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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22413]

Synonyms

E-NPP 1;
Membrane component chromosome 6 surface marker 1;
Phosphodiesterase I/nucleotide pyrophosphatase 1;
Plasma-cell membrane glycoprotein PC-1

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Compounds (8)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
alpha,beta-methyleneadenosine 5'-triphosphateHomo sapiens (human)Ki12.852544
adenosine 5'-methylenediphosphateHomo sapiens (human)Ki16.876055
3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphateHomo sapiens (human)Ki8.780022
methylthio-adpHomo sapiens (human)Ki23.520044
Reactive blue 2Homo sapiens (human)Ki0.520011
2-methylthio-atpHomo sapiens (human)Ki22.742544
adenosine 5'-diphosphate 2',3'-dialdehydeHomo sapiens (human)Ki4.860055
arl-67156Homo sapiens (human)Ki12.000033

Enables

This protein enables 20 target(s):

TargetCategoryDefinition
nucleic acid bindingmolecular functionBinding to a nucleic acid. [GOC:jl]
3',5'-cyclic-AMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]
exonuclease activitymolecular functionCatalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. [GOC:mah, ISBN:0198547684]
phosphodiesterase I activitymolecular functionCatalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1]
dinucleotide phosphatase activitymolecular functionCatalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. [PMID:2848456, PMID:4405504]
scavenger receptor activitymolecular functionCombining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
insulin receptor bindingmolecular functionBinding to an insulin receptor. [GOC:ai]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
phosphatase activitymolecular functionCatalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]
polysaccharide bindingmolecular functionBinding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah]
GTP diphosphatase activitymolecular functionCatalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate. [GOC:dgf, PMID:22531138, RHEA:29391]
UTP diphosphatase activitymolecular functionCatalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate. [GOC:dgf, PMID:17899088, RHEA:29395]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
nucleoside triphosphate diphosphatase activitymolecular functionCatalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. [EC:3.6.1.9]
ATP diphosphatase activitymolecular functionCatalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. [RHEA:14245]
3'-phosphoadenosine 5'-phosphosulfate bindingmolecular functionBinding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]
cyclic-GMP-AMP hydrolase activitymolecular functionCatalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP. [GOC:sp, PMID:25344812, RHEA:58808]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosomal membranecellular componentThe lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surfacecellular componentThe external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membranecellular componentThe region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surfacecellular componentThe external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Involved In

This protein is involved in 27 target(s):

TargetCategoryDefinition
generation of precursor metabolites and energybiological processThe chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. [GOC:jl]
phosphate-containing compound metabolic processbiological processThe chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai]
immune responsebiological processAny immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
nucleoside triphosphate catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
response to inorganic substancebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]
gene expressionbiological processThe process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
vesicle-mediated transportbiological processA cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. [GOC:ai, GOC:mah, ISBN:08789310662000]
bone mineralizationbiological processThe deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]
negative regulation of cell growthbiological processAny process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
melanocyte differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]
regulation of bone mineralizationbiological processAny process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]
negative regulation of bone mineralizationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. [GOC:go_curators]
inorganic diphosphate transportbiological processThe directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
intracellular phosphate ion homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. [GOC:mah]
sequestering of triglyceridebiological processThe process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:mah, ISBN:0198506732]
negative regulation of protein autophosphorylationbiological processAny process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
response to ATPbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:sl]
negative regulation of fat cell differentiationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
negative regulation of glycogen biosynthetic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]
ATP metabolic processbiological processThe chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
negative regulation of glucose importbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai]
negative regulation of insulin receptor signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf]
3'-phosphoadenosine 5'-phosphosulfate metabolic processbiological processThe chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732]
phosphate ion homeostasisbiological processAny process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. [GOC:jid, GOC:mah]
nucleic acid metabolic processbiological processAny cellular metabolic process involving nucleic acids. [GOC:dph, GOC:tb]
negative regulation of hh target transcription factor activitybiological processAny process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling. [GOC:bhm, PMID:24311597]