorus storage form in seeds, and its hydrolysis products act as a chelator and reduce protein and mineral bioavailability in intestinal absorption." | ( Engineered phytases for emerging biotechnological applications beyond animal feeding. Herrmann, KR; Infanzón, B; Ruff, AJ; Schwaneberg, U, 2019) | 0.51 |
| " It is commonly eaten cooked; however, in the germinated form, it can improve nutritional quality by reducing the antinutritional factors and consequently improving the bioavailability of elements." | ( Bioaccessibility and bioavailability of iron in biofortified germinated cowpea. Antunes, PT; Costa, NMB; Meira, EF; Reis, TCD; Sant' Ana, CT; Váz-Tostes, MDG, 2019) | 0.51 |
| "The iron bioavailability from the biofortified and germinated beans was comparable to ferrous sulfate." | ( Bioaccessibility and bioavailability of iron in biofortified germinated cowpea. Antunes, PT; Costa, NMB; Meira, EF; Reis, TCD; Sant' Ana, CT; Váz-Tostes, MDG, 2019) | 0.51 |
| " For the first time the mineral bioavailability from the gluten and gluten-free flakes was evaluated and compared." | ( Minerals and their bioavailability in relation to dietary fiber, phytates and tannins from gluten and gluten-free flakes. Kiewlicz, J; Rybicka, I, 2020) | 0.56 |
| "Phytase is commonly used as a feed enzyme in monogastric animals to increase the bioavailability of phytate phosphorus and other nutrients." | ( Effect of Phytase on in Vitro Hydrolysis of Phytate and the Formation of Ahonen, I; Hirvonen, J; Lehtinen, MJ; Liljavirta, J; Nurminen, P; Saarinen, MT, 2019) | 0.51 |
| " Phytic acid is considered as a major antinutrient, because the negatively charged phytic acid chelates cations, including essential micronutrients, and decreases their bioavailability to human beings and monogastric animals." | ( Mutational Analysis of Basnet, R; Islam, SA; Khan, MSS; Shu, Q, 2019) | 1.42 |
| " However, in maize endosperms, it was also observed that the proportion of Zn present as Zn-phytate increased as the kernel matured, thereby also probably decreasing its bioavailability in these mature maize kernels." | ( Comparison of Zn accumulation and speciation in kernels of sweetcorn and maize differing in maturity. Bell, MJ; Cheah, ZX; Kopittke, PM; Noerpel, MR; Scheckel, KG, 2020) | 0.56 |
| "The apparent low bioavailability of Zn supplied in maize at its consumption stage (i." | ( Comparison of Zn accumulation and speciation in kernels of sweetcorn and maize differing in maturity. Bell, MJ; Cheah, ZX; Kopittke, PM; Noerpel, MR; Scheckel, KG, 2020) | 0.56 |
| " It is known to reduce mineral bioavailability and inhibit starch-digesting α-amylase (which requires calcium for activity) in the human gut." | ( Phytic acid content may affect starch digestibility and glycemic index value of rice (Oryza sativa L.). Baig, MJ; Behera, L; Biswal, M; Chattopadhyay, K; Kumar, A; Lal, MK; Panda, PA; Sah, RP; Sahu, C; Sharma, S; Swain, P, 2020) | 2 |
| " The antinutrient effect of phytate results because it can decrease the bioavailability of important minerals under certain circumstances." | ( Key Aspects of Myo-Inositol Hexaphosphate (Phytate) and Pathological Calcifications. Costa-Bauza, A; Grases, F, 2019) | 0.51 |
| " Our objective was to assess iron bioavailability from a novel iron fortificant consisting of ferric iron complexed with phytic acid and hydrolyzed corn protein (Fe-PA-HCP), used in bouillon with and without an inhibitory food matrix." | ( Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II). Dold, S; Galaffu, N; Grathwohl, D; Habeych, E; Jeroense, F; Merinat, S; Moretti, D; Rey, B; Sabatier, M; Tajeri Foman, J; Zeder, C; Zimmermann, MB, 2020) | 0.77 |
| "Seed phytic acid reduces mineral bioavailability by chelating minerals." | ( Calcium redistribution contributes to the hard-to-cook phenotype and increases PHA-L lectin thermal stability in common bean low phytic acid 1 mutant seeds. Bollini, R; Cichy, KA; Cominelli, E; Daminati, MG; Galimberti, M; Landoni, M; Losa, A; Paolo, D; Pongrac, P; Sparvoli, F; Vogel-Mikuš, K, 2020) | 1.28 |
