A lysine-specific demethylase 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4C1]
EC 1.14.11.65;
JmjC domain-containing histone demethylation protein 2A;
Jumonji domain-containing protein 1A;
[histone H3]-dimethyl-L-lysine(9) demethylase 3A
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,4-pyridinedicarboxylic acid | Homo sapiens (human) | IC50 | 8.0043 | 3 | 10 |
| 5-carboxy-8-hydroxyquinoline | Homo sapiens (human) | IC50 | 0.1762 | 3 | 3 |
| (1R,2S)-tranylcypromine hydrochloride | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| oxalylglycine | Homo sapiens (human) | IC50 | 65.8696 | 3 | 11 |
| 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid | Homo sapiens (human) | IC50 | 19.7901 | 2 | 8 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| histone H3K9 demethylase activity | molecular function | Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. [PMID:16362057] |
| nuclear androgen receptor binding | molecular function | Binding to a nuclear androgen receptor. [GOC:ai] |
| histone H3K9me/H3K9me2 demethylase activity | molecular function | Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16603238] |
| transcription coregulator activity | molecular function | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] |
| chromatin DNA binding | molecular function | Binding to DNA that is assembled into chromatin. [GOC:mah] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| male germ cell nucleus | cellular component | The nucleus of a male germ cell, a reproductive cell in males. [CL:0000015, GOC:hjd, GOC:mtg_sensu] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| histone deacetylase complex | cellular component | A protein complex that possesses histone deacetylase activity. [GOC:mah] |
| chromatin | cellular component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin remodeling | biological process | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] |
| spermatid nucleus elongation | biological process | The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation. [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] |
| hormone-mediated signaling pathway | biological process | The series of molecular signals mediated by the detection of a hormone. [GOC:sm] |
| androgen receptor signaling pathway | biological process | The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah] |
| positive regulation of DNA-templated transcription | biological process | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| positive regulation of transcription by RNA polymerase II | biological process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
| formaldehyde biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde. [GOC:ai] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |
| cellular response to leukemia inhibitory factor | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913] |
| regulation of stem cell population maintenance | biological process | Any process that modulates the frequency, rate or extent of stem cell population maintenance. [GOC:obol] |
| regulation of stem cell differentiation | biological process | Any process that modulates the frequency, rate or extent of stem cell differentiation. [GOC:obol] |
| regulation of transcription by RNA polymerase II | biological process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |