A histone-lysine N-methyltransferase SETD7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WTS6]
EC 2.1.1.364;
Histone H3-K4 methyltransferase SETD7;
H3-K4-HMTase SETD7;
Lysine N-methyltransferase 7;
SET domain-containing protein 7;
SET7/9
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (84.62) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cyproheptadine | Homo sapiens (human) | IC50 | 8.1333 | 3 | 3 |
| cyproheptadine | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| pimethixene | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| lawsone | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 2-methoxy-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| sinefungin | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| s-adenosylhomocysteine | Homo sapiens (human) | IC50 | 38.5000 | 2 | 2 |
| eriodictyol | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| shikonin | Homo sapiens (human) | IC50 | 21.6200 | 1 | 1 |
| N-(3-nitrophenyl)-1,3-benzodioxole-5-carboxamide | Homo sapiens (human) | IC50 | 61.7500 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 6.0800 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| galangin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| kaempferide | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 6.0200 | 1 | 1 |
| scutellarein | Homo sapiens (human) | IC50 | 1.9600 | 1 | 1 |
| unc 0321 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| gsk343 | Homo sapiens (human) | IC50 | 63.0000 | 1 | 1 |
| (r)-pfi-2 | Homo sapiens (human) | IC50 | 0.0020 | 3 | 3 |
| (r)-pfi-2 | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| 6,7-dimethoxy-2-(pyrrolidin-1-yl)-n-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| p53 binding | molecular function | Binding to one of the p53 family of proteins. [GOC:hjd] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein-lysine N-methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. [PMID:12054878] |
| histone methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators] |
| histone H3 methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737] |
| histone H3K4 monomethyltransferase activity | molecular function | Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me. [RHEA:60264] |
| chromatin binding | molecular function | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| chromosome | cellular component | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684] |
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| chromosome | cellular component | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin organization | biological process | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130] |
| chromatin remodeling | biological process | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] |
| peptidyl-lysine monomethylation | biological process | The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. [RESID:AA0076] |
| peptidyl-lysine dimethylation | biological process | The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. [RESID:AA0075] |
| response to ethanol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators] |
| positive regulation of DNA-templated transcription | biological process | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| heterochromatin organization | biological process | Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. [GOC:mah] |