| " We suggest that the LP line benefits from higher bioavailability of P and macro-minerals unlike the NP line." | ( Physiological Characteristics, Phytase Activity, and Mineral Bioavailability of a Low-Phytate Soybean Line during Germination. Dong, Q; Saneoka, H, 2020) | 0.56 |
| " The microspheres had a relative pharmacological bioavailability of 10." | ( Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology. Kim, JU; Kim, T; Lee, H; Park, J; Roh, YH; Shahbaz, HM; Yang, K, 2020) | 0.9 |
| "This study measured PA, Zn and Ca concentrations in selected infant cereals sold in Canada and investigated the effects of dietary PA and Ca at concentrations present in infant cereals on Zn bioavailability in rats." | ( Calcium exacerbates the inhibitory effects of phytic acid on zinc bioavailability in rats. Bertinato, J; Brooks, SPJ; Dam, D; Griffin, P; Huliganga, E; Matias, FMG, 2020) | 0.82 |
| "These results show that, in rats, higher concentrations of dietary Ca and PA interact to potentiate a decrease in bioavailable Zn and may suggest lower Zn bioavailability in infant cereals with higher PA and Ca concentrations." | ( Calcium exacerbates the inhibitory effects of phytic acid on zinc bioavailability in rats. Bertinato, J; Brooks, SPJ; Dam, D; Griffin, P; Huliganga, E; Matias, FMG, 2020) | 0.82 |
| " These findings indicate that the lower phytate content in LP natto than that in NP natto, could facilitate a higher bioavailability of P and other minerals." | ( Characteristics and Quality of Japanese Traditional Fermented Soybean (Natto) from a Low-phytate Line. Hara, Y; Qin, D; Raboy, V; Saneoka, H, 2020) | 0.56 |
| "Knowledge of genetic variation, genetics, physiology/molecular basis and breeding (including biotechnological approaches) for biofortification and bioavailability for Zn, Fe and Se will help in developing nutritionally improved wheat." | ( Biofortification and bioavailability of Zn, Fe and Se in wheat: present status and future prospects. Balyan, HS; Gupta, PK; Kumar, R; Sharma, S, 2021) | 0.62 |
| " This study evaluated the relationship between human cystatin SN levels and iron bioavailability after a phytic acid rich meal." | ( Salivary cystatin SN is a factor predicting iron bioavailability after phytic acid rich meals in female participants. Delimont, NM; Nickel, S, 2021) | 1.07 |
| " In plants, bioavailability of such nutrients is reduced by presence of compounds such as phytic acid, that can chelate minerals and reduce their absorption." | ( European landrace diversity for common bean biofortification: a genome-wide association study. Caproni, L; Negri, V; Raggi, L; Talsma, EF; Wenzl, P, 2020) | 0.78 |
| "Natural or synthetic compounds that interfere with the bioavailability of nutrients are called antinutrients." | ( Diverse role of phytic acid in plants and approaches to develop low-phytate grains to enhance bioavailability of micronutrients. Aggarwal, PR; Joel, AJ; Muthamilarasan, M; Pramitha, JL; Rana, S; Ravikesavan, R, 2021) | 0.97 |
| " Only one of the cultivars studied (Sunrise) have adequate estimated bioavailability of iron, which is of major concern for a diet in which legumes and grains serve as important sources of iron." | ( Nutritional and antinutritional composition of fava bean (Vicia faba L., var. minor) cultivars. Frøkiær, H; Mayer Labba, IC; Sandberg, AS, 2021) | 0.62 |
| "Phytic acid (PA) is a major antinutrient that cannot be digested by monogastric animals, but it can decrease the bioavailability of micronutrients (e." | ( Transcriptome analysis identifies differentially expressed genes in the progenies of a cross between two low phytic acid soybean mutants. Fu, X; Jin, H; Yang, Q; Yu, X; Yuan, F, 2021) | 2.28 |
