Proteins > Metabotropic glutamate receptor 8
Page last updated: 2024-08-07 13:26:12
Metabotropic glutamate receptor 8
A metabotropic glutamate receptor 8 that is encoded in the genome of rat. [OMA:P70579, PRO:DNx]
Synonyms
mGluR8
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 25, Issue:12, 2015
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.Bioorganic & medicinal chemistry, , May-01, Volume: 15, Issue:9, 2007
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 16, Issue:1, 2006
New probes of the agonist binding site of metabotropic glutamate receptors.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 25, Issue:12, 2015
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.Journal of medicinal chemistry, , Sep-20, Volume: 50, Issue:19, 2007
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.Bioorganic & medicinal chemistry, , May-01, Volume: 15, Issue:9, 2007
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 16, Issue:1, 2006
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008-present.MedChemComm, , Feb-01, Volume: 10, Issue:2, 2019
Discovery of VU6005649, a CNS Penetrant mGluACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008-present.MedChemComm, , Feb-01, Volume: 10, Issue:2, 2019
Discovery of VU6005649, a CNS Penetrant mGluACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017