Page last updated: 2024-12-05

disulfoton

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Disulfoton: An organothiophosphate insecticide. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

disulfoton : An organic thiophosphate that is the diethyl ester of S-[2-(ethylsulfanyl)ethyl] dihydrogen phosphorodithioate. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3118
CHEMBL ID1332314
CHEBI ID38661
SCHEMBL ID27180
MeSH IDM0006608

Synonyms (141)

Synonym
bay 19639
phosphorodithioic acid, o,o-diethyl s-[2-(ethylthio)ethyl] ester
KBIO1_001394
DIVK1C_006450
o,o-diethyl s-[2-(ethylthio)ethyl] dithiophosphate
phosphorodithioic acid, o,o-diethyl s-(2-(ethylthio)ethyl) ester
298-04-4
o,o-diethyl s-[2-(ethylsulfanyl)ethyl] dithiophosphate
o,o-diethyl s-(2-ethylmercaptoethyl) dithiophosphate
CHEBI:38661 ,
o,o-diethyl s-(2-(ethylthio)ethyl) dithiophosphate
disulfoton
SPECTRUM_001771
dution
frumin g
ent 23,437
s-2-(ethylthio)ethyl o,o-diethyl ester of phosphorodithioic acid
brn 1709167
ethyl thiometon
epa pesticide chemical code 032501
solvigran
rcra waste no. p039
s 276
ekatine
o,o-diaethyl-s-(2-aethylthio-aethyl)-dithiophosphat [german]
ent 23437
dithiodemeton
ekatin td
m-74
hsdb 379
insyst-d
caswell no. 341
vuagt 1964
frumin
einecs 206-054-3
vuagt 1-4
bayer 19639
frumin al
o,o-diaethyl-s-(3-thia-pentyl)-dithiophosphat [german]
disulfoton [bsi:iso]
o,o-diethyl-s-(2-ethylthio-ethyl)-dithiofosfaat [dutch]
di-syston g
ccris 1011
o,o-diethyl-s-ethylmercapto-ethyl dithiophosphate
o,o-dietil-s-(2-etiltio-etil)-ditiofosfato [italian]
ethylthiometon b
o,o-diethyl s-2-(ethylthio)ethyl phosphorodithioate
m-74 (pesticide)
o,o-diethyl 2-ethylthioethyl phosphorodithioate
o,o-diethyl s-(2-eththioethyl) phosphorodithioate
di-syston
o,o-diethyl s-(2-(ethylthio)ethyl)phosphorodithioate
ai3-23437
dithiosystox
glebofos
o,o-diethyl s-(2-eththioethyl) thiothionophosphate
dithiophosphate de o,o-diethyle et de s-(2-ethylthio-ethyle) [french]
rcra waste number p039
solvirex
ethylthiometon
thiodemeton
NCGC00091485-01
MLS001065622
smr000568480
disulfoton, analytical standard
NCGC00091485-02
KBIOGR_000993
KBIOSS_002252
KBIO2_007387
KBIO2_004819
KBIO3_001773
KBIO2_002251
SPECTRUM3_000807
SPECPLUS_000354
SPECTRUM4_000647
SPECTRUM2_001856
SPBIO_001672
SPECTRUM5_001926
BSPBIO_002273
NCGC00091485-04
NCGC00091485-03
diethoxy-(2-ethylsulfanylethylsulfanyl)-sulfanylidenephosphorane
inchi=1/c8h19o2ps3/c1-4-9-11(12,10-5-2)14-8-7-13-6-3/h4-8h2,1-3h3
dofzazxdosgajz-uhfffaoysa-
disulfaton
NCGC00091485-06
NCGC00091485-05
C18400
HMS3039H04
dtxcid702018
tox21_300861
NCGC00254764-01
dtxsid0022018 ,
NCGC00259892-01
cas-298-04-4
tox21_202343
CHEMBL1332314
CCG-39394
3cy5ekl6mt ,
o,o-diaethyl-s-(3-thia-pentyl)-dithiophosphat
o,o-diethyl-s-(2-ethylthio-ethyl)-dithiofosfaat
unii-3cy5ekl6mt
o,o-diaethyl-s-(2-aethylthio-aethyl)-dithiophosphat
o,o-dietil-s-(2-etiltio-etil)-ditiofosfato
dithiophosphate de o,o-diethyle et de s-(2-ethylthio-ethyle)
AKOS015898788
o,o-diethyl-s-ethylmercaptoethyl dithiophosphate
baysiston
disulfoton [iso]
bay s276
disulfoton [mi]
bay-s276
disulfoton [hsdb]
ent-23347
bay-19639
SCHEMBL27180
phosphorodithionic acid, s-2-(ethylthio)ethyl-o,o-diethyl ester
o,o-ethyl s-2(ethylthio)ethyl phosphorodithioate
phosphonodithioic acid, o,o-diethyl s-[2-(ethylthio)ethyl] ester
disystox
disipton
m 74
o,o-diethyl s-[2-(ethylthio)ethyl] phosphorodithioate
thiodemetron
ent-23437
o,o-diethyl s-[2-(ethylsulfanyl)ethyl] dithiophosphate #
m 74 (pesticide)
dimaz
DOFZAZXDOSGAJZ-UHFFFAOYSA-N
phosphorodithioic acid,o,o-diethyl s-[2-(ethylthio)ethyl]ester
disulfoton, pestanal(r), analytical standard
disulfoton 100 microg/ml in acetonitrile
disulfoton 100 microg/ml in cyclohexane
disulfoton 10 microg/ml in cyclohexane
phosphorodithioic acid o,o-diethyl s-(2-(ethylthio)ethyl) ester
J-017649
Q413904
o,o-diethyl s-[2-(ethylthio)ethyl]dithiophosphate
diethoxy-(2-ethylsulfanylethylsulfanyl)-sulfanylidene-lambda5-phosphane
o,o-diethyl s-(2-(ethylthio)ethyl) phosphorodithioate
disulfoton 1000 microg/ml in methanol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Cognitive function, as measured in the Morris water maze, and passive avoidance procedures were assessed near the end of the dosing regimen."( Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure.
Ali, SF; Crofton, KM; Llorens, J; Mundy, WR; Tilson, HA, 1993
)
0.61
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
EC 3.1.1.7 (acetylcholinesterase) inhibitorAn EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
acaricideA substance used to destroy pests of the subclass Acari (mites and ticks).
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organic thiophosphate
organothiophosphate insecticide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (34)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID886
Chain B, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID886
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency56.23410.631035.7641100.0000AID504339
interleukin 8Homo sapiens (human)Potency66.82420.047349.480674.9780AID651758
acetylcholinesteraseHomo sapiens (human)Potency61.85760.002541.796015,848.9004AID1347395; AID1347398
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.05180.006038.004119,952.5996AID1159521
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency14.12540.011212.4002100.0000AID1030
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency22.38720.000214.376460.0339AID588532
pregnane X nuclear receptorHomo sapiens (human)Potency35.48130.005428.02631,258.9301AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency56.70680.000229.305416,493.5996AID743075
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.11870.707936.904389.1251AID504333
thyroid stimulating hormone receptorHomo sapiens (human)Potency23.40630.001628.015177.1139AID1224843; AID1224895; AID1259395
chromobox protein homolog 1Homo sapiens (human)Potency56.23410.006026.168889.1251AID540317
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency44.66843.548119.542744.6684AID743266
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency1.00000.01789.637444.6684AID588834
gemininHomo sapiens (human)Potency0.18360.004611.374133.4983AID624297
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency19.95260.031610.279239.8107AID884; AID885
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency22.38723.981146.7448112.2020AID720708
GABA theta subunitRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency19.95261.000012.224831.6228AID885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (10)

Processvia Protein(s)Taxonomy
adaptive immune responseRap guanine nucleotide exchange factor 4Homo sapiens (human)
G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
calcium-ion regulated exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of synaptic vesicle cycleRap guanine nucleotide exchange factor 4Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein-macromolecule adaptor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
small GTPase bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
cytosolRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1101168Resistance index, ratio of LC50 for organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs to LC50 for organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1101171Insecticidal activity against organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs assessed as insect mortality after 8 hr2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101172Insecticidal activity against organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs assessed as insect mortality after 8 hr2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101169Resistance index, ratio of LC50 for organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs to LC50 for organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101170Insecticidal activity against organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs assessed as insect mortality after 8 hr2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (104)

TimeframeStudies, This Drug (%)All Drugs %
pre-199051 (49.04)18.7374
1990's21 (20.19)18.2507
2000's16 (15.38)29.6817
2010's13 (12.50)24.3611
2020's3 (2.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 49.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index49.84 (24.57)
Research Supply Index4.77 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index80.05 (26.88)
Search Engine Supply Index2.03 (0.95)

This Compound (49.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.86%)5.53%
Reviews1 (0.86%)6.00%
Case Studies6 (5.17%)4.05%
Observational0 (0.00%)0.25%
Other108 (93.10%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]