Proteins > Pancreatic triacylglycerol lipase
Page last updated: 2024-08-07 23:10:03
Pancreatic triacylglycerol lipase
[no definition available]
Synonyms
PL;
PTL;
Pancreatic lipase;
EC 3.1.1.3
Research
Bioassay Publications (19)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 17 (89.47) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
Compounds (42)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gallic acid | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| vanillin | Sus scrofa (pig) | IC50 | 74.4000 | 1 | 1 |
| phloretin | Sus scrofa (pig) | IC50 | 50.4000 | 1 | 1 |
| phlorhizin | Sus scrofa (pig) | IC50 | 300.0000 | 1 | 1 |
| rotenone | Sus scrofa (pig) | IC50 | 500.0000 | 1 | 1 |
| vanillic acid | Sus scrofa (pig) | IC50 | 250.0000 | 1 | 1 |
| catechin | Sus scrofa (pig) | IC50 | 500.0000 | 1 | 1 |
| aromadedrin | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| moracin c | Sus scrofa (pig) | IC50 | 32.0000 | 1 | 1 |
| moracin m | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| naringenin | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| lusianthridin | Sus scrofa (pig) | Ki | 4.9600 | 1 | 1 |
| Hircinol | Sus scrofa (pig) | Ki | 8.5700 | 1 | 1 |
| 6,8-diprenylgenistein | Sus scrofa (pig) | IC50 | 65.0000 | 1 | 1 |
| 8-isopentenylnaringenin | Sus scrofa (pig) | IC50 | 76.9000 | 1 | 1 |
| hydroxyphenethylferulate | Sus scrofa (pig) | IC50 | 50.0000 | 1 | 1 |
| chalcone | Sus scrofa (pig) | IC50 | 84.4100 | 1 | 1 |
| caffeic acid | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| orlistat | Sus scrofa (pig) | IC50 | 0.4214 | 14 | 14 |
| orlistat | Sus scrofa (pig) | Ki | 5.0300 | 2 | 2 |
| quercetin | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| biochanin a | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| quercetin 3-o-glucopyranoside | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| kaempferol | Sus scrofa (pig) | IC50 | 85.0000 | 2 | 2 |
| genistein | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| 5,7-dihydroxychromone | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| 3-methylquercetin | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| morin | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| trans-2,3',4,5'-tetrahydroxystilbene | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| wighteone | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| astragalin | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| broussonin a | Sus scrofa (pig) | IC50 | 98.7000 | 1 | 1 |
| broussonin b | Sus scrofa (pig) | IC50 | 75.4000 | 1 | 1 |
| 3'-o-methylorobol | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| Norartocarpetin | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| lipstatin | Sus scrofa (pig) | IC50 | 0.1400 | 1 | 1 |
| morachalcone a | Sus scrofa (pig) | IC50 | 6.2000 | 1 | 1 |
| 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | Sus scrofa (pig) | Ki | 3.3400 | 1 | 1 |
| batatasin-iii | Sus scrofa (pig) | Ki | 6.7900 | 1 | 1 |
| 1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one | Sus scrofa (pig) | Ki | 1.9200 | 1 | 1 |
| Norartocarpanone | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| cudraflavanone a | Sus scrofa (pig) | IC50 | 6.5000 | 1 | 1 |
Drugs with Other Measurements
A new approach to procyanidins synthesis with potent anti-adipogenic effects.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 29, Issue:16, 2019
Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum.Journal of natural products, , 04-27, Volume: 81, Issue:4, 2018
Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors.ACS medicinal chemistry letters, , Jul-12, Volume: 9, Issue:7, 2018
Stereochemical Structure Activity Relationship Studies (S-SAR) of Tetrahydrolipstatin.ACS medicinal chemistry letters, , Mar-08, Volume: 9, Issue:3, 2018
[no title available]Bioorganic & medicinal chemistry letters, , 08-15, Volume: 27, Issue:16, 2017
Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 25, Issue:11, 2015
Benzylated and prenylated flavonoids from the root barks of Cudrania tricuspidata with pancreatic lipase inhibitory activity.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 25, Issue:17, 2015
Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Radiolytic transformation of rotenone with potential anti-adipogenic activity.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
A new pancreatic lipase inhibitor from Broussonetia kanzinoki.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 22, Issue:8, 2012
Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Benzylated and prenylated flavonoids from the root barks of Cudrania tricuspidata with pancreatic lipase inhibitory activity.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 25, Issue:17, 2015
Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 25, Issue:11, 2015