A voltage-gated potassium channel KCND3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UK17]
Voltage-gated potassium channel subunit Kv4.3
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide | Homo sapiens (human) | IC50 | 54,954,100,000.0000 | 1 | 1 |
| alfuzosin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| duloxetine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| nelfinavir | Homo sapiens (human) | IC50 | 5,011.8700 | 1 | 1 |
| nebivolol | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| paliperidone | Homo sapiens (human) | IC50 | 63.0957 | 1 | 1 |
| desvenlafaxine | Homo sapiens (human) | IC50 | 5,011.8700 | 1 | 1 |
| solifenacin | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| etravirine | Homo sapiens (human) | IC50 | 3,162.2800 | 1 | 1 |
| darunavir | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| deferasirox | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| tolterodine | Homo sapiens (human) | IC50 | 12.5892 | 1 | 1 |
| darifenacin | Homo sapiens (human) | IC50 | 12.5892 | 1 | 1 |
| s 1033 | Homo sapiens (human) | IC50 | 3,162.2800 | 1 | 1 |
| dasatinib | Homo sapiens (human) | IC50 | 316.2280 | 1 | 1 |
| sitagliptin | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 9.3000 | 1 | 0 |
| silodosin | Homo sapiens (human) | IC50 | 316.2280 | 1 | 1 |
| su 11248 | Homo sapiens (human) | IC50 | 50.1187 | 1 | 1 |
| everolimus | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| 6-cyano-4-(n-ethylsulfonyl-n-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(+))-isomer | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| lu 208075 | Homo sapiens (human) | IC50 | 251.1890 | 1 | 1 |
| raltegravir | Homo sapiens (human) | IC50 | 5,011.8700 | 1 | 1 |
| sildenafil | Homo sapiens (human) | IC50 | 501.1870 | 1 | 1 |
| vardenafil | Homo sapiens (human) | IC50 | 79.4328 | 1 | 1 |
| amg531 | Homo sapiens (human) | IC50 | 1,584.8900 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| transmembrane transporter binding | molecular function | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| voltage-gated potassium channel activity | molecular function | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| sarcolemma | cellular component | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732] |
| GABA-ergic synapse | cellular component | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos] |
| postsynaptic specialization membrane | cellular component | The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| dendritic spine | cellular component | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| postsynaptic membrane | cellular component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated potassium channel complex | cellular component | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| potassium ion transport | biological process | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| protein homooligomerization | biological process | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai] |
| membrane repolarization | biological process | The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane repolarization during cardiac muscle cell action potential | biological process | The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of heart rate by cardiac conduction | biological process | A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| potassium ion export across plasma membrane | biological process | The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440] |
| membrane repolarization during ventricular cardiac muscle cell action potential | biological process | The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] |
| ventricular cardiac muscle cell membrane repolarization | biological process | The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| action potential | biological process | A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] |