| ID Source | ID |
|---|---|
| PubMed CID | 159278 |
| CHEMBL ID | 465208 |
| CHEBI ID | 9009 |
| SCHEMBL ID | 148079 |
| MeSH ID | M0053645 |
| Synonym |
|---|
| AC-6071 |
| 2-(4-hydroxyphenyl)ethyl beta-d-glucopyranoside |
| beta-d-glucopyranoside, 2-(4-hydroxyphenyl)ethyl |
| glucopyranoside, p-hydroxyphenethyl |
| rhodosin |
| rhodioloside |
| 10338-51-9 |
| tyrosol glucoside |
| C06046 |
| p-hydroxyphenethyl alcohol 1-o-beta-d-glucoside |
| salidroside |
| ACON1_000366 |
| MEGXP0_000478 |
| NCGC00169145-01 |
| BRD-K66030860-001-01-0 |
| nsc-741643 |
| nsc741643 |
| bdbm50269651 |
| chebi:9009 , |
| CHEMBL465208 , |
| (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol |
| A800725 |
| 8-o-b-d-glucoside of tyrosol |
| tox21_113565 |
| dtxcid9028960 |
| dtxsid4049034 , |
| cas-10338-51-9 |
| unii-m983h6n1s9 |
| nsc 741643 |
| m983h6n1s9 , |
| SALIDROSIDE - RHODIOLOSIDE |
| (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol |
| sallidroside |
| beta-d-glucopyranoside, 2-(4-hydroxyphenyl)ethyl- |
| salidroside, (-)- |
| AKOS015895134 |
| S2396 |
| smr001294679 |
| MLS006010734 |
| SCHEMBL148079 |
| tox21_113565_1 |
| CS-5300 |
| HY-N0109 |
| Q-100031 |
| salidroside [usp-rs] |
| tyrosol .alpha.-(.beta.-d-glucopyranoside) |
| 2-(4-hydroxyphenyl)ethyl-.beta.-d-glucopyranoside |
| salidroside (constituent of rhodiola rosea) [dsc] |
| .beta.-d-glucopyranoside, 2-(4-hydroxyphenyl)ethyl- |
| (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahydro-2h-pyran-3,4,5-triol |
| 2-(4-hydroxyphenyl)ethyl ?-d-glucopyranoside |
| p-hydroxyphenethyl glucopyranoside |
| salidroside (rhodioloside) |
| 4-hydroxyphenyl-2-ethylglucopyranoside |
| (2r,3r,4s,5s,6r)-2-[2-(4-hydroxyphenyl)ethoxy]-6-methylol-tetrahydropyran-3,4,5-triol |
| salidroside, united states pharmacopeia (usp) reference standard |
| salidroside, analytical standard |
| salidroside, primary pharmaceutical reference standard |
| salidroside, >=95% (lc/ms-elsd) |
| NCGC00169145-03 |
| SW219124-1 |
| (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6- |
| salidroside,(s) |
| pyran-3,4,5-triol |
| (4-hydroxyphenethoxy)tetrahydro-2h- |
| Q7404463 |
| AMY22501 |
| HMS3884N15 |
| CCG-267467 |
| salidroside (constituent of rhodiola rosea) |
| tyrosol alpha-(beta-d-glucopyranoside) |
| salidroside (usp-rs) |
Rhodioloside is a glucoside of tyrosol isolated from Rhodiola rosea.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Rhodioloside is a glucoside of tyrosol isolated from Rhodiola rosea. " | ( Modulation of hepatic lipidome by rhodioloside in high-fat diet fed apolipoprotein E knockout mice. Chen, YY; Jiang, MM; Liang, QQ; Lu, JX; Shi, H; Wen, SY; Wu, Q; Yao, ZH; Zhu, Y, 2020) | 2.28 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " With confirmation from further toxicity studies, salidroside would hopefully prove to be a safe anti-Coxsackie virus agent." | ( Evaluation of salidroside in vitro and in vivo genotoxicity. Ma, X; Wan, X; Zhang, T; Zheng, Y; Zhu, J; Zhu, Y, 2010) | 0.36 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The objective of the present study is to investigate the pharmacological mechanism of action of SAL on intestinal IR injury using a network pharmacology approach combined with experimental validation." | ( Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion. Chai, YH; Chen, F; Leng, YF; Liu, YQ; Shi, YJ; Zhang, F; Zhang, JM; Zhang, Y, 2023) | 0.91 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cultured NRK52E cells were divided into control group, Co group and Co plus salidroside treatment groups at a dosage of 10 micromol/L, 50 micromol/L, and 100 micromol/L." | ( [Effects of salidroside on tubular epithelial to myofibroblast transition under cobaltous chloride induced hypoxic status]. Fan, JM; Li, FY; Liu, C; Xie, XS; Zhang, HP; Zhang, L, 2010) | 0.36 |
| " Several important parameters influencing purification efficiency including sample concentration, sample volume, adsorption rate, type and dosage of eluent were optimized." | ( [Purification of salidroside in Rhodiola crenulata with macroporous resin]. Chen, J; Wang, CQ, 2011) | 0.37 |
| "Cells irradiated by UVB at various dosage and their viability was assessed by MTT assays, cell cycle was analysed by flow cytometry." | ( Differential responses to UVB irradiation in human keratinocytes and epidermoid carcinoma cells. Ding, ZH; Guo, L; Jiang, LH; Liu, WL; Lv, C; Ou, CS; Zheng, L; Zhou, MJ, 2012) | 0.38 |
| " Cells were pre-treated with various doses of salidroside (1, 5 and 10 μM) followed by the sublethal dosage of UVB exposure and then were harvested for various detections, including senescence-associated phenotypes and molecules, alteration of oxidative stress, matrix metalloproteinase-1 (MMP-1) secretion and inflammatory response." | ( Salidroside protects against premature senescence induced by ultraviolet B irradiation in human dermal fibroblasts. Jia, BB; Jin, XQ; Mao, GX; Wang, GF; Wang, YZ; Wen, XL; Xing, WM; Yan, J; Yang, ZX, 2015) | 0.42 |
| " This method has the advantages of simple process and operation, less dosage of organic solvent, highly yield and reproducibility, suitable for the simultaneously preparation of tyrosol, crenulatin and salidroside." | ( [Simultaneously preparation of grams of high purity tyrosol, crenulatin and salidroside from Rhodiola crenulata]. Li, SP; Luo, X; Wang, XJ; Wang, ZZ; Xiao, W; Zhang, Q; Zhao, YW, 2015) | 0.42 |
| " With extraction rate of salidroside, tyrosol, crenulatin and gallic acid as indexes, orthogonal test was used to evaluate effect of 4 factors on extracting technology, including concentration of solvent, the dosage of solvent, duration of extraction, and frequency of extraction." | ( [Optimization of extraction technology for salidroside, tyrosol, crenulatin and gallic acid in Rhodiolae Crenulatae Radix et Rhizoma with orthogonal test]. Huang, WZ; Luo, X; Wang, XJ; Wang, ZZ; Xiao, W; Zhao, YW, 2015) | 0.42 |
