A polycomb protein SUZ12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15022]
Chromatin precipitated E2F target 9 protein;
ChET 9 protein;
Joined to JAZF1 protein;
Suppressor of zeste 12 protein homolog
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tanshinone | Homo sapiens (human) | IC50 | 8.9000 | 1 | 1 |
| przewaquinone d | Homo sapiens (human) | IC50 | 0.5500 | 1 | 1 |
| przewaquinone d | Homo sapiens (human) | Ki | 0.1940 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | IC50 | 28.1000 | 1 | 1 |
| epz-6438 | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| gsk-2816126 | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| gsk343 | Homo sapiens (human) | IC50 | 0.1220 | 2 | 2 |
| gsk343 | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular function | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| transcription corepressor binding | molecular function | Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| enzyme activator activity | molecular function | Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb] |
| methylated histone binding | molecular function | Binding to a histone in which a residue has been modified by methylation. [GOC:bf, PMID:14585615] |
| histone methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| lncRNA binding | molecular function | Binding to a long noncoding RNA (lncRNA). [PMID:25578728] |
| promoter-specific chromatin binding | molecular function | Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729] |
| chromatin DNA binding | molecular function | Binding to DNA that is assembled into chromatin. [GOC:mah] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 5 target(s):
| Target | Category | Definition |
|---|---|---|
| sex chromatin | cellular component | Chromatin that is part of a sex chromosome. [GOC:dos, ISBN:0198506732] |
| chromatin silencing complex | cellular component | Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. [GOC:mah] |
| ESC/E(Z) complex | cellular component | A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] |
| ribonucleoprotein complex | cellular component | A macromolecular complex that contains both RNA and protein molecules. [GOC:krc, GOC:vesicles] |
| RSC-type complex | cellular component | A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| cell population proliferation | biological process | The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| negative regulation of cell differentiation | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. [GOC:go_curators] |
| oligodendrocyte differentiation | biological process | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. [GOC:vp, PMID:15139015] |
| random inactivation of X chromosome | biological process | Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex. [GOC:dph, GOC:sdb_2009, GOC:tb, PMID:32189388] |
| facultative heterochromatin formation | biological process | The compaction of chromatin into a conformation that is refactory to transcription but that be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). [PMID:17936700] |