Page last updated: 2024-08-07 16:12:04
Acetylcholinesterase
An acetylcholinesterase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22303]
Synonyms
AChE;
EC 3.1.1.7
Research
Bioassay Publications (466)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 5 (1.07) | 18.7374 |
| 1990's | 24 (5.15) | 18.2507 |
| 2000's | 89 (19.10) | 29.6817 |
| 2010's | 271 (58.15) | 24.3611 |
| 2020's | 77 (16.52) | 2.80 |
Compounds (323)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quinacrine | Homo sapiens (human) | IC50 | 2.6670 | 1 | 0 |
| carbamic acid | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
| choline | Homo sapiens (human) | IC50 | 3,013.0100 | 1 | 1 |
| coumarin | Homo sapiens (human) | Ki | 9.3000 | 1 | 1 |
| salicylic acid | Homo sapiens (human) | IC50 | 346.0000 | 1 | 1 |
| 3-cresol | Homo sapiens (human) | IC50 | 2.4729 | 2 | 2 |
| diacetyl | Homo sapiens (human) | Ki | 100.0000 | 3 | 8 |
| thioctic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 2 |
| melatonin | Homo sapiens (human) | IC50 | 0.1000 | 1 | 2 |
| toluene | Homo sapiens (human) | IC50 | 2.4526 | 2 | 2 |
| xanthine | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| huperzine a | Homo sapiens (human) | IC50 | 4.4288 | 4 | 7 |
| huperzine a | Homo sapiens (human) | Ki | 0.3505 | 2 | 3 |
| bw 284 c 51 | Homo sapiens (human) | IC50 | 12.0085 | 3 | 4 |
| 3-methylcholanthrene | Homo sapiens (human) | IC50 | 22.6830 | 1 | 0 |
| 6,7-dichloroquinoxaline-2,3-dione | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 6-methoxytryptoline | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| oxyquinoline | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| tacrine | Homo sapiens (human) | IC50 | 0.2576 | 169 | 187 |
| tacrine | Homo sapiens (human) | Ki | 0.0687 | 18 | 21 |
| ethacridine | Homo sapiens (human) | Ki | 0.4900 | 1 | 1 |
| alendronate | Homo sapiens (human) | IC50 | 27,450.0000 | 1 | 1 |
| alfuzosin | Homo sapiens (human) | IC50 | 0.0180 | 1 | 1 |
| ambenonium | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| benextramine | Homo sapiens (human) | IC50 | 7.2429 | 3 | 3 |
| benzo(a)pyrene | Homo sapiens (human) | IC50 | 28.0000 | 1 | 0 |
| berberine | Homo sapiens (human) | IC50 | 0.4000 | 2 | 2 |
| butenafine | Homo sapiens (human) | IC50 | 6.9071 | 1 | 0 |
| caffeine | Homo sapiens (human) | IC50 | 7.2500 | 1 | 1 |
| chelerythrine | Homo sapiens (human) | IC50 | 1.4500 | 1 | 1 |
| ciglitazone | Homo sapiens (human) | IC50 | 15.0260 | 1 | 0 |
| citalopram | Homo sapiens (human) | IC50 | 73.3000 | 1 | 1 |
| clebopride | Homo sapiens (human) | IC50 | 0.8900 | 1 | 1 |
| clotrimazole | Homo sapiens (human) | IC50 | 19.4100 | 1 | 0 |
| 4-cresol | Homo sapiens (human) | IC50 | 2.4509 | 2 | 2 |
| decamethonium | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| decamethonium | Homo sapiens (human) | Ki | 3,000.2300 | 2 | 2 |
| diazinon | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| dichlorvos | Homo sapiens (human) | IC50 | 1.4685 | 2 | 2 |
| benzophenone | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| donepezil | Homo sapiens (human) | IC50 | 1.0326 | 135 | 141 |
| donepezil | Homo sapiens (human) | Ki | 0.5949 | 10 | 12 |
| dyclonine | Homo sapiens (human) | IC50 | 0.1810 | 1 | 1 |
| ebastine | Homo sapiens (human) | IC50 | 7.4799 | 1 | 0 |
| ebselen | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| econazole | Homo sapiens (human) | IC50 | 13.6770 | 1 | 0 |
| edrophonium | Homo sapiens (human) | Ki | 66.4200 | 2 | 3 |
| profenamine | Homo sapiens (human) | IC50 | 0.2700 | 3 | 4 |
| profenamine | Homo sapiens (human) | Ki | 86.6100 | 1 | 2 |
| fenofibrate | Homo sapiens (human) | IC50 | 15.5510 | 1 | 0 |
| fluoxetine | Homo sapiens (human) | IC50 | 5.0650 | 2 | 2 |
| gallamine triethiodide | Homo sapiens (human) | IC50 | 2,110.0000 | 1 | 1 |
| gallamine triethiodide | Homo sapiens (human) | Ki | 37.0000 | 1 | 1 |
| harmaline | Homo sapiens (human) | IC50 | 23.7000 | 1 | 1 |
| hexachlorophene | Homo sapiens (human) | IC50 | 3.0149 | 1 | 0 |
| huprine x | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| huprine x | Homo sapiens (human) | Ki | 0.0400 | 2 | 3 |
| velnacrine | Homo sapiens (human) | IC50 | 0.8280 | 2 | 2 |
| ibuprofen | Homo sapiens (human) | IC50 | 235.1100 | 1 | 1 |
| memantine | Homo sapiens (human) | IC50 | 0.0049 | 1 | 1 |
| methoctramine | Homo sapiens (human) | IC50 | 5.3703 | 3 | 3 |
| methoxsalen | Homo sapiens (human) | IC50 | 27.3800 | 2 | 2 |
| 3,7-bis(dimethylamino)phenothiazin-5-ium | Homo sapiens (human) | Ki | 0.1100 | 1 | 1 |
| metoclopramide | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| miconazole | Homo sapiens (human) | IC50 | 18.6590 | 1 | 0 |
| minaprine | Homo sapiens (human) | IC50 | 85.0000 | 1 | 1 |
| clorgyline | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| nefazodone | Homo sapiens (human) | IC50 | 1.0370 | 1 | 1 |
| neostigmine | Homo sapiens (human) | IC50 | 1.1000 | 2 | 3 |
| neostigmine | Homo sapiens (human) | Ki | 35.5000 | 1 | 2 |
| nizatidine | Homo sapiens (human) | IC50 | 5.6146 | 1 | 0 |
| quinone | Homo sapiens (human) | Ki | 57.7086 | 2 | 7 |
| papaverine | Homo sapiens (human) | IC50 | 24.3300 | 1 | 1 |
| pentoxifylline | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| 1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate | Homo sapiens (human) | IC50 | 0.0194 | 4 | 8 |
| duodote | Homo sapiens (human) | IC50 | 664.0000 | 4 | 4 |
| procainamide | Homo sapiens (human) | IC50 | 1.0000 | 2 | 2 |
| procainamide | Homo sapiens (human) | Ki | 1.0000 | 1 | 2 |
| propentofylline | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| propidium | Homo sapiens (human) | IC50 | 17.2630 | 1 | 3 |
| propidium | Homo sapiens (human) | Ki | 4.1400 | 2 | 3 |
| propoxur | Homo sapiens (human) | IC50 | 1.4450 | 2 | 2 |
| protopine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| pyridostigmine | Homo sapiens (human) | IC50 | 8,020.0000 | 1 | 2 |
| raloxifene | Homo sapiens (human) | IC50 | 0.4000 | 1 | 0 |
| ranitidine | Homo sapiens (human) | IC50 | 1.4750 | 2 | 2 |
| sanguinarine | Homo sapiens (human) | IC50 | 1.2200 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | IC50 | 145.2400 | 1 | 1 |
| tetraisopropylpyrophosphamide | Homo sapiens (human) | IC50 | 170.2785 | 3 | 4 |
| donepezil hydrochloride | Homo sapiens (human) | IC50 | 0.0431 | 5 | 5 |
| neostigmine methylsulfate | Homo sapiens (human) | IC50 | 23.0536 | 3 | 3 |
| isoflurophate | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| isoflurophate | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| physostigmine | Homo sapiens (human) | IC50 | 0.9114 | 44 | 46 |
| n,n-dimethyltryptamine | Homo sapiens (human) | Ki | 0.0650 | 1 | 1 |
| berlition | Homo sapiens (human) | IC50 | 666.6670 | 3 | 3 |
| ficusin | Homo sapiens (human) | IC50 | 6.4800 | 1 | 1 |
| acenaphthenequinone | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| 5-bromoisatin | Homo sapiens (human) | Ki | 51.3743 | 2 | 7 |
| isatin | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 2-xylene | Homo sapiens (human) | IC50 | 2.4550 | 2 | 2 |
| 3-nitrotoluene | Homo sapiens (human) | IC50 | 2.4520 | 2 | 2 |
| 4-nitrotoluene | Homo sapiens (human) | IC50 | 2.5000 | 2 | 2 |
| pyridostigmine bromide | Homo sapiens (human) | IC50 | 13.5700 | 3 | 3 |
| 4-methyl anisole | Homo sapiens (human) | IC50 | 4.2654 | 2 | 2 |
| 4-xylene | Homo sapiens (human) | IC50 | 2.4699 | 2 | 2 |
| 4-toluidine | Homo sapiens (human) | IC50 | 2.4682 | 2 | 2 |
| 3-xylene | Homo sapiens (human) | IC50 | 2.4510 | 2 | 2 |
| neostigmine bromide | Homo sapiens (human) | IC50 | 0.1112 | 11 | 10 |
| edrophonium chloride | Homo sapiens (human) | IC50 | 3.2080 | 5 | 5 |
| edrophonium chloride | Homo sapiens (human) | Ki | 2.3414 | 6 | 7 |
| chloranil | Homo sapiens (human) | Ki | 0.1317 | 2 | 6 |
| benzoin | Homo sapiens (human) | Ki | 76.1838 | 4 | 8 |
| dibenzoylmethane | Homo sapiens (human) | Ki | 71.6583 | 2 | 6 |
| benzethonium chloride | Homo sapiens (human) | IC50 | 2.2460 | 1 | 0 |
| benzil | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| benzil | Homo sapiens (human) | Ki | 75.0136 | 7 | 12 |
| sterogenol | Homo sapiens (human) | IC50 | 2.7530 | 1 | 0 |
| acridines | Homo sapiens (human) | IC50 | 6.8400 | 1 | 1 |
| edrophonium bromide | Homo sapiens (human) | IC50 | 1.8399 | 3 | 3 |
| edrophonium bromide | Homo sapiens (human) | Ki | 0.0016 | 1 | 1 |
| paraoxon | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| galantamine | Homo sapiens (human) | IC50 | 27.8215 | 71 | 75 |
| galantamine | Homo sapiens (human) | Ki | 0.1685 | 4 | 4 |
| benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide | Homo sapiens (human) | IC50 | 0.0276 | 5 | 5 |
| benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide | Homo sapiens (human) | Ki | 0.1238 | 8 | 8 |
| rhein | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| vasicinone | Homo sapiens (human) | IC50 | 76.6000 | 1 | 1 |
| carvacrol | Homo sapiens (human) | IC50 | 283.6000 | 1 | 1 |
| 1,3-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 2 | 7 |
| dibromsalicil | Homo sapiens (human) | Ki | 66.6877 | 2 | 6 |
| 1,2-naphthoquinone | Homo sapiens (human) | Ki | 0.3200 | 2 | 2 |
| decamethonium dibromide | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| gentian violet | Homo sapiens (human) | IC50 | 5.8470 | 1 | 0 |
| jkl 1073a | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 1-acetylisatin | Homo sapiens (human) | Ki | 89.3333 | 2 | 6 |
| 1-phenyl-1,2-propanedione | Homo sapiens (human) | Ki | 58.8629 | 3 | 7 |
| 2,3-pentanedione | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 5-methylisatin | Homo sapiens (human) | Ki | 87.7000 | 2 | 6 |
| Berberine chloride (TN) | Homo sapiens (human) | IC50 | 4.7060 | 4 | 3 |
| 1,2-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| ethylestrenol | Homo sapiens (human) | IC50 | 6.5040 | 1 | 0 |
| chlormequat | Homo sapiens (human) | IC50 | 2,387.8100 | 1 | 1 |
| 3-hydroxyphenyltrimethylammonium | Homo sapiens (human) | IC50 | 0.9728 | 1 | 1 |
| 4-octylphenol | Homo sapiens (human) | IC50 | 11.4710 | 1 | 0 |
| n-methylisatin | Homo sapiens (human) | Ki | 73.9300 | 2 | 6 |
| thioflavin t | Homo sapiens (human) | Ki | 3.2033 | 2 | 3 |
| butyrylcholine | Homo sapiens (human) | IC50 | 229.0870 | 1 | 1 |
| palmatine | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| 9-amino-6-chloro-2-methoxyacridine | Homo sapiens (human) | Ki | 0.0490 | 1 | 1 |
| butyrylthiocholine | Homo sapiens (human) | IC50 | 125.8930 | 1 | 1 |
| imidocarb | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| n-methylacridine | Homo sapiens (human) | Ki | 0.3100 | 1 | 1 |
| selegiline | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| metergoline | Homo sapiens (human) | IC50 | 1.3440 | 1 | 0 |
| acetylacetone | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| thiocholine | Homo sapiens (human) | IC50 | 439.5420 | 1 | 1 |
| 5-Methoxyisatin | Homo sapiens (human) | Ki | 87.7833 | 2 | 6 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | Homo sapiens (human) | IC50 | 2,090.7000 | 2 | 2 |
| closantel | Homo sapiens (human) | IC50 | 2.9510 | 1 | 0 |
| bambuterol | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| zifrosilone | Homo sapiens (human) | IC50 | 0.1889 | 2 | 2 |
| irinotecan | Homo sapiens (human) | IC50 | 1.8270 | 1 | 0 |
| irinotecan | Homo sapiens (human) | Ki | 0.0505 | 1 | 1 |
| 3-methyl-1,2-cyclopentanedione | Homo sapiens (human) | Ki | 85.9500 | 2 | 6 |
| xanthyletine | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| pralidoxime iodide | Homo sapiens (human) | IC50 | 995.7000 | 1 | 1 |
| pralidoxime iodide | Homo sapiens (human) | Ki | 180.0000 | 1 | 1 |
| geneserine | Homo sapiens (human) | IC50 | 0.1040 | 2 | 3 |
| physostigmine heptyl | Homo sapiens (human) | IC50 | 0.0349 | 9 | 11 |
| physostigmine heptyl | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| isoimperatorin | Homo sapiens (human) | IC50 | 69.0000 | 1 | 1 |
| alpha-furil | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 3,4-dimethoxytoluene | Homo sapiens (human) | IC50 | 4.4405 | 2 | 2 |
| 2,3-trimethylene-4-quinazolone | Homo sapiens (human) | IC50 | 60.0533 | 3 | 3 |
| 4-benzoylbenzoic acid | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| adrenoglomerulotropin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| sr 95191 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| hesperetin | Homo sapiens (human) | IC50 | 2,476.1000 | 1 | 1 |
| chelerythrine chloride | Homo sapiens (human) | IC50 | 1.5400 | 1 | 1 |
| chelerythrine chloride | Homo sapiens (human) | Ki | 0.7200 | 2 | 2 |
| lycorine | Homo sapiens (human) | IC50 | 177.5000 | 2 | 2 |
| 1,10-phenanthroline-5,6-dione | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| 1,2,3,6-tetragalloylglucose | Homo sapiens (human) | IC50 | 11.8600 | 1 | 1 |
| nodakenin | Homo sapiens (human) | IC50 | 68.0000 | 1 | 1 |
| 2-chloranil | Homo sapiens (human) | Ki | 2.3150 | 2 | 6 |
| 3,5-di-tert-butyl-1,2-benzoquinone | Homo sapiens (human) | Ki | 50.3624 | 2 | 6 |
| rivastigmine | Homo sapiens (human) | IC50 | 4.7159 | 49 | 54 |
| hexyltrimethylammonium | Homo sapiens (human) | IC50 | 816.5820 | 1 | 1 |
| 5-Chloro-1H-indole-2,3-dione | Homo sapiens (human) | Ki | 53.4150 | 2 | 6 |
| 5-iodoisatin | Homo sapiens (human) | Ki | 58.4767 | 2 | 6 |
| 2,2-dimethoxy-2-phenylacetophenone | Homo sapiens (human) | Ki | 85.8833 | 2 | 6 |
| trimethyl(4-oxopentyl)ammonium | Homo sapiens (human) | IC50 | 84.7227 | 1 | 1 |
| 1-phenazinecarboxylic acid | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| anisoin | Homo sapiens (human) | Ki | 85.6500 | 2 | 6 |
| hydrobenzoin | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| malabaricone c | Homo sapiens (human) | IC50 | 1.9400 | 1 | 1 |
| malabaricone c | Homo sapiens (human) | Ki | 5.8600 | 1 | 1 |
| rimonabant | Homo sapiens (human) | IC50 | 25.1189 | 1 | 1 |
| propidium iodide | Homo sapiens (human) | IC50 | 26.8108 | 13 | 13 |
| propidium iodide | Homo sapiens (human) | Ki | 7.1400 | 1 | 1 |
| methoctramine | Homo sapiens (human) | IC50 | 5.3703 | 1 | 1 |
| deguelin | Homo sapiens (human) | IC50 | 126.7000 | 1 | 1 |
| territrem b | Homo sapiens (human) | IC50 | 0.0072 | 3 | 3 |
| territrem b | Homo sapiens (human) | Ki | 0.0017 | 2 | 2 |
| tephrosin | Homo sapiens (human) | IC50 | 127.1800 | 1 | 1 |
| tanshinone | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| tanshinone | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| 7-methoxytacrine | Homo sapiens (human) | IC50 | 11.7273 | 11 | 11 |
| 7-methoxytacrine | Homo sapiens (human) | Ki | 4.2150 | 4 | 4 |
| razadyne | Homo sapiens (human) | IC50 | 3.2000 | 3 | 3 |
| profenamine hydrochloride | Homo sapiens (human) | IC50 | 1,020.0000 | 3 | 3 |
| profenamine hydrochloride | Homo sapiens (human) | Ki | 4,854.8800 | 5 | 5 |
| 1,3-indandione | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| glabranin | Homo sapiens (human) | IC50 | 0.0064 | 1 | 1 |
| dihydrosanguinarine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| gamma-carboline | Homo sapiens (human) | IC50 | 21.4000 | 1 | 1 |
