Proteins > G-protein coupled bile acid receptor 1
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G-protein coupled bile acid receptor 1
A G-protein coupled bile acid receptor 1 that is encoded in the genome of mouse. [OMA:Q80SS6, PRO:DNx]
Synonyms
Membrane-type receptor for bile acids;
M-BAR
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cholic acid | Mus musculus (house mouse) | IC50 | 5.3000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| obeticholic acid | Mus musculus (house mouse) | EC50 | 5.7400 | 1 | 1 |
| int-777 | Mus musculus (house mouse) | EC50 | 0.2477 | 3 | 3 |
Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists.Bioorganic & medicinal chemistry, , 02-15, Volume: 32, 2021
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects.European journal of medicinal chemistry, , Oct-01, Volume: 203, 2020
Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold.European journal of medicinal chemistry, , Volume: 69, 2013