Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22413]

Synonyms

E-NPP 1;
Membrane component chromosome 6 surface marker 1;
Phosphodiesterase I/nucleotide pyrophosphatase 1;
Plasma-cell membrane glycoprotein PC-1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Compounds (8)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alpha,beta-methyleneadenosine 5'-triphosphate	Homo sapiens (human)	Ki	12.8525	4	4
adenosine 5'-methylenediphosphate	Homo sapiens (human)	Ki	16.8760	5	5
3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate	Homo sapiens (human)	Ki	8.7800	2	2
methylthio-adp	Homo sapiens (human)	Ki	23.5200	4	4
Reactive blue 2	Homo sapiens (human)	Ki	0.5200	1	1
2-methylthio-atp	Homo sapiens (human)	Ki	22.7425	4	4
adenosine 5'-diphosphate 2',3'-dialdehyde	Homo sapiens (human)	Ki	4.8600	5	5
arl-67156	Homo sapiens (human)	Ki	12.0000	3	3

Enables

This protein enables 20 target(s):

Target	Category	Definition
nucleic acid binding	molecular function	Binding to a nucleic acid. [GOC:jl]
3',5'-cyclic-AMP phosphodiesterase activity	molecular function	Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]
exonuclease activity	molecular function	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. [GOC:mah, ISBN:0198547684]
phosphodiesterase I activity	molecular function	Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1]
dinucleotide phosphatase activity	molecular function	Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. [PMID:2848456, PMID:4405504]
scavenger receptor activity	molecular function	Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
insulin receptor binding	molecular function	Binding to an insulin receptor. [GOC:ai]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
phosphatase activity	molecular function	Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]
polysaccharide binding	molecular function	Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah]
GTP diphosphatase activity	molecular function	Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate. [GOC:dgf, PMID:22531138, RHEA:29391]
UTP diphosphatase activity	molecular function	Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate. [GOC:dgf, PMID:17899088, RHEA:29395]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
nucleoside triphosphate diphosphatase activity	molecular function	Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. [EC:3.6.1.9]
ATP diphosphatase activity	molecular function	Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. [RHEA:14245]
3'-phosphoadenosine 5'-phosphosulfate binding	molecular function	Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]
cyclic-GMP-AMP hydrolase activity	molecular function	Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP. [GOC:sp, PMID:25344812, RHEA:58808]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Involved In

This protein is involved in 27 target(s):

Target	Category	Definition
generation of precursor metabolites and energy	biological process	The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. [GOC:jl]
phosphate-containing compound metabolic process	biological process	The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
nucleoside triphosphate catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
response to inorganic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]
gene expression	biological process	The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
vesicle-mediated transport	biological process	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. [GOC:ai, GOC:mah, ISBN:08789310662000]
bone mineralization	biological process	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]
negative regulation of cell growth	biological process	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
melanocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]
regulation of bone mineralization	biological process	Any process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]
negative regulation of bone mineralization	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. [GOC:go_curators]
inorganic diphosphate transport	biological process	The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
intracellular phosphate ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. [GOC:mah]
sequestering of triglyceride	biological process	The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:mah, ISBN:0198506732]
negative regulation of protein autophosphorylation	biological process	Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]
cellular response to insulin stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
response to ATP	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:sl]
negative regulation of fat cell differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
negative regulation of glycogen biosynthetic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]
ATP metabolic process	biological process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
negative regulation of glucose import	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai]
negative regulation of insulin receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf]
3'-phosphoadenosine 5'-phosphosulfate metabolic process	biological process	The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732]
phosphate ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. [GOC:jid, GOC:mah]
nucleic acid metabolic process	biological process	Any cellular metabolic process involving nucleic acids. [GOC:dph, GOC:tb]
negative regulation of hh target transcription factor activity	biological process	Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling. [GOC:bhm, PMID:24311597]

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