| " Here, we examined obese mice treated with salidroside at the dosage of 50 mg/kg/day for 48 days." | ( Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus. Guo, S; Jiang, K; Liu, X; Luo, L; Shen, N; Sun, C; Wang, C; Wang, M; Xu, M; Yang, Y; Yao, L, 2016) | 0.43 |
| " Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n = 10); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500 ppm for 60 days, n = 10); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150 mg/kg body weight for 60 days, n = 10); and high dosage of SDS-treated group (PbAc-SDS-H, lead acetate exposed animals were given intragastric SDS 300 mg/kg body weight for 60 days, n = 10)." | ( Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats. Chen, C; He, J; Lin, B; Qi, S; Zheng, H, 2019) | 0.51 |
| "Salidroside significantly increased the ADSCs viability at a dose-response manner." | ( Salidroside promoted osteogenic differentiation of adipose-derived stromal cells through Wnt/β-catenin signaling pathway. Chen, FL; Li, XH; Shen, HL, 2021) | 0.62 |
| " Additionally, the appropriate dosage and side effects of SAL on the clinical outcomes of CNS diseases have not been fully determined due to the limited number of clinical studies on SAL." | ( Pharmacological effects of salidroside on central nervous system diseases. Han, D; Jin, M; Wang, C; Wu, X; Xu, Y; Ye, R; Zhang, Q; Zhang, Z, 2022) | 0.72 |
| " The expression of smad3 and β-catenin was suppressed and positively correlated with the dosage of SAL." | ( Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis. Ji, X; Lan, Y; Li, Y; Ma, J; Ma, L; Wang, A, 2023) | 0.91 |
| Class | Description |
|---|---|
| glycoside | A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| salidroside biosynthesis | 2 | 15 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.3491 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 21.1317 | 0.0010 | 22.6508 | 76.6163 | AID1224838 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Ribonuclease HI | Escherichia coli K-12 | IC50 (µMol) | 20.0000 | 2.0000 | 2.2500 | 2.5000 | AID594714 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 (µMol) | 72.0000 | 0.0002 | 1.5574 | 10.0000 | AID403341 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 (µMol) | 0.8100 | 0.0000 | 1.8914 | 9.5700 | AID1706736 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 0.9200 | 0.0006 | 1.7771 | 10.0000 | AID1706738 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1856006 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as downregulation of cecal ligation induced GRP78 level at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818711 | Angiogenic activity in mouse MOVAS-1 cells assessed as suppression of F-actin polymerization at 30 uM using conditioned medium of mouse C2C12 cells treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 12 hrs by phalloidin stai | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1855995 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in serum IL-1beta at 50 mg/kg, ip and measured after 24 hrs by ELISA | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818722 | Metabolic stability in rat leg muscle homogenates assessed as compound remaining after 30 min by HPLC analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID594715 | Inhibition of human recombinant ribonuclease H after 30 mins by FRET quenching assay | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. |
| AID1818730 | Antidiabetic activity in diabetic HLI C57BL/6 mouse model assessed as morphological changes at 100 mg/kg administered intramuscularly | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1706735 | n-Octanol/saturated water patition coefficient, logP of the compound at 0.05 mg/ml incubated for 24 hrs by HPLC analysis | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID594717 | Inhibition of HIV2 recombinant ribonuclease H after 30 mins by FRET quenching assay | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. |
| AID1815717 | Decrease in MDR1 gene expression in DOX induced human HeLa cells by RT-PCR analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677334 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as late apoptotic cells at 300 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 0.13%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856010 | Upregulation of PPP1R15A expression in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hrs by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID625307 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric analysis | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Secoiridoid glucosides and related compounds from Syringa reticulata and their antioxidant activities. |
| AID1706737 | Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate preincubated with enzyme for 10 mins followed by addition of substrate and measured afte | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID677326 | Cytoprotective activity in human erythrocytes assessed as protection against H202-induced hemolysis at 50 to 100 uM from 2 to 24 hrs by spectrophotometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856018 | Induction of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as early apoptotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=11%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815730 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as change in body weight at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1855996 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in serum TNF-alpha at 50 mg/kg, ip and measured after 24 hrs by ELISA | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818650 | Octanol/Water partition coefficient, log P of the compound by HPLC-UV analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1856011 | Cytotoxicity against LPS-stimulated human HBE cells assessed as increase in cell viability at 40 uM and measured for 24 to 72 hrs by CCK-8 assay | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID403341 | Inhibition of COX1 | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7 | Expanding the ChemGPS chemical space with natural products. |
| AID1818694 | Reversal of hyperglycemia-induced PDGF-BB protein level reduction in mouse C2C12 cells measured at 30 uM by ELISA | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815712 | Downregulation of doxorubicin induced MMP-2 protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677420 | Cytoprotective activity in human erythrocytes assessed as decrease in ionomycin-induced cytosolic free calcium level at 100 uM after 24 hrs by Fluo4 staining-based assay (Rvb = 1.76%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856003 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in albumin content in alveolar lavage fluid supernatant at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677340 | Induction of eryptosis in human erythrocytes assessed as early apoptotic cells at 300 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 2.59%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID614465 | Neuroprotective activity in rat differentiated PC12 cells assessed reduction of hypoglycemia and serum limitation-induced caspase 3 activity at 40 uM after 24 hrs by colorimetric assay relative to control | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. |
| AID1856036 | Inhibition of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as late apoptotic cells at 40 uM incubated for 1 hr in presence of TUDCA by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=5.08%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818746 | Angiogenesis activity in diabetic HLI C57BL/6 mouse model assessed as PDGF-BB protein expression at 100 mg/kg, im administered for 21 days followed by surgery by Western blot analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID677331 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as early apoptotic cells at 100 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 9.34%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID677416 | Cytoprotective activity in human erythrocytes assessed as decrease in caspase-3-mediated FAM-DEVD-FMK cleavage at 300 uM after 24 hrs by fluorometric assay (Rvb = 0.28%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID677413 | Cytoprotective activity against H202-induced apoptosis in human erythrocytes assessed as decrease in cytosolic free calcium level after 24 hrs by PE-annexinV/Fluor4 flow cytometric analysis | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815693 | Induction of morphological change in human HeLa cells assessed as reduction in size measured after 48 hrs by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1818708 | Induction proliferation of mouse MOVAS-1 cells assessed as increase in number of EdU-positive cells using conditioned medium of mouse C2C12 cells treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs by EdU-incorporation | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1855994 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in lung injury at 50 mg/kg, ip and measured after 24 hrs by H and E staining based analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677337 | Induction of eryptosis in human erythrocytes assessed as very early apoptotic cells at 100 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 0.2%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815694 | Induction of morphological change in human HeLa cells assessed as potentiation of doxorubicin induced cell shrinkage measured after 48 hrs in by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856035 | Inhibition of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as early apoptotic cells at 40 uM incubated for 1 hr in presence of TUDCA by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=9.22%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1856000 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in neutrophil elastase activity in BALF at 50 mg/kg, ip and measured after 24 hrs by Elastase assay | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815708 | Downregulation of PI3K protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1818648 | Water solubility of the compound by HPLC analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1856024 | Downregulation of CHOP expression in LPS-stimulated human HBE cells at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815690 | Effect on DOX induced tissue damage in BALB/c nude mouse xenografted with human HeLa cells assessed as appearance of lesions in glomerular tubule at 80 mg/kg, ig for administered every 2 days for 18 days by H and E staining | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1855998 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in total cell number in BALF at 50 mg/kg, ip and measured after 24 hrs by cell counter analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815689 | Effect on DOX induced tissue damage in BALB/c nude mouse xenografted with human HeLa cells assessed as spleen enlargement at 80 mg/kg, ig administered every 2 days for 18 days by H and E staining | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677426 | Antioxidant activity in human