Page last updated: 2024-08-07 14:43:22
Polycomb protein EED
A polycomb protein EED that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75530]
Synonyms
hEED;
Embryonic ectoderm development protein;
WD protein associating with integrin cytoplasmic tails 1;
WAIT-1
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs.European journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
Targeting EZH2 for cancer therapy: From current progress to novel strategies.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Small Molecule Approaches for Targeting the Polycomb Repressive Complex 2 (PRC2) in Cancer.Journal of medicinal chemistry, , 12-24, Volume: 63, Issue:24, 2020
Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma.ACS medicinal chemistry letters, , Feb-08, Volume: 9, Issue:2, 2018
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.Journal of medicinal chemistry, , 03-23, Volume: 60, Issue:6, 2017
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| transcription corepressor binding | molecular function | Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| enzyme activator activity | molecular function | Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb] |
| histone methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| chromosome | cellular component | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| ESC/E(Z) complex | cellular component | A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| spinal cord development | biological process | The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| negative regulation of DNA-templated transcription | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| heterochromatin formation | biological process | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. [PMID:25192661, PMID:33827924] |
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |