NUAK family SNF1-like kinase 1

A NUAK family SNF1-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60285]

Synonyms

EC 2.7.11.1;
AMPK-related protein kinase 5;
ARK5;
Omphalocele kinase 1

Research

Bioassay Publications (16)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (12.50)	29.6817
2010's	13 (81.25)	24.3611
2020's	1 (6.25)	2.80

Compounds (90)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
staurosporine	Homo sapiens (human)	IC50	0.0030	4	4
birb 796	Homo sapiens (human)	IC50	30.0000	1	1
quercetin	Homo sapiens (human)	IC50	5.0900	1	1
norlichexanthone	Homo sapiens (human)	IC50	33.0000	1	1
ellagic acid	Homo sapiens (human)	IC50	0.5100	1	1
astrogorgiadiol	Homo sapiens (human)	IC50	100.0000	1	1
su 11248	Homo sapiens (human)	IC50	0.0480	1	1
palbociclib	Homo sapiens (human)	IC50	5.0000	1	1
bx795	Homo sapiens (human)	IC50	0.0050	1	1
mrt67307	Homo sapiens (human)	IC50	0.2300	1	1
4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide	Homo sapiens (human)	IC50	0.0040	1	1
thiopental sodium	Homo sapiens (human)	IC50	0.0250	1	1
bay 1000394	Homo sapiens (human)	IC50	0.0100	1	1
on123300	Homo sapiens (human)	IC50	0.0050	2	2
cep-28122	Homo sapiens (human)	IC50	0.0260	1	1
wz4003	Homo sapiens (human)	IC50	0.0138	2	2
unc2025	Homo sapiens (human)	IC50	0.0080	2	2
hth-01-015	Homo sapiens (human)	IC50	0.1000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	10.0000	2	2
staurosporine	Homo sapiens (human)	Kd	0.0044	2	2
gefitinib	Homo sapiens (human)	Kd	10.0000	2	2
lestaurtinib	Homo sapiens (human)	Kd	0.0037	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	1.8000	2	2
canertinib	Homo sapiens (human)	Kd	10.0000	2	2
birb 796	Homo sapiens (human)	Kd	10.0000	2	2
cyc 202	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	10.0000	1	1
erlotinib	Homo sapiens (human)	Kd	10.0000	2	2
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	10.0000	3	3
pd 173955	Homo sapiens (human)	Kd	10.0000	1	1
s 1033	Homo sapiens (human)	Kd	10.0000	1	1
bms 387032	Homo sapiens (human)	Kd	10.0000	2	2
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	10.0000	2	2
zd 6474	Homo sapiens (human)	Kd	10.0000	2	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	10.0000	2	2
bosutinib	Homo sapiens (human)	Kd	5.9000	1	1
su 11248	Homo sapiens (human)	Kd	0.0480	3	3
jnj-7706621	Homo sapiens (human)	Kd	0.1800	1	1
vx680	Homo sapiens (human)	Kd	0.2000	2	2
ekb 569	Homo sapiens (human)	Kd	10.0000	1	1
axitinib	Homo sapiens (human)	Kd	10.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	0.0410	3	3
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hki 272	Homo sapiens (human)	Kd	1.5000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	10.0000	1	1
masitinib	Homo sapiens (human)	Kd	10.0000	1	1
pazopanib	Homo sapiens (human)	Kd	10.0000	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	0.4600	2	2
bibw 2992	Homo sapiens (human)	Kd	10.0000	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	0.6200	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	0.0750	1	1
brivanib	Homo sapiens (human)	Kd	10.0000	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	10.0000	2	2
kw 2449	Homo sapiens (human)	Kd	10.0000	1	1
abt 869	Homo sapiens (human)	Kd	10.0000	2	2
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
crizotinib	Homo sapiens (human)	Kd	10.0000	1	1
chir-265	Homo sapiens (human)	Kd	10.0000	2	2
motesanib	Homo sapiens (human)	Kd	10.0000	2	2
mln8054	Homo sapiens (human)	Kd	10.0000	2	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	2	2
nvp-tae684	Homo sapiens (human)	Kd	0.0130	2	2
fedratinib	Homo sapiens (human)	Kd	0.0340	1	1
gsk690693	Homo sapiens (human)	Kd	0.4200	1	1
gdc 0941	Homo sapiens (human)	Kd	10.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
incb-018424	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	10.0000	1	1
wz4003	Homo sapiens (human)	EC50	3.0000	1	0
chir 258	Homo sapiens (human)	Kd	0.2400	2	2
nintedanib	Homo sapiens (human)	Kd	0.1600	1	1
pp242	Homo sapiens (human)	Kd	10.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
p53 binding	molecular function	Binding to one of the p53 family of proteins. [GOC:hjd]
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
microtubule cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
regulation of cell adhesion	biological process	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah]
regulation of myosin-light-chain-phosphatase activity	biological process	Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity. [GOC:bf, GOC:go_curators]
regulation of cell population proliferation	biological process	Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
regulation of signal transduction by p53 class mediator	biological process	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]
regulation of cellular senescence	biological process	Any process that modulates the frequency, rate or extent of cellular senescence. [GOC:BHF]

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