erythrocytes assessed as decrease in H202-induced ROS production at 300 uM after 24 hrs by DCF-based flow cytometric analysis (Rvb = 68.32%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815695 | Induction of morphological change in human HeLa cells assessed as potentiation of doxorubicin induced reduction in size measured after 48 hrs in presence of doxorubicin by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1815687 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID458986 | Hepatoprotective activity in ddY mouse primary cultured hepatocytes assessed as inhibition of D-galactosamine-induced cytotoxicity at 100 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID1815716 | Upregulation of doxorubicin induced BAX protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677425 | Antioxidant activity in human erythrocytes assessed as decrease in H202-induced ROS production at 100 uM after 24 hrs by DCF-based flow cytometric analysis (Rvb = 68.32%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815704 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as potentiation of doxorubicin induced inflammation in myocardial tissue at 80 mg/kg, ig administered every 2 days for 18 days by H and E staining | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856014 | Inhibition of apoptosis in LPS-stimulated human HBE cells assessed as early apoptotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=21.5%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815711 | Downregulation of doxorubicin induced Bcl-2 protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677414 | Cytoprotective activity against H202-induced apoptosis in human erythrocytes assessed as decrease in phosphatidylserine externalization after 24 hrs by PE-annexinV/Fluor4 flow cytometric analysis | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID677415 | Cytoprotective activity in human erythrocytes assessed as decrease in caspase-3-mediated FAM-DEVD-FMK cleavage at 100 uM after 24 hrs by fluorometric assay (Rvb = 0.28%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856013 | Inhibition of apoptosis in LPS-stimulated human HBE cells assessed as necrotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=0.444%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID614463 | Neuroprotective activity in rat differentiated PC12 cells assessed protection against hypoglycemia and serum limitation-induced early stage of apoptosis at 40 uM after 24 hrs using annexin V/propidium iodide double staining by flow cytometry | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. |
| AID1815733 | Antitumor activity against DOX induced human HeLa cells xenografted in BALB/c nude mouse assessed as induction of apoptosis by measuring increase in TUNEL positive nuclei at 80 mg/kg, ig administered every 2 days for 18 days by TUNEL staining based assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1815718 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as induction of convulsions at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856030 | Downregulation of GRP78 in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr in presence of TUDCA by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818640 | Protein binding in human plasma by balanced dialysis method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID677330 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as very early apoptotic cells at 300 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 27.15%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815732 | Toxicity in DOX induced BALB/c nude mouse xenografted with human HeLa cells assessed as change in body weight at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1815709 | Downregulation of AKT protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677325 | Cytoprotective activity in human erythrocytes assessed as protection against H202-induced hemolysis from 2 to 24 hrs by spectrophotometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856029 | Downregulation of phosphorylated eIF-2alpha expression in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr in presence of TUDCA by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1856027 | Downregulation of ATF4 expression in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818692 | Reversal of hyperglycemia-induced PDGF-BB protein level reduction in mouse C2C12 cells measured at 30 uM by Western blot analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1818706 | Angiogenesis activity in mouse MOVAS-1 assessed as increase of cell migration using conditioned medium of mouse C2C12 cells with silenced HIF-1alpha treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs by crystal violet | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1855997 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in serum IL-6 at 50 mg/kg, ip and measured after 24 hrs by ELISA | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815684 | Cytotoxicity against human HeLa cells assessed as potentiation of doxorubicin induced cell survival measured after 72 hrs by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID594716 | Inhibition of HIV1 recombinant ribonuclease H after 30 mins by FRET quenching assay | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. |
| AID677332 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as early apoptotic cells at 300 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 9.34%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID614464 | Neuroprotective activity in rat differentiated PC12 cells assessed protection against hypoglycemia and serum limitation-induced late stage of apoptosis at 40 uM after 24 hrs using annexin V/propidium iodide double staining by flow cytometry | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. |
| AID1856026 | Downregulation of GRP78 expression in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID614466 | Neuroprotective activity in rat differentiated PC12 cells assessed reversal of hypoglycemia and serum limitation-induced mitochondrial membrane potential at 40 uM after 24 hrs using Rhodamine dye by confocal microscopic analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. |
| AID677339 | Induction of eryptosis in human erythrocytes assessed as early apoptotic cells at 100 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 2.59%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1706736 | Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate preincubated with enzyme for 10 mins followed by addition of substrate and measured afte | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID1815728 | Toxicity in DOX induced BALB/c nude mouse xenografted with human HeLa cells assessed as induction of fainting at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1818747 | Angiogenesis activity in diabetic HLI C57BL/6 mouse model assessed as VEGF-A protein expression at 100 mg/kg, im administered for 21 days followed by surgery by Western blot analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815727 | Toxicity in DOX induced BALB/c nude mouse xenografted with human HeLa cells assessed as induction of breathing difficulties at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1818651 | Permeability coefficient across apical to basolateral side in human Caco-2 cells by HPLC-UV analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID677411 | Induction of eryptosis in human erythrocytes assessed as late apoptotic cells at 100 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 0%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1706732 | Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability at 1 uM pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID1815719 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as induction of breathing difficulties at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1815714 | Downregulation of doxorubicin induced PI3K protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID458985 | Hepatoprotective activity in ddY mouse primary cultured hepatocytes assessed as inhibition of D-galactosamine-induced cytotoxicity at 30 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID677323 | Toxicity in human erythrocytes assessed as hemolysis up to 800 uM after 2 hrs by spectrophotometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1818649 | Dissociation constant, pKa of compound by UV-visible spectrometric method | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815688 | Inhibition of hypoxia-inducible factor 1 alpha in DOX induced human HeLa cells assessed as downregulation of protein at 0.017 mmol/L after 48 hrs by Western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856033 | Cytotoxicity against LPS-stimulated human HBE cells with silenced PPP1R15A assessed as increase in cell viability at 40 uM and measured for 24 to 72 hrs in presence of TUDCA by CCK-8 assay | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1856031 | Downregulation of ATF4 in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr in presence of TUDCA by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815706 | Downregulation of MMP-2 protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856002 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in lung water content at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1855999 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in neutrophil number in BALF at 50 mg/kg, ip and measured after 24 hrs by cell counter analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677412 | Induction of eryptosis in human erythrocytes assessed as late apoptotic cells at 300 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 0%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1818695 | Induction of F-actin polymerization in mouse C2C12 cells at 30 uM pretreated with compound for 12 hr followed by hypoxic condition for 24 hrs by phalloidin staining based confocal microscopy | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815683 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as inflammation in myocardial tissue at 80 mg/kg, ig administered every 2 days for 18 days by H and E staining | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677324 | Toxicity in human erythrocytes assessed as hemolysis up to 400 uM after 24 hrs by spectrophotometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1818720 | Stability in rat plasma assessed as compound remaining at 6.25 to 25 mg/L after 12 hrs by HPLC analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID677424 | Antioxidant activity in human erythrocytes assessed as decrease in H202-induced ROS production after 24 hrs by DCF-based flow cytometric analysis | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID677423 | Cytoprotective activity in human erythrocytes assessed as decrease in STS-mediated caspase3 activation at 300 uM after 24 hrs by fluorimetric assay (Rvb = 58.78%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856034 | Inhibition of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as necrotic cells at 40 uM incubated for 1 hr in presence of TUDCA by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=2.48%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1706739 | Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI cells assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate at 0.025 to 0.125 uM preincubated