| " However, in crop plants phytate decreases bioavailability of seed-sourced mineral elements for humans, livestock and poultry, and contributes to phosphate-related water pollution." | ( Integrating a genome-wide association study with transcriptomic data to predict candidate genes and favourable haplotypes influencing Brassica napus seed phytate. Cai, H; Ding, G; King, GJ; Li, X; Liu, H; Liu, L; Shi, L; Wang, C; Wang, S; Xu, F; Yuan, P; Zhang, Q, 2021) | 0.62 |
| "Some bioactive compounds found in pulses (phytates, saponins, tannins) display antinutritional properties and interfere with fat-soluble vitamin bioavailability (i." | ( Reduction of pulse "antinutritional" content by optimizing pulse canning process is insufficient to improve fat-soluble vitamin bioavailability. Antoine, T; Aupy, F; Desmarchelier, C; Georgé, S; Gervais, S; Halimi, C; Leca, A; Marconot, G; Reboul, E, 2022) | 0.72 |
| " The Sodium-potassium ratio of the foods exceeded standard values, while most soups including ogbono, ila alasepo, egusi, and gbegiri, had poor predicted bioavailability for iron, calcium, and zinc." | ( Micronutrient composition, antioxidant properties, and mineral safety index of selected Nigerian cooked foods. Adegunwa, MO; Akinbule, AS; Akinbule, OO; Onabanjo, OO; Sanni, SA, 2022) | 0.72 |
| " Estimating the phytate-iron molar ratio is a traditional method to assess the bioavailability of dietary iron, and a ratio >1 is suggestive of poor absorption of iron through the intestinal mucosa." | ( Phytate-iron molar ratio and bioavailability of iron in Bangladesh. Rahman, S; Shaheen, N, 2022) | 0.72 |
| " It is not possible to accurately predict the influence of sprouting on nutrient bioavailability because so few studies have been conducted." | ( Can sprouting reduce phytate and improve the nutritional composition and nutrient bioaccessibility in cereals and legumes? Elliott, H; Green, BD; Nugent, AP; Woods, P, 2022) | 0.72 |
| "Phytic acid is an antinutritional compound that reduces the bioavailability of minerals and proteins." | ( Dephytinized flaxseed flours by phytase enzyme and fermentation: functional ingredients to enhance the nutritional quality of noodles. Yaver, E, 2023) | 2.35 |
| " Due to the influences of phytate and protein on zinc absorption, successful zinc fortification strategies should consider the impact on zinc bioavailability in the whole diet." | ( Zinc Fortification: Current Trends and Strategies. Hall, AG; King, JC, 2022) | 0.72 |
| " Bioavailability of iron and zinc was estimated based on the phytate:mineral molar ratio." | ( Nutritional Composition and Estimated Iron and Zinc Bioavailability of Meat Substitutes Available on the Swedish Market. Almius, L; Bach Knudsen, KE; Mayer Labba, IC; Sandberg, AS; Steinhausen, H, 2022) | 0.72 |
| "Novel feeds for improved feed intake and for enhanced nutrient bioavailability have recently attracted attention." | ( Dephytinization of wheat and rice bran by cross-linked enzyme aggregates of Mucor indicus phytase: a viable prospect for food and feed industries. Vaidyanathan, VK; Venkataraman, S, 2023) | 0.91 |
| " Additionally, we investigated the potential of recent popular bread making recipes in German bakeries to reduce phytic acid content, and thus increase mineral bioavailability in bread." | ( Mineral and Phytic Acid Content as Well as Phytase Activity in Flours and Breads Made from Different Wheat Species. Afzal, M; Bertsche, U; Heger, C; Longin, CFH; Melzer, T; Pfaff, T; Pfannstiel, J; Rodehutscord, M; Ruf, A; Schollenberger, M, 2023) | 1.5 |
| " However, beyond the concept of zinc absorption, few studies have explored the molecular basis of zinc bioavailability that determines the proportion of dietary zinc utilized in zinc-dependent processes in the body." | ( The Molecular Basis for Zinc Bioavailability. Hall, AG; King, JC, 2023) | 0.91 |
| " These results should help to: (i) enhance the design of future research studies comparing different feed additive performances; (ii) assess Cu and Zn bioavailability in the digestive tract; (iii) gain further insight into the fate of Cu and Zn in cultivated soils when poultry manure is used as fertilizer." | ( Unexpected Cu and Zn speciation patterns in the broiler feed-animal-excreta system revealed by XAS spectroscopy. Doelsch, E; Durosoy, S; Forouzandeh, A; Legros, S; Monteiro, ANTR; Penen, F; Tella, M, 2023) | 0.91 |
| " Secondly, microbial phytases enhance mineral bioavailability and nutrient assimilation in plant-based food products, counteracting the negative effects of phytic acid on human health." | ( Microbial Phytases: Properties and Applications in the Food Industry. Aria, N; Emami-Karvani, Z; Hamblin, MR; Joudaki, H; Moravej, R; Rezaei Yazdi, M, 2023) | 1.11 |
| "The mineralization and bioavailability of phytic acid, the predominant organic phosphorus (OP) species in many soils, have generally been rendered limited due to its interaction with soil minerals." | ( Spectroscopic Investigation of Phosphorus Mineralization as Affected by the Calcite-Water Interfacial Chemistry. Arai, Y; Chen, A; Han, HS; Zhu, L, 2023) | 1.17 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to determine whether InsP6 (i) shows a dose-response inhibition of LIC, and (ii) retains its anti-neoplastic effect at physiological pH." | ( Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Shamsuddin, AM; Ullah, A, 1990) | 0.28 |
| " acidophilus at 37 degrees C for 24 h at a dosage of 100,000 cells/ml." | ( Probiotic fermentation: effect on antinutrients and digestibility of starch and protein of indigenously developed food mixture. Binita, R; Khetarpaul, N, 1997) | 0.3 |
| " Because IP6 is particularly abundant in the bran part of certain mature seeds such as wheat, we investigated whether a high-fiber bran diet containing high IP6 shows a dose-response inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinogenesis." | ( Comparison of pure inositol hexaphosphate and high-bran diet in the prevention of DMBA-induced rat mammary carcinogenesis. Shamsuddin, AM; Vucenik, I; Yang, GY, 1997) | 0.3 |
| " Could eating high fiber diet afford the same protection as IP6? Thus, we investigated whether dietary fiber containing high IP6 shows a dose-response inhibition of DMBA-induced rat mammary carcinogenesis, and if pure IP6 is more active as a cancer preventive agent, compared to that in diet." | ( Mammary tumor inhibition by IP6: a review. Shamsuddin, AM; Vucenik, I, ) | 0.13 |
| " In conclusion, this approach is a novel use of ceramic delivery systems in tissue culture that gives breakthrough information for basic research on limiting and eliminating contamination and the logistical problems associated with intermittent dosing in tissue culture." | ( Development of sustained delivery system as a novel technique for tissue culture. Benghuzzi, H; Higdon, KK; Hughes, JL; Puckett, A; Scott, A; Tucci, M, 2000) | 0.31 |
| "We investigated the dose-response effect of small amounts of meat on nonheme-iron absorption from a meal presumed to have low iron bioavailability." | ( Nonheme-iron absorption from a phytate-rich meal is increased by the addition of small amounts of pork meat. Baech, SB; Bukhave, K; Hansen, M; Jensen, M; Kristensen, L; Purslow, PP; Sandström, B; Skibsted, LH; Sørensen, SS, 2003) | 0.32 |
| " No systematic study of this dose-response effect has been reported to this time." | ( Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. Almgren, A; Fredlund, K; Isaksson, M; Rossander-Hulthén, L; Sandberg, AS, 2006) | 0.33 |
| " With increase in the dosage of phytase, there was increase in growth and inorganic phosphate of plants, the highest being at 20 U per plant." | ( Plant growth promotion by an extracellular HAP-phytase of a thermophilic mold Sporotrichum thermophile. Satyanarayana, T; Singh, B, 2010) | 0.36 |
| " Three groups of ten 26-d-old apparently healthy broiler cockerels (Ross 308) were dosed with D-xylose solution (500 mg/kg BW, Group 1) or D-xylose solution + PA (330 or 660 mg/5 ml/bird, in groups 2 and 3), respectively." | ( D-Xylose absorption capacity of broiler intestine in response to phytic acid. Mansoori, B, 2010) | 0.6 |
| " Computing the effect of dietary variation on nonheme iron absorption has been challenging because of multiple influential dietary factors and incomplete knowledge of their chemical characteristics, food composition, interactions, and dose-response relationships." | ( Algorithms for iron and zinc bioavailability: are they accurate? Hunt, JR, 2010) | 0.36 |
| " This review discusses effects of phytate on fish, dephytinisation processes, phytase and pathway for phytate degradation, phytase production systems, mode of phytase application, bioefficacy of phytase, effects of phytase on growth performance, nutrient utilization and aquatic environment pollution, and optimum dosage of phytase in fish diets." | ( Phytate and phytase in fish nutrition. Becker, K; De Boeck, G; Kumar, V; Makkar, HP; Sinha, AK, 2012) | 0.38 |
| " Adjusting the dosage of HAuCl₄ resulted in different products, which possessed unique surface plasmon resonances (SPR)." | ( The IP₆ micelle-stabilized small Ag cluster for synthesizing Ag-Au alloy nanoparticles and the tunable surface plasmon resonance effect. Chen, X; Huan, S; Ling, B; Wang, N; Wang, Y; Wen, Y; Yang, H; Zhang, R, 2012) | 0.38 |
| " Ytterbium-labeled corn silage and Co-EDTA were dosed to the rumen 4 times daily as particulate and liquid phase markers, respectively, to measure ileal digesta flow." | ( Disappearance of infused phytate from the large intestine of dairy heifers. Knowlton, KF; Pearson, RE; Ray, PP; Shang, C, 2012) | 0.38 |
| " In the present study, to increase oral BA of the bisphosphonate, a novel enteric-coated tablet (ECT) dosage form of RS in combination with phytic acid (IP6), a natural chelating agent recognized as safe, was formulated." | ( Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability. Jang, SW; Kang, MJ; Kim, BM; Kim, JS; Son, M, 2016) | 0.87 |
| "To compare and explore the dose-response of phytate-containing 1150 ppm fluoride toothpastes on model caries lesions and to determine the impact of zinc ions." | ( Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model. Budhawant, C; Burnett, GR; Creeth, JE; Hara, AT; Lippert, F; Lynch, RJM; Parkinson, CR; Zero, DT, 2018) | 0.48 |
| " No differences between fluoride toothpastes were observed for any measure with little evidence of a dose-response for phytate." | ( Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model. Budhawant, C; Burnett, GR; Creeth, JE; Hara, AT; Lippert, F; Lynch, RJM; Parkinson, CR; Zero, DT, 2018) | 0.48 |
| " 1,2-Dimethylhydrazine (DMH) at a dosage of 30 mg/kg of body weight was injected weekly to induce CRC for 18 weeks." | ( Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) | 1.92 |
| "SNF472 is safe and well tolerated in HD patients after 2 schemes: multiple ascending doses for 1 week and after repeated dosing of 10 mg/kg for 4 weeks." | ( A phase 1b randomized, placebo-controlled clinical trial with SNF472 in haemodialysis patients. Campistol, JM; Canals, AZ; Ferrer, MD; Joubert, PH; Maduell, F; Ojeda, R; Perelló, J; Salcedo, C; Torregrosa, V, 2019) | 0.51 |
| "The objective of this present study was to determine the effects of phytase dosing on growth performance, mineral digestibility, phytate breakdown, and the level of glucose transporter type 4 (GLUT4) in muscle plasma membranes of weanling pigs." | ( Effect of phytase on intestinal phytate breakdown, plasma inositol concentrations, and glucose transporter type 4 abundance in muscle membranes of weanling pigs1. Adeola, O; Ajuwon, KM; Bedford, MR; Brearley, C; Kühn, I; Lu, H; Whitfield, H, 2019) | 0.51 |
| " Therefore, a suitable dosage form that can prevent the drugs from being absorbed from the upper gastrointestinal tract is required to be prepared, to target it to the colon." | ( Optimization of Inositol Hexaphosphate Colon Targeted Formulation for Anticarcinogenic Marker Modulation. Arya, M; Gupta, KP; Mishra, N; Saraf, SA, 2019) | 0.51 |