| quilostigmine | Homo sapiens (human) | IC50 | 0.1480 | 1 | 1 |
| barbigerone | Homo sapiens (human) | IC50 | 121.6000 | 1 | 1 |
| miltirone | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| cryptotanshinone | Homo sapiens (human) | Ki | 53.2050 | 2 | 2 |
| territrem c | Homo sapiens (human) | IC50 | 0.0068 | 1 | 1 |
| ar-turmerone | Homo sapiens (human) | IC50 | 191.1000 | 1 | 1 |
| asimilobine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| malabaricone b | Homo sapiens (human) | IC50 | 1.8400 | 1 | 1 |
| malabaricone b | Homo sapiens (human) | Ki | 4.3300 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | IC50 | 140.0000 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| chonemorphine | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| magnolin | Homo sapiens (human) | IC50 | 0.9030 | 1 | 1 |
| rs 67333 | Homo sapiens (human) | IC50 | 0.4030 | 2 | 2 |
| aflatoxin b1 | Homo sapiens (human) | Ki | 28.0000 | 1 | 1 |
| phenserine | Homo sapiens (human) | IC50 | 0.4837 | 8 | 10 |
| latrepirdine | Homo sapiens (human) | IC50 | 45.0000 | 1 | 1 |
| zanapezil | Homo sapiens (human) | IC50 | 0.2650 | 3 | 3 |
| tv3326 | Homo sapiens (human) | IC50 | 210.0543 | 4 | 7 |
| taspine | Homo sapiens (human) | IC50 | 0.5400 | 1 | 1 |
| ml 204 | Homo sapiens (human) | IC50 | 0.8400 | 1 | 1 |
| 5-Fluoroisatin | Homo sapiens (human) | Ki | 100.0000 | 2 | 7 |
| berbamine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| papaverinol | Homo sapiens (human) | IC50 | 10.7300 | 1 | 1 |
| N-butyl-1H-benzimidazol-2-amine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| malabaricone a | Homo sapiens (human) | IC50 | 1.3100 | 1 | 1 |
| marmesin | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
| aromoline | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3-(1-dimethylaminoethyl)phenol | Homo sapiens (human) | Ki | 16.8500 | 1 | 2 |
| naringenin | Homo sapiens (human) | IC50 | 2,045.0000 | 1 | 1 |
| eriodictyol | Homo sapiens (human) | IC50 | 1,663.8000 | 1 | 1 |
| obamegine | Homo sapiens (human) | IC50 | 97.0000 | 1 | 1 |
| terconazole | Homo sapiens (human) | IC50 | 21.5730 | 1 | 0 |
| hemanthamine | Homo sapiens (human) | IC50 | 276.0000 | 2 | 2 |
| physovenine | Homo sapiens (human) | IC50 | 0.0155 | 2 | 2 |
| decursin | Homo sapiens (human) | IC50 | 390.0000 | 1 | 1 |
| decursinol | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| Girgensonine | Homo sapiens (human) | IC50 | 93.0000 | 1 | 1 |
| 3-deoxyvasicine | Homo sapiens (human) | IC50 | 2.3700 | 1 | 1 |
| yangambin | Homo sapiens (human) | IC50 | 0.6160 | 1 | 1 |
| 1-O-Acetyllycorine | Homo sapiens (human) | IC50 | 0.9600 | 1 | 1 |
| 1-O-Acetyllycorine | Homo sapiens (human) | Ki | 0.4300 | 1 | 1 |
| floxacillin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| pseudolycorine | Homo sapiens (human) | IC50 | 187.6300 | 1 | 1 |
| sanguinine | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| lycoramine | Homo sapiens (human) | IC50 | 20.0700 | 1 | 1 |
| e-z cinnamic acid | Homo sapiens (human) | IC50 | 9,900.0000 | 1 | 1 |
| resveratrol | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| diethylstilbestrol | Homo sapiens (human) | IC50 | 25.5500 | 1 | 0 |
| ganoderiol f | Homo sapiens (human) | IC50 | 21.8400 | 1 | 1 |
| licoricidin | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| propolin c | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| propolin c | Homo sapiens (human) | Ki | 8.4000 | 1 | 1 |
| physostigmine salicylate | Homo sapiens (human) | IC50 | 0.0280 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | IC50 | 2,825.5000 | 2 | 2 |
| 3-(3,4-dimethoxyphenyl)propenoic acid | Homo sapiens (human) | IC50 | 7,204.0000 | 1 | 1 |
| huperzine a | Homo sapiens (human) | IC50 | 2.1226 | 5 | 5 |
| deltoin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| 1-(3-chloro-4-methoxyphenyl)-3-[2-(4-methyl-1-piperidinyl)ethyl]thiourea | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| capsaicin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione | Homo sapiens (human) | Ki | 18.1938 | 2 | 6 |
| tacrine hydrochloride | Homo sapiens (human) | IC50 | 0.3163 | 8 | 8 |
| tacrine hydrochloride | Homo sapiens (human) | Ki | 0.1630 | 2 | 2 |
| jnj-5207852 | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Ganodermanontriol | Homo sapiens (human) | IC50 | 22.3100 | 1 | 1 |
| n,n'-4-xylylenebis(pyridinium) | Homo sapiens (human) | IC50 | 1,540.0000 | 1 | 1 |
| azilect | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| rasagiline | Homo sapiens (human) | IC50 | 0.0190 | 1 | 1 |
| ungeremine | Homo sapiens (human) | IC50 | 3.8500 | 1 | 1 |
| 5-Nitroisatin | Homo sapiens (human) | Ki | 84.4050 | 2 | 6 |
| quercetin | Homo sapiens (human) | Ki | 38.3000 | 1 | 1 |
| apigenin | Homo sapiens (human) | Ki | 121.6000 | 1 | 1 |
| luteolin | Homo sapiens (human) | Ki | 65.8000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | IC50 | 168.6000 | 2 | 2 |
| rutin | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | Ki | 92.8000 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | IC50 | 14,550.0000 | 2 | 2 |
| fisetin | Homo sapiens (human) | Ki | 100.2000 | 1 | 1 |
| galangin | Homo sapiens (human) | Ki | 85.6000 | 1 | 1 |
| myricetin | Homo sapiens (human) | Ki | 37.8000 | 1 | 1 |
| 4'-hydroxychalcone | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| rosmarinic acid | Homo sapiens (human) | IC50 | 1,220.0000 | 1 | 1 |
| 7-demethylsuberosin | Homo sapiens (human) | IC50 | 2,400.0000 | 1 | 1 |
| 5,7-dihydroxy-4',6-dimethoxyflavone | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| su 11248 | Homo sapiens (human) | IC50 | 5.8700 | 1 | 1 |
| oxiconazole | Homo sapiens (human) | IC50 | 4.6465 | 1 | 0 |
| huperzine b | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| mimulone | Homo sapiens (human) | IC50 | 91.5000 | 1 | 1 |
| mimulone | Homo sapiens (human) | Ki | 120.5000 | 1 | 1 |
| 4-hydroxylonchocarpin | Homo sapiens (human) | IC50 | 23.3500 | 2 | 2 |
| 4-hydroxylonchocarpin | Homo sapiens (human) | Ki | 7.3900 | 1 | 1 |
| ciproxifan | Homo sapiens (human) | IC50 | 86.1000 | 2 | 2 |
| bis(7)-tacrine | Homo sapiens (human) | IC50 | 0.0011 | 8 | 8 |
| bis(7)-tacrine | Homo sapiens (human) | Ki | 0.0016 | 2 | 4 |
| cyclophostin | Homo sapiens (human) | IC50 | 0.0286 | 3 | 3 |
| cyclophostin | Homo sapiens (human) | Ki | 0.1400 | 1 | 1 |
| phenethylcymserine | Homo sapiens (human) | IC50 | 22.5015 | 3 | 4 |
| ganstigmine | Homo sapiens (human) | IC50 | 0.1467 | 2 | 3 |
| ap 2238 | Homo sapiens (human) | IC50 | 8.9273 | 10 | 11 |
| ap 2238 | Homo sapiens (human) | Ki | 0.0217 | 2 | 2 |
| cymserine | Homo sapiens (human) | IC50 | 0.4808 | 8 | 10 |
| memoquin | Homo sapiens (human) | IC50 | 9.0839 | 10 | 10 |
| memoquin | Homo sapiens (human) | Ki | 0.0026 | 3 | 3 |
| tolserine | Homo sapiens (human) | IC50 | 0.4988 | 6 | 8 |
| pf9601n | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| endophenazine a | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| caproctamine | Homo sapiens (human) | IC50 | 0.1633 | 10 | 10 |
| caproctamine | Homo sapiens (human) | Ki | 0.0694 | 3 | 3 |
| huprine y | Homo sapiens (human) | IC50 | 0.0350 | 9 | 14 |
| pazopanib | Homo sapiens (human) | IC50 | 0.9300 | 1 | 1 |
| hupc protein, bacteria | Homo sapiens (human) | IC50 | 0.4890 | 1 | 1 |
| arisugacin | Homo sapiens (human) | IC50 | 0.0010 | 4 | 4 |
| 6-chlorotacrine | Homo sapiens (human) | IC50 | 0.0535 | 20 | 22 |
| 4-Methoxylonchocarpin | Homo sapiens (human) | IC50 | 74.7100 | 1 | 1 |
| xanthostigmine | Homo sapiens (human) | IC50 | 0.0362 | 9 | 11 |
| montanine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| lipocrine | Homo sapiens (human) | IC50 | 10.0014 | 9 | 9 |
| lipocrine | Homo sapiens (human) | Ki | 0.1550 | 1 | 1 |
| Dihydrotanshinone I | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Dihydrotanshinone I | Homo sapiens (human) | Ki | 25.8250 | 4 | 4 |
| ganodermadiol | Homo sapiens (human) | IC50 | 26.7800 | 1 | 1 |
| lucidenic acid a | Homo sapiens (human) | IC50 | 24.0400 | 1 | 1 |
| 6-methoxydihydrosanguinarine | Homo sapiens (human) | IC50 | 96.8000 | 1 | 1 |
| lucidenic acid n | Homo sapiens (human) | IC50 | 25.9100 | 1 | 1 |
| tanshinone ii a sodium sulfonate | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| ass234 | Homo sapiens (human) | IC50 | 1.0933 | 6 | 6 |
| ganoderic acid y | Homo sapiens (human) | IC50 | 21.1050 | 2 | 2 |
| donecopride | Homo sapiens (human) | IC50 | 0.0160 | 4 | 4 |
| donecopride | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
| pralidoxime | Homo sapiens (human) | IC50 | 878.0000 | 1 | 1 |
| pyridine-2-aldoxime | Homo sapiens (human) | IC50 | 560.0000 | 1 | 1 |
| 2-hydroxyphenazine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| asoxime chloride | Homo sapiens (human) | IC50 | 154.5000 | 6 | 6 |
| asoxime chloride | Homo sapiens (human) | Ki | 25.0000 | 1 | 1 |
| pralidoxime chloride | Homo sapiens (human) | IC50 | 784.8571 | 7 | 7 |
| discorhabdin l | Homo sapiens (human) | IC50 | 158.0000 | 1 | 1 |
| trimedoxime bromide | Homo sapiens (human) | IC50 | 167.0000 | 1 | 1 |
| obidoxime chloride | Homo sapiens (human) | IC50 | 964.0000 | 6 | 6 |
Drugs with Activation Measurements
Drugs with Other Measurements
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells.Bioorganic chemistry, , Volume: 68, 2016
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.European journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model.RSC medicinal chemistry, , Aug-17, Volume: 13, Issue:8, 2022
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies.RSC medicinal chemistry, , Dec-14, Volume: 13, Issue:12, 2022
Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
[no title available]RSC medicinal chemistry, , Jul-20, Volume: 13, Issue:7, 2022
Isatoic anhydrides as novel inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
[no title available]Journal of natural products, , 06-24, Volume: 85, Issue:6, 2022
[no title available]Journal of medicinal chemistry, , 07-08, Volume: 64, Issue:13, 2021
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 43, 2021
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.Bioorganic & medicinal chemistry, , 01-15, Volume: 30, 2021
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.Journal of medicinal chemistry, , 09-10, Volume: 63, Issue:17, 2020
Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 30, Issue:24, 2020
Search for new multi-target compounds against Alzheimer's disease among histamine HEuropean journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 30, Issue:24, 2020
Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 30, Issue:9, 2020
Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum.Bioorganic & medicinal chemistry, , 01-15, Volume: 27, Issue:2, 2019
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.Journal of medicinal chemistry, , 10-24, Volume: 62, Issue:20, 2019
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.Bioorganic & medicinal chemistry, , 09-15, Volume: 27, Issue:18, 2019
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 29, Issue:24, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.European journal of medicinal chemistry, , Mar-25, Volume: 148, 2018
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
[no title available]ACS medicinal chemistry letters, , Mar-08, Volume: 9, Issue:3, 2018
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.Bioorganic & medicinal chemistry, , 09-01, Volume: 26, Issue:16, 2018
[no title available]Journal of medicinal chemistry, , 02-22, Volume: 61, Issue:4, 2018
Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.Journal of natural products, , 05-26, Volume: 80, Issue:5, 2017
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.Bioorganic & medicinal chemistry, , 11-01, Volume: 25, Issue:21, 2017
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
5-Methyl-MedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:5, 2016
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEuropean journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Iminosugars as a new class of cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum.Journal of natural products, , Dec-24, Volume: 78, Issue:12, 2015
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 25, Issue:14, 2015
Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.Bioorganic chemistry, , Volume: 61, 2015
Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives.Bioorganic chemistry, , Volume: 60, 2015
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.European journal of medicinal chemistry, , Feb-12, Volume: 73, 2014
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.Journal of medicinal chemistry, , Aug-28, Volume: 57, Issue:16, 2014
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Coumarin hybrids as novel therapeutic agents.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.Journal of medicinal chemistry, , Oct-09, Volume: 57, Issue:19, 2014
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 23, Issue:23, 2013
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry, , Jul-15, Volume: 21, Issue:14, 2013
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 54, 2012
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.European journal of medicinal chemistry, , Volume: 52, 2012
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:8, 2011
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.Journal of medicinal chemistry, , Apr-28, Volume: 54, Issue:8, 2011
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 21, Issue:9, 2011
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.Journal of medicinal chemistry, , Jul-08, Volume: 53, Issue:13, 2010
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.European journal of medicinal chemistry, , Volume: 45, Issue:3, 2010
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 20, Issue:20, 2010
Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism.Journal of medicinal chemistry, , Feb-11, Volume: 53, Issue:3, 2010
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.Bioorganic & medicinal chemistry, , Oct-01, Volume: 17, Issue:19, 2009
Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.Journal of natural products, , Volume: 72, Issue:6, 2009
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 18, Issue:19, 2008
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.Journal of medicinal chemistry, , Aug-14, Volume: 51, Issue:15, 2008
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.Journal of medicinal chemistry, , Dec-27, Volume: 50, Issue:26, 2007
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.Journal of natural products, , Volume: 70, Issue:9, 2007
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Rational approach to discover multipotent anti-Alzheimer drugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.Journal of medicinal chemistry, , Jan-13, Volume: 48, Issue:1, 2005
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.Chemistry & biology, , Volume: 10, Issue:4, 2003
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.Bioorganic & medicinal chemistry, , Volume: 8, Issue:3, 2000
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Aminopyridazines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.Journal of medicinal chemistry, , Jul-21, Volume: 38, Issue:15, 1995
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
[no title available],
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.Journal of natural products, , 02-22, Volume: 82, Issue:2, 2019
Isolation of cholinesterase and β-secretase 1 inhibiting compounds from Lycopodiella cernua.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies.RSC medicinal chemistry, , Dec-14, Volume: 13, Issue:12, 2022
Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.European journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
[no title available]RSC medicinal chemistry, , Jul-20, Volume: 13, Issue:7, 2022
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
[no title available]Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 09-15, Volume: 46, 2021
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation.European journal of medicinal chemistry, , Apr-05, Volume: 215, 2021
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HTEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.European journal of medicinal chemistry, , Oct-15, Volume: 222, 2021
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.European journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in thEuropean journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.Bioorganic & medicinal chemistry, , 01-15, Volume: 30, 2021
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease.European journal of medicinal chemistry, , Jul-15, Volume: 198, 2020
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.Journal of medicinal chemistry, , 12-24, Volume: 63, Issue:24, 2020
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 30, Issue:17, 2020
Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease.European journal of medicinal chemistry, , Jul-15, Volume: 198, 2020
Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 28, Issue:22, 2020
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Structure-activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Search for new multi-target compounds against Alzheimer's disease among histamine HEuropean journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors.European journal of medicinal chemistry, , Apr-01, Volume: 191, 2020
MicroRNA-Based Multitarget Approach for Alzheimer's Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis.Journal of medicinal chemistry, , 09-10, Volume: 63, Issue:17, 2020
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 30, Issue:24, 2020
Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 192, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019
Design and development of novel N-(pyrimidin-2-yl)-1,3,4-oxadiazole hybrids to treat cognitive dysfunctions.Bioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Indazolylketones as new multitarget cannabinoid drugs.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, β-amyloid aggregation and oxidative stress to treat Alzheimer's disease.Bioorganic & medicinal chemistry, , 08-15, Volume: 27, Issue:16, 2019
Novel multi target-directed ligands targeting 5-HTEuropean journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Novel multitarget-directed ligands targeting acetylcholinesterase and σEuropean journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 28, Issue:17, 2018
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.European journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , 01-01, Volume: 25, Issue:1, 2017
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 27, Issue:17, 2017
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Jun-16, Volume: 133, 2017
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease.MedChemComm, , Jul-01, Volume: 8, Issue:7, 2017
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:5, 2016
Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies.Bioorganic chemistry, , Volume: 67, 2016
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Apr-01, Volume: 24, Issue:7, 2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Stacking with No Planarity?ACS medicinal chemistry letters, , Apr-14, Volume: 7, Issue:4, 2016
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEuropean journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors.ACS medicinal chemistry letters, , May-12, Volume: 7, Issue:5, 2016
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.Journal of medicinal chemistry, , Apr-09, Volume: 58, Issue:7, 2015
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.Bioorganic chemistry, , Volume: 61, 2015
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.European journal of medicinal chemistry, , Feb-12, Volume: 73, 2014
Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 22, Issue:19, 2014
Synthesis of α, β-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid β-induced cytotoxicity.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 67, 2013
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 21, Issue:3, 2013
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.European journal of medicinal chemistry, , Volume: 63, 2013
Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.European journal of medicinal chemistry, , Volume: 57, 2012
Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 22, Issue:14, 2012
Synthesis and biological evaluation of 3-thiazolocoumarinyl Schiff-base derivatives as cholinesterase inhibitors.Chemical biology & drug design, , Volume: 80, Issue:4, 2012
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.Journal of medicinal chemistry, , Apr-28, Volume: 54, Issue:8, 2011
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 21, Issue:9, 2011
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.European journal of medicinal chemistry, , Volume: 45, Issue:3, 2010
Substituted spiro [2.3'] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 20, Issue:23, 2010
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.Bioorganic & medicinal chemistry, , Mar-01, Volume: 18, Issue:5, 2010
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.Journal of medicinal chemistry, , Aug-26, Volume: 53, Issue:16, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:3, 2009
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.Bioorganic & medicinal chemistry letters, , Sep-16, Volume: 12, Issue:18, 2002
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Aug-16, Volume: 44, Issue:17, 2001
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Aminopyridazines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Probing the peripheral site of human butyrylcholinesterase.Biochemistry, , Sep-11, Volume: 51, Issue:36, 2012
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.Journal of medicinal chemistry, , Oct-09, Volume: 57, Issue:19, 2014
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Synthesis and biological evaluation of 3-thiazolocoumarinyl Schiff-base derivatives as cholinesterase inhibitors.Chemical biology & drug design, , Volume: 80, Issue:4, 2012
The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:2, 2011
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Probing the peripheral site of human butyrylcholinesterase.Biochemistry, , Sep-11, Volume: 51, Issue:36, 2012
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE.Bioorganic & medicinal chemistry letters, , 07-15, Volume: 27, Issue:14, 2017
Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.Journal of natural products, , Dec-26, Volume: 77, Issue:12, 2014