with enzyme for 10 mins followed by addition of substr | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID458984 | Hepatoprotective activity in ddY mouse primary cultured hepatocytes assessed as inhibition of D-galactosamine-induced cytotoxicity at 10 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID1856028 | Downregulation of CHOP expression in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818707 | Angiogenesis activity in human HUVEC cells assessed as increase of cell migration using conditioned medium of mouse C2C12 cells with silenced HIF-1alpha treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs by crystal vi | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1706738 | Competitive inhibition of human recombinant MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of 4-hydroxyquinoline formation using varying concentration of kynuramine as substrate preincubated with enzyme for 10 mins followed by ad | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID1706733 | Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID1856007 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as downregulation of cecal ligation induced ATF4 level at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677338 | Induction of eryptosis in human erythrocytes assessed as very early apoptotic cells at 300 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 0.2%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856023 | Downregulation of ATF4 expression in LPS-stimulated human HBE cells at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID598191 | Antiproliferative activity against PDGF-BB-induced rat VSMC proliferation at 50 uM after 24 hrs by WST1 (CCK-8) assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11 | A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis. |
| AID1818726 | Antidiabetic activity in diabetic HLI C57BL/6 mouse model assessed as effect on blood glucose level at 15 mg/kg administered intramuscular | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1818715 | Induction proliferation of mouse MOVAS-1 assessed as increase in number of EdU-positive cells using conditioned medium of mouse C2C12 cells with silenced HIF-1alpha treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs b | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815705 | Downregulation of Bcl-2 protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856032 | Downregulation of CHOP in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr in presence of TUDCA by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815720 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as induction of fainting at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID614461 | Neuroprotective activity in rat differentiated PC12 cells assessed protection against hypoglycemia and serum limitation-induced decrease in cell viability at 40 uM after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. |
| AID1815692 | Induction of morphological change in human HeLa cells assessed as cell shrinkage measured after 48 hrs by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677418 | Cytoprotective activity in human erythrocytes assessed as decrease in H202-induced caspase-3-mediated FAM-DEVD-FMK cleavage at 100 uM after 24 hrs by fluorometric assay (Rvb = 51.22%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID677421 | Cytoprotective activity in human erythrocytes assessed as decrease in ionomycin-induced cytosolic free calcium level at 300 uM after 24 hrs by Fluo4 staining-based assay (Rvb = 57.79%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815701 | Antitumor activity against human HeLa cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 80 mg/kg, ig for administered every 2 days for 18 days by firefly luciferase based bioluminescence assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1722044 | Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as cell viability at 30 uM relative to control | 2020 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 30, Issue:17 | New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect. |
| AID1856022 | Downregulation of GRP78 expression in LPS-stimulated human HBE cells at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818712 | Angiogenesis activity in human HUVEC cells assessed as suppression of cell migration using conditioned medium of mouse C2C12 cells treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs by crystal violet dye based transwe | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1856025 | Downregulation of phosphorylated eIF-2alpha expression in LPS-stimulated human HBE cells with silenced PPP1R15A at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1651329 | Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Application of tandem biotransformation for biosynthesis of new pentacyclic triterpenoid derivatives with neuroprotective effect. |
| AID1706734 | Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay relative to control | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. |
| AID677419 | Cytoprotective activity in human erythrocytes assessed as decrease in H202-induced caspase-3-mediated FAM-DEVD-FMK cleavage at 300 uM after 24 hrs by fluorometric assay (Rvb = 51.22%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815691 | Effect on DOX induced tissue damage in BALB/c nude mouse xenografted with human HeLa cells assessed as inflammatory cell infiltration in liver at 80 mg/kg, ig administered every 2 days for 18 days by H and E staining | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677327 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as viable cells at 100 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 63.38%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815707 | Downregulation of MMP-9 protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1722043 | Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability | 2020 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 30, Issue:17 | New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect. |
| AID1856019 | Induction of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as late apoptotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=2.30%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818652 | Permeability coefficient across basolateral to apical side in human Caco-2 cells by HPLC-UV analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1856001 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as reduction in lung wet weight to dry weight ratio at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677328 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as viable cells at 300 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 63.38%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID458983 | Hepatoprotective activity in ddY mouse primary cultured hepatocytes assessed as inhibition of D-galactosamine-induced cytotoxicity at 3 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID1815715 | Downregulation of doxorubicin induced AKT protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1818727 | Antidiabetic activity in diabetic HLI C57BL/6 mouse model assessed as increase in blood perfusion recovery at 100 mg/kg administered intramuscularly | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID677335 | Induction of eryptosis in human erythrocytes assessed as viable cells at 100 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 97.21%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856020 | Induction of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as late apoptotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=85.7%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1856008 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as downregulation of cecal ligation induced CHOP level at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677336 | Induction of eryptosis in human erythrocytes assessed as viable cells at 300 uM after 24 hrs by by PE-annexinV/calcein flow cytometric assay (Rvb = 97.21%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID614462 | Neuroprotective activity in rat differentiated PC12 cells assessed protection against hypoglycemia and serum limitation-induced apoptosis at 40 uM after 24 hrs by Hoechst 33342 staining analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-β-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. |
| AID1818693 | Reversal of hyperglycemia-induced VEGF-A protein level reduction in mouse C2C12 cells measured at 30 uM by ELISA | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1818721 | Microsomal stability in rat liver microsomes assessed as compound remaining after 30 min by HPLC analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1818642 | Reversal of hyperglycemia-induced VEGF-A protein level reduction in mouse C2C12 cells measured at 30 uM by Western blot analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815697 | Antimigratory activity against human HeLa cells at 0.017 mmol/L measured upto 48 hrs by electron microscope based Wound healing assay relative to control | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID458989 | Cytoprotective activity in mouse L929 cells assessed as inhibition of TNF-alpha-induced cytotoxicity at 10 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID677333 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as late apoptotic cells at 100 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 0.13%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1856017 | Induction of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as necrotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=0.518%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID677329 | Cytoprotective activity against H202-induced eryptosis in human erythrocytes assessed as very early apoptotic cells at 100 uM after 24 hrs by PE-annexinV/calcein flow cytometric assay (Rvb = 27.15%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID677422 | Cytoprotective activity in human erythrocytes assessed as decrease in STS-mediated caspase3 activation at 100 uM after 24 hrs by fluorimetric assay (Rvb = 58.78%) | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815726 | Toxicity in DOX induced BALB/c nude mouse xenografted with human HeLa cells assessed as induction of convulsions at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID677417 | Cytoprotective activity in human erythrocytes assessed as decrease in H202-induced caspase-3-mediated FAM-DEVD-FMK cleavage after 24 hrs by fluorometric assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. |
| AID1815713 | Downregulation of doxorubicin induced MMP-9 protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID458991 | Cytoprotective activity in mouse L929 cells assessed as inhibition of TNF-alpha-induced cytotoxicity at 100 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID1815710 | Upregulation of BAX protein expression in human HeLa cells after 48 hrs by western blotting analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1815721 | Toxicity in BALB/c nude mouse xenografted with human HeLa cells assessed as induction of incontinence at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856004 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as upregulation of cecal ligation inhibited PPP1R15A at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818641 | Efflux ratio of Apparent permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815685 | Decrease in MDR1 gene expression in human HeLa cells by qRT-PCR analysis | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856009 | Upregulation of PPP1R15A expression in LPS-stimulated human HBE cells assessed as inhibition of LPS down regulated PPP1R15A expression at 40 uM incubated for 1 hrs by qRT-PCR analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID458988 | Cytoprotective activity in mouse L929 cells assessed as inhibition of TNF-alpha-induced cytotoxicity at 3 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID1856016 | Inhibition of apoptosis in LPS-stimulated human HBE cells assessed as viable cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=72.3%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID625306 | Antioxidant activity assessed as superoxide radical scavenging activity after 20 mins by spectrophotometric analysis | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Secoiridoid glucosides and related compounds from Syringa reticulata and their antioxidant activities. |
| AID1856015 | Inhibition of apoptosis in LPS-stimulated human HBE cells assessed as late apoptotic cells at 40 uM incubated for 1 hr by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=5.75%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815696 | Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1856012 | Cytotoxicity against LPS-stimulated human HBE cells with silenced PPP1R15A assessed as cell viability at 40 uM and measured for 24 to 72 hrs by CCK-8 assay | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1815698 | Inhibition of potentiation of doxorubicin induced cell migration in human HeLa cells measured upto 48 hrs by electron microscope based Wound healing assay relative to control | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1815729 | Toxicity in DOX induced BALB/c nude mouse xenografted with human HeLa cells assessed as induction of incontinence at 80 mg/kg, ig administered every 2 days for 18 days | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID594714 | Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. |
| AID1856005 | Protection against cecal ligation-induced Sprague-Dawley rat sepsis associated acute lung injury model assessed as downregulation of cecal ligation induced phosphorylated eIF-2alpha level at 50 mg/kg, ip and measured after 24 hrs | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818710 | Angiogenic activity in human HUVEC cells assessed as suppression of F-actin polymerization at 30 uM using conditioned medium of mouse C2C12 cells treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 12 hrs by phalloidin staini | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1815702 | Antitumor activity against human HeLa cells xenografted in BALB/c nude mouse assessed as potentiation of doxorubicin induced tumor growth inhibition at 80 mg/kg, ig administered every 2 days for 18 days by firefly luciferase based bioluminescence assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins. |
| AID1818713 | Angiogenesis activity in mouse MOVAS-1 cells assessed as suppression of cell migration using conditioned medium of mouse C2C12 cells treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs by crystal violet dye based trans | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1856037 | Inhibition of apoptosis in LPS-stimulated human HBE cells with silenced PPP1R15A assessed as necrotic cells at 40 uM incubated for 1 hr in presence of TUDCA by AnnexinV-FITC/PI staining based flow cytometric analysis (Rvb=83.2%) | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818709 | Induction proliferation of human HUVEC cells assessed as increase in number of EdU-positive cells using conditioned medium of mouse C2C12 cells treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 hrs by EdU-incorporation a | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID458990 | Cytoprotective activity in mouse L929 cells assessed as inhibition of TNF-alpha-induced cytotoxicity at 30 ug/mL after 44 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. |
| AID1818748 | Angiogenesis activity in diabetic HLI C57BL/6 mouse model assessed as HIF-1alpha protein expression at 100 mg/kg, im administered for 21 days followed by surgery by Western blot analysis | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1818696 | Induction of cell migration in mouse C2C12 cells at 30 uM under hyperglycemic condition incubated for 24 hrs by crystal violet dye based transwell chamber assay | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1856021 | Downregulation of phosphorylated eIF-2alpha expression in LPS-stimulated human HBE cells at 40 uM incubated for 1 hr by western blot analysis | 2022 | Bioorganic & medicinal chemistry, 10-01, Volume: 71 | Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. |
| AID1818714 | Induction proliferation of human HUVEC cells assessed as increase in number of EdU-positive cells using conditioned medium of mouse C2C12 cells with silenced HIF-1alpha treated at 30 uM under hyperglycemic condition for 12 hrs followed by hypoxia for 24 h | 2022 | Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1 | Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (1.14) | 18.2507 |
| 2000's | 68 (11.11) | 29.6817 |
| 2010's | 346 (56.54) | 24.3611 |
| 2020's | 191 (31.21) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.96) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.32%) | 5.53% |
| Reviews | 23 (3.70%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 1 (0.16%) | 0.25% |
| Other | 595 (95.81%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||