Sodium/potassium-transporting ATPase subunit beta-1

A sodium/potassium-transporting ATPase subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05026]

Synonyms

Sodium/potassium-dependent ATPase subunit beta-1

Research

Bioassay Publications (12)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (8.33)	18.7374
1990's	3 (25.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	5 (41.67)	24.3611
2020's	0 (0.00)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lansoprazole	Homo sapiens (human)	IC50	39.8107	1	1
omeprazole	Homo sapiens (human)	IC50	31.6228	1	1
pantoprazole	Homo sapiens (human)	IC50	199.5260	1	1
digoxigenin	Homo sapiens (human)	Ki	0.1345	1	2
digoxigenin-bis(digitoxoside)	Homo sapiens (human)	Ki	0.1350	1	2
rostafuroxin	Homo sapiens (human)	IC50	1.5000	1	1
ouabain	Homo sapiens (human)	IC50	6.0000	1	1
ouabain	Homo sapiens (human)	Ki	0.0935	1	2
digitoxin	Homo sapiens (human)	IC50	0.0080	1	1
digoxin	Homo sapiens (human)	IC50	0.3350	2	2
digoxin	Homo sapiens (human)	Ki	0.1220	1	2
digitoxigenin	Homo sapiens (human)	IC50	0.1673	5	6
phakellistatin 2	Homo sapiens (human)	IC50	100.0000	1	1
digitoxigenin monodigitoxoside	Homo sapiens (human)	IC50	0.0070	1	1
evomonoside	Homo sapiens (human)	IC50	0.0058	1	2
halisulfate 1	Homo sapiens (human)	IC50	3.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ouabain	Homo sapiens (human)	LC50	9.4000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
ATPase activator activity	molecular function	Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]
P-type sodium:potassium-exchanging transporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). [EC:7.2.2.13]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
MHC class II protein complex binding	molecular function	Binding to a class II major histocompatibility complex. [GOC:mtg_signal, GOC:vw]
protein-macromolecule adaptor activity	molecular function	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
ATPase binding	molecular function	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]

Located In

This protein is located in 12 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
intercalated disc	cellular component	A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
lateral plasma membrane	cellular component	The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]
T-tubule	cellular component	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]
organelle membrane	cellular component	A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. [GOC:dos, GOC:mah]
sperm flagellum	cellular component	A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. [GOC:cilia, GOC:sart, PMID:8441407]
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
extracellular vesicle	cellular component	Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
sodium:potassium-exchanging ATPase complex	cellular component	Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]

Involved In

This protein is involved in 28 target(s):

Target	Category	Definition
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
intracellular sodium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
establishment or maintenance of transmembrane electrochemical gradient	biological process	The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]
regulation of gene expression	biological process	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
regulation of cardiac muscle contraction by calcium ion signaling	biological process	Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. [GOC:BHF, GOC:dph, GOC:tb]
intracellular potassium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah]
positive regulation of ATP-dependent activity	biological process	Any process that activates or increases the rate of an ATP-dependent activity. [GOC:mah]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
sodium ion export across plasma membrane	biological process	The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]
protein transport into plasma membrane raft	biological process	The directed movement of a protein into a plasma membrane raft. [GOC:jl]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
ATP metabolic process	biological process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
protein stabilization	biological process	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]
relaxation of cardiac muscle	biological process	The process in which the extent of cardiac muscle contraction is reduced. [GOC:ecd]
cardiac muscle contraction	biological process	Muscle contraction of cardiac muscle tissue. [GOC:dph]
protein localization to plasma membrane	biological process	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]
membrane repolarization	biological process	The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane repolarization during cardiac muscle cell action potential	biological process	The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
cell communication by electrical coupling involved in cardiac conduction	biological process	The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
monoatomic cation transmembrane transport	biological process	The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. [GOC:dos, GOC:vw]
positive regulation of potassium ion transmembrane transporter activity	biological process	Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
positive regulation of sodium ion export across plasma membrane	biological process	Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720]
positive regulation of calcium:sodium antiporter activity	biological process	Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity. [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723]
positive regulation of potassium ion import across plasma membrane	biological process	Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]
positive regulation of P-type sodium:potassium-exchanging transporter activity	biological process	Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
potassium ion import across plasma membrane	biological process	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]