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.European journal of medicinal chemistry, , Volume: 63, 2013
Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.Bioorganic & medicinal chemistry, , Jul-01, Volume: 18, Issue:13, 2010
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies.RSC medicinal chemistry, , Dec-14, Volume: 13, Issue:12, 2022
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 51, 2021
[no title available]Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
Neuroprotective effects of prenylated flavanones isolated from Dalea species, in vitro and in silico studies.European journal of medicinal chemistry, , Nov-15, Volume: 206, 2020
Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase.Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
Natural cholinesterase inhibitors from Myristica cinnamomea King.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 26, Issue:15, 2016
Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.Journal of medicinal chemistry, , Mar-10, Volume: 59, Issue:5, 2016
Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies.Bioorganic chemistry, , Volume: 64, 2016
Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 23, Issue:14, 2013
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.Bioorganic & medicinal chemistry, , Jul-01, Volume: 18, Issue:13, 2010
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 16, Issue:22, 2006
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jan-04, Volume: 44, Issue:1, 2001
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Syntheses and anticholinesterase activities of (3aS)-N1, N8-bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine.Journal of medicinal chemistry, , Jun-18, Volume: 41, Issue:13, 1998
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.Journal of medicinal chemistry, , Aug-29, Volume: 40, Issue:18, 1997
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-31, Volume: 38, Issue:7, 1995
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.Journal of medicinal chemistry, , Jul-21, Volume: 38, Issue:15, 1995
Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.Journal of medicinal chemistry, , Volume: 33, Issue:9, 1990
[no title available],
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:11, 2011
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Rational approach to discover multipotent anti-Alzheimer drugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.Bioorganic & medicinal chemistry, , Jul-01, Volume: 18, Issue:13, 2010
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: deBioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.European journal of medicinal chemistry, , Volume: 44, Issue:10, 2009
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.Journal of medicinal chemistry, , Jul-24, Volume: 51, Issue:14, 2008
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation.Bioorganic & medicinal chemistry letters, , Mar-11, Volume: 12, Issue:5, 2002
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
[no title available],
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.European journal of medicinal chemistry, , Volume: 46, Issue:2, 2011
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies.RSC medicinal chemistry, , Dec-14, Volume: 13, Issue:12, 2022
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.Bioorganic & medicinal chemistry, , 07-15, Volume: 42, 2021
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 51, 2021
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Structure-activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer's disease.RSC medicinal chemistry, , Feb-01, Volume: 11, Issue:2, 2020
Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors.European journal of medicinal chemistry, , Apr-01, Volume: 191, 2020
Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase.Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Design, synthesis and cholinesterase inhibitory activity of novel spiropyrrolidine tethered imidazole heterocyclic hybrids.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 30, Issue:2, 2020
Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 29, Issue:10, 2019
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.Journal of natural products, , 02-22, Volume: 82, Issue:2, 2019
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.Journal of medicinal chemistry, , 01-11, Volume: 61, Issue:1, 2018
Mucroniferanines A-G, Isoquinoline Alkaloids from Corydalis mucronifera.Journal of natural products, , 02-23, Volume: 81, Issue:2, 2018
A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera.Journal of natural products, , 08-24, Volume: 81, Issue:8, 2018
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 27, Issue:2, 2017
Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata.Journal of natural products, , 09-22, Volume: 80, Issue:9, 2017
Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:5, 2016
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.Journal of natural products, , Feb-26, Volume: 79, Issue:2, 2016
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Sulfonamides as multifunctional agents for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Ionic liquid mediated synthesis of mono- and bis-spirooxindole-hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-15, Volume: 22, Issue:4, 2014
Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Coumarin hybrids as novel therapeutic agents.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 22, Issue:19, 2014
Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.Journal of natural products, , Apr-25, Volume: 77, Issue:4, 2014
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Oct-10, Volume: 56, Issue:19, 2013
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 23, Issue:10, 2013
Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.Journal of natural products, , Jul-27, Volume: 75, Issue:7, 2012
Prospective acetylcholinesterase inhibitory activity of indole and its analogs.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 22, Issue:8, 2012
Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 22, Issue:14, 2012
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
Biotransformation of turmerones by Aspergillus niger.Journal of natural products, , Jan-28, Volume: 74, Issue:1, 2011
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 21, Issue:9, 2011
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Phytochemical investigations of Stemona curtisii and synthetic studies on stemocurtisine alkaloids.Journal of natural products, , Nov-29, Volume: 73, Issue:11, 2010
Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity.Journal of natural products, , Nov-29, Volume: 73, Issue:11, 2010
Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.Journal of natural products, , Mar-27, Volume: 72, Issue:3, 2009
Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.Journal of natural products, , Volume: 71, Issue:8, 2008
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.Journal of natural products, , Volume: 70, Issue:9, 2007
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 16, Issue:22, 2006
Isoquinoline derivatives as potential acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.Journal of natural products, , Volume: 69, Issue:9, 2006
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products.Journal of medicinal chemistry, , Dec-02, Volume: 47, Issue:25, 2004
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.Bioorganic & medicinal chemistry letters, , Sep-16, Volume: 12, Issue:18, 2002