| " The findings highlight that phytase dose-response effects on mineral digestibility and utilization are different for high- and low-solubility limestones, and it is therefore recommended to use digestible rather than total Ca content during diet formulation to ensure an optimal balance of Ca and P, especially in low-Ca diets." | ( Effects of limestone solubility on the efficacy of a novel consensus bacterial 6-phytase variant to improve mineral digestibility, retention, and bone ash in young broilers fed low-calcium diets containing no added inorganic phosphate. Bello, A; Dersjant-Li, Y; Kwakernaak, C, 2022) | 0.72 |
| " Linear dose-response relationships were observed for ATTD of DM, CP, P, Ca, and PP." | ( Effect of a biosynthetic bacterial 6-phytase on the digestibility of phosphorus and phytate in midlactating dairy cows. Christensen, T; Dersjant-Li, Y; García-González, R; Kok, I; Marchal, L; Mereu, A; Westreicher-Kristen, E, 2023) | 0.91 |
| " Their use underpins industry practice: specifically dosing regimens for adjunct enzymes added to animal feed." | ( Accentuating the positive and eliminating the negative: Efficacy of TiO2 as digestibility index marker for poultry nutrition studies. Bedford, MR; Brearley, CA; Burton, E; Leftwich, PT; Scholey, D; Sprigg, C, 2023) | 0.91 |
| "The objective of this present study was to determine the effects of phytase dosing on growth performance, mineral digestibility, phytate breakdown, and the level of glucose transporter type 4 (GLUT4) in muscle plasma membranes of weanling pigs." | ( Effect of phytase on intestinal phytate breakdown, plasma inositol concentrations, and glucose transporter type 4 abundance in muscle membranes of weanling pigs1. Adeola, O; Ajuwon, KM; Bedford, MR; Brearley, C; Kühn, I; Lu, H; Whitfield, H, 2019) | 0.51 |
| Item | Process | Frequency |
|---|---|---|
| en:open-beauty-facts | core-ingredient | 1 |
| Class | Description |
|---|---|
| inositol phosphate | |
| inositol phosphate | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Inositol Metabolism | 22 | 26 |
| Inositol Phosphate Metabolism | 14 | 23 |
| Phytate Biosynthesis | 3 | 8 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 22.3872 | 0.0096 | 10.5250 | 35.4813 | AID1479145 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1) | Saccharomyces cerevisiae (brewer's yeast) | Ki | 4.0000 | 4.0000 | 5.0000 | 6.0000 | AID977610 |
| Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1) | Saccharomyces cerevisiae (brewer's yeast) | Ki | 4.0000 | 4.0000 | 5.0000 | 6.0000 | AID977610 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Beta-arrestin 1 | Bos taurus (cattle) | Kd | 0.0850 | 0.0850 | 0.0850 | 0.0850 | AID977611 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| virion membrane | Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1999 | Journal of molecular biology, Jun-18, Volume: 289, Issue:4 | Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1999 | Journal of molecular biology, Jun-18, Volume: 289, Issue:4 | Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2006 | The Journal of biological chemistry, Apr-07, Volume: 281, Issue:14 | Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2006 | The Journal of biological chemistry, Apr-07, Volume: 281, Issue:14 | Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 789 (22.18) | 18.7374 |
| 1990's | 574 (16.13) | 18.2507 |
| 2000's | 858 (24.11) | 29.6817 |
| 2010's | 938 (26.36) | 24.3611 |
| 2020's | 399 (11.21) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (87.26) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 176 (4.79%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 235 (6.39%) | 6.00% |
| Reviews | 7 (6.31%) | 6.00% |
| Case Studies | 98 (2.66%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3,169 (86.16%) | 84.16% |
| Other | 104 (93.69%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||