Page last updated: 2024-08-22

n-methylaspartate and Necrosis

n-methylaspartate has been researched along with Necrosis in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (7.81)	18.7374
1990's	27 (42.19)	18.2507
2000's	26 (40.63)	29.6817
2010's	5 (7.81)	24.3611
2020's	1 (1.56)	2.80

Authors

Authors	Studies
Dvoriantchikova, G; Fleishaker, M; Ivanov, D	1
Amorini, AM; Belli, A; Caruso, G; Ciaccio, M; Di Pietro, V; Lazzarino, G; Scazzone, C; Tavazzi, B; Yakoub, KM	1
Hanig, JP; Liu, F; Patterson, TA; Paule, MG; Rainosek, SW; Sadovova, N; Slikker, W; Wang, C	1
Antonov, SM; Dvoretskova, EA; Evstratova, AA; Mironova, EV	2
Goebel, DJ	1
Baud, O; Destot-Wong, KD; Favrais, G; Gressens, P; Gupta, SK; Lelièvre, V; Liang, K; Mani, S; Pansiot, J; Schwendimann, L; Spedding, M	1
Jantas, D; Jaworska-Feil, L; Lason, W; Lipkowski, AW	1
Desfeux, A; El Ghazi, F; Gonzalez, BJ; Jégou, S; Laudenbach, V; Legros, H; Marret, S	1
Chen, J; Chiang, CW; Song, SK; Zhang, H	1
Anagli, J; Cagmat, EB; Guingab-Cagmat, JD; Kobeissy, FH; Newsom, K; Vakulenko, A; Wang, KK; Zoltewicz, S	1
Beattie, MS; Bresnahan, JC; Burry, RW; Ha, BK; Rogers, RC; Vicini, S	1
Almaas, R; Lindstad, JK; Pleasure, D; Pytte, M; Rootwelt, T; Saugstad, OD; Wright, M	1
Gil, J; Malva, JO; Monteiro, NM; Oliveira, CR; Rego, AC; Silva, AP	1
George, J; Takase, S; Tsutsumi, M	1
Baronti, R; Meli, E; Moroni, F; Pangallo, M; Pellegrini-Giampietro, DE; Picca, R	1
Aono, M; Pearlstein, RD; Warner, DS; Wise-Faberowski, L	1
Chen, Z; Dai, H; Hu, W; Huang, Y; Leurs, R; Luo, J; Shen, Y; Timmerman, H; Zhang, Z; Zhu, Y	1
Chen, Z; Dai, H; Fan, Y; Fu, Q; Hu, W; Shen, Y	1
Inoue, H; Okada, Y	1
Chen, Z; Dai, H; Fu, Q; Hu, W; Leurs, R; Shen, Y; Timmerman, H; Zhang, Z	1
Balázs, R; Lucassen, PJ; van Lookeren Campagne, M; Vermeulen, JP	1
Ankarcrona, M; Bonfoco, E; Krainc, D; Lipton, SA; Nicotera, P	1
Choi, DW; Gwag, BJ; Koh, JY; Lobner, D	1
Gaspary, HL; Graham, SH; Simon, RP	1
Ingvar, M; Meller, D; Schmidt-Kastner, R	1
Auer, RN; Coulter, KC	1
Balázs, R; Berkelbach van der Sprenkel, JW; Nicolay, K; Tulleken, CA; van Lookeren Campagne, M; Verheul, HB	1
Farber, N; Fix, AS; Horn, JW; Johnson, CA; Long, GG; Olney, JW; Storts, RW; Wightman, KA; Wozniak, DF	1
Auer, RN	1
Clapp, I; Laidlaw, S; Mitchell, IJ; Waters, CM	1
Balázs, R; Boer, GJ; Nicolay, K; Van Lookeren Campagne, M; Verheul, HB; Vermeulen, JP	1
Catani, MV; Corasaniti, MT; Finazzi-Agrò, A; Melino, G; Navarra, M; Nisticò, G	1
Esclaire, F; Hugon, J; Lesort, M; Yardin, C	1
Choi, DW; Hsu, CY; Jacquin, MF; Kanellopoulos, GK; Kato, H; Kouchoukos, NT; Matsuo, S; Wu, YJ	1
Alcantara, F; Kirchgessner, AL; Liu, MT	1
Basile, AS; Fossom, L; Goping, G; Sei, Y; Skolnick, P	1
Chan, PH; Espanol, MT; Hasegawa, K; Litt, L; Sharp, FR	1
Benshoff, N; Dikranian, K; Jevtović-Todorović, V; Mennerick, S; Olney, JW; Powell, S; Todorović, SM; Zorumski, CF	1
Bossenmeyer, C; Chihab, R; Daval, JL; Oillet, J	1
Marsala, M; Vanický, I; Yaksh, TL	1
Auer, RN; Colbourne, F; Rakić, D	1
Battaglia, G; Bruno, V; Catania, MV; Di Grezia, R; Kingston, A; Nicoletti, F; O'Neill, MJ	1
Gwag, BJ; Jou, I; Ko, HW; Noh, JS; Ryu, BR	1
Choi, DW; Costa, E; Gwag, BJ; Hartley, DM; Jou, I; Ryu, BR	1
Cole, DJ; Drummond, JC; Harada, H; Kelly, PJ; Patel, PM	1
Calderó, J; Esquerda, JE; Lladó, J; Oppenheim, RW; Ribera, J; Tarabal, O	1
DeGregorio-Rocasolano, N; Gasull, T; Trullas, R; Zapata, A	1
Chan, SL; Glazner, GW; Lu, C; Mattson, MP	1
Gwag, BJ; Han, KS; Jung, YK; Kim, EY; Kim, SU; Ko, HW; Ryu, BR; Yoon, WJ	1
Barbieri, I; Basudev, H; Brusa, R; Casati, C; Grilli, M; Lozza, G; Ongini, E	1
Bittigau, P; Hansen, HH; Hansen, HS; Hansen, SH; Ikonomidou, C	1
Asrari, M; Lobner, D	1
Bushell, T; Cromie, W; Lee, RC; Marks, JD; Pan, CY	1
Ali, C; Buisson, A; Docagne, F; MacKenzie, ET; Nicole, O; Plawinski, L; Vivien, D	1
Avanzini, G; Ientile, R; Macaione, V; Oteri, G; Pedale, S; Pisani, F; Torre, V	1
Ientile, R; Macaione, S; Macaione, V; Pedale, S; Teletta, M; Torre, V	1
Anastasio, N; Hultman, M; Johnson, KM; McInnis, J; Salvemini, D; Wang, C; Ye, Y	1
Labruyere, J; Olney, JW; Price, MT; Zorumski, C	1
Acuff, CG; Clower, BR; Rockhold, RW	1
Labruyere, J; Olney, JW; Price, MT; Samson, L	1
Beart, PM; Christie, MJ; James, LB	1
Wieloch, T	1
Garthwaite, G; Garthwaite, J	1

Other Studies

64 other study(ies) available for n-methylaspartate and Necrosis

Article	Year
Molecular mechanisms of NMDA excitotoxicity in the retina. Scientific reports, 2023, 10-27, Volume: 13, Issue:1 Topics: Animals; Free Radicals; Inflammation; Iron; Mice; N-Methylaspartate; Necrosis; Retina; Retinal Diseases	2023
Fructose-1,6-Bisphosphate Protects Hippocampal Rat Slices from NMDA Excitotoxicity. International journal of molecular sciences, 2019, May-07, Volume: 20, Issue:9 Topics: Animals; Energy Metabolism; Fructose-Bisphosphatase; Fructose-Bisphosphate Aldolase; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; N-Methylaspartate; Necrosis; Neuroprotective Agents; Phosphofructokinases; Purine Nucleosides; Rats; Rats, Wistar	2019
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells. Molecular neurobiology, 2015, Volume: 52, Issue:2 Topics: Animals; Apoptosis; Astrocytes; Calcium; Cell Division; Cells, Cultured; Cerebral Cortex; Culture Media; DNA Damage; Dose-Response Relationship, Drug; Extracellular Fluid; Glycine; Intercellular Signaling Peptides and Proteins; Ketamine; Mitochondria; N-Methylaspartate; Necrosis; Nerve Degeneration; Neural Stem Cells; Neurogenesis; Neurons; Oligodendroglia; Rats; Rats, Sprague-Dawley	2015
[Apoptosis and its receptor selective pathways during neurotoxic action of glutamate]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2008, Volume: 94, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Tumor Suppressor Protein p53	2008
Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons. Brain research, 2009, Feb-23, Volume: 1256 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caspase 3; Cell Death; Cell Membrane; Cell Survival; Enzyme Activation; Male; N-Methylaspartate; Necrosis; Peptides; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Retinal Neurons; Signal Transduction	2009
Apoptosis and the receptor specificity of its mechanisms during the neurotoxic action of glutamate. Neuroscience and behavioral physiology, 2009, Volume: 39, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Tumor Suppressor Protein p53	2009
The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology, 2009, Volume: 57, Issue:3 Topics: Animals; Animals, Newborn; Apoptosis; Benzothiadiazines; Brain; Brain Diseases; Brain-Derived Neurotrophic Factor; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Male; Mice; N-Methylaspartate; Necrosis; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors	2009
Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents. Neuropeptides, 2009, Volume: 43, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins c-akt; Quisqualic Acid; Staurosporine; Thyrotropin-Releasing Hormone	2009
Dual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates. Cerebral cortex (New York, N.Y. : 1991), 2010, Volume: 20, Issue:5 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Calcium; Caspase 3; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Interneurons; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mice; Mice, Transgenic; N-Methylaspartate; Necrosis; RNA, Small Interfering	2010
Cell swelling contributes to thickening of low-dose N-methyl-D-aspartate-induced retinal edema. Investigative ophthalmology & visual science, 2012, May-09, Volume: 53, Issue:6 Topics: Animals; Apoptosis; Capillary Permeability; Contrast Media; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Excitatory Amino Acid Agonists; Gadolinium DTPA; In Situ Nick-End Labeling; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Necrosis; Papilledema; Retina; Retinal Vessels	2012
In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system. Electrophoresis, 2012, Volume: 33, Issue:24 Topics: Animals; Apoptosis; Biomarkers; Brain Injuries; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Glial Fibrillary Acidic Protein; Marine Toxins; Mass Spectrometry; N-Methylaspartate; Necrosis; Neuroglia; Neurons; Oxocins; Protein Interaction Maps; Proteomics; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Ubiquitin Thiolesterase	2012
Kainate-induced excitotoxicity is dependent upon extracellular potassium concentrations that regulate the activity of AMPA/KA type glutamate receptors. Journal of neurochemistry, 2002, Volume: 83, Issue:4 Topics: Animals; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Space; Fluorescent Antibody Technique; N-Methylaspartate; Necrosis; Neurons; Patch-Clamp Techniques; Potassium; Rats; Rats, Long-Evans; Receptors, AMPA	2002
Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation. Journal of neurochemistry, 2003, Volume: 84, Issue:5 Topics: Acidosis; Apoptosis; Caspase Inhibitors; Cell Death; Cell Hypoxia; Cell Line; Cell Nucleus; Cell Survival; Culture Media; DNA Fragmentation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Free Radicals; Glucose; Humans; Hydrogen-Ion Concentration; N-Methylaspartate; Necrosis; Neurons; Oxygen; Poly(ADP-ribose) Polymerases; Staurosporine	2003
Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures. Journal of neurochemistry, 2003, Volume: 86, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Caspases; Cells, Cultured; Cytochrome c Group; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Mitochondria; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Superoxide Dismutase; Superoxides	2003
Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats. The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:2 Topics: Actins; Animals; Body Weight; Dimethylnitrosamine; Fibrosis; Hyaluronan Receptors; Hyaluronic Acid; Immunohistochemistry; Liver; Male; Muscle, Smooth; N-Methylaspartate; Necrosis; Nitrosamines; Organ Size; Rats; Time Factors	2004
Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Molecular and cellular neurosciences, 2004, Volume: 25, Issue:1 Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; Models, Biological; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases	2004
Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. Anesthesia and analgesia, 2004, Volume: 99, Issue:6 Topics: Anesthetics, Inhalation; Animals; Apoptosis; Caspase 3; Caspases; Cell Nucleus; Coculture Techniques; Culture Media; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Isoflurane; N-Methylaspartate; Necrosis; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley	2004
Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor/cyclic AMP/protein kinase A and H receptor/GABA release pathways. Journal of neurochemistry, 2006, Volume: 96, Issue:5 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Apoptosis; Bicuculline; Cell Survival; Cells, Cultured; Cerebellar Cortex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Histamine; Histamine Agonists; Histamine Antagonists; N-Methylaspartate; Necrosis; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Histamine; Time Factors	2006
Neuroprotective effect of carnosine on necrotic cell death in PC12 cells. Neuroscience letters, 2007, Mar-06, Volume: 414, Issue:2 Topics: Animals; Carnosine; Central Nervous System; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Histamine H1 Antagonists; Methylhistidines; Mitochondria; N-Methylaspartate; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Pyrilamine; Rats; Receptors, Histamine H1	2007
Roles of volume-sensitive chloride channel in excitotoxic neuronal injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Feb-07, Volume: 27, Issue:6 Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Apoptosis; Benzothiadiazines; Bicuculline; Bumetanide; Cell Size; Cells, Cultured; Cerebral Cortex; Chlorides; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glycolates; Ion Channels; Mice; Mice, Inbred C57BL; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Nitrobenzoates; Patch-Clamp Techniques; Phloretin; Picrotoxin; Potassium Channel Blockers; Potassium Channels; Quinine; Receptors, N-Methyl-D-Aspartate; Sodium Chloride Symporter Inhibitors; Sodium Chloride Symporters; Somatosensory Cortex; Tetrodotoxin	2007
The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3 Topics: Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Histamine Agonists; Histamine Antagonists; Imidazoles; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Thiourea	2007
NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain. The European journal of neuroscience, 1995, Jul-01, Volume: 7, Issue:7 Topics: Animals; Animals, Newborn; Apoptosis; Brain; Dizocilpine Maleate; DNA Damage; Electrophoresis, Agar Gel; Genetic Techniques; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Necrosis; Neuroprotective Agents; Nucleosomes; Rats; Time Factors	1995
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings of the National Academy of Sciences of the United States of America, 1995, Aug-01, Volume: 92, Issue:16 Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine; DNA; Free Radicals; Kinetics; Molsidomine; N-Methylaspartate; Necrosis; Neurons; Nitrates; Nitric Oxide; Oxidative Stress; Rats; S-Nitrosothiols; Superoxide Dismutase; Superoxides	1995
Potentiated necrosis of cultured cortical neurons by neurotrophins. Science (New York, N.Y.), 1995, Apr-28, Volume: 268, Issue:5210 Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Mice; N-Methylaspartate; Necrosis; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotrophin 3; Quinoxalines; Receptors, AMPA	1995
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis. European journal of pharmacology, 1994, Sep-12, Volume: 262, Issue:3 Topics: Analysis of Variance; Animals; Binding, Competitive; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; N-Methylaspartate; Necrosis; Neurons; Observer Variation; Pipecolic Acids; Prosencephalon; Pyrimidines; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Receptors, AMPA; Reperfusion Injury	1994
Immunohistochemical markers for neurons and astrocytes show pan-necrosis following infusion of high-dose NMDA into rat cortex. Experimental neurology, 1994, Volume: 128, Issue:2 Topics: Animals; Astrocytes; Biomarkers; Cerebral Cortex; Dose-Response Relationship, Drug; Immunohistochemistry; Injections; Lactates; Male; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Wounds, Stab	1994
The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801. Acta neuropathologica, 1994, Volume: 87, Issue:1 Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Endoplasmic Reticulum; Gyrus Cinguli; Male; Microscopy, Electron; Mitochondria; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Time Factors; Vacuoles	1994
Temporal evolution of NMDA-induced excitoxicity in the neonatal rat brain measured with 1H nuclear magnetic resonance imaging. Brain research, 1993, Aug-06, Volume: 618, Issue:2 Topics: Animals; Animals, Newborn; Brain Diseases; Corpus Striatum; Diffusion; Dizocilpine Maleate; Histocytochemistry; Magnetic Resonance Spectroscopy; Microinjections; N-Methylaspartate; Necrosis; Rats	1993
Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex. Experimental neurology, 1993, Volume: 123, Issue:2 Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Male; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Vacuoles	1993
Effect of age and sex on N-methyl-D-aspartate antagonist-induced neuronal necrosis in rats. Stroke, 1996, Volume: 27, Issue:4 Topics: Age Factors; Animals; Brain; Cerebrovascular Disorders; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Gyrus Cinguli; Humans; Male; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Sex Factors	1996
Excitotoxic neurotoxicity in an in vitro brain slice model. Biochemical Society transactions, 1995, Volume: 23, Issue:4 Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ketamine; Mice; N-Methylaspartate; Necrosis; Receptors, N-Methyl-D-Aspartate	1995
Developmental changes in NMDA-induced cell swelling and its transition to necrosis measured with 1H magnetic resonance imaging, impedance and histology. Brain research. Developmental brain research, 1996, May-31, Volume: 93, Issue:1-2 Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Cell Size; Excitatory Amino Acid Agonists; Extracellular Space; Hydrogen; Magnetic Resonance Imaging; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Rats; Water	1996
NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain. Biochemical and biophysical research communications, 1996, Dec-04, Volume: 229, Issue:1 Topics: Calcium; Calpain; Cell Death; Cell Nucleus; Cysteine Proteinase Inhibitors; Enzyme Activation; HIV Envelope Protein gp120; Humans; N-Methylaspartate; Necrosis; Neuroblastoma; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Tumor Cells, Cultured	1996
NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells. Neuroscience letters, 1997, Jan-17, Volume: 221, Issue:2-3 Topics: Amyloid beta-Protein Precursor; Animals; Apoptosis; Cells, Cultured; Excitatory Amino Acid Agonists; Extracellular Space; Immunohistochemistry; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar	1997
Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: effects on necrosis and apoptosis. The Journal of thoracic and cardiovascular surgery, 1997, Volume: 114, Issue:4 Topics: Animals; Apoptosis; Cycloheximide; Dextrorphan; Excitatory Amino Acid Antagonists; Male; Microscopy, Electron; N-Methylaspartate; Necrosis; Neurons; Paraplegia; Premedication; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Spinal Cord; Time Factors	1997
Excitotoxicity in the enteric nervous system. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-15, Volume: 17, Issue:22 Topics: Animals; Antibody Specificity; Apoptosis; Cells, Cultured; Enteric Nervous System; Excitatory Amino Acid Agonists; Ganglia; Glutamic Acid; Guinea Pigs; Kainic Acid; Male; Membrane Potentials; Mitochondria; N-Methylaspartate; Necrosis; Neurites; Neurons; Neurotoxins; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate	1997
Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis. Neuroscience letters, 1998, Jan-30, Volume: 241, Issue:2-3 Topics: Animals; Apoptosis; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley	1998
Expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices during NMDA-induced necrosis and apoptosis. Brain research, 1998, Mar-02, Volume: 785, Issue:2 Topics: Animals; Animals, Newborn; Apoptosis; Cerebral Cortex; Dizocilpine Maleate; DNA Fragmentation; Genes, fos; HSP70 Heat-Shock Proteins; In Vitro Techniques; N-Methylaspartate; Necrosis; Neurons; Perfusion; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transcription, Genetic	1998
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature medicine, 1998, Volume: 4, Issue:4 Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Neurotoxins; Nitrous Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism	1998
Glutamate triggers cell death specifically in mature central neurons through a necrotic process. Molecular genetics and metabolism, 1998, Volume: 63, Issue:2 Topics: Animals; Cell Death; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Necrosis; Nerve Tissue Proteins; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; Time Factors	1998
Neurodegeneration induced by reversed microdialysis of NMDA; a quantitative model for excitotoxicity in vivo. Brain research, 1998, Apr-13, Volume: 789, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Drug Combinations; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Magnesium; Male; Microdialysis; N-Methylaspartate; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Somatosensory Cortex	1998
The effects of temperature and scopolamine on N-methyl-D-aspartate antagonist-induced neuronal necrosis in the rat. Neuroscience, 1999, Volume: 90, Issue:1 Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Female; Gyrus Cinguli; Hot Temperature; Hypothermia, Induced; Male; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Olfactory Pathways; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Scopolamine; Sex Characteristics; Stereotaxic Techniques	1999
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept Neuropharmacology, 1999, Volume: 38, Issue:2 Topics: Animals; Astrocytes; Benzoates; Caudate Nucleus; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fetus; Gerbillinae; Glycine; Ischemic Attack, Transient; Male; Mice; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiophenes	1999
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I. Journal of neurobiology, 1999, Jun-15, Volume: 39, Issue:4 Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin	1999
Attenuation of cortical neuronal apoptosis by gangliosides. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2 Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Cyclosporine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; G(M1) Ganglioside; Gangliosides; Ionomycin; Mice; N-Methylaspartate; Necrosis; Neurons; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases	1999
Isoflurane reduces N-methyl-D-aspartate toxicity in vivo in the rat cerebral cortex. Anesthesia and analgesia, 1999, Volume: 89, Issue:6 Topics: Anesthetics, Inhalation; Animals; Binding, Competitive; Cerebral Cortex; Cerebral Infarction; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoflurane; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate	1999
Opposing effects of excitatory amino acids on chick embryo spinal cord motoneurons: excitotoxic degeneration or prevention of programmed cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-15, Volume: 19, Issue:24 Topics: Animals; Apoptosis; Chick Embryo; Down-Regulation; Drug Tolerance; Excitatory Amino Acid Agonists; Motor Neurons; N-Methylaspartate; Necrosis; Nerve Degeneration; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors	1999
Choline release and inhibition of phosphatidylcholine synthesis precede excitotoxic neuronal death but not neurotoxicity induced by serum deprivation. The Journal of biological chemistry, 2000, Jun-16, Volume: 275, Issue:24 Topics: Animals; Blood; Cell Death; Cells, Cultured; Cerebellum; Cerebral Cortex; Choline; Cytidine Diphosphate Choline; Glutamic Acid; Hydrolysis; Membrane Lipids; N-Methylaspartate; Necrosis; Neurons; Phosphatidylcholines; Phospholipids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2000
Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, May-15, Volume: 20, Issue:10 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Caspases; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; N-Methylaspartate; Necrosis; Neocortex; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptosomes	2000
Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neurons. Journal of neurochemistry, 2000, Volume: 74, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetus; Imidazoles; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Receptors, N-Methyl-D-Aspartate; tau Proteins	2000
Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage. The European journal of neuroscience, 2000, Volume: 12, Issue:7 Topics: Animals; Brain; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glucose; Infarction, Middle Cerebral Artery; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Oxygen; Recombinant Proteins; Tumor Necrosis Factor-alpha	2000
Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death. Journal of neurochemistry, 2001, Volume: 76, Issue:1 Topics: Animals; Apoptosis; Arachidonic Acids; Brain Injuries; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Endocannabinoids; Ethanolamines; Male; N-Methylaspartate; Necrosis; Neurodegenerative Diseases; Neurons; Phospholipids; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Species Specificity; Wounds, Nonpenetrating	2001
Calcitonin potentiates oxygen-glucose deprivation-induced neuronal death. Experimental neurology, 2001, Volume: 167, Issue:1 Topics: Animals; Apoptosis; Calcitonin; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glucose; Hypoxia-Ischemia, Brain; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Neurons; Oxygen; Receptors, AMPA; Salmon; Staurosporine	2001
Amphiphilic, tri-block copolymers provide potent membrane-targeted neuroprotection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:6 Topics: Animals; Apoptosis Inducing Factor; Calcium; Cell Membrane; Cell Membrane Structures; Cytoprotection; Drug Interactions; Excitatory Amino Acid Agonists; Flavoproteins; Lipid Peroxidation; Membrane Proteins; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Poloxamer; Rats; Receptors, N-Methyl-D-Aspartate	2001
Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, May-01, Volume: 21, Issue:9 Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; Calcium; Cerebral Cortex; Chelating Agents; Drosophila Proteins; Fluorescent Dyes; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glycosylphosphatidylinositols; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidation-Reduction; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; RNA, Messenger	2001
Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retina. Experimental neurology, 2001, Volume: 170, Issue:1 Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase; Lamotrigine; N-Methylaspartate; Necrosis; Neuroprotective Agents; Phenethylamines; Retina; Retinal Ganglion Cells; Triazines	2001
Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina. Journal of neurochemistry, 2001, Volume: 79, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Chick Embryo; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Necrosis; Receptors, Glutamate; Retina	2001
The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apoptosis. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cells, Cultured; Electrophoretic Mobility Shift Assay; Excitatory Amino Acid Agonists; N-Methylaspartate; Necrosis; NF-kappa B; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides	2002
L-cysteine, a bicarbonate-sensitive endogenous excitotoxin. Science (New York, N.Y.), 1990, May-04, Volume: 248, Issue:4955 Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Bicarbonates; Caudate Nucleus; Chick Embryo; Cysteine; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; Zinc	1990
Excitotoxin-induced myocardial necrosis. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Animals; Aspartic Acid; Blood Pressure; Cardiomyopathies; Heart Rate; Hypothalamus, Middle; Injections; Injections, Intraventricular; Kainic Acid; Male; Myocardium; N-Methylaspartate; Necrosis; Rats; Rats, Inbred Strains	1989
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina. Brain research bulletin, 1985, Volume: 14, Issue:4 Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Nicotinic Acids; Nimodipine; Pyrrolidines; Retina	1985
An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray. Brain research bulletin, 1986, Volume: 16, Issue:1 Topics: Animals; Aspartic Acid; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Necrosis; Neurotransmitter Agents; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synaptosomes	1986
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Science (New York, N.Y.), 1985, Nov-08, Volume: 230, Issue:4726 Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Electroencephalography; Hypoglycemia; Male; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1985
Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration. Neuroscience letters, 1986, May-15, Volume: 66, Issue:2 Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Golgi Apparatus; Granulocytes; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Osmolar Concentration; Rats; Receptors, Amino Acid; Receptors, Cell Surface	1986