The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'.Journal of natural products, , Volume: 63, Issue:6, 2000
[no title available],
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.European journal of medicinal chemistry, , Volume: 46, Issue:2, 2011
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.European journal of medicinal chemistry, , Oct-01, Volume: 203, 2020
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
[no title available],
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Probing the peripheral site of human butyrylcholinesterase.Biochemistry, , Sep-11, Volume: 51, Issue:36, 2012
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:4, 2011
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 04-01, Volume: 61, 2022
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.European journal of medicinal chemistry, , May-26, Volume: 132, 2017
Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.Journal of medicinal chemistry, , 12-13, Volume: 61, Issue:23, 2018
Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase.Bioorganic & medicinal chemistry, , 08-15, Volume: 25, Issue:16, 2017
Nonquaternary cholinesterase reactivators. Dialkylaminoalkyl thioesters of alpha-ketothiohydroximic acids as reactivators of diisopropyl phosphorofluoridate inhibited acetylcholinesterase.Journal of medicinal chemistry, , Volume: 24, Issue:10, 1981
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.European journal of medicinal chemistry, , Nov-10, Volume: 140, 2017
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 18, Issue:13, 2008
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.European journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
[no title available]Journal of medicinal chemistry, , 09-22, Volume: 65, Issue:18, 2022
Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model.RSC medicinal chemistry, , Aug-17, Volume: 13, Issue:8, 2022
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 04-01, Volume: 35, 2021
Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study.Bioorganic & medicinal chemistry, , 06-15, Volume: 40, 2021
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HTEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.European journal of medicinal chemistry, , Oct-15, Volume: 222, 2021
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , May-15, Volume: 194, 2020
Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 11-15, Volume: 28, Issue:22, 2020
Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.Journal of medicinal chemistry, , 10-24, Volume: 62, Issue:20, 2019
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Indazolylketones as new multitarget cannabinoid drugs.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.Journal of medicinal chemistry, , 10-24, Volume: 62, Issue:20, 2019
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.Journal of medicinal chemistry, , 01-11, Volume: 61, Issue:1, 2018
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors.Bioorganic & medicinal chemistry, , 01-01, Volume: 25, Issue:1, 2017
[no title available]European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.European journal of medicinal chemistry, , Feb-12, Volume: 73, 2014
Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.Journal of medicinal chemistry, , Oct-09, Volume: 57, Issue:19, 2014
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?ACS medicinal chemistry letters, , Mar-08, Volume: 3, Issue:3, 2012
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:11, 2011
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 21, Issue:9, 2011
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.Journal of medicinal chemistry, , May-22, Volume: 51, Issue:10, 2008
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 16, Issue:22, 2006
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
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Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.Journal of medicinal chemistry, , Nov-17, Volume: 48, Issue:23, 2005
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.Journal of medicinal chemistry, , Jan-13, Volume: 48, Issue:1, 2005
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
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Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 43, 2021
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.Journal of medicinal chemistry, , Aug-28, Volume: 57, Issue:16, 2014
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 55, 2012
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 20, Issue:20, 2010
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Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.European journal of medicinal chemistry, , Volume: 46, Issue:2, 2011
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Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.ACS medicinal chemistry letters, , Nov-14, Volume: 4, Issue:11, 2013
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
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Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 55, 2012
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Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
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Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin.Bioorganic & medicinal chemistry, , Dec-15, Volume: 23, Issue:24, 2015
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Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.Bioorganic & medicinal chemistry, , 08-01, Volume: 25, Issue:15, 2017
Coumarin derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies.Bioorganic & medicinal chemistry, , 10-01, Volume: 24, Issue:19, 2016
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Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.Journal of medicinal chemistry, , Jun-05, Volume: 46, Issue:12, 2003
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.Journal of medicinal chemistry, , Oct-09, Volume: 57, Issue:19, 2014
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 23, Issue:23, 2013
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:11, 2011
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Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.Journal of medicinal chemistry, , Aug-26, Volume: 53, Issue:16, 2010
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Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.Journal of medicinal chemistry, , Apr-06, Volume: 49, Issue:7, 2006
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease.European journal of medicinal chemistry, , May-01, Volume: 169, 2019
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.European journal of medicinal chemistry, , Volume: 45, Issue:3, 2010
Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.Journal of medicinal chemistry, , Aug-26, Volume: 53, Issue:16, 2010
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.Journal of medicinal chemistry, , Jan-13, Volume: 48, Issue:1, 2005
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jan-04, Volume: 44, Issue:1, 2001
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
[no title available]Journal of medicinal chemistry, , 01-14, Volume: 64, Issue:1, 2021
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 24, Issue:23, 2014
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.Bioorganic & medicinal chemistry, , Oct-01, Volume: 22, Issue:19, 2014
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.Journal of medicinal chemistry, , 03-22, Volume: 61, Issue:6, 2018
A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , May-01, Volume: 21, Issue:9, 2011
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Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 43, 2021
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.Journal of medicinal chemistry, , 04-22, Volume: 64, Issue:8, 2021
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.Journal of medicinal chemistry, , 09-10, Volume: 63, Issue:17, 2020
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 25, Issue:7, 2015
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.European journal of medicinal chemistry, , Volume: 45, Issue:3, 2010
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 240, 2022
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Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.European journal of medicinal chemistry, , Volume: 45, Issue:3, 2010
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
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Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Success stories of natural product-based hybrid molecules for multi-factorial diseases.European journal of medicinal chemistry, , May-10, Volume: 151, 2018
Oxidative stress in Alzheimer's disease: are we connecting the dots?Journal of medicinal chemistry, , Apr-10, Volume: 57, Issue:7, 2014
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:11, 2011
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Multi-target-directed ligands to combat neurodegenerative diseases.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Rational approach to discover multipotent anti-Alzheimer drugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.ACS medicinal chemistry letters, , Nov-14, Volume: 4, Issue:11, 2013
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 30, Issue:3, 2020
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Multi-target design strategies for the improved treatment of Alzheimer's disease.European journal of medicinal chemistry, , Aug-15, Volume: 176, 2019
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.Journal of medicinal chemistry, , Dec-26, Volume: 57, Issue:24, 2014
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y.European journal of medicinal chemistry, , Jul-15, Volume: 174, 2019
Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Design, synthesis and evaluation of 2-(2-oxoethyl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 72, 2022
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease.European journal of medicinal chemistry, , May-01, Volume: 169, 2019
Novel multitarget-directed ligands targeting acetylcholinesterase and σEuropean journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.Journal of medicinal chemistry, , Apr-09, Volume: 58, Issue:7, 2015
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.Journal of medicinal chemistry, , 12-13, Volume: 61, Issue:23, 2018
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Oct-10, Volume: 56, Issue:19, 2013
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Molecular modeling-guided optimization of acetylcholinesterase reactivators: A proof for reactivation of covalently inhibited targets.European journal of medicinal chemistry, , Apr-05, Volume: 215, 2021
Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.Journal of medicinal chemistry, , 11-22, Volume: 60, Issue:22, 2017
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).Bioorganic & medicinal chemistry, , May-01, Volume: 22, Issue:9, 2014
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication.Journal of medicinal chemistry, , Volume: 34, Issue:4, 1991
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxicationJournal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.Journal of medicinal chemistry, , Volume: 29, Issue:11, 1986
Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 24, Issue:19, 2014
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.Journal of medicinal chemistry, , 03-24, Volume: 65, Issue:6, 2022
Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.Journal of medicinal chemistry, , 11-22, Volume: 60, Issue:22, 2017
Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).Bioorganic & medicinal chemistry, , May-01, Volume: 22, Issue:9, 2014
New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 24, Issue:24, 2014
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Enables
This protein enables 10 target(s):
| Target | Category | Definition |
|---|
| amyloid-beta binding | molecular function | Binding to an amyloid-beta peptide/protein. [GOC:hjd] |
| acetylcholinesterase activity | molecular function | Catalysis of the reaction: acetylcholine + H2O = choline + acetate. [EC:3.1.1.7] |
| cholinesterase activity | molecular function | Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. [EC:3.1.1.8] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| collagen binding | molecular function | Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732] |
| hydrolase activity | molecular function | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732] |
| serine hydrolase activity | molecular function | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase] |
| acetylcholine binding | molecular function | Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| laminin binding | molecular function | Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. [GOC:ecd] |
Located In
This protein is located in 13 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| basement membrane | cellular component | A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. [ISBN:0198547684, PMID:22505934] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| neuromuscular junction | cellular component | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. [GOC:nln] |
| synaptic cleft | cellular component | The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| side of membrane | cellular component | A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos] |
Involved In
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|
| acetylcholine catabolic process in synaptic cleft | biological process | The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission. [GOC:ai] |
| regulation of receptor recycling | biological process | Any process that modulates the frequency, rate, or extent of receptor recycling. [GOC:add] |
| osteoblast development | biological process | The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. [GOC:dph] |
| acetylcholine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. [GOC:jl, ISBN:0192800752] |
| cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| nervous system development | biological process | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh] |
| synapse assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). [GOC:mah] |
| receptor internalization | biological process | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] |
| negative regulation of synaptic transmission, cholinergic | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. [GOC:mah] |
| amyloid precursor protein metabolic process | biological process | The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators] |
| positive regulation of protein secretion | biological process | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai] |
| retina development in camera-type eye | biological process | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. [GOC:bf, GOC:dph, ISBN:0815340729] |
| acetylcholine receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. [GOC:mah] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |